Published in Nature on February 12, 1986
The influence of intracellular calcium concentration on degranulation of dialysed mast cells from rat peritoneum. J Physiol (1988) 3.03
Phase tracking: an improved phase detection technique for cell membrane capacitance measurements. Biophys J (1989) 2.86
Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol (1993) 1.80
The exocytotic fusion pore of small granules has a conductance similar to an ion channel. J Cell Biol (1995) 1.63
Second messenger-activated calcium influx in rat peritoneal mast cells. J Physiol (1989) 1.62
Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells. J Gen Physiol (1999) 1.59
Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils. Proc Natl Acad Sci U S A (2000) 1.58
Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages. J Biol Chem (2009) 1.37
Voltage-gated and agonist-mediated rises in intracellular Ca2+ in rat clonal pituitary cells (GH3) held under voltage clamp. J Physiol (1989) 1.35
Membrane chloride conductance and capacitance in Jurkat T lymphocytes during osmotic swelling. Biophys J (1994) 1.27
Immunoglobulin E receptor-activated calcium conductance in rat mast cells. J Physiol (1995) 1.27
Rat basophilic leukemia cells stiffen when they secrete. J Cell Biol (1987) 1.26
Gradual and stepwise changes in the membrane capacitance of rat peritoneal mast cells. J Physiol (1987) 1.25
Membrane capacitance changes associated with particle uptake during phagocytosis in macrophages. Biophys J (1998) 1.21
An optimized approach to membrane capacitance estimation using dual-frequency excitation. Biophys J (1997) 1.19
Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells. Proc Natl Acad Sci U S A (1988) 1.16
A patch-clamp study of mammalian platelets and their voltage-gated potassium current. J Physiol (1987) 1.14
G protein control of potassium channel activity in a mast cell line. J Gen Physiol (1990) 1.10
Improved surface-patterned platinum microelectrodes for the study of exocytotic events. Anal Chem (2009) 1.05
Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils. J Exp Med (1990) 1.03
Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release. J Cell Biol (1987) 1.01
Anion transport and GABA signaling. Front Cell Neurosci (2013) 0.91
Fusion of membranes during fertilization. Increases of the sea urchin egg's membrane capacitance and membrane conductance at the site of contact with the sperm. J Gen Physiol (1992) 0.90
Immunologically activated chloride channels involved in degranulation of rat mucosal mast cells. EMBO J (1991) 0.85
Mechanisms of granule membrane recapture following exocytosis in intact mast cells. J Biol Chem (2013) 0.83
IgE-receptor activated chloride uptake in relation to histamine secretion from rat mast cells. Br J Pharmacol (1994) 0.76
Analysis of electrophysiological properties and responses of neutrophils. Methods Mol Biol (2014) 0.76
Nobel lecture. Ion channels for communication between and within cells. EMBO J (1992) 0.76
A comparison of serotonin neuromodulation of mouse spinal V2a interneurons using perforated patch and whole cell recording techniques. Front Cell Neurosci (2012) 0.76
Involvement of apamin-sensitive K+ channels in antigen-induced spasm of guinea-pig isolated trachea. Br J Pharmacol (1994) 0.75
The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase. Immunol Rev (2016) 0.75
Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. Elife (2017) 0.75
Zf-and-Hsys-based Cm measurement under the whole-cell patch-clamp recording. Pflugers Arch (2008) 0.75
Ultrasonic bath depth control and regulation in single cell recordings. Pflugers Arch (2006) 0.75
Reversible unfolding of individual titin immunoglobulin domains by AFM. Science (1997) 19.62
Lambda ZAP: a bacteriophage lambda expression vector with in vivo excision properties. Nucleic Acids Res (1988) 16.27
Mechanical and chemical unfolding of a single protein: a comparison. Proc Natl Acad Sci U S A (1999) 7.74
The molecular elasticity of the extracellular matrix protein tenascin. Nature (1998) 6.98
Mechanical unfolding intermediates in titin modules. Nature (1999) 6.12
Capacitance measurements reveal stepwise fusion events in degranulating mast cells. Nature (1985) 5.41
The exocytotic event in chromaffin cells revealed by patch amperometry. Nature (1997) 3.69
High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism. Nat Cell Biol (1999) 3.40
Membrane patches and whole-cell membranes: a comparison of electrical properties in rat clonal pituitary (GH3) cells. J Physiol (1984) 3.17
Stepwise unfolding of titin under force-clamp atomic force microscopy. Proc Natl Acad Sci U S A (2001) 3.13
Aspartic acid-96 is the internal proton donor in the reprotonation of the Schiff base of bacteriorhodopsin. Proc Natl Acad Sci U S A (1989) 3.06
Atomic force microscopy reveals the mechanical design of a modular protein. Proc Natl Acad Sci U S A (2000) 3.04
Mechanical design of proteins studied by single-molecule force spectroscopy and protein engineering. Prog Biophys Mol Biol (2000) 3.00
Phase tracking: an improved phase detection technique for cell membrane capacitance measurements. Biophys J (1989) 2.86
Capacitance measurements. An analysis of the phase detector technique used to study exocytosis and endocytosis. Biophys J (1988) 2.85
Polysaccharide elasticity governed by chair-boat transitions of the glucopyranose ring. Nature (1998) 2.47
The study of protein mechanics with the atomic force microscope. Trends Biochem Sci (1999) 2.34
Atomic force microscopy captures length phenotypes in single proteins. Proc Natl Acad Sci U S A (1999) 2.28
Multiple conformations of PEVK proteins detected by single-molecule techniques. Proc Natl Acad Sci U S A (2001) 2.22
Stretching single molecules into novel conformations using the atomic force microscope. Nat Struct Biol (2000) 2.21
Point mutations alter the mechanical stability of immunoglobulin modules. Nat Struct Biol (2000) 2.12
The exocytotic fusion pore. J Cell Biol (1992) 2.10
Localization of the site of Ca2+ release at the level of a single sarcomere in skeletal muscle fibres. Nature (1994) 2.05
The secretory granule matrix: a fast-acting smart polymer. Science (1993) 2.04
The exocytotic fusion pore and neurotransmitter release. Neuron (1994) 2.01
The exocytotic fusion pore modeled as a lipidic pore. Biophys J (1992) 1.99
Tension in secretory granule membranes causes extensive membrane transfer through the exocytotic fusion pore. Proc Natl Acad Sci U S A (1990) 1.95
Axonal stimulation for end-plate jitter studies. J Neurol Neurosurg Psychiatry (1986) 1.94
Distributed kinetics of the charge movements in bacteriorhodopsin: evidence for conformational substates. Biophys J (1988) 1.89
Single protein misfolding events captured by atomic force microscopy. Nat Struct Biol (1999) 1.67
Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils. Biophys J (2001) 1.67
The exocytotic fusion pore of small granules has a conductance similar to an ion channel. J Cell Biol (1995) 1.63
Pre- and postfusion regulation of transmitter release. Neuron (1997) 1.49
Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells. Proc Natl Acad Sci U S A (1995) 1.49
A patch-clamp study of histamine-secreting cells. J Gen Physiol (1986) 1.44
A low-cost method for rapid transfer function measurements with direct application to biological impedance analysis. Pflugers Arch (1981) 1.43
Fingerprinting polysaccharides with single-molecule atomic force microscopy. Nat Biotechnol (2001) 1.43
Exo-endocytosis and closing of the fission pore during endocytosis in single pituitary nerve terminals internally perfused with high calcium concentrations. Proc Natl Acad Sci U S A (1994) 1.42
Exocytotic fusion is activated by Rab3a peptides. Nature (1992) 1.41
The fusion pore and mechanisms of biological membrane fusion. Curr Opin Cell Biol (1996) 1.41
Compound versus multigranular exocytosis in peritoneal mast cells. J Gen Physiol (1990) 1.41
Is swelling of the secretory granule matrix the force that dilates the exocytotic fusion pore? Biophys J (1991) 1.40
Pulsed laser imaging of rapid Ca2+ gradients in excitable cells. Biophys J (1994) 1.40
The dynamics of exocytosis in human neutrophils. J Cell Biol (1988) 1.31
ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells. J Gen Physiol (1990) 1.29
Focal exocytosis by eosinophils--compound exocytosis and cumulative fusion. EMBO J (1993) 1.28
Events leading to the opening and closing of the exocytotic fusion pore have markedly different temperature dependencies. Kinetic analysis of single fusion events in patch-clamped mouse mast cells. Biophys J (1992) 1.26
Fusion pore expansion in horse eosinophils is modulated by Ca2+ and protein kinase C via distinct mechanisms. EMBO J (1998) 1.24
Atomic levers control pyranose ring conformations. Proc Natl Acad Sci U S A (1999) 1.23
Atomic force microscopy captures quantized plastic deformation in gold nanowires. Proc Natl Acad Sci U S A (2000) 1.20
Resolution of patch capacitance recordings and of fusion pore conductances in small vesicles. Biophys J (2000) 1.19
Simultaneous capacitance and amperometric measurements of exocytosis: a comparison. Biophys J (1996) 1.19
Kinetics of release of serotonin from isolated secretory granules. II. Ion exchange determines the diffusivity of serotonin. Biophys J (1997) 1.17
Patch-clamp measurements reveal multimodal distribution of granule sizes in rat mast cells. J Cell Biol (1990) 1.15
Occupational radiation doses in interventional cardiology: a 15-year follow-up. Br J Radiol (2006) 1.14
Individual differences in vowel production. J Acoust Soc Am (1993) 1.13
A novel Ca(2+)-dependent step in exocytosis subsequent to vesicle fusion. FEBS Lett (1995) 1.12
Thin-section ratiometric Ca2+ images obtained by optical sectioning of fura-2 loaded mast cells. J Cell Biol (1992) 1.11
Atomic force microscopy study of the secretory granule lumen. Biophys J (1996) 1.07
GTP gamma S stimulates exocytosis in patch-clamped rat melanotrophs. Neuron (1993) 1.06
Single molecular force spectroscopy of modular proteins in the nervous system. Neuron (2000) 1.05
The events leading to secretory granule fusion. Soc Gen Physiol Ser (1988) 1.04
Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study. Dement Geriatr Cogn Disord (2010) 1.04
Influence of patient thickness and operation modes on occupational and patient radiation doses in interventional cardiology. Radiat Prot Dosimetry (2006) 1.03
Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils. J Exp Med (1990) 1.03
The exocytotic fusion pore interface: a model of the site of neurotransmitter release. Mol Membr Biol (1995) 1.02
Influence of conductance changes on patch clamp capacitance measurements using a lock-in amplifier and limitations of the phase tracking technique. Biophys J (1995) 1.02
Capacitance flickers and pseudoflickers of small granules, measured in the cell-attached configuration. Biophys J (1998) 1.02
Hydrophobic ions amplify the capacitive currents used to measure exocytotic fusion. Biophys J (1995) 1.01
Image retake analysis in digital radiography using DICOM header information. J Digit Imaging (2008) 1.00
Kinetics of release of serotonin from isolated secretory granules. I. Amperometric detection of serotonin from electroporated granules. Biophys J (1997) 0.98
Skin dose and dose-area product values for interventional cardiology procedures. Br J Radiol (2001) 0.98
Patient dose reference levels for interventional radiology: a national approach. Cardiovasc Intervent Radiol (2008) 0.98
Intracellular stimulation of mast cells with guanine nucleotides mimic antigenic stimulation. FEBS Lett (1987) 0.98
Mechanism of peptide-induced mast cell degranulation. Translocation and patch-clamp studies. J Gen Physiol (1998) 0.97
Autosomal dominant limb-girdle muscular dystrophy: a large kindred with evidence for anticipation. Neurology (2001) 0.95
Detection of the 5'-cap structure of messenger RNAs with the use of the cap-jumping approach. Nucleic Acids Res (2001) 0.95
Robust, high-resolution, whole cell patch-clamp capacitance measurements using square wave stimulation. Biophys J (2001) 0.94
Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells. J Biol Chem (2001) 0.94
Nonlinear voltage dependence of the light-driven proton pump current of bacteriorhodopsin. Biophys J (1988) 0.94
Regulation of granule size in human and horse eosinophils by number of fusion events among unit granules. J Physiol (1995) 0.93
Peripheral neuropathy in essential mixed cryoglobulinemia. Arch Neurol (1988) 0.93
Characterization of a novel myeloid antigen regulated during differentiation of monocytic cells. Eur J Immunol (1989) 0.93
Patch clamp studies of single intact secretory granules. Biophys J (1993) 0.92
A fusion pore phenotype in mast cells of the ruby-eye mouse. Proc Natl Acad Sci U S A (1996) 0.91
Paediatric entrance doses from exposure index in computed radiography. Phys Med Biol (2008) 0.91
Membrane capacitance techniques to monitor granule exocytosis in neutrophils. J Immunol Methods (1999) 0.91
Patient radiation dose management in the follow-up of potential skin injuries in neuroradiology. AJNR Am J Neuroradiol (2012) 0.91
Single molecules. Proc Natl Acad Sci U S A (2001) 0.90
RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells. FEBS Lett (1994) 0.89
Ion-exchange gel regulates neurotransmitter release through the exocytotic fusion pore. Soc Gen Physiol Ser (1996) 0.89
The micro-mechanics of single molecules studied with atomic force microscopy. J Physiol (1999) 0.88
Intracellular Ca(2+) channel immunoreactivity in neuroendocrine axon terminals. FEBS Lett (2000) 0.88
Rhythmic opening and closing of vesicles during constitutive exo- and endocytosis in chromaffin cells. EMBO J (2000) 0.88
Patient dosimetry and image quality in digital radiology from online audit of the X-ray system. Radiat Prot Dosimetry (2006) 0.87
Evaluation of risk of deterministic effects in fluoroscopically guided procedures. Radiat Prot Dosimetry (2006) 0.86
The calcium signal in human neutrophils and its relation to exocytosis investigated by patch-clamp capacitance and Fura-2 measurements. Cell Calcium (1993) 0.86