PubRank

Curtis D Klaassen

Author PubWeight™ 195.30‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 2007 2.11
2 NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. J Pharmacol Exp Ther 2008 2.05
3 Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. Toxicol Sci 2004 1.98
4 Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metab Dispos 2005 1.90
5 Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology 2012 1.77
6 Tissue distribution and ontogeny of sulfotransferase enzymes in mice. Toxicol Sci 2006 1.69
7 Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med 2013 1.67
8 Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos 2005 1.61
9 Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicol Appl Pharmacol 2007 1.60
10 Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab Dispos 2005 1.55
11 Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicol Sci 2009 1.54
12 Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metab Dispos 2006 1.53
13 Introducing the "TCDD-inducible AhR-Nrf2 gene battery". Toxicol Sci 2009 1.50
14 Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps). Drug Metab Dispos 2005 1.49
15 Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips. Pharmacogenet Genomics 2007 1.49
16 Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. Toxicol Sci 2007 1.46
17 Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J Lipid Res 2010 1.45
18 Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol 2006 1.43
19 Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice. Drug Metab Dispos 2012 1.43
20 Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2008 1.42
21 Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicol Sci 2011 1.41
22 Tissue distribution and ontogeny of organic cation transporters in mice. Drug Metab Dispos 2005 1.40
23 Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int 2011 1.34
24 Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J Pharmacol Exp Ther 2010 1.32
25 Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metab Dispos 2004 1.31
26 Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug Metab Dispos 2007 1.29
27 Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology 2010 1.29
28 Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J Biol Chem 2011 1.27
29 Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. Drug Metab Dispos 2009 1.27
30 Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol 2010 1.26
31 Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice. Toxicol Sci 2009 1.26
32 Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Drug Metab Dispos 2006 1.25
33 Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis. Cell Stress Chaperones 2006 1.23
34 CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicol Appl Pharmacol 2009 1.23
35 Oxidative stress and the pathogenesis of cholestasis. Semin Liver Dis 2010 1.22
36 Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun 2005 1.22
37 Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci 2008 1.22
38 Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. J Pharmacol Exp Ther 2010 1.21
39 Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem Pharmacol 2009 1.21
40 Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport. Drug Metab Dispos 2007 1.21
41 Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicol Sci 2008 1.20
42 ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. Toxicol Sci 2009 1.18
43 Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther 2002 1.18
44 Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. Drug Metab Dispos 2008 1.17
45 Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metab Dispos 2008 1.15
46 Gender-specific and developmental influences on the expression of rat organic anion transporters. J Pharmacol Exp Ther 2002 1.15
47 Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS One 2011 1.14
48 Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab 2011 1.14
49 Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicol Sci 2011 1.13
50 Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats. Toxicology 2002 1.13
51 Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice. J Pharmacol Exp Ther 2007 1.12
52 Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. Toxicol Sci 2011 1.12
53 Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. Mol Pharmacol 2002 1.12
54 Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney. Drug Metab Dispos 2009 1.11
55 Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol 2012 1.11
56 Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochem Pharmacol 2007 1.10
57 Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Mol Pharmacol 2009 1.09
58 Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice. Toxicol Sci 2007 1.09
59 Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice. Drug Metab Dispos 2008 1.09
60 Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab Dispos 2003 1.09
61 The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos 2008 1.08
62 Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos 2004 1.08
63 Nrf2 protection against liver injury produced by various hepatotoxicants. Oxid Med Cell Longev 2013 1.07
64 Bromobenzene-induced hepatotoxicity at the transcriptome level. Toxicol Sci 2004 1.07
65 Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. Drug Metab Dispos 2003 1.06
66 Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Mol Pharmacol 2006 1.06
67 Molecular targets of epigenetic regulation and effectors of environmental influences. Toxicol Appl Pharmacol 2010 1.05
68 Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicol Sci 2009 1.04
69 Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers. Toxicol Sci 2008 1.04
70 The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicol Sci 2007 1.04
71 Diurnal variation of hepatic antioxidant gene expression in mice. PLoS One 2012 1.04
72 Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochim Biophys Acta 2006 1.04
73 Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicol Sci 2002 1.03
74 The presence of xenobiotic transporters in rat placenta. Drug Metab Dispos 2003 1.03
75 Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicol Appl Pharmacol 2011 1.03
76 Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice. Life Sci 2008 1.02
77 Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity. Toxicol Appl Pharmacol 2008 1.01
78 Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology 2006 1.01
79 ChIPing the cistrome of PXR in mouse liver. Nucleic Acids Res 2010 1.01
80 Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. PLoS One 2012 1.00
81 Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS One 2012 0.99
82 Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicol Appl Pharmacol 2012 0.99
83 Th2 skewing by activation of Nrf2 in CD4(+) T cells. J Immunol 2012 0.99
84 Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metab Dispos 2009 0.99
85 Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. Mol Pharmacol 2006 0.99
86 Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. J Pharmacol Exp Ther 2006 0.98
87 Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. Toxicol Appl Pharmacol 2012 0.98
88 Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol Lett 2004 0.97
89 Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metab Dispos 2003 0.97
90 Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults). Xenobiotica 2010 0.97
91 Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice. PLoS One 2013 0.95
92 Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. J Pharmacol Exp Ther 2002 0.95
93 Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice. Drug Metab Dispos 2012 0.94
94 Tissue distribution and chemical induction of multiple drug resistance genes in rats. Drug Metab Dispos 2002 0.94
95 Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. Toxicol Sci 2011 0.94
96 Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. Toxicol Sci 2002 0.93
97 RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development. Drug Metab Dispos 2012 0.93
98 Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta. Drug Metab Dispos 2008 0.93
99 Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. Toxicology 2002 0.93
100 Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. Toxicol Sci 2008 0.93
101 Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites. Toxicol Sci 2002 0.92
102 Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy. Toxicol Sci 2012 0.92
103 Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats. Biochem Pharmacol 2005 0.92
104 Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice. Drug Metab Dispos 2009 0.92
105 Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake. Mol Pharmacol 2005 0.91
106 Final report of the safety assessment of methylisothiazolinone. Int J Toxicol 2010 0.91
107 Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock. J Biochem 2009 0.91
108 Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice. Am J Physiol Gastrointest Liver Physiol 2009 0.90
109 Nrf2 protects against diquat-induced liver and lung injury. Free Radic Res 2012 0.90
110 Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Toxicol Sci 2009 0.90
111 Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice. Toxicol Appl Pharmacol 2013 0.90
112 RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicol Sci 2012 0.90
113 Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. Am J Physiol Gastrointest Liver Physiol 2012 0.89
114 Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene. BMC Genet 2006 0.89
115 Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice. Drug Metab Dispos 2012 0.89
116 Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. Free Radic Biol Med 2002 0.89
117 Energy restriction does not compensate for the reduced expression of hepatic drug-processing genes in mice with aging. Drug Metab Dispos 2010 0.89
118 Ontogeny of novel cytochrome P450 gene isoforms during postnatal liver maturation in mice. Drug Metab Dispos 2012 0.88
119 Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats. Comp Biochem Physiol C Toxicol Pharmacol 2004 0.88
120 Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats. Toxicol Sci 2010 0.88
121 Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Drug Metab Dispos 2002 0.88
122 Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol 2005 0.88
123 Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. Int J Toxicol 2009 0.88
124 RNA-sequencing quantification of hepatic ontogeny of phase-I enzymes in mice. Drug Metab Dispos 2013 0.88
125 Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. J Pharmacol Exp Ther 2002 0.88
126 Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. Toxicol Sci 2011 0.88
127 Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice. Mol Cell Biochem 2004 0.87
128 Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice. Toxicol Appl Pharmacol 2002 0.87
129 Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity. Toxicol Sci 2009 0.87
130 Endocrine regulation of rat organic anion transporters. Drug Metab Dispos 2003 0.87
131 Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. Toxicol Appl Pharmacol 2008 0.87
132 Nuclear receptor-mediated regulation of carboxylesterase expression and activity. Expert Opin Drug Metab Toxicol 2010 0.86
133 Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny. Toxicology 2002 0.86
134 Hormonal and chemical regulation of paraoxonases in mice. J Pharmacol Exp Ther 2012 0.86
135 RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice. Drug Metab Dispos 2013 0.86
136 Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver. Toxicol Sci 2010 0.86
137 CYP2D plays a major role in berberine metabolism in liver of mice and humans. Xenobiotica 2011 0.86
138 Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. Toxicol Sci 2008 0.86
139 Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism. Toxicol Sci 2009 0.85
140 Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2011 0.84
141 Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity. Toxicol Appl Pharmacol 2002 0.84
142 Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. Toxicol Appl Pharmacol 2002 0.84
143 Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion. Transplantation 2006 0.84
144 Tissue distribution, ontogeny, and chemical induction of aldo-keto reductases in mice. Drug Metab Dispos 2013 0.84
145 Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). Toxicol Sci 2004 0.84
146 Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing. Epigenetics 2012 0.84
147 Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Toxicol Sci 2012 0.84
148 Gender-divergent profile of bile acid homeostasis during aging of mice. PLoS One 2012 0.84
149 Final report of the Cosmetic Ingredient Review Expert Panel safety assessment of polymethyl methacrylate (PMMA), methyl methacrylate crosspolymer, and methyl methacrylate/glycol dimethacrylate crosspolymer. Int J Toxicol 2011 0.83
150 Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. Toxicol Appl Pharmacol 2013 0.83
151 Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2). Toxicol Sci 2007 0.83
152 Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. Biochem Biophys Res Commun 2004 0.83
153 Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2. Toxicol Sci 2002 0.83
154 Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake. Arch Toxicol 2006 0.83
155 Cadmium accumulation and detoxification by alveolar macrophages of cigarette smokers. Chest 2003 0.82
156 Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4). Drug Metab Dispos 2004 0.82
157 CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats. Xenobiotica 2012 0.81
158 Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. Toxicol Lett 2009 0.81
159 Final report of the Cosmetic Ingredient Review Expert Panel amended safety assessment of Calendula officinalis-derived cosmetic ingredients. Int J Toxicol 2010 0.81
160 Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. J Ethnopharmacol 2011 0.81
161 Role of liver-enriched transcription factors in the down-regulation of organic anion transporting polypeptide 4 (oatp4; oatplb2; slc21a10) by lipopolysaccharide. Mol Pharmacol 2004 0.81
162 Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols. Int J Toxicol 2010 0.80
163 Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver. Drug Metab Dispos 2009 0.80
164 Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers. Toxicol Appl Pharmacol 2003 0.80
165 Final report of the safety assessment of allantoin and its related complexes. Int J Toxicol 2010 0.80
166 Final report of the safety assessment of Kojic acid as used in cosmetics. Int J Toxicol 2010 0.80
167 Role of CYP3A in isoniazid metabolism in vivo. Drug Metab Pharmacokinet 2013 0.80
168 Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase. Toxicol Sci 2004 0.79
169 Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Biochem Pharmacol 2013 0.79
170 Final amended safety assessment of hydroquinone as used in cosmetics. Int J Toxicol 2010 0.79
171 iNOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity. Toxicology 2002 0.79
172 Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity. Toxicol Appl Pharmacol 2012 0.79
173 Safety assessment of borosilicate glasses as used in cosmetics. Int J Toxicol 2013 0.78
174 Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction. Toxicol Appl Pharmacol 2002 0.78
175 Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway. PLoS One 2012 0.78
176 Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 di-methylation during mouse liver development. Toxicol Lett 2009 0.78
177 Determination of transcription start site and analysis of promoter sequence, splice junction sites, intron sequence and codon usage bias of rat liver-specific organic anion transporter-1 (rlst-1/Oatp-4/Slc21a10) gene. DNA Seq 2002 0.78
178 Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver. Drug Metab Dispos 2002 0.77
179 Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. Int J Toxicol 2009 0.77
180 Safety assessment of decyl glucoside and other alkyl glucosides as used in cosmetics. Int J Toxicol 2013 0.77
181 Expression of human CAR splicing variants in BAC-transgenic mice. Toxicol Sci 2012 0.77
182 Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression. Mol Pharmacol 2007 0.77
183 Hormonal regulation of Cyp4a isoforms in mouse liver and kidney. Xenobiotica 2013 0.77
184 Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats. Toxicol Sci 2010 0.77
185 Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. Toxicol Appl Pharmacol 2011 0.77
186 Safety assessment of alkyl benzoates as used in cosmetics. Int J Toxicol 2013 0.77
187 Amended safety assessment of formaldehyde and methylene glycol as used in cosmetics. Int J Toxicol 2013 0.76
188 Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation. Toxicol Appl Pharmacol 2010 0.76
189 Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate. Int J Toxicol 2009 0.76
190 Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane. Int J Toxicol 2011 0.76
191 Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of cocamidopropyl betaine (CAPB). Int J Toxicol 2012 0.76
192 Final report of the amended safety assessment of myristic acid and its salts and esters as used in cosmetics. Int J Toxicol 2010 0.76
193 Effect of various diets on the expression of phase-I drug-metabolizing enzymes in livers of mice. Xenobiotica 2015 0.75
194 Safety assessment of isoparaffins as used in cosmetics. Int J Toxicol 2013 0.75
195 Final report of the Amended Safety Assessment of PVM/MA copolymer and its related salts and esters as used in cosmetics. Int J Toxicol 2011 0.75
196 Final report of the amended safety assessment of Quaternium-15 as used in cosmetics. Int J Toxicol 2010 0.75
197 Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics. Int J Toxicol 2012 0.75
198 Safety assessment of α-amino acids as used in cosmetics. Int J Toxicol 2013 0.75
199 Safety assessment of silylates and surface-modified siloxysilicates. Int J Toxicol 2013 0.75
200 Safety assessment of alkyl PEG ethers as used in cosmetics. Int J Toxicol 2012 0.75
201 Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics. Int J Toxicol 2010 0.75
202 Final report of the safety assessment of cosmetic ingredients derived from Zea mays (corn). Int J Toxicol 2011 0.75
203 Safety assessment of xylene sulfonic acid, toluene sulfonic acid, and alkyl aryl sulfonate hydrotropes as used in cosmetics. Int J Toxicol 2011 0.75
204 Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate. Int J Toxicol 2011 0.75
205 Final amended report of the safety assessment of toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine as used in cosmetics. Int J Toxicol 2010 0.75
206 Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol. Int J Toxicol 2009 0.75
207 Amended safety assessment of sodium picramate and picramic acid. Int J Toxicol 2010 0.75
208 Safety assessment of lauriminodipropionic acid, sodium lauriminodipropionate, and disodium lauriminodipropionate as used in cosmetics. Int J Toxicol 2013 0.75
209 Safety assessment of trimoniums as used in cosmetics. Int J Toxicol 2013 0.75
210 Editorial overview. Xenobiotic and endobiotic transporters: structure, function and regulation. Xenobiotica 2008 0.75
211 Safety assessment of alkyl glyceryl ethers as used in cosmetics. Int J Toxicol 2013 0.75
212 Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine. Curr Drug Metab 2007 0.75
213 Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate. Int J Toxicol 2010 0.75
214 Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics. Int J Toxicol 2010 0.75
215 Safety assessment of diethanolamides as used in cosmetics. Int J Toxicol 2013 0.75
216 Safety assessment of ammonium hectorites as used in cosmetics. Int J Toxicol 2013 0.75
217 Final report on the safety assessment of sodium cetearyl sulfate and related alkyl sulfates as used in cosmetics. Int J Toxicol 2010 0.75
218 Final report on the safety assessment of Basic Violet 1, Basic Violet 3, and Basic Violet 4. Int J Toxicol 2010 0.75
219 Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of dicarboxylic acids, salts, and esters. Int J Toxicol 2012 0.75
220 Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats. Toxicol Sci 2002 0.75
221 Safety assessment of bis-diglyceryl polyacyladipate-2 and bis-diglyceryl polyacyladipate-1 as used in cosmetics. Int J Toxicol 2013 0.75
222 Safety assessment of 1,2-glycols as used in cosmetics. Int J Toxicol 2012 0.75
223 Final report on the safety assessment of Cocos nucifera (coconut) oil and related ingredients. Int J Toxicol 2011 0.75
224 Final report on the safety assessment of amino nitrophenols as used in hair dyes. Int J Toxicol 2010 0.75
225 Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid. Int J Toxicol 2009 0.75
226 Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of methyl acetate. Int J Toxicol 2012 0.75
227 Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of pelargonic acid (nonanoic acid) and nonanoate esters. Int J Toxicol 2011 0.75
228 Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics. Int J Toxicol 2012 0.75
229 Effect of nine diets on xenobiotic transporters in livers of mice. Xenobiotica 2015 0.75
230 Safety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics. Int J Toxicol 2013 0.75
231 Safety assessment of 2-amino-4-hydroxyethylaminoanisole and 2-amino-4-hydroxyethylaminoanisole sulfate as used in cosmetics. Int J Toxicol 2013 0.75