Modifiable risk factors for aneurysmal subarachnoid hemorrhage.

Estrogen protects against intracranial aneurysm rupture in ovariectomized mice. Hypertension (2014) 0.89

Alcohol consumption and risk of subarachnoid hemorrhage: A meta-analysis of 14 observational studies. Biomed Rep (2016) 0.81

THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Stroke (2016) 0.78

Clinical outcome prediction in aneurysmal subarachnoid hemorrhage - Alterations in brain-body interface. Surg Neurol Int (2016) 0.75

Morphological risk factors for the rupture of anterior communicating artery aneurysms: the significance of fenestration. Neuroradiology (2015) 0.75

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30

The DNA-damage response in human biology and disease. Nature (2009) 17.86

Cell-cycle checkpoints and cancer. Nature (2004) 13.19

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76

An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60

Human CtIP promotes DNA end resection. Nature (2007) 10.63

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol (2006) 6.52

The causes and consequences of genetic heterogeneity in cancer evolution. Nature (2013) 5.91

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol (2006) 5.34

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol (2003) 4.77

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57

MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature (2003) 4.56

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol (2002) 4.45

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat Cell Biol (2011) 4.23

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J Cell Biol (2005) 3.69

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell (2003) 3.58

Regulation of replication fork progression through histone supply and demand. Science (2007) 3.21

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20

Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat Rev Cancer (2004) 3.06

A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer. Am J Hum Genet (2002) 3.00

ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell (2013) 2.99

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet (2002) 2.97

Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol (2004) 2.97

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol (2004) 2.63

The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev (2009) 2.56

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem (2003) 2.54

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell (2012) 2.53

Human Asf1 regulates the flow of S phase histones during replicational stress. Mol Cell (2005) 2.51

Effect of caudal epidural steroid or saline injection in chronic lumbar radiculopathy: multicentre, blinded, randomised controlled trial. BMJ (2011) 2.48

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell (2006) 2.45

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair (Amst) (2004) 2.39

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J (2002) 2.39

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol (2009) 2.37

p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell (2006) 2.34

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle (2011) 2.31

ATM activation in normal human tissues and testicular cancer. Cell Cycle (2005) 2.25

Measuring elevated intracranial pressure through noninvasive methods: a review of the literature. J Neurosurg Anesthesiol (2013) 2.23

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med (2012) 2.21

NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet (2008) 2.18

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. J Cell Biol (2008) 2.18

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol (2006) 2.09

[Scandinavian guidelines for prehospital management of severe traumatic brain injury]. Tidsskr Nor Laegeforen (2008) 2.03

Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture. Stroke (2013) 2.01

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol (2002) 1.99

Outcome of accidental hypothermia with or without circulatory arrest: experience from the Danish Præstø Fjord boating accident. Resuscitation (2012) 1.94

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol (2010) 1.82

Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics (2010) 1.81

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res (2007) 1.79

Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res (2006) 1.73

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling. Cell Cycle (2010) 1.71

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation. Cancer Res (2004) 1.70

Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J (2003) 1.67

Transcranial Doppler sonography pulsatility index (PI) reflects intracranial pressure (ICP). Surg Neurol (2004) 1.67

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage. Cell Cycle (2012) 1.66

Osmotherapy in brain edema: a questionable therapy. J Neurosurg Anesthesiol (2012) 1.60

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene (2004) 1.58

CHEK2 variant I157T may be associated with increased breast cancer risk. Int J Cancer (2004) 1.56

Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients. Int J Cancer (2005) 1.55

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle (2004) 1.54

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol (2013) 1.52

Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity. PLoS One (2011) 1.50

Validity and reliability of the Behavioural Observational Pain Scale for postoperative pain measurement in children 1-7 years of age. Pediatr Crit Care Med (2007) 1.50

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. Cell Cycle (2012) 1.50

Structure meets function--centrosomes, genome maintenance and the DNA damage response. Exp Cell Res (2006) 1.49

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol Oncol (2008) 1.44

Alternative splicing and mutation status of CHEK2 in stage III breast cancer. Oncogene (2004) 1.42

Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. J Cell Biol (2009) 1.41

[An ethically credible intensive care shields the terminally ill patient]. Lakartidningen (2003) 1.39

Risk factors and short-term outcome in patients with angiographically negative subarachnoid hemorrhage. Clin Neurol Neurosurg (2013) 1.39

Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J Biol Chem (2007) 1.38

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities. J Cell Biol (2009) 1.34

Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges. Chromosoma (2005) 1.34

DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function. Cell Cycle (2007) 1.34

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'. Aging (Albany NY) (2012) 1.32

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene. Oncotarget (2013) 1.32

Computation of hemodynamics in the circle of Willis. Stroke (2007) 1.32

Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer. Oncogene (2004) 1.31

Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay. Cell Cycle (2008) 1.31

Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage. Mol Cell (2013) 1.30

Differentiation-induced radioresistance in muscle cells. Mol Cell Biol (2004) 1.30

LEDGF (p75) promotes DNA-end resection and homologous recombination. Nat Struct Mol Biol (2012) 1.27

Anticoagulation therapy a risk factor for the development of chronic subdural hematoma. Clin Neurol Neurosurg (2012) 1.26

Key concepts in glioblastoma therapy. J Neurol Neurosurg Psychiatry (2012) 1.26

Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J (2009) 1.24

MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer. PLoS One (2011) 1.24

The emerging phenotype of the testicular carcinoma in situ germ cell. APMIS (2003) 1.24

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin. J Cell Biol (2009) 1.23

Raised serum S100B levels after acute bone fractures without cerebral injury. J Trauma (2005) 1.23

Ventriculoperitoneal shunting for idiopathic intracranial hypertension. Neurology (2004) 1.19

S100B serum level predicts computed tomography findings after minor head injury. J Trauma (2007) 1.17