PubRank

Jiri Bartek

Author PubWeight™ 348.90‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005 18.30
2 The DNA-damage response in human biology and disease. Nature 2009 17.86
3 Cell-cycle checkpoints and cancer. Nature 2004 13.19
4 Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006 11.76
5 An oncogene-induced DNA damage model for cancer development. Science 2008 11.60
6 Human CtIP promotes DNA end resection. Nature 2007 10.63
7 RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 2007 9.25
8 ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2005 8.27
9 RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 2009 6.89
10 Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 2006 6.52
11 The causes and consequences of genetic heterogeneity in cancer evolution. Nature 2013 5.91
12 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 2010 5.59
13 Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol 2006 5.34
14 Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol 2003 4.77
15 The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 2005 4.62
16 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol 2011 4.57
17 MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 2003 4.56
18 Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol 2005 4.54
19 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol 2002 4.45
20 More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat Cell Biol 2011 4.23
21 Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J Cell Biol 2005 3.69
22 Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 2003 3.58
23 Regulation of replication fork progression through histone supply and demand. Science 2007 3.21
24 Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J 2004 3.20
25 Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat Rev Cancer 2004 3.06
26 A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer. Am J Hum Genet 2002 3.00
27 ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell 2013 2.99
28 The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet 2002 2.97
29 Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol 2004 2.97
30 Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol 2004 2.63
31 The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev 2009 2.56
32 Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem 2003 2.54
33 TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell 2012 2.53
34 Human Asf1 regulates the flow of S phase histones during replicational stress. Mol Cell 2005 2.51
35 Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell 2006 2.45
36 Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair (Amst) 2004 2.39
37 Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J 2002 2.39
38 HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol 2009 2.37
39 p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 2006 2.34
40 Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle 2011 2.31
41 ATM activation in normal human tissues and testicular cancer. Cell Cycle 2005 2.25
42 Measuring elevated intracranial pressure through noninvasive methods: a review of the literature. J Neurosurg Anesthesiol 2013 2.23
43 Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med 2012 2.21
44 NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet 2008 2.18
45 Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. J Cell Biol 2008 2.18
46 Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol 2006 2.09
47 Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol 2002 1.99
48 The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol 2010 1.82
49 Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics 2010 1.81
50 Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res 2007 1.79
51 Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res 2006 1.73
52 Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling. Cell Cycle 2010 1.71
53 Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation. Cancer Res 2004 1.70
54 Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J 2003 1.67
55 Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage. Cell Cycle 2012 1.66
56 Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene 2004 1.58
57 CHEK2 variant I157T may be associated with increased breast cancer risk. Int J Cancer 2004 1.56
58 Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients. Int J Cancer 2005 1.55
59 ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle 2004 1.54
60 Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol 2013 1.52
61 Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity. PLoS One 2011 1.50
62 Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. Cell Cycle 2012 1.50
63 Structure meets function--centrosomes, genome maintenance and the DNA damage response. Exp Cell Res 2006 1.49
64 Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol Oncol 2008 1.44
65 Alternative splicing and mutation status of CHEK2 in stage III breast cancer. Oncogene 2004 1.42
66 Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. J Cell Biol 2009 1.41
67 Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J Biol Chem 2007 1.38
68 Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol 2013 1.36
69 Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities. J Cell Biol 2009 1.34
70 Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges. Chromosoma 2005 1.34
71 DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function. Cell Cycle 2007 1.34
72 IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'. Aging (Albany NY) 2012 1.32
73 Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene. Oncotarget 2013 1.32
74 Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer. Oncogene 2004 1.31
75 Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay. Cell Cycle 2008 1.31
76 Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage. Mol Cell 2013 1.30
77 Differentiation-induced radioresistance in muscle cells. Mol Cell Biol 2004 1.30
78 LEDGF (p75) promotes DNA-end resection and homologous recombination. Nat Struct Mol Biol 2012 1.27
79 Key concepts in glioblastoma therapy. J Neurol Neurosurg Psychiatry 2012 1.26
80 Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J 2009 1.24
81 MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer. PLoS One 2011 1.24
82 The emerging phenotype of the testicular carcinoma in situ germ cell. APMIS 2003 1.24
83 USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin. J Cell Biol 2009 1.23
84 HCLK2 is required for activity of the DNA damage response kinase ATR. J Biol Chem 2008 1.17
85 Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines. Oncogene 2003 1.16
86 Checking out the centrosome. Cell Cycle 2004 1.14
87 Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells 2006 1.12
88 A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3. Cell Cycle 2007 1.10
89 Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4. J Biol Chem 2002 1.10
90 Epithelial junction opener JO-1 improves monoclonal antibody therapy of cancer. Cancer Res 2011 1.09
91 RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells. J Mol Biol 2007 1.09
92 Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res 2006 1.09
93 CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination. EMBO Rep 2012 1.07
94 Involvement of cyclin D activity in left ventricle hypertrophy in vivo and in vitro. Cardiovasc Res 2002 1.06
95 Watching the DNA repair ensemble dance. Cell 2004 1.05
96 JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks. Nat Struct Mol Biol 2013 1.05
97 Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst) 2007 1.03
98 The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling. Mol Cell 2013 1.02
99 Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events. Cell Cycle 2006 1.02
100 Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores. Proc Natl Acad Sci U S A 2011 1.01
101 Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis. Cell Cycle 2012 1.01
102 Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling. J Cell Mol Med 2009 1.00
103 DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle 2015 0.99
104 Cytokine loops driving senescence. Nat Cell Biol 2008 0.99
105 ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress. Genes Dev 2013 0.98
106 DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo. Cancer Cell 2012 0.98
107 Deregulation of the G1/S-phase control in human testicular germ cell tumours. APMIS 2003 0.98
108 Thresholds of replication stress signaling in cancer development and treatment. Nat Struct Mol Biol 2012 0.97
109 Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Am J Pathol 2009 0.97
110 Centrosome clustering and chromosomal (in)stability: a matter of life and death. Mol Oncol 2011 0.97
111 Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells. J Biol Chem 2007 0.97
112 The sunny side of p53. Cell 2007 0.95
113 Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy. Exp Cell Res 2004 0.94
114 DNA repair: Damage alert. Nature 2003 0.93
115 Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response. Cell Cycle 2013 0.93
116 DNA repair: New tales of an old tail. Nature 2009 0.93
117 Evaluation of RAD50 in familial breast cancer predisposition. Int J Cancer 2006 0.92
118 Cell-cycle regulatory proteins in human wound healing. Arch Oral Biol 2003 0.92
119 Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance. Cancer Res 2011 0.91
120 Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis. Cell Cycle 2009 0.91
121 DNA damage response, genetic instability and cancer: from mechanistic insights to personalized treatment. Mol Oncol 2011 0.90
122 Deregulation of the RB pathway in human testicular germ cell tumours. J Pathol 2003 0.90
123 Expression of human BRCA1Δ17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response. Cell Signal 2013 0.88
124 Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway. Exp Cell Res 2005 0.88
125 Cell division: the heart of the cycle. Nature 2004 0.86
126 Modifiable risk factors for aneurysmal subarachnoid hemorrhage. Stroke 2013 0.86
127 Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells. J Biol Chem 2012 0.86
128 Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring. J Med Chem 2014 0.86
129 Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease. PLoS One 2012 0.85
130 Protein phosphatase 2A associates with Rb2/p130 and mediates retinoic acid-induced growth suppression of ovarian carcinoma cells. J Biol Chem 2003 0.85
131 Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. Mol Cell Proteomics 2003 0.84
132 Sensitivity to growth suppression by 1alpha,25-dihydroxyvitamin D(3) among MCF-7 clones correlates with Vitamin D receptor protein induction. J Steroid Biochem Mol Biol 2002 0.83
133 NQO1 expression correlates inversely with NFκB activation in human breast cancer. Breast Cancer Res Treat 2011 0.83
134 Dynamics and organization of cortical microtubules as revealed by superresolution structured illumination microscopy. Plant Physiol 2014 0.82
135 Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression. Exp Cell Res 2003 0.81
136 Post-transplant aspergillosis and the role of combined neurosurgical and antifungal therapies under belatacept immunosuppression. Surg Neurol Int 2011 0.81
137 Regulation of stem cell plasticity: mechanisms and relevance to tissue biology and cancer. Mol Ther 2012 0.81
138 E2F activity is essential for survival of Myc-overexpressing human cancer cells. Oncogene 2002 0.81
139 Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy. J Cell Mol Med 2007 0.80
140 DNA repair: Cyclin D1 multitasks. Nature 2011 0.79
141 Cytokines shape chemotherapy-induced and 'bystander' senescence. Aging (Albany NY) 2010 0.78
142 Two new CHEK2 germ-line variants detected in breast cancer/sarcoma families negative for BRCA1, BRCA2, and TP53 gene mutations. Breast Cancer Res Treat 2011 0.78
143 Venous complications in supracerebellar infratentorial approach. Acta Neurochir (Wien) 2013 0.78
144 Long-term quality of life and tumour control following gamma knife radiosurgery for vestibular schwannoma. Acta Neurochir (Wien) 2013 0.76
145 On the origin of prostate fusion oncogenes. Nat Genet 2010 0.76
146 Cytokine-induced 'bystander' senescence in DDR and immuno-surveillance. Oncotarget 2013 0.76
147 ATM targets hnRNPK to control p53. Cell Cycle 2013 0.76
148 DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter. Mol Cell 2006 0.76
149 Idiopathic intracranial hypertension and transverse sinus stenoses. BMJ Case Rep 2013 0.75
150 Tethered genes get checked during replication. Cell 2011 0.75
151 Reply to comment by Albin on "measuring elevated intracranial pressure through noninvasive methods: a review of the literature". J Neurosurg Anesthesiol 2014 0.75
152 Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics. J Proteome Res 2016 0.75
153 Histone displacement during nucleotide excision repair. Int J Mol Sci 2012 0.75
154 In their own words: Interviews with Cell Cycle. Dr. Jiri Bartek on his highly cited paper published in Cell Cycle. Cell Cycle 2010 0.75
155 Cyclin D3-dependent kinases in lymphoma: redundancy and implications for therapy. Cell Cycle 2010 0.75
156 Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer. Hum Pathol 2011 0.75
157 HERCulean giant orchestrates ubiquitin-mediated signaling on damaged chromosomes. Cell Cycle 2010 0.75
158 DNA damage: a histone-code mediator leaves the stage. Nat Struct Mol Biol 2008 0.75
159 Analysis of EMT by flow cytometry and immunohistochemistry. Methods Mol Biol 2013 0.75