PubRank

Michael G Roth

Author PubWeight™ 47.47‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009 9.43
2 Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 2007 4.70
3 Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell 2003 3.75
4 Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts. J Cell Biol 2003 2.22
5 The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem 2004 1.75
6 High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem 2005 1.73
7 Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. PLoS Genet 2008 1.64
8 Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis. J Cell Biol 2003 1.63
9 Towards patient-based cancer therapeutics. Nat Biotechnol 2010 1.63
10 Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell 2013 1.60
11 Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1. J Biol Chem 2004 1.56
12 ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Mol Biol Cell 2003 1.29
13 Phospholipase D2 is required for efficient endocytic recycling of transferrin receptors. Mol Biol Cell 2005 1.11
14 Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized. Cancer Res 2007 1.05
15 Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nat Chem Biol 2011 1.04
16 Casein kinase I regulates membrane binding by ARF GAP1. Mol Biol Cell 2002 1.01
17 Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide. Bioorg Med Chem Lett 2008 0.99
18 Features of influenza HA required for apical sorting differ from those required for association with DRMs or MAL. Traffic 2003 0.96
19 Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. J Cell Biol 2012 0.94
20 Host modulators of H1N1 cytopathogenicity. PLoS One 2012 0.91
21 Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin. J Am Chem Soc 2012 0.86
22 A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance. Proc Natl Acad Sci U S A 2006 0.86
23 Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans. Mol Biol Cell 2010 0.86
24 Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. PLoS One 2010 0.85
25 The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway. J Biol Chem 2004 0.81
26 The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1. PLoS One 2011 0.78
27 TDP-43 identified from a genome wide RNAi screen for SOD1 regulators. PLoS One 2012 0.78
28 SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity. ACS Med Chem Lett 2013 0.77
29 Cell biology: porter and sorter. Nature 2008 0.76
30 The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation. Chem Biol 2015 0.75