Published in Acta Neuropathol Commun on June 19, 2013
Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein. Acta Neuropathol Commun (2014) 0.82
Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice. MBio (2015) 0.79
Increased infectivity of anchorless mouse scrapie prions in transgenic mice overexpressing human prion protein. J Virol (2015) 0.79
Shedding light on prion disease. Prion (2015) 0.79
Phosphorylated human tau associates with mouse prion protein amyloid in scrapie-infected mice but does not increase progression of clinical disease. Prion (2016) 0.75
Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann Neurol (1999) 6.98
Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science (2005) 5.52
The most infectious prion protein particles. Nature (2005) 5.37
Mammalian prion biology: one century of evolving concepts. Cell (2004) 3.46
Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int (2004) 3.16
Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol (2008) 2.90
The incidence of cerebral amyloid angiopathy in Alzheimer's disease. Neurology (1975) 2.89
Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke (1984) 2.86
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annu Rev Biochem (2009) 2.80
Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol (2008) 2.59
Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol Appl Neurobiol (2008) 2.32
Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol (1995) 2.10
Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein. EMBO J (2001) 1.95
Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP. Proc Natl Acad Sci U S A (1996) 1.94
Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol (1998) 1.92
Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]. J Virol (1994) 1.85
Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta Neuropathol (2009) 1.74
Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie. J Comp Pathol (2002) 1.73
Prion protein amyloidosis. Brain Pathol (1996) 1.64
Senile degenerative brain lesions and dementia. J Am Geriatr Soc (1975) 1.63
Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J Theor Biol (2005) 1.59
Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathol (2009) 1.57
Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2002) 1.51
Cerebral amyloid angiopathy: the vascular pathology and complications. J Neuropathol Exp Neurol (1986) 1.50
Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring. PLoS Pathog (2010) 1.49
Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy. Acta Neuropathol (2011) 1.41
Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis. J Neuropathol Exp Neurol (1998) 1.41
Prion protein amyloidosis with divergent phenotype associated with two novel nonsense mutations in PRNP. Acta Neuropathol (2009) 1.39
Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. Am J Pathol (1992) 1.37
Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science (2006) 1.23
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Ann Neurol (2011) 1.13
Cryptic epitopes in N-terminally truncated prion protein are exposed in the full-length molecule: dependence of conformation on pH. Proteins (2001) 1.11
Detection of prion infectivity in fat tissues of scrapie-infected mice. PLoS Pathog (2008) 1.08
Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection. J Virol (2010) 1.06
In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies. Neuropathol Appl Neurobiol (1997) 1.05
Proteinase-K-resistant prion protein isoforms in Gerstmann-Sträussler-Scheinker disease (Indiana kindred). J Neuropathol Exp Neurol (1996) 1.04
Infection specific prion protein (PrP) accumulates on neuronal plasmalemma in scrapie infected mice. Neurosci Lett (1992) 0.99
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. J Virol (2012) 0.90
Characteristics of dyshoric capillary cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2010) 0.89
Chain reaction of amyloid fibril formation with induction of basement membrane in familial amyloidotic polyneuropathy. J Pathol (2009) 0.82
Dyshoric capillary cerebral amyloid angiopathy mimicking Creutzfeldt-Jakob disease. J Neurol Sci (2010) 0.80
Non-amyloid and amyloid prion protein deposits in prion-infected mice differ in blockage of interstitial brain fluid. Neuropathol Appl Neurobiol (2013) 0.80
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annu Rev Biochem (2009) 2.80
Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog (2010) 2.63
Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors. J Biol Chem (2010) 2.57
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J (2002) 2.16
Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science (2008) 1.97
BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection. Blood (2013) 1.57
Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring. PLoS Pathog (2010) 1.49
Biomedicine. A view from the top--prion diseases from 10,000 feet. Science (2003) 1.48
Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein. J Virol (2007) 1.41
Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons. Neurobiol Dis (2005) 1.39
Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages. J Virol (2005) 1.34
Susceptibilities of nonhuman primates to chronic wasting disease. Emerg Infect Dis (2009) 1.33
Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages. J Infect Dis (2002) 1.28
Gene expression alterations in brains of mice infected with three strains of scrapie. BMC Genomics (2006) 1.27
Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions. Proc Natl Acad Sci U S A (2011) 1.26
Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PLoS One (2012) 1.25
Scrapie-specific neuronal lesions are independent of neuronal PrP expression. Ann Neurol (2004) 1.24
Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science (2006) 1.23
MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis. J Virol (2004) 1.17
Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. Invest Ophthalmol Vis Sci (2013) 1.17
Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion. J Virol (2002) 1.13
Detection of prion infectivity in fat tissues of scrapie-infected mice. PLoS Pathog (2008) 1.08
Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types. Am J Pathol (2004) 1.07
Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection. J Virol (2010) 1.06
Essential roles for CD8+ T cells and gamma interferon in protection of mice against retrovirus-induced immunosuppression. J Virol (2002) 1.05
Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels. J Virol (2009) 1.03
Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice. J Virol (2002) 1.01
Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins. J Virol (2012) 1.01
Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro. J Biol Chem (2004) 1.01
Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations. J Clin Microbiol (2012) 0.99
Role of cyclophilin A from brains of prion-infected mice in stimulation of cytokine release by microglia and astroglia in vitro. J Biol Chem (2011) 0.95
Novel role of CD8(+) T cells and major histocompatibility complex class I genes in the generation of protective CD4(+) Th1 responses during retrovirus infection in mice. J Virol (2002) 0.93
Levels of abnormal prion protein in deer and elk with chronic wasting disease. Emerg Infect Dis (2007) 0.93
Prion protein and susceptibility to kainate-induced seizures: genetic pitfalls in the use of PrP knockout mice. Prion (2013) 0.91
Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression. J Neuroimmunol (2008) 0.91
Prion infectivity in fat of deer with chronic wasting disease. J Virol (2009) 0.91
Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral replication and neurotoxicity. J Virol (2003) 0.91
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. J Virol (2007) 0.90
Characteristics of 263K scrapie agent in multiple hamster species. Emerg Infect Dis (2009) 0.90
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. J Virol (2012) 0.90
Proteolytic cleavage and shedding of the bovine prion protein in two cell culture systems. Virus Res (2005) 0.89
Separate sequences in a murine retroviral envelope protein mediate neuropathogenesis by complementary mechanisms with differing requirements for tumor necrosis factor alpha. J Virol (2004) 0.89
Functional characteristics of HIV-1 subtype C compatible with increased heterosexual transmissibility. AIDS (2009) 0.88
In vivo comparison of chronic wasting disease infectivity from deer with variation at prion protein residue 96. J Virol (2011) 0.88
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. PLoS Pathog (2011) 0.88
Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses. Virology (2006) 0.84
Separate mechanisms act concurrently to shed and release the prion protein from the cell. Prion (2012) 0.84
Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms. Adv Appl Bioinform Chem (2008) 0.83
Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain. J Virol (2008) 0.82
Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein. Acta Neuropathol Commun (2014) 0.82
Disinfection and sterilization of prion-contaminated medical instruments. Infect Control Hosp Epidemiol (2010) 0.81
Capillaries in the olfactory bulb but not the cortex are highly susceptible to virus-induced vascular leak and promote viral neuroinvasion. Acta Neuropathol (2015) 0.80
Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro. Glia (2011) 0.79
Chronic wasting disease agents in nonhuman primates. Emerg Infect Dis (2014) 0.79
Prion protein on astrocytes or in extracellular fluid impedes neurodegeneration induced by truncated prion protein. Exp Neurol (2009) 0.78
Proteomics analysis of amyloid and nonamyloid prion disease phenotypes reveals both common and divergent mechanisms of neuropathogenesis. J Proteome Res (2014) 0.77