Published in J Biol Chem on December 16, 2011
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. J Virol (2012) 0.90
Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD. Virol J (2013) 0.88
Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction. J Virol (2014) 0.82
Apolipoprotein D Internalization Is a Basigin-dependent Mechanism. J Biol Chem (2015) 0.77
Differential pro-inflammatory responses of astrocytes and microglia involve STAT3 activation in response to 1800 MHz radiofrequency fields. PLoS One (2014) 0.77
Label-free imaging to study phenotypic behavioural traits of cells in complex co-cultures. Sci Rep (2016) 0.76
Prion 2015 poster abstracts. Prion (2015) 0.75
Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis (1999) 45.01
A statistical model for identifying proteins by tandem mass spectrometry. Anal Chem (2003) 29.58
A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem (1984) 19.70
Molecular biology of prion diseases. Science (1991) 10.83
Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol (2009) 6.79
Microglia as neuroprotective, immunocompetent cells of the CNS. Glia (2002) 3.12
Role of microglia in central nervous system infections. Clin Microbiol Rev (2004) 2.69
Microglial activation and its implications in the brain diseases. Curr Med Chem (2007) 2.63
Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol (2010) 2.43
Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages. Proc Natl Acad Sci U S A (1992) 2.20
Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature (1996) 2.20
Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol (1995) 2.10
Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ Res (2000) 2.09
Isolation and structural studies of the intact scrapie agent protein. Arch Biochem Biophys (1987) 1.97
Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J Biol Chem (2002) 1.96
Extracellular cyclophilins contribute to the regulation of inflammatory responses. J Immunol (2005) 1.82
Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler Thromb Vasc Biol (2004) 1.61
Role of microglia in neuronal cell death in prion disease. Brain Pathol (1998) 1.49
Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes. Rev Physiol Biochem Pharmacol (2003) 1.48
Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein. J Virol (2007) 1.41
PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie. Exp Neurol (1997) 1.35
Cyclophilin A up-regulates MMP-9 expression and adhesion of monocytes/macrophages via CD147 signalling pathway in rheumatoid arthritis. Rheumatology (Oxford) (2008) 1.34
Atypical inflammation in the central nervous system in prion disease. Curr Opin Neurol (2002) 1.32
Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes. Circ Res (2007) 1.27
Regulating factors for microglial activation. Biol Pharm Bull (2002) 1.25
Cyclophilin A as a novel biphasic mediator of endothelial activation and dysfunction. Am J Pathol (2004) 1.18
Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury. Neurobiol Dis (2006) 1.16
Hypoxia followed by reoxygenation induces secretion of cyclophilin A from cultured rat cardiac myocytes. Biochem Biophys Res Commun (2004) 1.12
Subcellular localization of disease-associated prion protein in the human brain. Am J Pathol (2005) 1.11
Microglia and the pathogenesis of spongiform encephalopathies. Brain Res Brain Res Rev (2001) 1.11
Microglia and chemokines in infectious diseases of the nervous system: views and reviews. Front Biosci (2004) 1.11
Cryptic epitopes in N-terminally truncated prion protein are exposed in the full-length molecule: dependence of conformation on pH. Proteins (2001) 1.11
Detection of prion infectivity in fat tissues of scrapie-infected mice. PLoS Pathog (2008) 1.08
Regional heterogeneity and diversity in cytokine and chemokine production by astroglia: differential responses to HIV-1 Tat, gp120, and morphine revealed by multiplex analysis. J Proteome Res (2010) 1.08
Brain macrophages: neurotoxic or neurotrophic effector cells? J Leukoc Biol (1994) 1.07
Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons. Immunol Res (2010) 1.06
Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines. Neuroreport (1999) 1.04
Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells. EMBO J (2003) 1.03
Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels. J Virol (2009) 1.03
Pro-inflammatory activities induced by CyPA-EMMPRIN interaction in monocytes. Atherosclerosis (2010) 1.02
Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations. Proteomics (2010) 0.99
Enzyme assembly after de novo synthesis in rabbit reticulocyte lysate involves molecular chaperones and immunophilins. J Biol Chem (1995) 0.98
Inducible cytokine gene expression in the brain in the ME7/CV mouse model of scrapie is highly restricted, is at a strikingly low level relative to the degree of gliosis and occurs only late in disease. J Gen Virol (2003) 0.97
Chemokine control of West Nile virus infection. Exp Cell Res (2011) 0.95
Cyclophilin A differentially activates monocytes and endothelial cells: role of purity, activity, and endotoxin contamination in commercial preparations. Atherosclerosis (2007) 0.92
Role of cytokines and chemokines in prion infections of the central nervous system. Int J Dev Neurosci (2004) 0.92
JAK-STAT signaling pathway mediates astrogliosis in brains of scrapie-infected mice. J Neurochem (2007) 0.92
Simultaneous detections of 27 cytokines during cerebral wound healing by multiplexed bead-based immunoassay for wound age estimation. J Neurotrauma (2007) 0.88
Extracellular protein deposition correlates with glial activation and oxidative stress in Creutzfeldt-Jakob and Alzheimer's disease. Acta Neuropathol (2004) 0.88
Pathology of nonhuman spongiform encephalopathies: variations and their implications for pathogenesis. Dev Biol Stand (1993) 0.83
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. J Virol (2008) 0.83
Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2. Brain Res (2002) 0.82
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro. Ann N Y Acad Sci (2007) 0.82
Activation of CD147 with cyclophilin a induces the expression of IFITM1 through ERK and PI3K in THP-1 cells. Mediators Inflamm (2010) 0.81
Immune mechanisms in neurological disorders: protective or destructive? Trends Immunol (2001) 0.78
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nat Methods (2007) 3.74
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annu Rev Biochem (2009) 2.80
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat Methods (2008) 2.56
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J (2002) 2.16
Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science (2008) 1.97
Proteomic analysis of a highly active photosystem II preparation from the cyanobacterium Synechocystis sp. PCC 6803 reveals the presence of novel polypeptides. Biochemistry (2002) 1.86
Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian host. Infect Immun (2006) 1.55
Biomedicine. A view from the top--prion diseases from 10,000 feet. Science (2003) 1.48
Serologic proteome analysis of Borrelia burgdorferi membrane-associated proteins. Infect Immun (2006) 1.48
Glycerol-3-phosphate acquisition in spirochetes: distribution and biological activity of glycerophosphodiester phosphodiesterase (GlpQ) among Borrelia species. J Bacteriol (2003) 1.47
Immunohistochemical localization of aspartoacylase in the rat central nervous system. J Comp Neurol (2004) 1.47
Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein. J Virol (2007) 1.41
Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons. Neurobiol Dis (2005) 1.39
Myeloperoxidase produces nitrating oxidants in vivo. J Clin Invest (2002) 1.35
Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages. J Virol (2005) 1.34
Susceptibilities of nonhuman primates to chronic wasting disease. Emerg Infect Dis (2009) 1.33
Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages. J Infect Dis (2002) 1.28
Gene expression alterations in brains of mice infected with three strains of scrapie. BMC Genomics (2006) 1.27
Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions. Proc Natl Acad Sci U S A (2011) 1.26
Comparative proteome analysis of subcellular fractions from Borrelia burgdorferi by NEPHGE and IPG. Proteomics (2006) 1.25
Scrapie-specific neuronal lesions are independent of neuronal PrP expression. Ann Neurol (2004) 1.24
Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science (2006) 1.23
Modulation of virulence factors in Francisella tularensis determines human macrophage responses. Microb Pathog (2007) 1.22
Five-member gene family of Bartonella quintana. Infect Immun (2003) 1.20
MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis. J Virol (2004) 1.17
Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion. J Virol (2002) 1.13
Pleiotropic effects of inactivating a carboxyl-terminal protease, CtpA, in Borrelia burgdorferi. J Bacteriol (2004) 1.08
Detection of prion infectivity in fat tissues of scrapie-infected mice. PLoS Pathog (2008) 1.08
Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types. Am J Pathol (2004) 1.07
The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission. Proc Natl Acad Sci U S A (2010) 1.07
Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death. Immunity (2013) 1.07
Temporal expression analysis of the Borrelia burgdorferi paralogous gene family 54 genes BBA64, BBA65, and BBA66 during persistent infection in mice. Infect Immun (2007) 1.07
Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection. J Virol (2010) 1.06
Analysis of protein levels of 24 cytokines in scrapie agent-infected brain and glial cell cultures from mice differing in prion protein expression levels. J Virol (2009) 1.03
A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae. Protein Sci (2003) 1.02
Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase. Proc Natl Acad Sci U S A (2003) 1.01
Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins. J Virol (2012) 1.01
Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro. J Biol Chem (2004) 1.01
Combined charged residue-field emission model of macromolecular electrospray ionization. Anal Chem (2009) 0.99
Charge carrier field emission determines the number of charges on native state proteins in electrospray ionization. J Am Chem Soc (2008) 0.99
Regulation and expression of bba66 encoding an immunogenic infection-associated lipoprotein in Borrelia burgdorferi. Mol Microbiol (2006) 0.97
Hemin interactions and alterations of the subcellular localization of prion protein. J Biol Chem (2007) 0.94
Novel role of CD8(+) T cells and major histocompatibility complex class I genes in the generation of protective CD4(+) Th1 responses during retrovirus infection in mice. J Virol (2002) 0.93
Borrelia burgdorferi surface-localized proteins expressed during persistent murine infection are conserved among diverse Borrelia spp. Infect Immun (2008) 0.93
Levels of abnormal prion protein in deer and elk with chronic wasting disease. Emerg Infect Dis (2007) 0.93
Functional analysis of the Borrelia burgdorferi bba64 gene product in murine infection via tick infestation. PLoS One (2011) 0.92
Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression. J Neuroimmunol (2008) 0.91
Prion protein and susceptibility to kainate-induced seizures: genetic pitfalls in the use of PrP knockout mice. Prion (2013) 0.91
Borrelia burgdorferi expression of the bba64, bba65, bba66, and bba73 genes in tissues during persistent infection in mice. Microb Pathog (2008) 0.91
Regulated synthesis of the Borrelia burgdorferi inner-membrane lipoprotein IpLA7 (P22, P22-A) during the Lyme disease spirochaete's mammal-tick infectious cycle. Microbiology (2007) 0.91
Prion infectivity in fat of deer with chronic wasting disease. J Virol (2009) 0.91
Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral replication and neurotoxicity. J Virol (2003) 0.91
Characterization of the Bat proteins in the oxidative stress response of Leptospira biflexa. BMC Microbiol (2012) 0.90
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. J Virol (2012) 0.90
Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity. PLoS One (2013) 0.90
The catalytic machinery of a key enzyme in amino Acid biosynthesis. J Amino Acids (2010) 0.90
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. J Virol (2007) 0.90
Characterization and serologic analysis of the Treponema pallidum proteome. Infect Immun (2010) 0.90
Separate sequences in a murine retroviral envelope protein mediate neuropathogenesis by complementary mechanisms with differing requirements for tumor necrosis factor alpha. J Virol (2004) 0.89
Functional characteristics of HIV-1 subtype C compatible with increased heterosexual transmissibility. AIDS (2009) 0.88
In vivo comparison of chronic wasting disease infectivity from deer with variation at prion protein residue 96. J Virol (2011) 0.88
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. PLoS Pathog (2011) 0.88
Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein. Acta Neuropathol Commun (2013) 0.85
Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses. Virology (2006) 0.84
Complementary MS methods assist conformational characterization of antibodies with altered S-S bonding networks. J Am Soc Mass Spectrom (2013) 0.83
Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. Acta Crystallogr D Biol Crystallogr (2004) 0.83
The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. Acta Crystallogr D Biol Crystallogr (2004) 0.83
Geldanamycin-induced PCNA degradation in isolated Hsp90 complex from cancer cells. Cancer Invest (2010) 0.83
Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms. Adv Appl Bioinform Chem (2008) 0.83
Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain. J Virol (2008) 0.82
Disinfection and sterilization of prion-contaminated medical instruments. Infect Control Hosp Epidemiol (2010) 0.81
Dissociation of recombinant prion protein fibrils into short protofilaments: implications for the endocytic pathway and involvement of the N-terminal domain. Biochemistry (2012) 0.81
Proteomic strategies to elucidate pathogenic mechanisms of spirochetes. Proteomics Clin Appl (2007) 0.80
Borrelia burgdorferi bba66 gene inactivation results in attenuated mouse infection by tick transmission. Infect Immun (2013) 0.80
Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro. Glia (2011) 0.79
Host limits to accurate human growth hormone production in multiple plant systems. Biotechnol Bioeng (2005) 0.79
Chronic wasting disease agents in nonhuman primates. Emerg Infect Dis (2014) 0.79
Prion protein on astrocytes or in extracellular fluid impedes neurodegeneration induced by truncated prion protein. Exp Neurol (2009) 0.78
Two novel bovine somatotropin species generated from a common dehydroalanine intermediate. Protein J (2009) 0.78
Identification of prion inhibitors by a fluorescence-polarization-based competitive binding assay. Anal Biochem (2006) 0.78
Proteomics analysis of amyloid and nonamyloid prion disease phenotypes reveals both common and divergent mechanisms of neuropathogenesis. J Proteome Res (2014) 0.77
Examining the role of actin-plasma membrane association in Pseudomonas aeruginosa infection and type III secretion translocation in migratory T24 epithelial cells. Infect Immun (2012) 0.77
Synthesis and evaluation of alternative substrates for arginase. Bioorg Chem (2002) 0.77
Professionalism considerations. Anesthesiology (2009) 0.75
Correction: The Distribution of Prion Protein Allotypes Differs Between Sporadic and Iatrogenic Creutzfeldt-Jakob Disease Patients. PLoS Pathog (2016) 0.75
Temporal generation of multiple antifungal proteins in primed seeds. Biochem Biophys Res Commun (2002) 0.75