Published in J Biol Chem on December 02, 2013
Design and engineering of deimmunized biotherapeutics. Curr Opin Struct Biol (2016) 0.82
Measurement of protein using bicinchoninic acid. Anal Biochem (1985) 74.03
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A (2007) 15.88
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem (1979) 6.53
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. Scand J Clin Lab Invest Suppl (1968) 5.43
Separation of leukocytes from blood and bone marrow. Introduction. Scand J Clin Lab Invest Suppl (1968) 3.41
Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia. Blood (2006) 2.62
L-asparaginase: a review. Adv Enzymol Relat Areas Mol Biol (1973) 2.56
In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett (2005) 2.48
Asparaginase may influence dexamethasone pharmacokinetics in acute lymphoblastic leukemia. J Clin Oncol (2008) 2.29
Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498. Blood (1992) 1.97
Use of L-asparaginase in childhood ALL. Crit Rev Oncol Hematol (1998) 1.69
Upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells. Leukemia (2004) 1.66
Long-term results of a randomized trial on extended use of high dose L-asparaginase for standard risk childhood acute lymphoblastic leukemia. J Clin Oncol (2005) 1.58
Monitoring protein aggregation during thermal unfolding in circular dichroism experiments. Protein Sci (2006) 1.40
Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia. Cancer Res (1983) 1.39
Bacterial expression, purification, and characterization of rat kidney-type mitochondrial glutaminase. Protein Expr Purif (2003) 1.37
Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia. Int J Nanomedicine (2006) 1.28
Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. Proc Natl Acad Sci U S A (2011) 1.18
L-asparaginase: inhibition of early mitosis in regenerating rat liver. Science (1967) 1.14
Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia. Blood (2003) 1.11
Engineering the substrate specificity of Escherichia coli asparaginase. II. Selective reduction of glutaminase activity by amino acid replacements at position 248. Protein Sci (2000) 1.11
States and functions of tyrosine residues in Escherichia coli asparaginase II. Eur J Biochem (1994) 1.09
Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase. Leukemia (1997) 1.06
L-Asparaginase inhibits the rapamycin-targeted signaling pathway. Biochem Biophys Res Commun (1999) 1.06
Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol (2009) 1.02
Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia. Leukemia (2004) 1.00
Asparaginase revisited. Leuk Lymphoma (2011) 0.99
A pharmacological study on pegylated asparaginase used in front-line treatment of children with acute lymphoblastic leukemia. Haematologica (2006) 0.99
Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac: pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system. Br J Haematol (2001) 0.98
Cloning, expression and characterisation of Erwinia carotovora L-asparaginase. J Biotechnol (2005) 0.97
Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. PLoS One (2012) 0.96
Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity. Blood (2010) 0.96
ELISA to evaluate plasma anti-asparaginase IgG concentrations in patients with acute lymphoblastic leukemia. J Immunol Methods (2000) 0.94
Probing the role of threonine and serine residues of E. coli asparaginase II by site-specific mutagenesis. Protein Eng (1992) 0.94
Construction of expression systems for Escherichia coli asparaginase II and two-step purification of the recombinant enzyme from periplasmic extracts. Protein Expr Purif (1992) 0.91
Asparagine depletion after pegylated E. coli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children's Oncology Group study (CCG-1941). Pediatr Blood Cancer (2006) 0.90
Erwinia chrysanthemi L-asparaginase: epitope mapping and production of antigenically modified enzymes. Biochem J (1994) 0.90
Site-specific mutagenesis of Escherichia coli asparaginase II. None of the three histidine residues is required for catalysis. Eur J Biochem (1992) 0.88
Treatment of acute lymphoblastic leukaemia : a new era. Drugs (2007) 0.86
Glutaminase immunoreactivity and enzyme activity is increased in the rat dorsal root ganglion following peripheral inflammation. Pain Res Treat (2011) 0.84
Harmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007. Mutagenesis (2006) 0.84
A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release. Cell Death Differ (2004) 0.81
A radiometric technique for measuring L-asparagine in picomole quantities. Biochem J (1972) 0.81
Minimal residual disease (MRD) measurement as a tool to compare the efficacy of chemotherapeutic drug regimens using Escherichia Coli-asparaginase or Erwinia-asparaginase in childhood acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer (2006) 0.80
Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells. Cancer Chemother Pharmacol (2006) 0.78
Suppression of eIF4E expression by L-Asparaginase. Acta Haematol (2010) 0.78
Purification and properties of L-glutaminase-L-asparaginase from Pseudomonas acidovorans. J Bacteriol (1977) 0.78
Mapping of B-cell epitopes in E. coli asparaginase II, an enzyme used in leukemia treatment. Biol Chem (2005) 0.78
Probing the antigenicity of E. coli L-asparaginase by mutational analysis. Mol Biotechnol (2006) 0.76
The influence of human serum on the anti-tumour activity of two L-asparaginases. Br J Cancer (1969) 0.76
The effects of L-asparaginase on the amino acid incorporation of mouse lymphoid tumors. Cancer Res (1968) 0.76
The Children Leukemia Group: 30 years of research and achievements. Eur J Cancer (2002) 0.76
[Minimal residual disease analysis in acute lymphoblastic leukemia of childhood within the framework of COALL Study: results of an induction therapy without asparaginase]. Klin Padiatr (2000) 0.76
Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cell Microbiol (2010) 1.77
Systematic deletion of Salmonella small RNA genes identifies CyaR, a conserved CRP-dependent riboregulator of OmpX synthesis. Mol Microbiol (2008) 1.62
Extraovarian primary peritoneal papillary serous carcinoma. Arch Gynecol Obstet (2009) 1.57
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade. Apoptosis (2008) 1.44
Monitoring protein aggregation during thermal unfolding in circular dichroism experiments. Protein Sci (2006) 1.40
Development of a modified MTT assay for screening antimonial resistant field isolates of Indian visceral leishmaniasis. Parasitol Int (2005) 1.34
Natural products: promising resources for cancer drug discovery. Anticancer Agents Med Chem (2012) 1.23
A clinicopathological study of cutaneous tuberculosis at Dibrugarh district, Assam. Indian J Dermatol (2012) 1.19
Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition. FEBS Lett (2009) 1.08
An investigation on the antibacterial, cytotoxic, and antibiofilm efficacy of starch-stabilized silver nanoparticles. Nanomedicine (2011) 1.07
Toxicity and antibacterial assessment of chitosan-coated silver nanoparticles on human pathogens and macrophage cells. Int J Nanomedicine (2012) 1.05
Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol (2009) 1.02
Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation. Apoptosis (2009) 0.98
Aloe vera leaf exudate induces a caspase-independent cell death in Leishmania donovani promastigotes. J Med Microbiol (2007) 0.95
Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol Microbiol (2007) 0.95
Evaluation of antibacterial and cytotoxic activity of Artemisia nilagirica and Murraya koenigii leaf extracts against mycobacteria and macrophages. BMC Complement Altern Med (2014) 0.94
In vitro antileishmanial activity of Aloe vera leaf exudate: a potential herbal therapy in leishmaniasis. Glycoconj J (2007) 0.93
Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9. J Leukoc Biol (2012) 0.93
Racemoside A, an anti-leishmanial, water-soluble, natural steroidal saponin, induces programmed cell death in Leishmania donovani. J Med Microbiol (2007) 0.93
Role of C-reactive protein in complement-mediated hemolysis in Malaria. Glycoconj J (2006) 0.93
Variable degree of alternative complement pathway-mediated hemolysis in Indian visceral leishmaniasis induced by differential expression of 9-O-acetylated sialoglycans. J Infect Dis (2004) 0.93
Induction of glycosylation in human C-reactive protein under different pathological conditions. Biochem J (2003) 0.92
Detection and characterization of a sialoglycosylated bacterial ABC-type phosphate transporter protein from patients with visceral leishmaniasis. Glycoconj J (2009) 0.91
Four new dinuclear Cu(ii) hydrazone complexes using various organic spacers: syntheses, crystal structures, DNA binding and cleavage studies and selective cell inhibitory effect towards leukemic and normal lymphocytes. Dalton Trans (2009) 0.90
Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia. Leuk Res (2009) 0.89
In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis. Parasitol Res (2008) 0.89
Antibodies directed against O-acetylated sialoglycoconjugates accelerate complement activation in Leishmania donovani promastigotes. J Infect Dis (2004) 0.89
O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia. J Cell Biochem (2008) 0.89
Leishmania cell surface prohibitin: role in host-parasite interaction. Cell Microbiol (2009) 0.88
Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo. Int J Cancer (2012) 0.88
Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PLoS One (2012) 0.87
Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression. Toxicol Lett (2010) 0.86
Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes. Glycobiology (2002) 0.86
Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in sarcoma-180 bearing mice: involvement of MAP kinase, NF-kappa beta signal transduction pathway. Mol Immunol (2009) 0.86
High level of sialate-O-acetyltransferase activity in lymphoblasts of childhood acute lymphoblastic leukaemia (ALL): enzyme characterization and correlation with disease status. Glycoconj J (2008) 0.86
Sialoglycans in protozoal diseases: their detection, modes of acquisition and emerging biological roles. Glycoconj J (2004) 0.85
Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice. Vaccine (2011) 0.85
Differential expression of 9-O-acetylated sialoglycoconjugates on leukemic blasts: a potential tool for long-term monitoring of children with acute lymphoblastic leukemia. Int J Cancer (2004) 0.84
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma. Apoptosis (2014) 0.84
Azurophil granule proteins constitute the major mycobactericidal proteins in human neutrophils and enhance the killing of mycobacteria in macrophages. PLoS One (2012) 0.84
Coupling G2/M arrest to the Wnt/β-catenin pathway restrains pancreatic adenocarcinoma. Endocr Relat Cancer (2014) 0.83
Purification, characterization of O-acetylated sialoglycoconjugates-specific IgM, and development of an enzyme-linked immunosorbent assay for diagnosis and follow-up of indian visceral leishmaniasis patients. Diagn Microbiol Infect Dis (2004) 0.83
Glycobiology of Leishmania donovani. Indian J Med Res (2006) 0.83
Identification and quantification of the active component quercetin 3-O-rutinoside from Barringtonia racemosa, targets mitochondrial apoptotic pathway in acute lymphoblastic leukemia. J Asian Nat Prod Res (2010) 0.83
9-O-acetylated GD3 triggers programmed cell death in mature erythrocytes. Biochem Biophys Res Commun (2007) 0.83
Antibodies against 9-O-acetylated sialoglycans: a potent marker to monitor clinical status in childhood acute lymphoblastic leukemia. Clin Biochem (2004) 0.82
An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1. Parasitol Res (2009) 0.82
Characterization of the secretome of chickpea suspension culture reveals pathway abundance and the expected and unexpected secreted proteins. J Proteome Res (2011) 0.82
Purification and characterization of 9-O-acetylated sialoglycoproteins from leukemic cells and their potential as immunological tool for monitoring childhood acute lymphoblastic leukemia. Glycobiology (2004) 0.82
Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells. Int J Cancer (2010) 0.82
Protein A--a new ligand for human C-reactive protein. FEBS Lett (2004) 0.81
A sphingolipid rich lipid fraction isolated from attenuated Leishmania donovani promastigote induces apoptosis in mouse and human melanoma cells in vitro. Mol Cell Biochem (2006) 0.81
9-O-acetylated sialoglycoproteins are important immunomodulators in Indian visceral leishmaniasis. Clin Vaccine Immunol (2009) 0.81
Sialoglycotherapeutics in protozoal diseases. Mini Rev Med Chem (2008) 0.81
Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia. Br J Haematol (2005) 0.81
O-acetylation of sialic acids is required for the survival of lymphoblasts in childhood acute lymphoblastic leukemia (ALL). Glycoconj J (2007) 0.81
Membrane-active antimicrobial peptides and human placental lysosomal extracts are highly active against mycobacteria. Peptides (2011) 0.81
Mahanine, a DNA minor groove binding agent exerts cellular cytotoxicity with involvement of C-7-OH and -NH functional groups. J Med Chem (2013) 0.80
Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis. PLoS One (2011) 0.80
Sialoglycosylation of RBC in visceral leishmaniasis leads to enhanced oxidative stress, calpain-induced fragmentation of spectrin and hemolysis. PLoS One (2012) 0.80
Cationic antimicrobial peptides and biogenic silver nanoparticles kill mycobacteria without eliciting DNA damage and cytotoxicity in mouse macrophages. Antimicrob Agents Chemother (2013) 0.80
MEK inhibition prevents tumour-shed transforming growth factor-β-induced T-regulatory cell augmentation in tumour milieu. Immunology (2015) 0.80
Identification of sialic acids on Leishmania donovani amastigotes. Biol Chem (2004) 0.79
Disease-associated glycosylated molecular variants of human C-reactive protein activate complement-mediated hemolysis of erythrocytes in tuberculosis and Indian visceral leishmaniasis. Glycoconj J (2009) 0.79
Development of an assay for quantification of linkage-specific O-acetylated sialoglycans on erythrocytes; its application in Indian visceral leishmaniasis. J Immunol Methods (2002) 0.79
Significance of intracellular arsenic trioxide for therapeutic response in acute promyelocytic leukemia. Am J Hematol (2005) 0.79
Unraveling the C-reactive protein complement-cascade in destruction of red blood cells: potential pathological implications in Plasmodium falciparum malaria. Cell Physiol Biochem (2009) 0.79
Sialic acids in different Leishmania sp., its correlation with nitric oxide resistance and host responses. Glycobiology (2010) 0.79
Variations in binding characteristics of glycosylated human C-reactive proteins in different pathological conditions. Glycoconj J (2004) 0.79
RETRACTED: Sialic acids, important constituents and selective recognition factors of Pseudomonas aeruginosa, an opportunistic pathogen. Infect Immun (2009) 0.78
A perspective on the emergence of sialic acids as potent determinants affecting leishmania biology. Mol Biol Int (2011) 0.78
Distribution of Killer cell immunoglobulin like receptor genes in end stage renal disease among North Indian population. Hum Immunol (2013) 0.78
Interferon gamma promotes survival of lymphoblasts overexpressing 9-O-acetylated sialoglycoconjugates in childhood acute lymphoblastic leukaemia (ALL). J Cell Biochem (2005) 0.78
Targeting glycoproteins or glycolipids and their metabolic pathways for antiparasite therapy. Adv Exp Med Biol (2008) 0.78
Genome-wide identification of rice class I metallothionein gene: tissue expression patterns and induction in response to heavy metal stress. Funct Integr Genomics (2012) 0.78
Over-expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia. Int Immunol (2005) 0.78
Bafibrinase: A non-toxic, non-hemorrhagic, direct-acting fibrinolytic serine protease from Bacillus sp. strain AS-S20-I exhibits in vivo anticoagulant activity and thrombolytic potency. Biochimie (2012) 0.77
A network map of the gastrin signaling pathway. J Cell Commun Signal (2014) 0.77
Identification of 9-O-acetylated sialoglycans on peripheral blood mononuclear cells in Indian Visceral Leishmaniasis. Glycoconj J (2004) 0.77
Critical stoichiometric ratio of CD4(+) CD25(+) FoxP3(+) regulatory T cells and CD4(+) CD25(-) responder T cells influence immunosuppression in patients with B-cell acute lymphoblastic leukaemia. Immunology (2014) 0.77
Brugia malayi adult low molecular weight IgG4-reactive antigens induce differential cytokine response in lymphocytes of endemic normal and asymptomatic microfilariae carriers in vitro. J Clin Immunol (2007) 0.77
Identification and analysis of o-acetylated sialoglycoproteins. Methods Mol Biol (2013) 0.77
O-acetylated sialic acids: multifaceted role in childhood acute lymphoblastic leukaemia. Biotechnol J (2009) 0.77
9-O-acetylated sialic acids differentiating normal haematopoietic precursors from leukemic stem cells with high aldehyde dehydrogenase activity in children with acute lymphoblastic leukaemia. Glycoconj J (2014) 0.77
Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia. Glycobiology (2011) 0.77
Structure-based in silico design of a high-affinity dipeptide inhibitor for novel protein drug target Shikimate kinase of Mycobacterium tuberculosis. Chem Biol Drug Des (2010) 0.77
Withanolide D, carrying the baton of Indian rasayana herb as a lead candidate of antileukemic agent in modern medicine. Adv Exp Med Biol (2012) 0.77
Detection of immune-complexed 9-O-acetylated sialoglycoconjugates in the sera of patients with pediatric acute lymphoblastic leukemia. J Immunol Methods (2004) 0.77
Antibodies against 9-O-acetylated sialic acids in childhood acute lymphoblastic leukemia: a two-year study with 186 samples following protocol MCP 943. Indian J Biochem Biophys (2006) 0.77
Transformed yeast (Schizosaccharomyces pombe) overexpressing rice Tau class glutathione S-transferase (OsGSTU30 and OsGSTU41) shows enhanced resistance to hexavalent chromium. Metallomics (2014) 0.76
Sialic acids siglec interaction: a unique strategy to circumvent innate immune response by pathogens. Indian J Med Res (2013) 0.76
Altered erythrocyte membrane characteristics during anemia in childhood acute lymphoblastic leukemia. Ann Hematol (2004) 0.76
Clinical significance of P53 and Bcl-2 in acute myeloid leukemia patients of Eastern India. Hematol Rep (2011) 0.75
Melanotic neuroectodermal tumour of infancy. BMJ Case Rep (2010) 0.75
Killer immunoglobulin like receptor gene content diversity among Northern Indian population. Ann Hum Biol (2014) 0.75
Biocompatible chitosan nanoparticles as an efficient delivery vehicle for Mycobacterium tuberculosis lipids to induce potent cytokines and antibody response through activation of γδ T cells in mice. Nanotechnology (2017) 0.75
Highlights 2014 on glycoscience; glycosyltransferases and glycobiomarkers. Glycoconj J (2014) 0.75