Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma.

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Published in PLoS One on December 17, 2013

Authors

Lihua E Budde1, Carolina Berger2, Yukang Lin2, Jinjuan Wang2, Xubin Lin2, Shani E Frayo2, Shaunda A Brouns2, David M Spencer3, Brian G Till4, Michael C Jensen5, Stanley R Riddell6, Oliver W Press4

Author Affiliations

1: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, United States of America ; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America ; Departments of Medicine and Bioengineering, University of Washington, Seattle, Washington, United States of America.
2: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
3: Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America ; Bellicum Pharmaceuticals, Inc., Houston, Texas, United States of America.
4: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America ; Departments of Medicine and Bioengineering, University of Washington, Seattle, Washington, United States of America.
5: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America ; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, United States of America.
6: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America ; Departments of Medicine and Bioengineering, University of Washington, Seattle, Washington, United States of America ; Institute for Advanced Study, Technical University of Munich, Munich, Germany.

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