1
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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.
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Nature
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2008
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5.77
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2
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Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.
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Nat Rev Drug Discov
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2009
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3.26
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3
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A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family.
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Nature
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2006
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3.04
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4
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X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.
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Nature
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2011
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3.00
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5
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Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.
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Biophys J
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2005
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2.33
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6
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The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences.
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J Neurobiol
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2002
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2.20
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7
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Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
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Anesth Analg
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2009
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2.15
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8
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One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue.
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Proc Natl Acad Sci U S A
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2010
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1.81
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9
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A locally closed conformation of a bacterial pentameric proton-gated ion channel.
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Nat Struct Mol Biol
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2012
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1.56
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10
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Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.
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Proc Natl Acad Sci U S A
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2011
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1.52
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11
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Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels.
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EMBO J
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2013
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1.37
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12
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Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.
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Nat Commun
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2013
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1.35
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13
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Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.
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Proc Natl Acad Sci U S A
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2011
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1.34
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14
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Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.
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Proc Natl Acad Sci U S A
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2006
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1.32
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15
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Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.
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Proc Natl Acad Sci U S A
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2013
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1.32
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16
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Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor.
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Proc Natl Acad Sci U S A
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2002
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1.32
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17
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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.
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Proc Natl Acad Sci U S A
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2012
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1.22
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18
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3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels.
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Neuropharmacology
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2010
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1.16
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19
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Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel.
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J Mol Biol
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2009
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1.07
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20
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Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints.
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FEBS Lett
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2002
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0.96
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21
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Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment.
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J Biol Chem
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2013
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0.89
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22
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Smoke extracts and nicotine, but not tobacco extracts, potentiate firing and burst activity of ventral tegmental area dopaminergic neurons in mice.
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Neuropsychopharmacology
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2011
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0.86
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23
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Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons.
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Eur J Neurosci
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2004
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0.84
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24
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Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures.
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J Mol Graph Model
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2011
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0.80
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25
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Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC.
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J Med Chem
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2013
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0.78
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26
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Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.
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Proc Natl Acad Sci U S A
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2013
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0.78
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27
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Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors.
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Neuroreport
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2008
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0.77
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28
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Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR.
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Biochemistry
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2011
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0.77
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29
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[X-ray structures of general anesthetics bound to their molecular targets].
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Med Sci (Paris)
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2011
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0.76
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30
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Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
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J Clin Invest
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2016
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0.75
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