The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis.

PubWeight™: 0.84‹?›

🔗 View Article (PMC 3868527)

Published in PLoS Pathog on December 19, 2013

Authors

Jennifer N Walker1, Heidi A Crosby1, Adam R Spaulding1, Wilmara Salgado-Pabón1, Cheryl L Malone1, Carolyn B Rosenthal1, Patrick M Schlievert1, Jeffrey M Boyd2, Alexander R Horswill1

Author Affiliations

1: Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.
2: Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, New Jersey, United States of America.

Articles cited by this

Staphylococcus aureus infections. N Engl J Med (1998) 36.39

Genome and virulence determinants of high virulence community-acquired MRSA. Lancet (2002) 14.64

Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol (2009) 10.42

Community-associated meticillin-resistant Staphylococcus aureus. Lancet (2010) 9.07

Genetic systems in staphylococci. Methods Enzymol (1991) 9.00

Bacterial biofilms: an emerging link to disease pathogenesis. Annu Rev Microbiol (2003) 7.29

Improved method for electroporation of Staphylococcus aureus. FEMS Microbiol Lett (1992) 6.18

Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science (1999) 5.98

Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus. Mol Microbiol (1994) 5.62

Infective endocarditis. Lancet (2004) 4.64

Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands. J Bacteriol (2007) 4.07

Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med (2008) 4.01

Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog (2008) 3.91

Mutation of sarA in Staphylococcus aureus limits biofilm formation. Infect Immun (2003) 3.77

Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest (2009) 3.24

A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus. J Bacteriol (2000) 2.60

The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureus. Mol Microbiol (2001) 2.57

Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr Pulmonol (2009) 2.53

A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB. J Bacteriol (2008) 2.51

A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes. MBio (2013) 2.48

At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci. Microbiol Mol Biol Rev (2009) 2.41

Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation. PLoS One (2010) 2.27

Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis (2011) 2.19

Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions. BMC Microbiol (2010) 1.92

Peptide signaling in the staphylococci. Chem Rev (2010) 1.89

Staphylococcus aureus develops an alternative, ica-independent biofilm in the absence of the arlRS two-component system. J Bacteriol (2005) 1.88

Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation. Infect Immun (2009) 1.86

The action of fibrinogen on certain pathogenic cocci. J Gen Microbiol (1955) 1.82

Protein A-mediated multicellular behavior in Staphylococcus aureus. J Bacteriol (2008) 1.81

Biofilm dispersal of community-associated methicillin-resistant Staphylococcus aureus on orthopedic implant material. J Orthop Res (2010) 1.81

agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. J Innate Immun (2010) 1.77

Contribution of coagulases towards Staphylococcus aureus disease and protective immunity. PLoS Pathog (2010) 1.75

The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis (2009) 1.74

Global regulation of gene expression by ArlRS, a two-component signal transduction regulatory system of Staphylococcus aureus. J Bacteriol (2005) 1.72

Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One (2011) 1.71

Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections. FEMS Immunol Med Microbiol (2010) 1.68

Analysis of Ebh, a 1.1-megadalton cell wall-associated fibronectin-binding protein of Staphylococcus aureus. Infect Immun (2002) 1.63

Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS One (2010) 1.60

Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins. J Infect Dis (2011) 1.59

Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. PLoS Pathog (2011) 1.57

New approaches for treating staphylococcal biofilm infections. Ann N Y Acad Sci (2011) 1.56

Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds. J Clin Microbiol (2009) 1.55

A play in four acts: Staphylococcus aureus abscess formation. Trends Microbiol (2011) 1.53

Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain. J Bacteriol (2011) 1.48

The giant extracellular matrix-binding protein of Staphylococcus epidermidis mediates biofilm accumulation and attachment to fibronectin. Mol Microbiol (2009) 1.36

Large-scale identification of genes required for full virulence of Staphylococcus aureus. J Bacteriol (2004) 1.34

Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm. PLoS One (2011) 1.31

Clumping of Staphylococcus aureus in the peritoneal cavity of mice. J Bacteriol (1966) 1.30

Glucosyltransferase A (GtfA) and inulosucrase (Inu) of Lactobacillus reuteri TMW1.106 contribute to cell aggregation, in vitro biofilm formation, and colonization of the mouse gastrointestinal tract. Microbiology (2008) 1.27

Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase. J Bacteriol (2011) 1.22

Enhanced activation of bound plasminogen on Staphylococcus aureus by staphylokinase. FEBS Lett (2002) 1.17

Fibrinogen depletion attenuates Staphyloccocus aureus infection by preventing density-dependent virulence gene up-regulation. J Immunol (2003) 1.15

Identifying protective antigens of Staphylococcus aureus, a pathogen that suppresses host immune responses. FASEB J (2011) 1.15

Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability. Microbiologyopen (2012) 1.13

sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Mol Microbiol (2012) 1.08

Cytolysins, superantigens, and pneumonia due to community-associated methicillin-resistant Staphylococcus aureus. J Infect Dis (2009) 1.08

Formation of intraperitoneal abscesses by Staphylococcus aureus. Infect Immun (1980) 1.07

Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections. J Innate Immun (2012) 1.07

Planktonic aggregates of Staphylococcus aureus protect against common antibiotics. PLoS One (2012) 1.02

Comparison of Staphylococcus aureus strains for ability to cause infective endocarditis and lethal sepsis in rabbits. Front Cell Infect Microbiol (2012) 1.01

Enterococcus faecalis endocarditis severity in rabbits is reduced by IgG Fabs interfering with aggregation substance. PLoS One (2010) 0.98

Role of ArlRS in autolysis in methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains. J Bacteriol (2011) 0.93

Staphylococcus aureus clumping factor B mediates biofilm formation in the absence of calcium. Microbiology (2012) 0.91

A coverslip-based technique for evaluating Staphylococcus aureus biofilm formation on human plasma. Front Cell Infect Microbiol (2012) 0.90

Staphylococcus aureus giant protein Ebh is involved in tolerance to transient hyperosmotic pressure. Biochem Biophys Res Commun (2008) 0.89

Role of staphylokinase in the acquisition of plasmin(ogen)-dependent enzymatic activity by staphylococci. J Infect Dis (1996) 0.84

A helical string of alternately connected three-helix bundles for the cell wall-associated adhesion protein Ebh from Staphylococcus aureus. Structure (2008) 0.83

Electron microscopy and computational studies of Ebh, a giant cell-wall-associated protein from Staphylococcus aureus. Biochem Biophys Res Commun (2008) 0.81