Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions.

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Published in BMC Microbiol on June 15, 2010

Authors

Alex J McCarthy1, Jodi A Lindsay

Author Affiliations

1: Department of Cellular and Molecular Medicine, St George's, University of London, Centre for Infection, Cranmer Terrace, London SW17 0RE, UK. amccarth@sgul.ac.uk

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47

Locating proteins in the cell using TargetP, SignalP and related tools. Nat Protoc (2007) 19.50

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Molecular characterization and expression of a gene encoding a Staphylococcus aureus collagen adhesin. J Biol Chem (1992) 2.99

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Protein A is the von Willebrand factor binding protein on Staphylococcus aureus. Blood (2000) 2.12

Methicillin-resistant staphylococci in companion animals. Emerg Infect Dis (2005) 2.07

Staphylococcal complement evasion by various convertase-blocking molecules. J Exp Med (2007) 2.03

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Staphylococcus aureus synthesizes adenosine to escape host immune responses. J Exp Med (2009) 1.85

Structure of the collagen-binding domain from a Staphylococcus aureus adhesin. Nat Struct Biol (1997) 1.80

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Surface adhesins of Staphylococcus aureus. Adv Microb Physiol (2006) 1.77

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Signal peptides direct surface proteins to two distinct envelope locations of Staphylococcus aureus. EMBO J (2008) 1.35

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Multiple binding sites in the interaction between an extracellular fibrinogen-binding protein from Staphylococcus aureus and fibrinogen. J Biol Chem (1998) 1.32

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