Published in J Biol Chem on April 25, 1987
Amino acid sequence of the human fibronectin receptor. J Cell Biol (1987) 4.08
Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J Cell Biol (1989) 3.77
Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi. J Cell Biol (1988) 3.35
Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol (1988) 2.72
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex. J Exp Med (1989) 2.69
Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells. J Cell Biol (1988) 2.64
Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor. EMBO J (1988) 2.31
Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul (1990) 2.29
Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen. J Cell Biol (1988) 2.28
The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol (1989) 2.27
Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation. J Cell Biol (1988) 2.26
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood (2008) 2.22
Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells. J Cell Biol (1990) 2.16
Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J (1989) 2.04
Fibronectin receptors of phagocytes. Characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes. J Exp Med (1988) 1.86
Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cells. J Clin Invest (1989) 1.75
An alternative cytoplasmic domain of the integrin beta 3 subunit. Proc Natl Acad Sci U S A (1989) 1.61
A beta 1-integrin receptor for fibronectin in human kidney glomeruli. Am J Pathol (1989) 1.34
Platelet glycoprotein IIb. Chromosomal localization and tissue expression. J Clin Invest (1987) 1.31
Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors. J Clin Invest (1988) 1.22
Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function. Proc Natl Acad Sci U S A (1987) 1.15
In vivo analyses of integrin beta 1 subunit function in fibronectin matrix assembly. J Cell Biol (1990) 1.13
Homologous recombination among three intragene Alu sequences causes an inversion-deletion resulting in the hereditary bleeding disorder Glanzmann thrombasthenia. Am J Hum Genet (1993) 1.03
Ligand bridging mediates integrin alpha IIb beta 3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell-cell interactions. J Clin Invest (1991) 0.98
A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia. J Clin Invest (1991) 0.93
Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules. J Clin Invest (1993) 0.89
Vitronectin binds to activated human platelets and plays a role in platelet aggregation. J Clin Invest (1990) 0.88
Differential structural requirements for fibrinogen binding to platelets and to endothelial cells. J Cell Biol (1989) 0.85
Surface proteins and glycoproteins of human leucocytes. Biochem J (1988) 0.83
Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo. MBio (2016) 0.82
A vitronectin-receptor-related molecule in human placental brush border membranes. Biochem J (1991) 0.81
Reactivity of T cells from women with antibodies to the human platelet antigen (HPA)-1a to peptides encompassing the HPA-1 polymorphism. Clin Exp Immunol (2005) 0.79
Comparative study of the glycosylation of platelet glycoprotein GPIIb/IIIa and the vitronectin receptor. Differential processing of their beta-subunit. Biochem J (1990) 0.77
Integrin signaling. Science (1999) 16.44
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature (1984) 14.25
Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. Int J Cancer (1977) 11.99
Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol (1995) 8.88
Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell (1985) 8.55
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature (1997) 8.52
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science (1998) 8.11
Arg-Gly-Asp: a versatile cell recognition signal. Cell (1986) 7.89
Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol (1996) 5.62
Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors. Science (1986) 5.58
Integrins and anoikis. Curr Opin Cell Biol (1997) 5.38
Organ targeting in vivo using phage display peptide libraries. Nature (1996) 5.20
Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell (1990) 5.15
Variants of the cell recognition site of fibronectin that retain attachment-promoting activity. Proc Natl Acad Sci U S A (1984) 5.13
Ligand binding to integrins. J Biol Chem (2000) 4.94
The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem (1999) 4.92
Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature (1990) 4.90
Fibronectin: current concepts of its structure and functions. Coll Relat Res (1981) 4.82
Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature (1990) 4.64
Transforming growth factor-beta in disease: the dark side of tissue repair. J Clin Invest (1992) 4.49
Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem (1996) 4.45
Fibronectin: purification, immunochemical properties, and biological activities. Methods Enzymol (1982) 4.45
A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin. Proc Natl Acad Sci U S A (1985) 4.44
Amino acid sequence of the human fibronectin receptor. J Cell Biol (1987) 4.08
Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol (1994) 4.07
Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature (1992) 3.96
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J (1994) 3.92
Interaction of soluble fibroblast surface antigen with fribrinogen and fibrin. J Exp Med (1975) 3.91
Alpha v integrins as receptors for tumor targeting by circulating ligands. Nat Biotechnol (1997) 3.89
Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med (1999) 3.72
Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule. Cell (1981) 3.64
Human platelets possess an inducible and saturable receptor specific for fibrinogen. J Biol Chem (1979) 3.61
Affinity of fibronectin to collagens of different genetic types and to fibrinogen. J Exp Med (1978) 3.46
Disappearance of a major cell-type specific surface glycoprotein antigen (SF) after transformation of fibroblasts by Rous sarcoma virus. Int J Cancer (1974) 3.24
Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res (2000) 3.24
Serum spreading factor (vitronectin) is present at the cell surface and in tissues. Proc Natl Acad Sci U S A (1983) 3.23
Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J Cell Biol (1996) 3.18
Integrin cytoplasmic domain-binding proteins. J Cell Sci (2000) 3.17
Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci U S A (1993) 3.16
Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. Proc Natl Acad Sci U S A (1986) 3.16
Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A (2001) 3.07
A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell (2000) 3.03
The human laminin receptor is a member of the integrin family of cell adhesion receptors. Science (1988) 3.03
Synthetic peptide with cell attachment activity of fibronectin. Proc Natl Acad Sci U S A (1983) 2.97
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol (1996) 2.94
The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci U S A (1995) 2.90
Multiple domains of the large fibroblast proteoglycan, versican. EMBO J (1989) 2.86
Distribution of fibroblast surface antigen in the developing chick embryo. J Exp Med (1975) 2.85
Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell (1997) 2.84
Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Cell (1991) 2.81
Polysaccharide vaccines of group A Neisseria meningtitidis and Haemophilus influenzae type b: a field trial in Finland. J Infect Dis (1977) 2.79
Regulation of the fibronectin receptor affinity by divalent cations. J Biol Chem (1988) 2.78
PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev Cell (2001) 2.73
Fibroblast surface antigen: a new serum protein. Biochim Biophys Acta (1973) 2.71
Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin. EMBO J (1985) 2.69
Role of cell-surface lysines in plasminogen binding to cells: identification of alpha-enolase as a candidate plasminogen receptor. Biochemistry (1991) 2.66
Heterogeneity of Genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. J Neuropathol Exp Neurol (1981) 2.65
Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display. J Clin Invest (1998) 2.65
The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. Proc Natl Acad Sci U S A (1985) 2.64
Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Trends Biochem Sci (1991) 2.62
Distribution of fibroblast surface antigen: association with fibrillar structures of normal cells and loss upon viral transformation. J Exp Med (1974) 2.62
Complementation of dominant suppression implicates CD98 in integrin activation. Nature (1997) 2.62
Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. J Biol Chem (1987) 2.62
Basement membrane glycoprotein laminin binds to heparin. FEBS Lett (1980) 2.60
Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature (1999) 2.59
A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1). J Biol Chem (1990) 2.58
Laminin promotes neuritic regeneration from cultured peripheral and central neurons. J Cell Biol (1983) 2.58
cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. Proc Natl Acad Sci U S A (1986) 2.58
Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science (1991) 2.57
Association of insulin receptor substrate-1 with integrins. Science (1994) 2.56
Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J Clin Invest (1990) 2.56
beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci U S A (1998) 2.54
Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem (2000) 2.52
Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52
The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type. J Cell Biol (1986) 2.50
Integrin activation by R-ras. Cell (1996) 2.50
Involvement of C group chromosomes in five Burkitt lymphoma cell lines. J Natl Cancer Inst (1967) 2.49
Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem (1994) 2.46
Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins. Biotechnology (N Y) (1995) 2.45
A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science (1990) 2.42
Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF. EMBO J (1997) 2.40
Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science (1996) 2.38
Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation (1995) 2.38
Superfibronectin is a functionally distinct form of fibronectin. Nature (1994) 2.38
Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library. J Biol Chem (1993) 2.37
Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell (1995) 2.36