Ligand binding to integrins.

PubWeight™: 4.94‹?› | Rank: Top 1%

🔗 View Article (PMID 10801897)

Published in J Biol Chem on July 21, 2000

Authors

E F Plow1, T A Haas, L Zhang, J Loftus, J W Smith

Author Affiliations

1: Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. plowe@ccf.org

Articles citing this

(truncated to the top 100)

Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science (2001) 8.12

Integrin ligands at a glance. J Cell Sci (2006) 4.76

Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer (2008) 4.27

Molecular aspects of thyroid hormone actions. Endocr Rev (2010) 3.29

The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment. J Exp Med (2003) 2.94

Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol (2008) 2.88

Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol (2011) 2.58

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. J Clin Invest (2004) 2.57

A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. EMBO J (2007) 2.44

Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res (2011) 2.26

Leukocyte migration and graft-versus-host disease. Blood (2005) 2.17

Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build. Cell Mol Life Sci (2013) 2.14

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18). J Exp Med (2001) 2.12

Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med (2004) 2.04

Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography. Proc Natl Acad Sci U S A (2002) 1.93

Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-phosphatidylinositol 3-kinase-rho GTPase signal pathways and cytoskeletal rearrangements. J Virol (2004) 1.91

Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med Chem (2010) 1.87

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood (2010) 1.82

The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81

New insights into form and function of fibronectin splice variants. J Pathol (2008) 1.80

Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression. Proc Natl Acad Sci U S A (2005) 1.72

Improved targeting of the alpha(v)beta (3) integrin by multimerisation of RGD peptides. Eur J Nucl Med Mol Imaging (2006) 1.66

The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels. Proc Natl Acad Sci U S A (2005) 1.65

Genomic and proteomic analysis of thirty-nine structural proteins of shrimp white spot syndrome virus. J Virol (2004) 1.65

Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry. J Virol (2006) 1.64

Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis. Mol Biol Cell (2002) 1.61

Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis (2009) 1.58

PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation. Infect Immun (2005) 1.54

Nerve-independent formation of a topologically complex postsynaptic apparatus. J Cell Biol (2004) 1.54

Human herpesvirus 8 envelope glycoprotein B mediates cell adhesion via its RGD sequence. J Virol (2003) 1.53

Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem (2007) 1.52

Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover. J Cell Sci (2008) 1.49

Molecular biology of KSHV in relation to AIDS-associated oncogenesis. Cancer Treat Res (2007) 1.47

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum. J Cell Sci (2010) 1.45

Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res (2010) 1.34

Integrin alpha(M)beta(2)-mediated cell migration to fibrinogen and its recognition peptides. J Exp Med (2001) 1.34

Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor. J Virol (2007) 1.33

Kaposi's sarcoma-associated herpesvirus forms a multimolecular complex of integrins (alphaVbeta5, alphaVbeta3, and alpha3beta1) and CD98-xCT during infection of human dermal microvascular endothelial cells, and CD98-xCT is essential for the postentry stage of infection. J Virol (2008) 1.33

Integrin and growth factor receptor alliance in angiogenesis. Cell Biochem Biophys (2008) 1.31

Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30

Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide. Mol Imaging (2009) 1.27

Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis. Inflammopharmacology (2011) 1.24

Beta2 integrins separate graft-versus-host disease and graft-versus-leukemia effects. Blood (2007) 1.23

Gene expression and internalization following vector adsorption to immobilized proteins: dependence on protein identity and density. J Gene Med (2007) 1.23

The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. Blood (2005) 1.19

Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease. Acta Physiol (Oxf) (2009) 1.18

The emergence of integrins: a personal and historical perspective. Matrix Biol (2004) 1.18

Integrin affinity modulation in angiogenesis. Cell Cycle (2007) 1.17

Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. EMBO J (2003) 1.17

Arabidopsis NDR1 is an integrin-like protein with a role in fluid loss and plasma membrane-cell wall adhesion. Plant Physiol (2011) 1.16

Roles of integrins in tumor angiogenesis and lymphangiogenesis. Lymphat Res Biol (2008) 1.16

Order and disorder: the role of extracellular matrix in epithelial cancer. Cancer Invest (2002) 1.15

Tumor Targeting via Integrin Ligands. Front Oncol (2013) 1.15

Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities. J Mol Biol (2008) 1.12

Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer (2011) 1.12

Transmembrane signal transduction of the alpha(IIb)beta(3) integrin. Protein Sci (2002) 1.10

SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration. Mol Cell Biol (2004) 1.10

Antiangiogenic therapy for cancer: an update. Pharmacotherapy (2012) 1.10

Insidious changes in stromal matrix fuel cancer progression. Mol Cancer Res (2014) 1.09

The biomechanical integrin. J Biomech (2009) 1.09

The relationship between platelet adhesion on surfaces and the structure versus the amount of adsorbed fibrinogen. Biomaterials (2009) 1.09

Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells. Small (2011) 1.07

Advantages of RGD peptides for directing cell association with biomaterials. Biomaterials (2011) 1.06

Alpha4beta1 integrin acts as a cell receptor for murine polyomavirus at the postattachment level. J Virol (2003) 1.06

Fibrinogen induces endothelial cell permeability. Mol Cell Biochem (2007) 1.05

miR-31 is a broad regulator of β1-integrin expression and function in cancer cells. Mol Cancer Res (2011) 1.05

Continuum model of cell adhesion and migration. J Math Biol (2008) 1.04

Library of disordered patterns in 3D protein structures. PLoS Comput Biol (2010) 1.04

Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells. Dev Biol (2005) 1.03

Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. EMBO J (2006) 1.03

Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor. Exp Cell Res (2008) 1.02

Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface. PLoS Pathog (2013) 1.02

Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site. J Biol Chem (2010) 1.02

Targeting integrins to promote bone formation and repair. Nat Rev Endocrinol (2013) 1.02

Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice. Circ Res (2011) 1.01

PET imaging of αvβ₃ integrin expression in tumours with ⁶⁸Ga-labelled mono-, di- and tetrameric RGD peptides. Eur J Nucl Med Mol Imaging (2010) 1.00

Involvement of fibrinogen specific binding in erythrocyte aggregation. FEBS Lett (2002) 0.99

Binding of a fibrinogen mimetic stabilizes integrin alphaIIbbeta3's open conformation. Protein Sci (2001) 0.99

Mechanisms of neutrophil transendothelial migration. Front Biosci (Landmark Ed) (2009) 0.98

S100A9 mediates neutrophil adhesion to fibronectin through activation of beta2 integrins. Biochem Biophys Res Commun (2007) 0.97

AMPA receptor stimulation increases alpha5beta1 integrin surface expression, adhesive function and signaling. J Neurochem (2005) 0.97

The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells. Mol Cell Biol (2005) 0.96

Fibrinogen induces alterations of endothelial cell tight junction proteins. J Cell Physiol (2009) 0.95

Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β₃ affinity modulation. Br J Cancer (2012) 0.94

Rotavirus enterotoxin NSP4 binds to the extracellular matrix proteins laminin-beta3 and fibronectin. J Virol (2004) 0.94

Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem (2008) 0.94

ADP-ribosylation of integrin alpha7 modulates the binding of integrin alpha7beta1 to laminin. Biochem J (2005) 0.94

Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells. Clin Exp Metastasis (2007) 0.93

Thyroid hormones and cardiovascular disease. Nat Rev Cardiol (2016) 0.93

Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield. J Virol (2007) 0.92

Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci (2006) 0.92

A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen (2007) 0.92

Nongenomic actions of thyroid hormone. Nat Rev Endocrinol (2015) 0.92

Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development (2010) 0.92

Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues. Biochemistry (2011) 0.91

Fibrinogen-induced increased pial venular permeability in mice. J Cereb Blood Flow Metab (2011) 0.90

Identification of novel agonists of the integrin CD11b/CD18. Bioorg Med Chem Lett (2009) 0.90

Integrins in the optic nerve head: potential roles in glaucomatous optic neuropathy (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc (2006) 0.90

Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration. PLoS One (2012) 0.90

Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers. Acta Biomater (2011) 0.90

Articles by these authors

Serial analysis of gene expression. Science (1995) 60.15

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med (1999) 14.30

Characterization of the yeast transcriptome. Cell (1997) 11.33

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62

A public database for gene expression in human cancers. Cancer Res (1999) 8.81

Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med (1995) 8.23

PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95

14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20

Extended use of nursing services in general practice. Br Med J (1967) 6.35

Analysis of human transcriptomes. Nat Genet (1999) 6.14

The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87

The practice nurse--a new look. Br Med J (1970) 5.16

Studies on the epidemiology of adverse drug reactions. V. Clinical factors influencing susceptibility. Ann Intern Med (1966) 5.11

Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation (2000) 5.09

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68

VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest (2000) 4.36

Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet (1999) 4.36

Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol (2004) 4.28

Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J Exp Anal Behav (1999) 4.23

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet (2000) 4.17

The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med (2000) 4.08

Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 4.07

A quantum dot single-photon turnstile device. Science (2000) 3.89

DNA supercoiling promotes formation of a bent repression loop in lac DNA. J Mol Biol (1987) 3.81

A multifactorial analysis of melanoma. IV. Prognostic factors in 200 melanoma patients with distant metastases (stage III). J Clin Oncol (1983) 3.80

Diagnosis of chlamydial infection in women attending antenatal and gynecologic clinics. J Clin Microbiol (1987) 3.70

The genome reconstruction manager: a software environment for supporting high-throughput DNA sequencing. Genomics (1994) 3.69

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med (1992) 3.63

TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J (1998) 3.49

HIV-1 drug resistance in newly infected individuals. JAMA (1999) 3.49

An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene (2006) 3.48

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34

A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells. Cell (1989) 3.34

Reactions to tetanus toxoid. J Hyg (Lond) (1973) 3.33

Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers. Science (1995) 3.16

Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol (1999) 3.15

A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med (1998) 3.15

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A (2000) 3.12

PUMA, a potent killer with or without p53. Oncogene (2008) 3.09

TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer. Proc Natl Acad Sci U S A (1994) 3.08

Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A (1999) 3.07

Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A (2001) 3.07

Human lymphocytic metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutinin. J Clin Invest (1971) 3.01

Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res (2001) 2.98

Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. J Biol Chem (1995) 2.93

Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol (2013) 2.92

Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green alga Chlamydomonas reinhardtii. Plant Physiol (2000) 2.92

Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol (2001) 2.91

Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience (2001) 2.84

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78

Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop. J Virol (1996) 2.77

NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature (2005) 2.74

Local immune response in experimental pyelonephritis. J Clin Invest (1969) 2.73

Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res (2000) 2.71

Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66

Localization of urinary-tract infections by detection of antibody-coated bacteria in urine sediment. N Engl J Med (1974) 2.63

Cultivation of Pneumocystis carinii with WI-38 cells. J Clin Microbiol (1979) 2.63

Eikenella corrodens, a recently recognized pathogen: infections in medical-surgical patients and in association with methylphenidate abuse. Medicine (Baltimore) (1974) 2.61

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature (1994) 2.61

Cyclic adenosine 3',5'-monophosphate in human lymphocytes. Alterations after phytohemagglutinin stimulation. J Clin Invest (1971) 2.61

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci U S A (2001) 2.58

Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem (2001) 2.57

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol Cell Biol (1992) 2.55

Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol (2001) 2.51

Involvement of C group chromosomes in five Burkitt lymphoma cell lines. J Natl Cancer Inst (1967) 2.49

Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients. Clin Diagn Lab Immunol (1998) 2.48

HIV-1 subtype and second-receptor use. Nature (1996) 2.46

Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob Agents Chemother (1998) 2.44

Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to -adrenergic agents. J Clin Invest (1973) 2.42

HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. J Clin Invest (1999) 2.42

Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics (2006) 2.38

Meta-analysis: prevalence of HIV infection and syphilis among MSM in China. Sex Transm Infect (2009) 2.36

Ultrasonic hydrophone based on short in-fiber bragg gratings. Appl Opt (1998) 2.35

Trends in incidence and prevalence of major transfusion-transmissible viral infections in US blood donors, 1991 to 1996. Retrovirus Epidemiology Donor Study (REDS) JAMA (2000) 2.33

Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation. Am J Hum Genet (2004) 2.33

Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med (2000) 2.31

Survival time comparison between Hawley and clear overlay retainers: a randomized trial. J Dent Res (2011) 2.26

Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci (1999) 2.26

Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J Virol (2000) 2.26

RED: a red-cell antibody identification expert module. J Med Syst (1985) 2.24

General practitioners in hospital. Br Med J (1970) 2.22

Accurate control of contrast on microcomputer displays. Vision Res (1991) 2.21

New rat model of Pneumocystis carinii infection. J Clin Microbiol (1988) 2.21

New structural picture of the Ge2Sb2Te5 phase-change alloy. Phys Rev Lett (2011) 2.21

Excess mortality associated with influenza in England and Wales. Int J Epidemiol (1977) 2.20

Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development (1999) 2.20

Current therapy for cutaneous melanoma. J Am Acad Dermatol (1995) 2.19

Chemical mapping of a single molecule by plasmon-enhanced Raman scattering. Nature (2013) 2.19

Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes. J Clin Microbiol (1994) 2.17

Frequency of immediate adverse effects associated with therapeutic apheresis. Transfusion (1999) 2.17

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 2.16

Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys. J Virol (1997) 2.16

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A (1995) 2.14

Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review. Clin Pharmacol Ther (2010) 2.13

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. J Cell Biol (1989) 2.12

MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells. Exp Cell Res (2001) 2.12

Excess deaths attributable to influenza in England and Wales: age at death and certified cause. Int J Epidemiol (1983) 2.12