Published in Br J Pharmacol on May 01, 2014
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Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene. Biochem Pharmacol (2011) 0.89
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Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther (2003) 0.92
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Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2. Drug Metab Dispos (2007) 0.91
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Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo. Clin Exp Pharmacol Physiol (2006) 0.90
P-glycoprotein expression and distribution in the rat placenta during pregnancy. Reprod Toxicol (2004) 0.90
Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene. Biochem Pharmacol (2011) 0.89
Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. PLoS One (2012) 0.88
The role of residues T248, Y249 and T422 in the function of human pregnane X receptor. Arch Toxicol (2012) 0.88
Metabolism of ophthalmic timolol: new aspects of an old drug. Basic Clin Pharmacol Toxicol (2011) 0.88
Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact (2008) 0.87
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients. Diabetes Care (2004) 0.86
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Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood. PLoS One (2013) 0.83
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Regulation of CYP3A genes in the human respiratory tract. Chem Biol Interact (2005) 0.83
Changes in diurnal sympathoadrenal balance and pituitary hormone secretion in subjects with Leu7Pro polymorphism in the prepro-neuropeptide Y. J Clin Endocrinol Metab (2003) 0.83
Regulation of the Cyp2a5 gene involves an aryl hydrocarbon receptor-dependent pathway. Mol Pharmacol (2005) 0.82
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Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cells. Mol Pharmacol (2007) 0.81
Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicol Lett (2013) 0.80
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Obesity in transgenic female mice with constitutively elevated luteinizing hormone secretion. Am J Physiol Endocrinol Metab (2003) 0.78
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol (2014) 0.78
Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines. Toxicol Lett (2010) 0.78
Characterization of human cytochrome P450 induction by pesticides. Toxicology (2012) 0.78
Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes. Basic Clin Pharmacol Toxicol (2009) 0.78
Pregnane X receptor (PXR)--a contributor to the diabetes epidemic? Drug Metabol Drug Interact (2014) 0.78
Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. Pharmacol Res (2011) 0.78
Sympathetic nervous system-targeted neuropeptide Y overexpression in mice enhances neointimal formation in response to vascular injury. Peptides (2008) 0.78
Characterization of androgen-regulated expression of CYP3A5 in human prostate. Carcinogenesis (2006) 0.78
The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients. Rheumatol Int (2015) 0.78
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Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line. Toxicol Lett (2013) 0.77
Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia? Toxicol Lett (2010) 0.77
Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells. Eur J Pharm Sci (2010) 0.77
Poxvirus-based vaccines for cancer immunotherapy: new insights from combined cytokines/co-stimulatory molecules delivery and "uncommon" strains. Anticancer Agents Med Chem (2014) 0.77
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Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Toxicol Lett (2013) 0.77
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Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD. Invest Ophthalmol Vis Sci (2009) 0.76
Valproate activates ERK signaling pathway in primary human hepatocytes. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub (2012) 0.76
New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.76
Placental transfer of quetiapine in relation to P-glycoprotein activity. J Psychopharmacol (2007) 0.76
The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test. J Clin Endocrinol Metab (2005) 0.76
Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2. Toxicology (2012) 0.76
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Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells. Eur J Pharmacol (2011) 0.75
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Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration. Acta Ophthalmol Scand (2007) 0.75
Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells). Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub (2012) 0.75
Cytochromes P450, induction and cholesterol--what are the connections? Eur J Clin Pharmacol (2008) 0.75
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