Published in Nat Genet on January 26, 2014
Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet (2014) 3.42
Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. Nat Genet (2016) 1.71
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA (2014) 1.22
Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel) (2015) 1.16
Recent advances in understanding the genetic architecture of type 2 diabetes. Hum Mol Genet (2015) 1.16
Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PLoS Genet (2015) 1.12
Rare variant association studies: considerations, challenges and opportunities. Genome Med (2015) 1.05
Fast and accurate long-range phasing in a UK Biobank cohort. Nat Genet (2016) 1.00
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun (2016) 0.94
Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor. Diabetes (2016) 0.93
Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits. Brief Funct Genomics (2014) 0.91
Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals. J Hum Genet (2015) 0.89
Identification of a novel gene for diabetic traits in rats, mice, and humans. Genetics (2014) 0.89
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis. Nat Commun (2015) 0.88
New basal cell carcinoma susceptibility loci. Nat Commun (2015) 0.87
Rare coding variants and X-linked loci associated with age at menarche. Nat Commun (2015) 0.87
Rare and low-frequency coding variants alter human adult height. Nature (2017) 0.85
Height-reducing variants and selection for short stature in Sardinia. Nat Genet (2015) 0.84
Sequence Kernel Association Analysis of Rare Variant Set Based on the Marginal Regression Model for Binary Traits. Genet Epidemiol (2015) 0.84
Recent progress in genetic and epigenetic research on type 2 diabetes. Exp Mol Med (2016) 0.83
Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition. Sci Rep (2016) 0.83
Insights from exome sequencing for endocrine disorders. Nat Rev Endocrinol (2015) 0.83
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nat Genet (2016) 0.82
Repurposing cAMP-modulating medications to promote β-cell replication. Mol Endocrinol (2014) 0.82
Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland. Diabetologia (2016) 0.82
Deeper, longer phenotyping to accelerate the discovery of the genetic architectures of diseases. Genome Biol (2014) 0.82
Type 2 diabetes: genetic data sharing to advance complex disease research. Nat Rev Genet (2016) 0.82
Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. Int J Mol Med (2015) 0.81
Using genetically isolated populations to understand the genomic basis of disease. Genome Med (2014) 0.81
Communication is the key. : Part 2 : Direct to consumer genetics in our future daily life ? J Cell Commun Signal (2014) 0.80
The pancreatic β cell: recent insights from human genetics. Trends Endocrinol Metab (2014) 0.80
Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery. Nat Rev Endocrinol (2016) 0.79
On Efficient and Accurate Calculation of Significance P-Values for Sequence Kernel Association Testing of Variant Set. Ann Hum Genet (2016) 0.79
A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease. PLoS Genet (2015) 0.79
Strategies for Imputing and Analyzing Rare Variants in Association Studies. Trends Genet (2015) 0.79
Genetics of Insulin Resistance and the Metabolic Syndrome. Curr Cardiol Rep (2016) 0.78
Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer. Hum Mol Genet (2016) 0.78
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev (2016) 0.78
Genome-wide association study revealed genomic regions related to white/red earlobe color trait in the Rhode Island Red chickens. BMC Genet (2016) 0.78
Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes. Nat Rev Endocrinol (2016) 0.78
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes (2017) 0.78
10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet (2017) 0.78
Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet (2014) 0.77
Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis. Med Sci Monit (2015) 0.77
Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population. Metabolism (2015) 0.77
60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C. J Mol Endocrinol (2015) 0.77
Diabetes: Still a geneticist's nightmare. Nature (2016) 0.77
Variants associated with type 2 diabetes identified by the transethnic meta-analysis study: assessment in American Indians and evidence for a new signal in LPP. Diabetologia (2014) 0.77
Mechanisms of Type 2 Diabetes Risk Loci. Curr Diab Rep (2017) 0.76
Islet biology, the CDKN2A/B locus and type 2 diabetes risk. Diabetologia (2016) 0.76
Discovery of rare variants for complex phenotypes. Hum Genet (2016) 0.76
Diabetes in Population Isolates: Lessons from Greenland. Rev Diabet Stud (2016) 0.76
Evaluating the Calibration and Power of Three Gene-Based Association Tests of Rare Variants for the X Chromosome. Genet Epidemiol (2015) 0.75
Transcriptomics in type 2 diabetes: Bridging the gap between genotype and phenotype. Genom Data (2015) 0.75
A Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med (2016) 0.75
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. Genome Med (2017) 0.75
The impact of rare and low-frequency genetic variants in common disease. Genome Biol (2017) 0.75
Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity. J Cell Sci (2016) 0.75
Can genomics help usher schizophrenia into the age of RDoC and DSM-6? Schizophr Bull (2015) 0.75
Association Between KCNQ1 Genetic Variants and Type 2 Diabetes in the Uyghur Population. Genet Test Mol Biomarkers (2015) 0.75
Vejle Diabetes Biobank - a resource for studies of the etiologies of diabetes and its comorbidities. Clin Epidemiol (2016) 0.75
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res (2017) 0.75
Low-, high-coverage, and two-stage DNA sequencing in the design of the genetic association study. Genet Epidemiol (2016) 0.75
New insights from monogenic diabetes for "common" type 2 diabetes. Front Genet (2015) 0.75
Epigenetic and genetic components of height regulation. Nat Commun (2016) 0.75
Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status - The HUNT Study. PLoS One (2015) 0.75
Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes. Front Genet (2017) 0.75
Human genetics as a model for target validation: finding new therapies for diabetes. Diabetologia (2017) 0.75
Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability. Nat Genet (2017) 0.75
Truncating mutations in RBM12 are associated with psychosis. Nat Genet (2017) 0.75
Identification of candidate protective variants for common diseases and evaluation of their protective potential. BMC Genomics (2017) 0.75
Prioritising Causal Genes at Type 2 Diabetes Risk Loci. Curr Diab Rep (2017) 0.75
Large-scale whole-genome sequencing of the Icelandic population. Nat Genet (2015) 4.54
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet (2014) 4.24
Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes. Diabetes (2015) 2.87
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet (2014) 2.39
Identification of a large set of rare complete human knockouts. Nat Genet (2015) 2.28
Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. Nat Genet (2016) 1.71
GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study. Diabetes (2015) 1.65
Obesity Paradox and Risk of Mortality Events in Chronic Kidney Disease Patients: A Decade of Follow-up in Tehran Lipid and Glucose Study. J Ren Nutr (2015) 1.48
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. Nat Genet (2015) 1.46
Is systolic blood pressure below 150 mm Hg an appropriate goal for primary prevention of cardiovascular events among elderly population? J Am Soc Hypertens (2014) 1.46
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet (2017) 1.44
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet (2015) 1.39
Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Nat Genet (2017) 1.39
Appropriate waist circumference cut-off points among Iranian adults: the first report of the Iranian National Committee of Obesity. Arch Iran Med (2010) 1.33
Appropriate definition of metabolic syndrome among Iranian adults: report of the Iranian National Committee of Obesity. Arch Iran Med (2010) 1.25
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet (2016) 1.24
Common and low-frequency variants associated with genome-wide recombination rate. Nat Genet (2013) 1.22
The impact of low-frequency and rare variants on lipid levels. Nat Genet (2015) 1.20
The germline sequence variant rs2736100_C in TERT associates with myeloproliferative neoplasms. Leukemia (2014) 1.15
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. PLoS Genet (2015) 1.08
Sex specific incidence rates of type 2 diabetes and its risk factors over 9 years of follow-up: Tehran Lipid and Glucose Study. PLoS One (2014) 1.02
Factor analysis of metabolic syndrome components and predicting type 2 diabetes: Results of 10-year follow-up in a Middle Eastern population. J Diabetes (2015) 0.99
The Y-chromosome point mutation rate in humans. Nat Genet (2015) 0.95
Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion. Diabetes (2015) 0.94
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol (2016) 0.92
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. Nat Commun (2015) 0.92
Loss-of-function variants in ATM confer risk of gastric cancer. Nat Genet (2015) 0.91
Diabetes-specific quality of life but not health status is independently associated with glycaemic control among patients with type 2 diabetes: a cross-sectional analysis of the ADDITION-Europe trial cohort. Diabetes Res Clin Pract (2014) 0.88
Weighting sequence variants based on their annotation increases power of whole-genome association studies. Nat Genet (2016) 0.88
Rare coding variants and X-linked loci associated with age at menarche. Nat Commun (2015) 0.87
Management of hyperthyroidism during pregnancy in Asia. Endocr J (2014) 0.86
The incidence of coronary heart disease and the population attributable fraction of its risk factors in Tehran: a 10-year population-based cohort study. PLoS One (2014) 0.85
Reliability and validity of the modifiable activity questionnaire for an Iranian urban adolescent population. Int J Prev Med (2015) 0.85
Sugar-Sweetened Beverage Consumption and Risk of General and Abdominal Obesity in Iranian Adults: Tehran Lipid and Glucose Study. Iran J Public Health (2015) 0.84
Applying decision tree for identification of a low risk population for type 2 diabetes. Tehran Lipid and Glucose Study. Diabetes Res Clin Pract (2014) 0.84
Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet (2016) 0.84
Thyroid dysfunction and pregnancy outcomes. Iran J Reprod Med (2015) 0.83
Insulin Resistance Is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation. Diabetes (2016) 0.82
Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications. Nutr Metab (Lond) (2015) 0.82
Adherence to the Mediterranean diet is associated with reduced risk of incident chronic kidney diseases among Tehranian adults. Hypertens Res (2016) 0.82
Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population. PLoS One (2015) 0.80
Is dietary nitrate/nitrite exposure a risk factor for development of thyroid abnormality? A systematic review and meta-analysis. Nitric Oxide (2015) 0.80
Effect of early multifactorial therapy compared with routine care on microvascular outcomes at 5 years in people with screen-detected diabetes: a randomized controlled trial: the ADDITION-Europe Study. Diabetes Care (2014) 0.80
A new approach to test validity and clinical usefulness of the 2013 ACC/AHA guideline on statin therapy: A population-based study. Int J Cardiol (2015) 0.80
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun (2017) 0.80
Dietary Approaches to Stop Hypertension (DASH) Dietary Pattern Is Associated with Reduced Incidence of Metabolic Syndrome in Children and Adolescents. J Pediatr (2016) 0.79
Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma. EBioMedicine (2016) 0.79