Radiotherapy and the tumor stroma: the importance of dose and fractionation.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 3896881)

Published in Front Oncol on January 21, 2014

Authors

Turid Hellevik1, Iñigo Martinez-Zubiaurre2

Author Affiliations

1: Department of Oncology, University Hospital of Northern-Norway , Tromsø , Norway ; Translational Cancer Research Group, Department of Clinical Medicine, University of Tromsø , Tromsø , Norway.
2: Translational Cancer Research Group, Department of Clinical Medicine, University of Tromsø , Tromsø , Norway.

Articles citing this

Radiation and inflammation. Semin Radiat Oncol (2015) 0.86

Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation. Front Oncol (2016) 0.83

Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients. Oncotarget (2015) 0.81

Your neighbours matter - non-autonomous control of apoptosis in development and disease. Cell Death Differ (2016) 0.79

Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities. Sci Rep (2016) 0.78

Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation. Front Oncol (2015) 0.78

Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment. Mol Pharm (2016) 0.76

Exploiting Gene Expression Kinetics in Conventional Radiotherapy, Hyperfractionation, and Hypofractionation for Targeted Therapy. Semin Radiat Oncol (2016) 0.76

Delayed vertebral body collapse after stereotactic radiosurgery and radiofrequency ablation: Case report with histopathologic-MRI correlation. Interv Neuroradiol (2015) 0.76

Evaluation of immune cell markers in tumor tissue treated with radioimmunotherapy in an immunocompetent rat colon carcinoma model. EJNMMI Res (2015) 0.75

The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death. Front Oncol (2016) 0.75

A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II). BMC Cancer (2016) 0.75

A meta-analysis of the abscopal effect in preclinical models: Is the biologically effective dose a relevant physical trigger? PLoS One (2017) 0.75

Virus-Specific CD8(+) T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression. J Immunol (2017) 0.75

Stromal contributions to the carcinogenic process. Mol Carcinog (2016) 0.75

Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation. PLoS One (2016) 0.75

Ionizing radiation abrogates the pro-tumorigenic capacity of cancer-associated fibroblasts co-implanted in xenografts. Sci Rep (2017) 0.75

Chemotherapeutic tumor microparticles combining low-dose irradiation reprogram tumor-promoting macrophages through a tumor-repopulating cell-curtailing pathway. Oncoimmunology (2017) 0.75

Articles cited by this

(truncated to the top 100)

Hallmarks of cancer: the next generation. Cell (2011) 140.01

Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36

Isolation of putative progenitor endothelial cells for angiogenesis. Science (1997) 30.27

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med (2004) 22.96

Fibroblasts in cancer. Nat Rev Cancer (2006) 18.95

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90

Putting tumours in context. Nat Rev Cancer (2001) 12.37

The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol (1953) 12.04

Stromal fibroblasts in cancer initiation and progression. Nature (2004) 11.69

VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell (2006) 9.32

Distinct role of macrophages in different tumor microenvironments. Cancer Res (2006) 9.29

Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell (2012) 8.71

Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med (2012) 8.46

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell (2008) 8.01

Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science (2001) 7.13

Four faces of cellular senescence. J Cell Biol (2011) 6.86

The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res (1996) 6.62

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. Cancer Cell (2010) 6.33

Glioblastoma stem-like cells give rise to tumour endothelium. Nature (2010) 6.18

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature (2010) 6.13

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med (2011) 5.54

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22

Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res (2008) 5.21

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood (2009) 5.21

Aging, cellular senescence, and cancer. Annu Rev Physiol (2012) 5.08

Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy. Int J Radiat Oncol Biol Phys (2008) 5.03

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med (2006) 4.84

Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67

Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res (2009) 4.58

Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol (2005) 4.18

Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer (2011) 4.08

Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol (2005) 3.86

High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys (2008) 3.78

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest (2010) 3.74

The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol (2010) 3.57

Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell (2008) 3.56

Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A (2011) 3.45

Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol (1995) 3.08

Histopathology of arteriovenous malformations after gamma knife radiosurgery. J Neurosurg (1997) 3.03

Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A (2010) 3.03

Stereotactic ablative radiotherapy should be combined with a hypoxic cell radiosensitizer. Int J Radiat Oncol Biol Phys (2010) 2.97

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res (2007) 2.94

The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res (1999) 2.91

Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell (2013) 2.89

Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circ Res (2007) 2.71

Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys (1982) 2.69

Hypoxic radiosensitization: adored and ignored. J Clin Oncol (2007) 2.67

Radiation and the microenvironment - tumorigenesis and therapy. Nat Rev Cancer (2005) 2.65

The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity. Cancer Res (2011) 2.60

The stereotaxic method and radiosurgery of the brain. Acta Chir Scand (1951) 2.43

Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions. Cancer Res (2004) 2.42

ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med (2005) 2.28

CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS One (2010) 2.28

Outcomes of stereotactic ablative radiotherapy for central lung tumours: a systematic review. Radiother Oncol (2013) 2.21

Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy. Phys Med Biol (2004) 2.15

Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys (1982) 2.05

Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest (1994) 2.01

Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Cancer Res (2009) 1.99

Radiation oncology: a century of achievements. Nat Rev Cancer (2004) 1.98

Dose escalation, not "new biology," can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer. Int J Radiat Oncol Biol Phys (2013) 1.94

American Society for Therapeutic Radiology and Oncology and American College of Radiology practice guideline for the performance of stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys (2004) 1.94

The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Semin Radiat Oncol (2008) 1.93

Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. J Immunol (2008) 1.93

Molecular characteristics of immunogenic cancer cell death. Cell Death Differ (2007) 1.92

Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol (2012) 1.90

Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysis. Cancer (2011) 1.87

Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation. Cancer Res (2010) 1.84

Stereotactic body radiation therapy: a novel treatment modality. Nat Rev Clin Oncol (2009) 1.76

The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction. Semin Radiat Oncol (2008) 1.74

Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS). Radiat Res (2012) 1.70

Maximizing tumor immunity with fractionated radiation. Int J Radiat Oncol Biol Phys (2011) 1.60

Imaging hypoxia to improve radiotherapy outcome. Nat Rev Clin Oncol (2012) 1.57

Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo. Cancer J Sci Am (2006) 1.56

Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation. J Immunol (2012) 1.48

Genetic variants and normal tissue toxicity after radiotherapy: a systematic review. Radiother Oncol (2009) 1.48

European Organisation for Research and Treatment of Cancer recommendations for planning and delivery of high-dose, high-precision radiotherapy for lung cancer. J Clin Oncol (2010) 1.48

Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy. Cancer Res (2010) 1.46

Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling. Cancer Res (2011) 1.46

Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes. Cancer Res (2008) 1.45

Human non-small cell lung cancer cells express a type 2 cytokine pattern. Cancer Res (1995) 1.44

Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy. J Leukoc Biol (2010) 1.42

The effects of irradiation on breast cancer and the breast. CA Cancer J Clin (1988) 1.41

The phenomenon of reoxygenation and its implications for fractionated radiotherapy. Radiology (1972) 1.35

Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res (2003) 1.35

Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis. PLoS One (2010) 1.33

Microarray analysis of radiation response genes in primary human fibroblasts. Int J Radiat Oncol Biol Phys (2006) 1.28

Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth. Int J Radiat Oncol Biol Phys (2007) 1.28

A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl Oncol (2012) 1.24

The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol (2012) 1.24

Vascular endothelium as the vulnerable element in tumours. Acta Radiol Oncol (1984) 1.20

Outcome of four-dimensional stereotactic radiotherapy for centrally located lung tumors. Radiother Oncol (2012) 1.20

Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? J Natl Cancer Inst (2012) 1.19

Combination of gamma-irradiation and dendritic cell administration induces a potent antitumor response in tumor-bearing mice: approach to treatment of advanced stage cancer. Int J Cancer (2001) 1.19

Stereotactic percutaneous single dose irradiation of brain metastases with a linear accelerator. Int J Radiat Oncol Biol Phys (1987) 1.18

Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy. Oncoimmunology (2012) 1.16

American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guidelines for image-guided radiation therapy (IGRT). Int J Radiat Oncol Biol Phys (2010) 1.16