| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens.
|
Nature
|
1980
|
2.85
|
|
2
|
Effect of environmental factors on drug metabolism: decreased plasma half-life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides.
|
Clin Pharmacol Ther
|
1969
|
2.75
|
|
3
|
Response of hepatic microbodies to a hypolipidemic agent, ethyl chlorophenoxyisobutyrate (CPIB).
|
J Cell Biol
|
1966
|
2.29
|
|
4
|
Report of the Institute of Medicine Committee on the Efficacy and Safety of Halcion.
|
Arch Gen Psychiatry
|
1999
|
2.03
|
|
5
|
Drugs as etiologic factors in the Stevens-Johnson syndrome.
|
Am J Med
|
1968
|
1.98
|
|
6
|
Plasma protein binding of tricyclic anti-depressants in man.
|
Biochem Pharmacol
|
1969
|
1.86
|
|
7
|
Pharmacokinetics of methotrexate.
|
Clin Pharmacol Ther
|
1973
|
1.55
|
|
8
|
The effect of spironolactone on antipyrine metabolism in man.
|
Pharmacology
|
1973
|
1.31
|
|
9
|
Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers.
|
Anesthesiology
|
1993
|
1.30
|
|
10
|
Correlation of the plasma elimination of antipyrine and the appearance of 4-hydroxy antipyrine in the urine of man.
|
Biochem Pharmacol
|
1974
|
1.28
|
|
11
|
Absorption of orally given digoxin preparations.
|
JAMA
|
1972
|
1.27
|
|
12
|
The effects of urine pH and plasma protein binding on the renal clearance of disopyramide.
|
Clin Pharmacokinet
|
1977
|
1.25
|
|
13
|
Effect of route of administration and effusions on methotrexate pharmacokinetics.
|
Cancer Res
|
1974
|
1.22
|
|
14
|
Nafenopin-induced hepatic microbody (peroxisome) proliferation and catalase synthesis in rats and mice. Absence of sex difference in response.
|
J Cell Biol
|
1974
|
1.21
|
|
15
|
Di-(2-ethylhexyl)phthalate: an industrial plasticizer induces hypolipidemia and enhances hepatic catalase and carnitine acetyltransferase activities in rat and mice.
|
Life Sci
|
1976
|
1.14
|
|
16
|
Phenytoin: pharmacokinetics and bioavailability.
|
Clin Pharmacol Ther
|
1976
|
1.14
|
|
17
|
Long-term effects of clofibrate (Atromid-S) on serum lipids in man.
|
Circulation
|
1969
|
1.11
|
|
18
|
Theophylline bioavailability following chronic dosing of an elixir and two solid dosage forms.
|
J Pharm Sci
|
1978
|
1.09
|
|
19
|
Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver.
|
Cancer Res
|
1979
|
1.09
|
|
20
|
Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicyclic acid in sewage water effluent.
|
Life Sci
|
1977
|
1.07
|
|
21
|
Clinical complications of corticosteroid therapy. A selected review.
|
Med Clin North Am
|
1973
|
1.06
|
|
22
|
Metabolic responses to acute and chronic L-dopa administration in patients with parkinsonism.
|
N Engl J Med
|
1972
|
1.04
|
|
23
|
Effect of in vivo elevation of free fatty acids on protein binding of drugs.
|
Pharmacology
|
1974
|
1.02
|
|
24
|
Tumors in male rats fed ethyl chlorophenoxyisobutyrate, a hypolipidemic drug.
|
Cancer Res
|
1979
|
1.00
|
|
25
|
The alteration of plasma proteins in uremia as reflected in their ability to bind digitoxin and diphenylhydantoin.
|
Pharmacology
|
1972
|
1.00
|
|
26
|
Correlation between plasma diphenhydramine level and sedative and antihistamine effects.
|
Clin Pharmacol Ther
|
1978
|
0.99
|
|
27
|
Clinical pharmacokinetics of methotrexate.
|
Clin Pharmacokinet
|
1978
|
0.99
|
|
28
|
Prescription writing by generic name and drug cost.
|
J Chronic Dis
|
1967
|
0.96
|
|
29
|
Hepatic effects of some [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (WY-14,643) analogs in the mouse.
|
Arch Int Pharmacodyn Ther
|
1977
|
0.95
|
|
30
|
A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats.
|
Eur J Pharmacol
|
1970
|
0.95
|
|
31
|
Drug interactions with warfarin.
|
Arch Intern Med
|
1968
|
0.95
|
|
32
|
Effect of portacaval shunt on the disposition of drugs with and without first-pass effect.
|
J Pharmacol Exp Ther
|
1975
|
0.94
|
|
33
|
Microbodies in experimentally altered cells. VI. Thyroxine displacement from plasma proteins and clofibrate effect.
|
Arch Int Pharmacodyn Ther
|
1969
|
0.93
|
|
34
|
Drug interactions.
|
Pharmacol Physicians
|
1970
|
0.93
|
|
35
|
Drug protein binding and the nephrotic syndrome.
|
Clin Pharmacokinet
|
1976
|
0.92
|
|
36
|
Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine in humans.
|
Cancer Res
|
1974
|
0.92
|
|
37
|
Pharmacokinetics of drugs in patients with the nephrotic syndrome.
|
J Clin Invest
|
1975
|
0.92
|
|
38
|
The effect of butoxamine on catecholamine-induced metabolic changes in humans.
|
Clin Pharmacol Ther
|
1966
|
0.87
|
|
39
|
Induction of salicyluric acid formation in rheumatoid arthritis patients treated with salicylates.
|
Clin Pharmacokinet
|
1983
|
0.87
|
|
40
|
Clofibrate effect on catecholamine-induced metabolic changes in humans.
|
Metabolism
|
1968
|
0.86
|
|
41
|
Absorption and excretion of clindamycin-2-phosphate in children after intramuscular injection.
|
Clin Pharmacol Ther
|
1972
|
0.86
|
|
42
|
Plasma levels and excretion of estrogens in urine in chronic lever disease.
|
Gastroenterology
|
1975
|
0.85
|
|
43
|
Hepatic peroxisome proliferation: induction by BR-931, a hypolipidemic analog of WY-14,643.
|
Arch Int Pharmacodyn Ther
|
1978
|
0.85
|
|
44
|
Association between clinical cardiac status, laboratory parameters, and digoxin usage.
|
Am Heart J
|
1976
|
0.85
|
|
45
|
Absorption of digoxin from different oral preparations in normal subjects during steady state.
|
Clin Pharmacol Ther
|
1974
|
0.85
|
|
46
|
Theophylline bioavailability: a comparison of the oral absorption of a theophylline elixir and two combination theophylline tablets to intravenous aminophylline.
|
Am Rev Respir Dis
|
1977
|
0.84
|
|
47
|
Disposition kinetics of disopyramide in patients with renal insufficiency.
|
Biopharm Drug Dispos
|
1981
|
0.84
|
|
48
|
Diphenylhydantoin potency and plasma protein binding.
|
J Pharmacol Exp Ther
|
1975
|
0.83
|
|
49
|
Effects of selected hypolipidemic drugs on cell ultrastructure.
|
Fed Proc
|
1971
|
0.83
|
|
50
|
Bioavailability of aminosalicylic acid and its various salts in humans. 3. Absorption from tablets.
|
J Pharm Sci
|
1974
|
0.83
|
|
51
|
1-methyl-4piperidyl-bis (P-chlorophenoxy) acetate: a new hypolipidemic peroxisome proliferator.
|
Res Commun Chem Pathol Pharmacol
|
1975
|
0.82
|
|
52
|
Metabolic disposition of antipyrine in patients with lung cancer.
|
Cancer Res
|
1977
|
0.82
|
|
53
|
Diphenylhydantoin: correlation between protein binding and albumin concentration.
|
Klin Wochenschr
|
1975
|
0.81
|
|
54
|
Metabolic responses to plasma concentrations of theophylline.
|
Clin Pharmacol Ther
|
1979
|
0.81
|
|
55
|
Quantitation of lidocaine and its deethylated metabolites in plasma and urine by gas chromatography-mass fragmentography.
|
J Chromatogr
|
1978
|
0.81
|
|
56
|
Topical application of lindane cream (Kwell) and antipyrine metabolism.
|
J Invest Dermatol
|
1980
|
0.81
|
|
57
|
Kinetics, salivary excretion of amphetamine isomers, and effect of urinary pH.
|
Clin Pharmacol Ther
|
1978
|
0.81
|
|
58
|
Pharmacology of hypolipidemic drugs. Introduction.
|
Fed Proc
|
1971
|
0.81
|
|
59
|
Pharmacokinetic investigations in elderly patients. Clinical and ethical considerations.
|
Clin Pharmacokinet
|
1990
|
0.80
|
|
60
|
Comparison of charcoal and attapulgite as gastrointestinal sequestrants in acute drug ingestions.
|
Clin Toxicol
|
1971
|
0.80
|
|
61
|
A two-year crossover therapeutic trial with halofenate and clofibrate.
|
Am J Med Sci
|
1977
|
0.80
|
|
62
|
The interaction between halofenate and propranolol.
|
Clin Pharmacol Ther
|
1976
|
0.80
|
|
63
|
Serum digitoxin in uremic patients.
|
Clin Pharmacol Ther
|
1972
|
0.79
|
|
64
|
Species differences in the plasma protein binding of desipramine.
|
J Pharm Pharmacol
|
1968
|
0.79
|
|
65
|
The effect of DDD on barbiturate and steroid-induced hypnosis in the dog and rat.
|
Biochem Pharmacol
|
1966
|
0.79
|
|
66
|
Gynecomastia induced in normal males by spironolactone.
|
Clin Pharmacol Ther
|
1978
|
0.79
|
|
67
|
Bioavailability of aminosalicylic acid and its various salts in humans IV: comparison of four brands of the sodium salt.
|
J Pharm Sci
|
1974
|
0.78
|
|
68
|
The alteration of plasma proteins in uremia as reflected in the ability to bind diphenylhydantoin.
|
Ann N Y Acad Sci
|
1973
|
0.78
|
|
69
|
Placental transfer and fetal urinary excretion of gentamicin during constant rate maternal infusion.
|
Pediatr Res
|
1975
|
0.78
|
|
70
|
Hepatic catalase is not essential for the hypolipidemic action of peroxisome proliferators.
|
Proc Soc Exp Biol Med
|
1977
|
0.78
|
|
71
|
Inhibition of amphetamine tolerance and metabolism by propranolol.
|
J Pharmacol Exp Ther
|
1974
|
0.77
|
|
72
|
One-year trials with halofenate, clofibrate, and placebo.
|
Clin Pharmacol Ther
|
1976
|
0.76
|
|
73
|
Clinical pharmacokinetics of disopyramide.
|
J Pharmacokinet Biopharm
|
1982
|
0.76
|
|
74
|
Bioavailability studies on p-aminosalicylic acid and its various salts in man. II. Comparison of parasal and pascorbic.
|
Am Rev Respir Dis
|
1973
|
0.76
|
|
75
|
Pharmacokinetics of hydralazine and its acid-labile hydrazone metabolites in relation to acetylator phenotype.
|
J Pharmacokinet Biopharm
|
1980
|
0.75
|
|
76
|
Current status of drugs used to treat hyperlipoproteinemias.
|
Drug Ther
|
1982
|
0.75
|
|
77
|
Quantitation of chlordiazepoxide and its metabolites in biological fluids by thin-layer chromatography.
|
J Chromatogr
|
1978
|
0.75
|
|
78
|
Physiologic factors in selecting human volunteers for drug studies.
|
Clin Pharmacol Ther
|
1972
|
0.75
|
|
79
|
Half-life of methotrexate: new evidence.
|
Arch Dermatol
|
1972
|
0.75
|
|
80
|
Placental transfer of penicillin G during constant-rate infusion in the goat.
|
Am J Obstet Gynecol
|
1973
|
0.75
|
|
81
|
Proceedings: Pharmacokinetics of drugs in patients with nephrotic syndrome.
|
Arzneimittelforschung
|
1976
|
0.75
|
|
82
|
In defense of the Drug Research Board.
|
JAMA
|
1975
|
0.75
|
|
83
|
Intersubject variation in absorption of digoxin in normal volunteers.
|
J Pharm Sci
|
1975
|
0.75
|
|
84
|
Quantitation of N-demethylantipyrine in biological samples and isolation and characterization of its glucuronic acid conjugate.
|
Drug Metab Dispos
|
1978
|
0.75
|
|
85
|
Pharmacokinetics of methotrexate.
|
Clin Pharmacol Ther
|
1974
|
0.75
|
|
86
|
Peroxisome-associated enzymes and serum lipids in tumour-bearing rats treated with peroxisome-proliferating agents.
|
Biochem Pharmacol
|
1984
|
0.75
|
|
87
|
Pharmacokinetics, cortisol release, and hemodynamics after intravenous and subcutaneous injection of human corticotropin-releasing factor in humans.
|
Clin Pharmacol Ther
|
1998
|
0.75
|
|
88
|
Therapeutic implications of bioavailability.
|
Annu Rev Pharmacol Toxicol
|
1976
|
0.75
|
|
89
|
In vitro inhibition of rat liver cholest-5en-3 beta-ol (cholesterol) biosynthesis by non-mercurial sulfhydryl reagents.
|
Steroids
|
1976
|
0.75
|
|
90
|
Use of pharmacokinetic principles in therapy.
|
N Engl J Med
|
1973
|
0.75
|
|
91
|
Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis.
|
Biochem Pharmacol
|
1977
|
0.75
|
|
92
|
Effective drug use. Drug utilization by the practicing physician.
|
J Kans Med Soc
|
1972
|
0.75
|
|
93
|
Clinical principles of drug interactions in the adult patient.
|
Ann N Y Acad Sci
|
1976
|
0.75
|
|
94
|
Bioavailability of digoxin-hydroquinone complex: a new oral digoxin formulation.
|
J Pharm Sci
|
1977
|
0.75
|
|
95
|
Separation and identification of impurities in parenteral methotrexate dosage forms.
|
Cancer Treat Rep
|
1978
|
0.75
|
|
96
|
The use of digitalis.
|
Ration Drug Ther
|
1974
|
0.75
|
|
97
|
Tumors potentiating catecholamine-induced hypertension.
|
Life Sci I
|
1971
|
0.75
|
|
98
|
Application of blood level data to clinical trials.
|
Clin Pharmacol Ther
|
1974
|
0.75
|
|
99
|
The effect of concurrent oral administration of propranolol and disopyramide on cardiac function in healthy men.
|
Circulation
|
1980
|
0.75
|
|
100
|
Proceedings: Alterations in the pharmacokinetics of drugs by portocaval shunt.
|
Naunyn Schmiedebergs Arch Pharmacol
|
1975
|
0.75
|
|
101
|
The effect of spironolactone on plasma levels and excretion of testosterone and oestrogens in the urine in males. (A preliminary report).
|
J Int Med Res
|
1974
|
0.75
|
|
102
|
A new method for increasing the chemotherapeutic drug concentration in the tumor tissue.
|
Panminerva Med
|
1976
|
0.75
|
|
103
|
Evidence that inhibition of hepatic drug oxidation by tumors is mediated by a circulating humor.
|
Proc Soc Exp Biol Med
|
1972
|
0.75
|
|
104
|
The profession of medicine.
|
Pharmacology
|
1972
|
0.75
|
|
105
|
Drug interactions: clinical significance.
|
Clin Pharmacol Ther
|
1974
|
0.75
|
|
106
|
Clinical implications of drug metabolism--introduction.
|
Chem Biol Interact
|
1971
|
0.75
|
|
107
|
Methapyrilene kinetics and dynamics.
|
Clin Pharmacol Ther
|
1981
|
0.75
|
|
108
|
High-pressure liquid chromatographic assay of theophylline in biological fluids.
|
J Chromatogr
|
1974
|
0.75
|
|
109
|
Glutethimide and 4-OH glutethimide: pharmacokinetics and effect on performance in man.
|
Clin Pharmacol Ther
|
1977
|
0.75
|
|
110
|
Drug inhibition of catecholamine-induced metabolic effects in humans.
|
Ann N Y Acad Sci
|
1967
|
0.75
|
|
111
|
Identification of methotrexate and folic acid analogs by mass spectrometry.
|
Biomed Mass Spectrom
|
1978
|
0.75
|
|
112
|
Effect of oxygen tension on drug levels and pharmacological action in the intact animal.
|
Proc Soc Exp Biol Med
|
1969
|
0.75
|
|
113
|
Effect of colestipol on gastrointestinal absorption of chlorothiazide in man.
|
Clin Pharmacol Ther
|
1973
|
0.75
|
|
114
|
The effect of hypocholesterolemic drugs on adrenal corticosteroid secretion.
|
Steroids
|
1967
|
0.75
|
|
115
|
Colestipol and clofibrate in hypercholesterolemia.
|
Clin Pharmacol Ther
|
1974
|
0.75
|
|
116
|
Pamatolol: phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug.
|
Clin Pharmacol Ther
|
1978
|
0.75
|
|
117
|
The value of plasma-digoxin assay.
|
Lancet
|
1972
|
0.75
|
|
118
|
Glucuronic acid conjugates of clofibrate: four isomeric structures.
|
Life Sci
|
1981
|
0.75
|
|
119
|
Hyperinsulinemia secondary to chronic administration of mazindol and d-amphetamine.
|
Am J Med Sci
|
1971
|
0.75
|
|
120
|
Panel 3: phase III investigations.
|
Clin Pharmacol Ther
|
1975
|
0.75
|
|
121
|
Drug development: risks and problems.
|
Ann N Y Acad Sci
|
1984
|
0.75
|
|
122
|
The clinical use of plasma drug concentrations.
|
Ration Drug Ther
|
1976
|
0.75
|
|
123
|
Individualization of treatment of hyperlipoproteinemic disorders.
|
Med Clin North Am
|
1974
|
0.75
|
|
124
|
Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker.
|
Clin Pharmacol Ther
|
1979
|
0.75
|
|
125
|
Separation and quantitative analysis of furosemide and 4-chloro-5-sulfamoylanthranilic adid (CSA) by high pressure liquid chromatography.
|
Res Commun Chem Pathol Pharmacol
|
1975
|
0.75
|
|
126
|
Nitroglycerin patches: further comments.
|
Am Pharm
|
1982
|
0.75
|
|
127
|
Insecticides: effect on drug metabolism.
|
Clin Pharmacol Ther
|
1977
|
0.75
|
|
128
|
Effect of warfarin in treatment of cancer.
|
Panminerva Med
|
1976
|
0.75
|
|
129
|
Placental transfer of diphenylhydantoin in the goat.
|
Biochem Pharmacol
|
1972
|
0.75
|
|
130
|
Application of metabolic data to the evaluation of drugs.
|
JAMA
|
1970
|
0.75
|
|
131
|
Treatment of angina pectoris with chromonar hydrochloride.
|
Clin Pharmacol Ther
|
1968
|
0.75
|
|
132
|
A comparative trial of clofibrate and nicotinyl alcohol tartrate in hyperlipoproteinemic patients.
|
Am J Med Sci
|
1979
|
0.75
|