Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial.

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Published in Eur Heart J on February 20, 2014

Authors

Sigrun Halvorsen1, Dan Atar2, Hongqiu Yang3, Raffaele De Caterina4, Cetin Erol5, David Garcia6, Christopher B Granger3, Michael Hanna7, Claes Held8, Steen Husted9, Elaine M Hylek10, Petr Jansky11, Renato D Lopes3, Witold Ruzyllo12, Laine Thomas3, Lars Wallentin8

Author Affiliations

1: Department of Cardiology B, Oslo University Hospital, Oslo 0407, Norway sigrun.h@online.no.
2: Department of Cardiology B, Oslo University Hospital, Oslo 0407, Norway Institute of Clinical Medicine, University of Oslo, Norway.
3: Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
4: G. D'Annunzio Università - Chieti and Fondazione Toscana G. Monasterio, Pisa, Italy.
5: Faculty of Medicine, Ankara University, Ankara, Turkey.
6: Division of Hematology, University of Washington, Seattle, WA, USA.
7: Bristol-Myers Squibb, Princeton, NJ, USA.
8: Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
9: Medical Department, Hospital Unit West, Herning/Holstbro, Denmark.
10: Boston University Medical Center, Boston, MA, USA.
11: Cardiovascular Centre, University Hospital Motol, Prague, Czech Republic.
12: National Institute of Cardiology, Warsaw, Poland.

Associated clinical trials:

Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation (ARISTOTLE) | NCT00412984

Trial to Evaluate Anticoagulation Therapy in Hemodialysis Patients With Atrial Fibrillation (RENAL-AF) | NCT02942407

Direct Oral Anticoagulants Pharmacodynamics in Octogenarian Patients With Atrial Fibrillation | NCT02623049

Tooth Extraction in Patients With Atrial Fibrillation in Use of New Oral Anticoagulants | NCT03181386

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