Brain barriers and a subpopulation of astroglial progenitors of developing human forebrain are immunostained for the glycoprotein YKL-40.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 4005366)

Published in J Histochem Cytochem on March 04, 2014

Authors

Camilla Bjørnbak1, Christian B Brøchner, Lars A Larsen, Julia S Johansen, Kjeld Møllgård

Author Affiliations

1: Department of Cellular and Molecular Medicine (CB,CBB,LAL,KM), Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

Articles cited by this

Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02

The cell biology of neurogenesis. Nat Rev Mol Cell Biol (2005) 9.35

A public database for gene expression in human cancers. Cancer Res (1999) 8.81

Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature (2010) 5.47

Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature (2010) 5.10

Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development (2000) 4.14

Development of the human cerebral cortex: Boulder Committee revisited. Nat Rev Neurosci (2008) 4.01

Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol (2011) 3.25

Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res (2005) 3.10

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem (1993) 3.04

Microglia: scapegoat, saboteur, or something else? Science (2013) 2.94

Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol Dis (2008) 2.88

Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol (2010) 2.68

Retinoic acid from the meninges regulates cortical neuron generation. Cell (2009) 2.46

Identification of neural stem cells in the adult vertebrate brain. Brain Res Bull (2002) 2.21

Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry (2007) 2.12

Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. Genomics (1997) 1.91

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest (2012) 1.90

Differential gene expression profiling in human brain tumors. Physiol Genomics (2001) 1.88

Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J Neurosci (2013) 1.86

Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma. Cancer Res (2002) 1.82

YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma. Clin Cancer Res (2005) 1.81

Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences. Nat Neurosci (2013) 1.74

Biology of glioma cancer stem cells. Mol Cells (2009) 1.64

YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils. Proc Assoc Am Physicians (1999) 1.62

Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain. Nat Neurosci (2008) 1.60

YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry (2010) 1.59

An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis. Angiogenesis (2007) 1.56

Radial glial cell heterogeneity--the source of diverse progeny in the CNS. Prog Neurobiol (2007) 1.55

YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas. Clin Cancer Res (2006) 1.53

Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J Biol Chem (2011) 1.50

Barriers in the brain: a renaissance? Trends Neurosci (2008) 1.49

Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. J Biol Chem (2005) 1.42

Plasma YKL-40: a potential new cancer biomarker? Future Oncol (2009) 1.37

A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers. Mol Cancer Ther (2011) 1.34

YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis. Clin Diagn Lab Immunol (2002) 1.29

Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2. Cell Rep (2013) 1.24

Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer. Lung Cancer (2005) 1.22

In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. J Neuroinflammation (2010) 1.20

The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation. J Biol Chem (2006) 1.19

Identification of genes differentially expressed in glioblastoma versus pilocytic astrocytoma using Suppression Subtractive Hybridization. Oncogene (2006) 1.16

In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133. J Neurosci Res (2007) 1.15

We have got you 'covered': how the meninges control brain development. Curr Opin Genet Dev (2011) 1.14

Clonal identity determines astrocyte cortical heterogeneity. Cereb Cortex (2012) 1.13

YKL-40 protein expression in the early developing human musculoskeletal system. J Histochem Cytochem (2007) 1.10

Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2. J Neuropathol Exp Neurol (2006) 1.10

CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells. Int J Cancer (2011) 1.07

Early microglial colonization of the human forebrain and possible involvement in periventricular white-matter injury of preterm infants. J Anat (2010) 1.06

Radial glial origin of the adult neural stem cells in the subventricular zone. Prog Neurobiol (2006) 1.04

The development of the human blood-brain and blood-CSF barriers. Neuropathol Appl Neurobiol (1986) 1.01

Building a human cortex: the evolutionary differentiation of Cajal-Retzius cells and the cortical hem. J Anat (2010) 1.01

Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene. Synapse (2003) 1.01

Elevated plasma YKL-40 levels and ischemic stroke in the general population. Ann Neurol (2010) 1.01

Serum YKL-40 is a marker of prognosis and disease status in high-grade gliomas. Neuro Oncol (2011) 1.00

Microglia in the cerebral wall of the human telencephalon at second trimester. Cereb Cortex (2004) 1.00

Cell junctions and membrane specializations in the ventricular zone (germinal matrix) of the developing sheep brain: a CSF-brain barrier. J Neurocytol (1987) 0.97

On the origin and growth of gliomas. Anticancer Res (2010) 0.95

HC gp-39 gene is upregulated in glioblastomas. Cancer Lett (2003) 0.95

Diverse pathological implications of YKL-40: answers may lie in 'outside-in' signaling. Cell Signal (2013) 0.92

Radial glia cells in the developing human brain. Neuroscientist (2008) 0.92

YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas. Int J Clin Exp Pathol (2010) 0.91

CSF-brain permeability in the immature sheep fetus: a CSF-brain barrier. Brain Res (1985) 0.91

YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers. J Histochem Cytochem (2011) 0.90

Plasma YKL-40 and total and disease-specific mortality in the general population. Clin Chem (2010) 0.90

Topographical and cytological evolution of the glial phase during prenatal development of the human brain: histochemical and electron microscopic study. J Neuropathol Exp Neurol (1988) 0.89

p73 and Reelin in Cajal-Retzius cells of the developing human hippocampal formation. Cereb Cortex (2004) 0.88

Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis. Mult Scler (2010) 0.87

The human transient subpial granular layer: an optical, immunohistochemical, and ultrastructural analysis. J Comp Neurol (1992) 0.87

Intracellular plasma proteins in human fetal choroid plexus during development. I. Developmental stages in relation to the number of epithelial cells which contain albumin in telencephalic, diencephalic and myelencephalic choroid plexus. Brain Res (1982) 0.86

Serum YKL-40 following resection for cerebral glioblastoma. J Neurooncol (2011) 0.82

Glial cell differentiation in neuron-free and neuron-rich regions. I. Selective appearance of S-100 protein in radial glial cells of the hippocampal fimbria in human fetuses. Anat Embryol (Berl) (1991) 0.81

Immunohistochemical identification of some plasma proteins in human embryonic and fetal forebrain with particular reference to the development of the neocortex. Brain Res (1984) 0.80

Articles by these authors

Mutations in the HERG K+-ion channel: a novel link between long QT syndrome and sudden infant death syndrome. Am J Cardiol (2005) 2.20

Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach. PLoS One (2013) 1.64

T wave morphology analysis distinguishes between KvLQT1 and HERG mutations in long QT syndrome. Heart Rhythm (2004) 1.46

MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma. Mod Pathol (2012) 1.43

High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer. Clin Cancer Res (2003) 1.42

Metabolomic NMR fingerprinting to identify and predict survival of patients with metastatic colorectal cancer. Cancer Res (2011) 1.41

Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol (2010) 1.35

YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis. Clin Diagn Lab Immunol (2002) 1.29

Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Dev Dyn (2008) 1.27

Pierre Robin sequence may be caused by dysregulation of SOX9 and KCNJ2. J Med Genet (2007) 1.27

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Ann Rheum Dis (2010) 1.25

Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Prostate (2006) 1.24

Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer. Lung Cancer (2005) 1.22

High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival. Cancer (2002) 1.18

Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease. J Hepatol (2003) 1.18

Pre-analytical and biological variability in circulating interleukin 6 in healthy subjects and patients with rheumatoid arthritis. Biomarkers (2008) 1.18

Genetic and phenotypic characterization of mutations in myosin-binding protein C (MYBPC3) in 81 families with familial hypertrophic cardiomyopathy: total or partial haploinsufficiency. Eur J Hum Genet (2004) 1.16

In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133. J Neurosci Res (2007) 1.15

Plasma YKL-40: a BMI-independent marker of type 2 diabetes. Diabetes (2008) 1.14

Prognostic microRNAs in cancer tissue from patients operated for pancreatic cancer--five microRNAs in a prognostic index. World J Surg (2012) 1.14

The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci (2009) 1.12

High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease. Eur Heart J (2009) 1.12

Recombinant Adeno-Associated Virus-Mediated microRNA Delivery into the Postnatal Mouse Brain Reveals a Role for miR-134 in Dendritogenesis in Vivo. Front Neural Circuits (2010) 1.12

YKL-40 protein expression in the early developing human musculoskeletal system. J Histochem Cytochem (2007) 1.10

Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells. Cancer Sci (2005) 1.10

Mutations in c10orf11, a melanocyte-differentiation gene, cause autosomal-recessive albinism. Am J Hum Genet (2013) 1.10

IL-6, but not TNF-α, increases plasma YKL-40 in human subjects. Cytokine (2011) 1.09

Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial. Ann Rheum Dis (2013) 1.09

High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Oncol Rep (2003) 1.09

Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A (2012) 1.08

Serum levels of YKL-40 increases in patients with acute myocardial infarction. Coron Artery Dis (2008) 1.08

Therapeutic dendritic cell vaccination of patients with metastatic renal cell carcinoma: a clinical phase 1/2 trial. J Immunother (2008) 1.07

The frequency of anti-infliximab antibodies in patients with rheumatoid arthritis treated in routine care and the associations with adverse drug reactions and treatment failure. Rheumatology (Oxford) (2013) 1.07

Plasma YKL-40 levels in healthy subjects from the general population. Clin Chim Acta (2011) 1.07

Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. Cancer Immunol Immunother (2007) 1.05

Serum YKL-40 predicts relapse-free and overall survival in patients with American Joint Committee on Cancer stage I and II melanoma. J Clin Oncol (2006) 1.04

Haploinsufficiency of TAB2 causes congenital heart defects in humans. Am J Hum Genet (2010) 1.04

High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia. Clin Cancer Res (2005) 1.04

Elevated plasma YKL-40 levels and ischemic stroke in the general population. Ann Neurol (2010) 1.01

Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation. Hum Reprod (2008) 1.01

Delineation of a 2.2 Mb microdeletion at 5q35 associated with microcephaly and congenital heart disease. Am J Med Genet A (2006) 1.00

Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease. Scand J Infect Dis (2002) 1.00

Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach. PLoS One (2012) 1.00

Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis. Pharmacogenet Genomics (2012) 1.00

Elevated pretreatment serum concentration of YKL-40-An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer. Cancer (2010) 0.99

YKL-40 tissue expression and plasma levels in patients with ovarian cancer. BMC Cancer (2009) 0.97

Serum YKL-40 and interleukin 6 levels in Hodgkin lymphoma. Clin Cancer Res (2008) 0.97

Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas. Pancreas (2012) 0.97

Biomarkers of inflammation in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity and radiographic outcome. J Rheumatol (2008) 0.97

Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain. J Histochem Cytochem (2010) 0.96

YKL-40 protein expression is not a prognostic marker in patients with primary breast cancer. Breast Cancer Res Treat (2007) 0.96

Responsiveness of the Ankylosing Spondylitis Disease Activity Score (ASDAS) and clinical and MRI measures of disease activity in a 1-year follow-up study of patients with axial spondyloarthritis treated with tumour necrosis factor alpha inhibitors. Ann Rheum Dis (2009) 0.95

A homogeneous assay for analysis of FMR1 promoter methylation in patients with fragile X syndrome. Clin Chem (2007) 0.95

Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain. Dev Neurosci (2010) 0.94

YKL-40 protein expression in normal adult human tissues--an immunohistochemical study. J Mol Histol (2007) 0.93

Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial. Cytotherapy (2010) 0.93

Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer. Acta Obstet Gynecol Scand (2003) 0.93

Subplate in the developing cortex of mouse and human. J Anat (2010) 0.91

YKL-40: a novel marker shared by chronic inflammation and oncogenic transformation. Methods Mol Biol (2009) 0.91

YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers. J Histochem Cytochem (2011) 0.90

Stem cell factor and c-Kit in human primordial germ cells and fetal ovaries. Mol Cell Endocrinol (2005) 0.90

High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival. Int J Cancer (2008) 0.89

The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure. Immunobiology (2011) 0.89

Serum interleukin-6 as a prognostic biomarker in patients with metastatic melanoma. Melanoma Res (2012) 0.89

Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients. Biochem Biophys Res Commun (2007) 0.88

High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. Eur J Haematol (2007) 0.88

Detecting 22q11.2 deletions by use of multiplex ligation-dependent probe amplification on DNA from neonatal dried blood spot samples. J Mol Diagn (2010) 0.88

Plasma YKL-40 and recovery of left ventricular function after acute myocardial infarction. Scand J Clin Lab Invest (2010) 0.87

Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects. Arthritis Res Ther (2011) 0.86

Diagnostic and Prognostic Impact of Circulating YKL-40, IL-6, and CA 19.9 in Patients with Pancreatic Cancer. PLoS One (2013) 0.86

Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation. Inflamm Res (2009) 0.86

Plasma YKL-40 in relation to the degree of coronary artery disease in patients with stable ischemic heart disease. Scand J Clin Lab Invest (2011) 0.86

The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease. Inflamm Res (2010) 0.85

Serum YKL-40 predicts long-term mortality in patients with stable coronary disease: a prognostic study within the CLARICOR trial. Immunobiology (2012) 0.85

Genetic variants in CHI3L1 influencing YKL-40 levels: resequencing 900 individuals and genotyping 9000 individuals from the general population. J Med Genet (2013) 0.84

Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis-experience from two prospective cohorts. Immunobiology (2013) 0.83

YKL-40-A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients? Cancers (Basel) (2010) 0.83

The prognostic value of YKL-40 concentrations in nonmyeloablative conditioning allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant (2011) 0.83

Zbtb20 defines a hippocampal neuronal identity through direct repression of genes that control projection neuron development in the isocortex. Cereb Cortex (2013) 0.82

Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver. BMC Dev Biol (2011) 0.82

YKL-40 expression in benign and malignant lesions of the breast: a methodologic study. Appl Immunohistochem Mol Morphol (2007) 0.82

Regional differences in expression of specific markers for human embryonic stem cells. Reprod Biomed Online (2007) 0.82

CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients. Arthritis Res Ther (2014) 0.81

Minimum information about animal experiments: supplier is also important. J Neurosci Res (2009) 0.81

Characterization of a t(5;8)(q31;q21) translocation in a patient with mental retardation and congenital heart disease: implications for involvement of RUNX1T1 in human brain and heart development. Eur J Hum Genet (2009) 0.81

Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells. Eur J Haematol (2006) 0.81

Serum YKL-40 and bone marrow angiogenesis in multiple myeloma. Int J Cancer (2009) 0.81

Sequence analysis of 17 NRXN1 deletions. Am J Med Genet B Neuropsychiatr Genet (2013) 0.80

Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone. Endocrinology (2006) 0.80

Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development. Exp Mol Med (2009) 0.80

Plasma YKL-40 and all-cause mortality in patients with chronic obstructive pulmonary disease. BMC Pulm Med (2013) 0.80

Immunohistochemical markers for corneal stem cells in the early developing human eye. Exp Eye Res (2008) 0.79

Using nucleofection of siRNA constructs for knockdown of primary cilia in P19.CL6 cancer stem cell differentiation into cardiomyocytes. Methods Cell Biol (2009) 0.79