Published in J Biol Chem on October 18, 2005
Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol (2011) 3.25
Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J Clin Invest (2011) 2.55
YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry (2010) 1.59
YKL-40--an emerging biomarker in cardiovascular disease and diabetes. Cardiovasc Diabetol (2009) 1.39
Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. Am J Hum Genet (2006) 1.37
Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes. Proc Natl Acad Sci U S A (2010) 1.35
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. Am J Pathol (2008) 1.23
Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. Am J Respir Cell Mol Biol (2010) 1.15
Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia. Transl Psychiatry (2013) 1.07
Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol (2012) 1.07
Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis Res Ther (2007) 1.03
Multipotent stem cells from trabecular meshwork become phagocytic TM cells. Invest Ophthalmol Vis Sci (2012) 1.03
The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. J Biol Chem (2010) 1.03
High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality. Clin Exp Immunol (2007) 1.01
Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation. Brain Pathol (2011) 0.99
A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40. J Biol Chem (2011) 0.97
Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension. BMC Genet (2016) 0.97
Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Am J Respir Cell Mol Biol (2013) 0.90
Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD. PLoS One (2011) 0.90
YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers. J Histochem Cytochem (2011) 0.90
Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation. Respir Res (2011) 0.87
Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects. Arthritis Res Ther (2011) 0.86
Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation. Inflamm Res (2009) 0.86
YKL-40-A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients? Cancers (Basel) (2010) 0.83
Expression of CHI3L1 and CHIT1 in osteoarthritic rat cartilage model. A morphological study. Eur J Histochem (2014) 0.82
Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer. Curr Mol Med (2013) 0.81
Chitinase-like proteins in lung injury, repair, and metastasis. Proc Am Thorac Soc (2012) 0.81
Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis. Inflamm Bowel Dis (2014) 0.81
Chitinase-like proteins are candidate biomarkers for sepsis-induced acute kidney injury. Mol Cell Proteomics (2012) 0.81
Brain barriers and a subpopulation of astroglial progenitors of developing human forebrain are immunostained for the glycoprotein YKL-40. J Histochem Cytochem (2014) 0.80
RelB/p50 complexes regulate cytokine-induced YKL-40 expression. J Immunol (2015) 0.80
Lack of evidence for association of two functional SNPs of CHI3L1 gene (HC-gp39) with rheumatoid arthritis. Rheumatol Int (2010) 0.79
Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells. Front Pharmacol (2015) 0.78
Identification of an altered peptide ligand based on the endogenously presented, rheumatoid arthritis-associated, human cartilage glycoprotein-39(263-275) epitope: an MHC anchor variant peptide for immune modulation. Arthritis Res Ther (2007) 0.78
Acceleration of bone repair in NOD/SCID mice by human monoosteophils, novel LL-37-activated monocytes. PLoS One (2013) 0.78
Expression of the chitinase family glycoprotein YKL-40 in undifferentiated, differentiated and trans-differentiated mesenchymal stem cells. PLoS One (2013) 0.78
How to target small cell lung cancer. Oncoscience (2015) 0.78
Gene expression profiling in the lung tissue of cynomolgus monkeys in response to repeated exposure to welding fumes. Arch Toxicol (2010) 0.78
Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease. Sci Rep (2016) 0.76
Changes in plasma IL-6, plasma VEGF and serum YKL-40 during Treatment with Etanercept and Methotrexate or Etanercept alone in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy. Biomark Insights (2009) 0.76
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat Genet (2010) 3.63
The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. Genet Epidemiol (2010) 3.48
Emergence of a new disease as a result of interspecific virulence gene transfer. Nat Genet (2006) 2.80
Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. Mol Syst Biol (2011) 2.59
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet (2012) 2.55
Quality control procedures for genome-wide association studies. Curr Protoc Hum Genet (2011) 2.48
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. Genet Epidemiol (2011) 1.47
Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis. Arthritis Res Ther (2007) 1.43
Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years. PLoS One (2013) 1.36
Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study. Atherosclerosis (2007) 1.36
The induction of CCN2 by TGFbeta1 involves Ets-1. Arthritis Res Ther (2006) 1.33
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genet Epidemiol (2011) 1.26
TNFalpha suppresses link protein and type II collagen expression in chondrocytes: Role of MEK1/2 and NF-kappaB signaling pathways. J Cell Physiol (2003) 1.22
Molecular epidemiology of measles viruses in China, 1995-2003. Virol J (2007) 1.20
Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells. Mol Cancer Ther (2008) 1.08
Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants. Cell Commun Adhes (2006) 1.07
Imputation-based genomic coverage assessments of current human genotyping arrays. G3 (Bethesda) (2013) 1.06
Rubella virus genotypes in the People's Republic of China between 1979 and 2007: a shift in endemic viruses during the 2001 Rubella Epidemic. J Clin Microbiol (2010) 1.06
Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. Arthritis Rheum (2007) 1.04
ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. J Bone Miner Res (2008) 1.03
Genetic characterization of measles viruses in China, 2004. Virol J (2008) 0.99
The Tsn1-ToxA interaction in the wheat-Stagonospora nodorum pathosystem parallels that of the wheat-tan spot system. Genome (2006) 0.98
Flavivirus RNA cap methyltransferase: structure, function, and inhibition. Front Biol (Beijing) (2010) 0.97
Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling. Arthritis Res Ther (2009) 0.96
Short communication: emerging transmitted HIV type 1 drug resistance mutations among patients prior to start of first-line antiretroviral therapy in middle and low prevalence sites in China. AIDS Res Hum Retroviruses (2012) 0.96
Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PLoS One (2010) 0.95
Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae. Biotechnol Biofuels (2013) 0.94
Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for a highly sensitive detection of enterovirus in the stool samples of acute flaccid paralysis cases. BMC Infect Dis (2009) 0.92
Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte. Arthritis Res Ther (2004) 0.92
Proteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage. Matrix Biol (2007) 0.92
Genome-wide association analysis of ischemic stroke in young adults. G3 (Bethesda) (2011) 0.92
[Surveillance on HIV-1 incidence among men who have sex with men in Chongqing, China, 2006 - 2008]. Zhonghua Liu Xing Bing Xue Za Zhi (2009) 0.92
Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice. Int Immunopharmacol (2008) 0.91
LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity. J Leukoc Biol (2003) 0.91
Genomic analysis of a newly isolated of Japanese encephalitis virus strain, CQ11-66, from a pediatric patient in China. Virol J (2013) 0.91
P2Y nucleotide receptor signaling through MAPK/ERK is regulated by extracellular matrix: involvement of beta3 integrins. J Cell Physiol (2007) 0.90
Microbial engineering strategies to improve cell viability for biochemical production. Biotechnol Adv (2013) 0.89
Over-expression GbERF2 transcription factor in tobacco enhances brown spots disease resistance by activating expression of downstream genes. Gene (2007) 0.86
Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. J Mol Med (Berl) (2008) 0.85
Regulation of Sox9 activity by crosstalk with nuclear factor-kappaB and retinoic acid receptors. Arthritis Res Ther (2008) 0.85
Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in Chongqing, China. BMC Infect Dis (2009) 0.85
Genetic characterization of the hemagglutinin genes of wild-type measles virus circulating in china, 1993-2009. PLoS One (2013) 0.84
Overexpression of GbERF confers alteration of ethylene-responsive gene expression and enhanced resistance to Pseudomonas syringae in transgenic tobacco. J Biosci (2006) 0.83
Prevalence and trend of HIV infection among voluntary blood donors in China since implementation of the Blood Donation Law: a systematic review and meta-analysis. Trop Med Int Health (2012) 0.81
Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data. PLoS One (2011) 0.81
A predicted immunity protein confers resistance to pyocin S5 in a sensitive strain of Pseudomonas aeruginosa. Chembiochem (2013) 0.80
Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata. J Plant Physiol (2007) 0.80
Epidermal growth factor stimulates proton efflux from chondrocytic cells. J Cell Physiol (2002) 0.80
Bioactive glass/polymer composite materials with mechanical properties matching those of cortical bone. J Biomed Mater Res A (2006) 0.79
Human leukocyte antigen profile in HIV-1 infected individuals and AIDS patients from Chongqing, China. Microbiol Immunol (2009) 0.78
PKC inhibition increases gap junction intercellular communication and cell adhesion in human neuroblastoma. Cell Tissue Res (2010) 0.78
Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes. Matrix Biol (2009) 0.78
Novel short antibacterial and antifungal peptides with low cytotoxicity: Efficacy and action mechanisms. Biochem Biophys Res Commun (2010) 0.78
Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic conditions. Mol Biosyst (2012) 0.78
Isolation of a novel lipase gene from Serratia liquefaciens S33 DB-1, functional expression in Pichia pastoris and its properties. Mol Biotechnol (2007) 0.77
[An outbreak of human orf disease caused by introduced black goats]. Zhonghua Liu Xing Bing Xue Za Zhi (2011) 0.77
N-butyryl glucosamine increases matrix gene expression by chondrocytes. J Pharmacol Exp Ther (2004) 0.77
Therapeutic microbes for infectious disease. Methods Mol Biol (2014) 0.77
Norovirus GII.P16/GII.2-Associated Gastroenteritis, China, 2016. Emerg Infect Dis (2017) 0.76
Polymorphisms in the SOCS7 gene and glucose homeostasis traits. BMC Res Notes (2013) 0.76
Activity restriction increases deoxypyridinoline excretion in hospitalized high-risk pregnant women. Biol Res Nurs (2012) 0.76
Ablative hypofractionated radiotherapy normalizes tumor vasculature in lewis lung carcinoma mice model. Radiat Res (2013) 0.76
Study of drug resistance and molecular typing of 59 cholerae01 clinical isolates from 1984 to 2002 in Chongqing, China. Int J Clin Exp Med (2013) 0.75
[The bio-effects of high single-dose radiation on xenografts of Lewis lung carcinoma]. Sichuan Da Xue Xue Bao Yi Xue Ban (2014) 0.75
Isolation and characterization of a class III homeodomain-leucine zipper-like gene from Gossypium barbadense. DNA Seq (2006) 0.75
A time-course transcriptome analysis of Escherichia coli with direct electrochemistry behavior in microbial fuel cells. Chem Commun (Camb) (2009) 0.75
[Genetic characterization of Chinese rubella virus isolates from 2003 to 2007]. Bing Du Xue Bao (2008) 0.75