Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 4023701)

Published in Mol Cancer on March 05, 2014

Authors

Rebeca Sanz-Pamplona, Antoni Berenguer, David Cordero, David G Molleví, Marta Crous-Bou, Xavier Sole, Laia Paré-Brunet, Elisabet Guino, Ramón Salazar, Cristina Santos, Javier de Oca, Xavier Sanjuan, Francisco Rodriguez-Moranta, Victor Moreno1

Author Affiliations

1: Unit of Biomarkers and Susceptibility, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain. v.moreno@iconcologia.net.

Articles citing this

Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer. Clin Cancer Res (2015) 1.46

Genetic Determinants of the Gut Microbiome in UK Twins. Cell Host Microbe (2016) 1.08

Expression Profiles of miRNA Subsets Distinguish Human Colorectal Carcinoma and Normal Colonic Mucosa. Clin Transl Gastroenterol (2016) 1.03

Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis. Carcinogenesis (2014) 0.90

The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer. J Exp Clin Cancer Res (2015) 0.82

Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer. Clin Epigenetics (2015) 0.81

Discovery and validation of new potential biomarkers for early detection of colon cancer. PLoS One (2014) 0.79

Microarray analysis of differentially-expressed genes and linker genes associated with the molecular mechanism of colorectal cancer. Oncol Lett (2016) 0.78

S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma. BMC Cancer (2015) 0.75

Identification of Key Candidate Genes and Pathways in Colorectal Cancer by Integrated Bioinformatical Analysis. Int J Mol Sci (2017) 0.75

Altered pathways and colorectal cancer prognosis. BMC Med (2015) 0.75

Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis. World J Surg Oncol (2016) 0.75

Reduced NOV expression correlates with disease progression in colorectal cancer and is associated with survival, invasion and chemoresistance of cancer cells. Oncotarget (2017) 0.75

Mutanome and expression of immune response genes in microsatellite stable colon cancer. Oncotarget (2016) 0.75

Altered expression of cytokeratin 7 and CD117 in transitional mucosa adjacent to human colorectal cancer. Oncol Lett (2017) 0.75

Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component. Br J Cancer (2017) 0.75

Analysis of the interplay between methylation and expression reveals its potential role in cancer aetiology. Funct Integr Genomics (2016) 0.75

Articles cited by this

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46

Hallmarks of cancer: the next generation. Cell (2011) 140.01

KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res (2000) 117.00

Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76

Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (2003) 100.88

Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13

Towards a proteome-scale map of the human protein-protein interaction network. Nature (2005) 24.76

A human protein-protein interaction network: a resource for annotating the proteome. Cell (2005) 18.97

Systems biology: a brief overview. Science (2002) 14.69

ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics (2006) 14.49

Reactome: a knowledge base of biologic pathways and processes. Genome Biol (2007) 13.36

The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res (2005) 12.94

PID: the Pathway Interaction Database. Nucleic Acids Res (2008) 12.92

Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer (1953) 11.45

Human protein reference database as a discovery resource for proteomics. Nucleic Acids Res (2004) 9.99

A census of human transcription factors: function, expression and evolution. Nat Rev Genet (2009) 9.19

AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer (2003) 8.88

Computing topological parameters of biological networks. Bioinformatics (2007) 5.36

A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res (2003) 5.04

The MIPS mammalian protein-protein interaction database. Bioinformatics (2004) 4.66

Gene expression omnibus: microarray data storage, submission, retrieval, and analysis. Methods Enzymol (2006) 4.30

Tumors as organs: complex tissues that interface with the entire organism. Dev Cell (2010) 3.98

DIP: The Database of Interacting Proteins: 2001 update. Nucleic Acids Res (2001) 3.38

Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell (2010) 3.34

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 2.94

Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol (2010) 2.79

Cancer: a Systems Biology disease. Biosystems (2006) 2.29

Novel roles for Slits and netrins: axon guidance cues as anticancer targets? Nat Rev Cancer (2011) 1.84

Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J Biol Chem (2008) 1.72

Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations. Gut (2012) 1.68

Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration. Angiogenesis (2008) 1.64

The renin-angiotensin system and malignancy. Carcinogenesis (2008) 1.62

Gut microbiota and inflammation. Nutrients (2011) 1.60

The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. Mol Cell Biol (2003) 1.44

Translational regulation mechanisms of AP-1 proteins. Mutat Res (2009) 1.42

Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration. Nature (2011) 1.38

Normal colon epithelium: a dataset for the analysis of gene expression and alternative splicing events in colon disease. BMC Genomics (2010) 1.31

Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol (2011) 1.25

Clinical value of prognosis gene expression signatures in colorectal cancer: a systematic review. PLoS One (2012) 1.25

The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon. J Biol Chem (2004) 1.22

TFClass: an expandable hierarchical classification of human transcription factors. Nucleic Acids Res (2012) 1.22

A roundabout way to cancer. Adv Cancer Res (2012) 1.11

Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate. J Biol Chem (2007) 1.07

Field effect of human colon carcinoma on normal mucosa: relevance of carcinoembryonic antigen expression. Tumour Biol (1996) 1.07

Biana: a software framework for compiling biological interactions and analyzing networks. BMC Bioinformatics (2010) 1.03

Gene expression differences between colon and rectum tumors. Clin Cancer Res (2011) 1.03

LIF-dependent signaling: new pieces in the Lego. Stem Cell Rev (2012) 0.98

Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype. Exp Mol Pathol (2012) 0.97

Stromal cells and integrins: conforming to the needs of the tumor microenvironment. Neoplasia (2009) 0.95

Reelin is involved in transforming growth factor-β1-induced cell migration in esophageal carcinoma cells. PLoS One (2012) 0.94

CLU and colon cancer. The dual face of CLU: from normal to malignant phenotype. Adv Cancer Res (2009) 0.92

Expression of interleukin-6, leukemia inhibitory factor and their receptors by colonic epithelium and pericryptal fibroblasts. J Gastroenterol Hepatol (2001) 0.91

Signaling pathways bridging microbial-triggered inflammation and cancer. Cell Signal (2012) 0.90

Prognostic value of innate and adaptive immunity in colorectal cancer. World J Gastroenterol (2013) 0.90

SLIT2 inhibits cell migration in colorectal cancer through the AKT-GSK3β signaling pathway. Int J Colorectal Dis (2013) 0.88

Evidence for field effect cancerization in colorectal cancer. Genomics (2013) 0.87

Secreted clusterin in colon tumor cell models and its potential as diagnostic marker for colorectal cancer. Cancer Invest (2012) 0.86

CLU "in and out": looking for a link. Adv Cancer Res (2009) 0.84

Immune microenvironment in colorectal cancer: a new hallmark to change old paradigms. Clin Dev Immunol (2011) 0.83

INOH: ontology-based highly structured database of signal transduction pathways. Database (Oxford) (2011) 0.83

Path lengths in protein-protein interaction networks and biological complexity. Proteomics (2011) 0.82

Why do essential proteins tend to be clustered in the yeast interactome network? Mol Biosyst (2010) 0.82

Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death. Neoplasia (2011) 0.80

Articles by these authors

Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer. J Clin Oncol (2010) 3.30

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A (2009) 2.63

Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. Cancer Res (2003) 2.18

ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms of the digestive system: well-differentiated pancreatic non-functioning tumors. Neuroendocrinology (2012) 2.12

The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med (2010) 1.93

Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. Clin Cancer Res (2006) 1.77

Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas. J Pathol (2010) 1.68

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. Nat Med (2012) 1.56

Early predictors of oxaliplatin-induced cumulative neuropathy in colorectal cancer patients. J Neurol Neurosurg Psychiatry (2013) 1.55

A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. Pharmacogenet Genomics (2005) 1.53

Changes in food supply in Mediterranean countries from 1961 to 2001. Public Health Nutr (2006) 1.52

Prediction of neonatal acidemia by computer analysis of fetal heart rate and ST event signals. Am J Obstet Gynecol (2009) 1.49

Community pharmacy services in Portugal. Ann Pharmacother (2006) 1.43

Chemotherapy and role of the proliferation marker Ki-67 in digestive neuroendocrine tumors. Endocr Relat Cancer (2007) 1.42

Adherence to the Mediterranean diet and risk of coronary heart disease in the Spanish EPIC Cohort Study. Am J Epidemiol (2009) 1.28

Clinical value of prognosis gene expression signatures in colorectal cancer: a systematic review. PLoS One (2012) 1.25

Outcome of reintubated patients after scheduled extubation. J Crit Care (2011) 1.23

DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer. Cancer Prev Res (Phila) (2013) 1.21

Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment. J Clin Oncol (2006) 1.20

Human mitochondrial DNA complete amplification and sequencing: a new validated primer set that prevents nuclear DNA sequences of mitochondrial origin co-amplification. Electrophoresis (2009) 1.12

Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: etiopathogenic similarities, differences and paradoxes. Mutat Res (2009) 1.09

Clinical pattern and associations of oxaliplatin acute neurotoxicity: a prospective study in 170 patients with colorectal cancer. Cancer (2012) 1.08

Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer. Eur J Cancer (2008) 1.04

Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer. Clin Cancer Res (2012) 1.04

Gene expression differences between colon and rectum tumors. Clin Cancer Res (2011) 1.03

Association between habitual dietary flavonoid and lignan intake and colorectal cancer in a Spanish case-control study (the Bellvitge Colorectal Cancer Study). Cancer Causes Control (2012) 1.03

Novel methylation panel for the early detection of colorectal tumors in stool DNA. Clin Colorectal Cancer (2010) 1.02

Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize. Mol Cancer Res (2010) 1.01

Nuclear insertions of mitochondrial origin: Database updating and usefulness in cancer studies. Mitochondrion (2011) 1.00

A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency. J Pathol (2012) 1.00

Outcome and quality of life in patients with postoperative delirium during an ICU stay following major surgery. Crit Care (2013) 0.98

Polymorphisms within inflammatory genes and colorectal cancer. J Negat Results Biomed (2006) 0.98

Nanofluidic digital PCR for KRAS mutation detection and quantification in gastrointestinal cancer. Clin Chem (2012) 0.98

Biological convergence of cancer signatures. PLoS One (2009) 0.97

Refining the role of PMS2 in Lynch syndrome: germline mutational analysis improved by comprehensive assessment of variants. J Med Genet (2013) 0.96

Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumour: a phase II study of Spanish Neuroendocrine Tumour Group (GETNE0801). Eur J Cancer (2013) 0.96

Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency. Cancer Res (2008) 0.95

Frequency and pattern of heteroplasmy in the complete human mitochondrial genome. PLoS One (2013) 0.95

Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk. Eur J Cancer (2007) 0.94

Genome-wide association study of endometrial cancer in E2C2. Hum Genet (2013) 0.93

Promoting spontaneous adverse drug reaction reporting in hospitals using a hyperlink to the online reporting form: an ecological study in Portugal. Drug Saf (2012) 0.93

Effects of robotic guidance on the coordination of locomotion. J Neuroeng Rehabil (2013) 0.93

Evaluation of two methods for computational HLA haplotypes inference using a real dataset. BMC Bioinformatics (2008) 0.92

Engineering of weak helper interactions for high-efficiency FRET probes. Nat Methods (2013) 0.92

Biological processes, properties and molecular wiring diagrams of candidate low-penetrance breast cancer susceptibility genes. BMC Med Genomics (2008) 0.92

The APOE ε2 allele increases the risk of earlier age at onset in Machado-Joseph disease. Arch Neurol (2011) 0.91

Epigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer. J Natl Cancer Inst (2013) 0.91

Polymorphisms of the dopamine receptor gene DRD2 and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev (2005) 0.90

Intrinsic cancer subtypes--next steps into personalized medicine. Cell Oncol (Dordr) (2015) 0.90

Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients. Inflamm Bowel Dis (2013) 0.88

[Relationship between COMT gene genotypes and severity of fibromyalgia]. Reumatol Clin (2008) 0.88

Increased transcript diversity: novel splicing variants of Machado-Joseph disease gene (ATXN3). Neurogenetics (2009) 0.88

Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype. Mol Carcinog (2011) 0.88

Tools for protein-protein interaction network analysis in cancer research. Clin Transl Oncol (2012) 0.88

Tracing the origin of the east-west population admixture in the Altai region (Central Asia). PLoS One (2012) 0.87

Validated primer set that prevents nuclear DNA sequences of mitochondrial origin co-amplification: a revision based on the New Human Genome Reference Sequence (GRCh37). Electrophoresis (2011) 0.87

"Omics" research, monetization of intellectual property and fragmentation of knowledge: can clinical epidemiology strengthen integrative research? J Clin Epidemiol (2007) 0.87

Innovations therapy: mammalian target of rapamycin (mTOR) inhibitors for the treatment of neuroendocrine tumors. Cancer Metastasis Rev (2011) 0.86

Phase I clinical and pharmacokinetic study of kahalalide F administered weekly as a 1-hour infusion to patients with advanced solid tumors. Clin Cancer Res (2008) 0.86

Segregation distortion of wild-type alleles at the Machado-Joseph disease locus: a study in normal families from the Azores islands (Portugal). J Hum Genet (2008) 0.86

Promoting interaction amongst autistic adolescents using robots. Conf Proc IEEE Eng Med Biol Soc (2010) 0.86

Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer. J Epidemiol Community Health (2007) 0.86

Identification of MST1/STK4 and SULF1 proteins as autoantibody targets for the diagnosis of colorectal cancer by using phage microarrays. Mol Cell Proteomics (2011) 0.86

Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3): a two-case report. BMC Neurol (2011) 0.85

Analysis of segregation patterns in Machado-Joseph disease pedigrees. J Hum Genet (2008) 0.85

Future perspectives on neuroendocrine tumors. Cancer Metastasis Rev (2011) 0.85

Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM). Clin Transl Oncol (2012) 0.84

Microsatellite instability of the colorectal carcinoma can be predicted in the conventional pathologic examination. A prospective multicentric study and the statistical analysis of 615 cases consolidate our previously proposed logistic regression model. Virchows Arch (2010) 0.84

Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancer. Int J Cancer (2005) 0.84

Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: results from a prospective multicenter study. Cancer (2013) 0.84

Large differences in global transcriptional regulatory programs of normal and tumor colon cells. BMC Cancer (2014) 0.83

Phase I and pharmacokinetic study of trabectedin 3-hour infusion every three weeks in patients with advanced cancer and alteration of hepatic function. Med Oncol (2011) 0.83

Y-chromosome variation in South Iberia: insights into the North African contribution. Am J Hum Biol (2009) 0.83

Exploring the link between germline and somatic genetic alterations in breast carcinogenesis. PLoS One (2010) 0.83

Optic neuritis in an adult patient with chickenpox. Case Rep Ophthalmol Med (2012) 0.83

Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice. Aging Dis (2013) 0.82

Short-term psychological impact of predictive testing for Machado-Joseph disease: depression and anxiety levels in individuals at risk from the Azores (Portugal). Community Genet (2004) 0.82

Analysis of the pathologic response to primary chemotherapy in patients with locally advanced breast cancer grouped according to estrogen receptor, progesterone receptor, and HER2 status. Clin Breast Cancer (2007) 0.82

Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer. PLoS One (2013) 0.82