Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy.

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Published in Sci Transl Med on March 05, 2014

Authors

Dmitriy Zamarin1,2,3, Rikke B Holmgaard1,3, Sumit K Subudhi4, Joon Seok Park5,6, Mena Mansour7,8, Peter Palese7, Taha Merghoub1,3, Jedd D Wolchok1,2,3,9, James P Allison4

Author Affiliations

1: Swim Across America Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA.
2: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
3: Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
4: Department of Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA.
5: Laboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, New York, NY 10065, USA.
6: Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021.
7: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
8: Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
9: Weill Cornell Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY 10065, USA.

Associated clinical trials:

Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma | NCT01740297

Phase I-II Study of Intratumoral Urelumab Combined With Nivolumab in Patients With Solid Tumors (INTRUST) | NCT03792724

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