Have lessons from past failures brought us closer to the success of immunotherapy in metastatic pancreatic cancer?

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Published in Oncoimmunology on December 18, 2015

Authors

Laura Rosa Brunet1, Thorsten Hagemann1, Gayab Andrew2, Satvinder Mudan3, Aurelien Marabelle4

Author Affiliations

1: Immodulon Therapeutics Ltd, Stockley Park , Uxbridge, UK.
2: Deparment of Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust , London, UK.
3: Royal Marsden Hospital , Fulham Road , London, UK.
4: INSERM, U1015, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France; Drug Development Department, Gustave Roussy Cancer Campus, Villejuif, France.

Associated clinical trials:

Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma | NCT01740297

CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer | NCT01583686

A Study On An Immunostimulant Antibody In Combination With Chemotherapy For Advanced Cancer Of The Pancreas | NCT00711191

Pembrolizumab With or Without Talimogene Laherparepvec or Talimogene Laherparepvec Placebo in Unresected Melanoma | NCT02263508

GVAX Pancreas Vaccine (With CY) and CRS-207 With or Without Nivolumab | NCT02243371

A Phase 2, Multicenter Study of FOLFIRINOX Followed by Ipilimumab With Allogenic GM-CSF Transfected Pancreatic Tumor Vaccine in the Treatment of Metastatic Pancreatic Cancer | NCT01896869

Study of Mogamulizumab + MEDI4736 and Mogamulizumab + Tremelimumab in Subjects w/ Advanced Solid Tumors | NCT02301130

Ipilimumab and Gemcitabine Hydrochloride in Treating Patients With Stage III-IV or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery | NCT01473940

Gemcitabine and CT-011 for Resected Pancreatic Cancer | NCT01313416

DNX-2401 With Interferon Gamma (IFN-γ) for Recurrent Glioblastoma or Gliosarcoma Brain Tumors (TARGET-I) | NCT02197169

TLR9 Agonist SD-101, Ipilimumab, and Radiation Therapy in Treating Patients With Low-Grade Recurrent B-cell Lymphoma | NCT02254772

In Situ Vaccine for Low-Grade Lymphoma: Combination of Intratumoral Flt3L and Poly-ICLC With Low-Dose Radiotherapy | NCT01976585

A Clinical Research of CAR T Cells Targeting CEA Positive Cancer | NCT02349724

A Phase I Study of Intralesional Bacillus Calmette-Guerin (BCG) and Followed by Ipilimumab Therapy in Patients With Advanced Metastatic Melanoma | NCT01838200

Pilot Study of Autologous T-cells in Patients With Metastatic Pancreatic Cancer | NCT02465983

A Trial Comparing Gemcitabine With and Without IMM-101 in Advanced Pancreatic Cancer | NCT01303172

A Study of Combination Treatment With HF10 and Ipilimumab in Patients With Unresectable or Metastatic Melanoma | NCT02272855

Study of SD-101 in Combination With Localized Low-dose Radiation in Patients With Untreated Low-grade B-cell Lymphoma | NCT02266147

TVEC and Preop Radiation for Sarcoma | NCT02453191

Study of Intratumoral CAVATAK™ (Coxsackievirus A21) and Ipilimumab in Patients With Advanced Melanoma | NCT02307149

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