Published in Annu Rev Biochem on March 03, 2014
Don't edit the human germ line. Nature (2015) 4.49
Saturation editing of genomic regions by multiplex homology-directed repair. Nature (2014) 3.30
Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila. Proc Natl Acad Sci U S A (2014) 2.97
Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs. PLoS One (2014) 2.69
Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system. Sci Rep (2014) 1.83
Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice. Genome Biol (2015) 1.64
Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans. Genetics (2014) 1.61
Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design. Genetics (2015) 1.52
CRISPR multitargeter: a web tool to find common and unique CRISPR single guide RNA targets in a set of similar sequences. PLoS One (2015) 1.51
Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9. Nat Commun (2014) 1.48
Genome editing technologies: defining a path to clinic. Mol Ther (2015) 1.41
A CRISPR view of development. Genes Dev (2014) 1.41
Genome engineering with CRISPR-Cas9 in the mosquito Aedes aegypti. Cell Rep (2015) 1.28
Quantifying on- and off-target genome editing. Trends Biotechnol (2015) 1.15
TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci U S A (2015) 1.14
Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J Mol Cell Biol (2015) 1.07
Genome editing of the germline: broadening the discussion. Mol Ther (2015) 1.07
Induced Pluripotent Stem Cells Meet Genome Editing. Cell Stem Cell (2016) 1.06
Functional footprinting of regulatory DNA. Nat Methods (2015) 1.04
A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation. Plant Physiol (2015) 1.03
Targeted gene addition in human CD34(+) hematopoietic cells for correction of X-linked chronic granulomatous disease. Nat Biotechnol (2016) 1.03
TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol (2014) 1.02
ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes. Nat Commun (2016) 0.99
Rapid editing and evolution of bacterial genomes using libraries of synthetic DNA. Nat Protoc (2014) 0.92
Synthetic CRISPR RNA-Cas9-guided genome editing in human cells. Proc Natl Acad Sci U S A (2015) 0.91
Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway. Sci Rep (2015) 0.91
Enabling functional genomics with genome engineering. Genome Res (2015) 0.90
Oligonucleotide-directed mutagenesis for precision gene editing. Plant Biotechnol J (2015) 0.89
Mammalian interspecies substitution of immune modulatory alleles by genome editing. Sci Rep (2016) 0.89
Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis. G3 (Bethesda) (2016) 0.89
CRISPR-mediated Activation of Latent HIV-1 Expression. Mol Ther (2015) 0.88
Fast and sensitive detection of indels induced by precise gene targeting. Nucleic Acids Res (2015) 0.88
Biological techniques: Edit the genome to understand it. Nature (2014) 0.87
Genome-editing technologies and their potential application in horticultural crop breeding. Hortic Res (2015) 0.86
Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease. Blood (2016) 0.86
Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution. Evodevo (2014) 0.86
Genome engineering in cattle: recent technological advancements. Chromosome Res (2015) 0.85
Genome engineering with TALENs and ZFNs: repair pathways and donor design. Methods (2014) 0.85
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome. Mol Ther (2015) 0.84
Origins of Programmable Nucleases for Genome Engineering. J Mol Biol (2015) 0.83
The societal opportunities and challenges of genome editing. Genome Biol (2015) 0.83
Towards a new era in medicine: therapeutic genome editing. Genome Biol (2015) 0.83
CRISPR/Cas9-mediated reporter knock-in in mouse haploid embryonic stem cells. Sci Rep (2015) 0.83
Heterodimeric TALENs induce targeted heritable mutations in the crustacean Daphnia magna. Biol Open (2015) 0.82
MorTAL Kombat: the story of defense against TAL effectors through loss-of-susceptibility. Front Plant Sci (2015) 0.82
Genome editing for crop improvement: Challenges and opportunities. GM Crops Food (2015) 0.82
Expansins: roles in plant growth and potential applications in crop improvement. Plant Cell Rep (2016) 0.82
Heritable genome editing with CRISPR/Cas9 induces anosmia in a crop pest moth. Sci Rep (2016) 0.81
Insecticide Resistance and Management Strategies in Urban Ecosystems. Insects (2016) 0.81
Simultaneous live imaging of the transcription and nuclear position of specific genes. Nucleic Acids Res (2015) 0.81
Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease. ACS Chem Biol (2014) 0.80
New vectors for simple and streamlined CRISPR-Cas9 genome editing in Saccharomyces cerevisiae. Yeast (2015) 0.80
Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study. Front Endocrinol (Lausanne) (2015) 0.79
Protein engineering of Cas9 for enhanced function. Methods Enzymol (2014) 0.79
Highly specific targeted mutagenesis in plants using Staphylococcus aureus Cas9. Sci Rep (2016) 0.78
Precise Correction of Disease Mutations in Induced Pluripotent Stem Cells Derived From Patients With Limb Girdle Muscular Dystrophy. Mol Ther (2016) 0.78
The history and market impact of CRISPR RNA-guided nucleases. Curr Opin Virol (2015) 0.78
Non-viral delivery of genome-editing nucleases for gene therapy. Gene Ther (2016) 0.77
Single-Base Pair Genome Editing in Human Cells by Using Site-Specific Endonucleases. Int J Mol Sci (2015) 0.77
The genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discovery. Cell Oncol (Dordr) (2016) 0.77
High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cells. Acta Biomater (2015) 0.77
CRISPRing into the woods. GM Crops Food (2015) 0.77
Genome engineering: Drosophila melanogaster and beyond. Wiley Interdiscip Rev Dev Biol (2015) 0.77
TALEN-mediated homologous recombination in Daphnia magna. Sci Rep (2015) 0.76
Precise genome editing by homologous recombination. Methods Cell Biol (2016) 0.75
Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation. J Vis Exp (2016) 0.75
A Perspective on the State of Genome Editing. Mol Ther (2016) 0.75
Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes. Sci Rep (2017) 0.75
Genomics Approaches For Improving Salinity Stress Tolerance in Crop Plants. Curr Genomics (2016) 0.75
Conservative site-specific and single-copy transgenesis in human LINE-1 elements. Nucleic Acids Res (2015) 0.75
Fulfilling the dream of a perfect genome editing tool. Proc Natl Acad Sci U S A (2014) 0.75
RAC-tagging: Recombineering And Cas9-assisted targeting for protein tagging and conditional analyses. Sci Rep (2016) 0.75
Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease. Proc Natl Acad Sci U S A (2016) 0.75
Whole Organism Genome Editing: Targeted Large DNA Insertion via ObLiGaRe Nonhomologous End-Joining in Vivo Capture. G3 (Bethesda) (2015) 0.75
Regulate genome-edited products, not genome editing itself. Nat Biotechnol (2016) 0.75
The Power of CRISPR-Cas9-Induced Genome Editing to Speed Up Plant Breeding. Int J Genomics (2016) 0.75
Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs. Nucleic Acids Res (2016) 0.75
TALEN-mediated knock-in via non-homologous end joining in the crustacean Daphnia magna. Sci Rep (2016) 0.75
A Split Staphylococcus aureus Cas9 as a Compact Genome-Editing Tool in Plants. Plant Cell Physiol (2017) 0.75
Chromatin organization in pluripotent cells: emerging approaches to study and disrupt function. Brief Funct Genomics (2015) 0.75
CRISPR-FOCUS: A web server for designing focused CRISPR screening experiments. PLoS One (2017) 0.75
Mechanisms of precise genome editing using oligonucleotide donors. Genome Res (2017) 0.75
Understanding the DNA damage response in order to achieve desired gene editing outcomes in mosquitoes. Chromosome Res (2015) 0.75
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Sci Rep (2017) 0.75
Promoterless gene targeting without nucleases rescues lethality of a Crigler-Najjar syndrome mouse model. EMBO Mol Med (2017) 0.75
The contribution of homology arms to nuclease-assisted genome engineering. Nucleic Acids Res (2017) 0.75