Published in Cell Stem Cell on May 05, 2016
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell (2016) 1.08
The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat Med (2016) 0.81
Induced pluripotent stem cell technology: a decade of progress. Nat Rev Drug Discov (2016) 0.77
Patient-derived induced pluripotent stem cells in cancer research and precision oncology. Nat Med (2016) 0.77
Induced pluripotent stem cells, past and future. Science (2016) 0.76
Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization. Mol Biol Cell (2017) 0.76
A Comprehensive TALEN-Based Knockout Library for Generating Human Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Circ Res (2017) 0.75
Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration. Curr Neurol Neurosci Rep (2016) 0.75
Using induced pluripotent stem cells to understand retinal ciliopathy disease mechanisms and develop therapies. Biochem Soc Trans (2016) 0.75
Implications for a Stem Cell Regenerative Medicine Based Approach to Human Intervertebral Disk Degeneration. Front Cell Dev Biol (2017) 0.75
Reprogramming cell fates by small molecules. Protein Cell (2017) 0.75
Organoid technologies meet genome engineering. EMBO Rep (2017) 0.75
Endogenous TERT N-terminal tagging affects human telomerase function at telomeres in vivo. Mol Cell Biol (2016) 0.75
Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. Development (2017) 0.75
To CRISPR and beyond: the evolution of genome editing in stem cells. Regen Med (2016) 0.75
Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. Stem Cell Reports (2017) 0.75
Manufacturing Cell Therapies Using Engineered Biomaterials. Trends Biotechnol (2017) 0.75
Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination. Brain (2017) 0.75
Osteosarcoma: Molecular Pathogenesis and iPSC Modeling. Trends Mol Med (2017) 0.75
Human hepatic organoids for the analysis of human genetic diseases. JCI Insight (2017) 0.75
Drusen in patient-derived hiPSC-RPE models of macular dystrophies. Proc Natl Acad Sci U S A (2017) 0.75
The use of brain organoids to investigate neural development and disease. Nat Rev Neurosci (2017) 0.75
Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Res (2017) 0.75
Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease. Front Mol Neurosci (2017) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Embryonic stem cell lines derived from human blastocysts. Science (1998) 65.53
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) 48.17
Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 30.49
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol (2013) 21.32
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature (2005) 19.15
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 18.96
Genome editing with engineered zinc finger nucleases. Nat Rev Genet (2010) 18.88
Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol (2007) 13.56
New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature (2007) 13.54
Development and applications of CRISPR-Cas9 for genome engineering. Cell (2014) 13.50
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40
Genome-scale CRISPR-Cas9 knockout screening in human cells. Science (2013) 12.36
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature (2007) 11.72
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27
Genetic screens in human cells using the CRISPR-Cas9 system. Science (2013) 10.75
Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell (2009) 10.52
Targeted genome editing across species using ZFNs and TALENs. Science (2011) 9.84
Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature (2009) 9.29
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol (2007) 9.23
Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics (2002) 9.09
Cerebral organoids model human brain development and microcephaly. Nature (2013) 9.07
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell (2009) 8.97
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics (2013) 8.56
Enhancing gene targeting with designed zinc finger nucleases. Science (2003) 8.42
Highly recurrent TERT promoter mutations in human melanoma. Science (2013) 8.40
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
Sheep cloned by nuclear transfer from a cultured cell line. Nature (1996) 7.86
TERT promoter mutations in familial and sporadic melanoma. Science (2013) 7.82
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell (2015) 7.80
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med (2014) 7.64
Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res (2013) 7.41
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
Naive and primed pluripotent states. Cell Stem Cell (2009) 7.15
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A (2013) 6.88
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol (2014) 6.85
Rare and common variants: twenty arguments. Nat Rev Genet (2012) 6.67
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51
An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol (2011) 6.44
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature (1988) 6.12
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell (2014) 6.11
Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol Cell Biol (1994) 6.08
Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells. Proc Natl Acad Sci U S A (2006) 6.00
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System. Cell (2015) 5.97
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature (2010) 5.81
Homologous recombination in human embryonic stem cells. Nat Biotechnol (2003) 5.77
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat Biotechnol (2014) 5.69
High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases. Nat Methods (2011) 5.68
Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci (2009) 5.58
Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature (2013) 5.43
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell (2014) 5.43
Playing the end game: DNA double-strand break repair pathway choice. Mol Cell (2012) 5.42
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell (2013) 5.40
Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells. Proc Natl Acad Sci U S A (1994) 5.37
In vivo genome editing using Staphylococcus aureus Cas9. Nature (2015) 5.26
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature (2014) 5.19
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat Biotechnol (2014) 5.07
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells. Nature (2014) 4.95
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92
Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep (2013) 4.72
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Gene conversion tracts from double-strand break repair in mammalian cells. Mol Cell Biol (1998) 4.46
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat Biotechnol (2014) 4.41
The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. J Embryol Exp Morphol (1962) 4.37
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16
iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell (2009) 4.04
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature (2015) 3.77
Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases. Proc Natl Acad Sci U S A (2008) 3.70
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol (2015) 3.64
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat Methods (2013) 3.59
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature (2016) 3.54
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53
Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood (2011) 3.43
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (2013) 3.43
Identification and characterization of essential genes in the human genome. Science (2015) 3.14
Genome engineering with targetable nucleases. Annu Rev Biochem (2014) 3.14
Rationally engineered Cas9 nucleases with improved specificity. Science (2015) 3.14
Human stem cell-based disease modeling: prospects and challenges. Curr Opin Cell Biol (2015) 0.78