Published in Biochemistry on March 26, 2014
Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature (2014) 1.00
Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products. Chem Res Toxicol (2015) 0.95
Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin. Tetrahedron Lett (2015) 0.79
Removal of oxidatively generated DNA damage by overlapping repair pathways. Free Radic Biol Med (2016) 0.78
Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA. J Biol Chem (2016) 0.76
Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts. J Org Chem (2015) 0.75
Effect of Base-Pairing Partner on the Thermodynamic Stability of the Diastereomeric Spiroiminodihydantoin Lesion. Chem Res Toxicol (2016) 0.75
Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA. Chem Res Toxicol (2015) 0.75
8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA. Org Biomol Chem (2017) 0.75
Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. Structure (2003) 2.77
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. EMBO J (2004) 2.43
The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry (2003) 1.92
The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol (2007) 1.77
Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts. Biochemistry (2010) 1.18
Effect of the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin on proofreading by Escherichia coli DNA polymerase I (Klenow fragment) in different sequence contexts. Biochemistry (2003) 1.17
Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Proc Natl Acad Sci U S A (2011) 1.09
Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context. J Biol Chem (2013) 1.05
Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin. Biochemistry (2010) 0.97
Kinetics of mismatch formation opposite lesions by the replicative DNA polymerase from bacteriophage RB69. Biochemistry (2010) 0.97
Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin. J Am Chem Soc (2013) 0.97
DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic Acids Res (2012) 0.95
Absolute configurations of spiroiminodihydantoin and allantoin stereoisomers: comparison of computed and measured electronic circular dichroism spectra. Chem Res Toxicol (2009) 0.94
Spiroiminodihydantoin lesions derived from guanine oxidation: structures, energetics, and functional implications. Biochemistry (2005) 0.93
Isomorphous difference methods. Methods Enzymol (2003) 0.93
Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP and dGMP to be inserted opposite Guanidinohydantoin . Biochemistry (2010) 0.88
The E295K cancer variant of human polymerase β favors the mismatch conformational pathway during nucleotide selection. J Biol Chem (2013) 0.84
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. EMBO J (2004) 2.43
Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site. EMBO J (2004) 2.14
Is there a link between DNA polymerase beta and cancer? Cell Cycle (2004) 2.10
The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry (2003) 1.92
Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. Structure (2011) 1.82
Unzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore. J Am Chem Soc (2012) 1.80
The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol (2007) 1.77
Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1. Biochemistry (2008) 1.62
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo. Proc Natl Acad Sci U S A (2010) 1.61
In vitro nucleotide misinsertion opposite the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin and DNA synthesis past the lesions using Escherichia coli DNA polymerase I (Klenow fragment). Biochemistry (2002) 1.60
A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol. Proc Natl Acad Sci U S A (2007) 1.56
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. Nucleic Acids Res (2007) 1.46
Formation of 13C-, 15N-, and 18O-labeled guanidinohydantoin from guanosine oxidation with singlet oxygen. Implications for structure and mechanism. J Am Chem Soc (2003) 1.42
Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Biochemistry (2005) 1.41
Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7. Nat Struct Mol Biol (2004) 1.40
A DNA polymerase beta mutant from colon cancer cells induces mutations. Proc Natl Acad Sci U S A (2004) 1.40
Nanopore detection of 8-oxo-7,8-dihydro-2'-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site. J Am Chem Soc (2010) 1.39
Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family. J Biol Chem (2006) 1.36
DNA polymerase family X: function, structure, and cellular roles. Biochim Biophys Acta (2009) 1.34
Interactions of the human telomere sequence with the nanocavity of the α-hemolysin ion channel reveal structure-dependent electrical signatures for hybrid folds. J Am Chem Soc (2013) 1.29
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase. J Mol Biol (2004) 1.26
Base excision repair and cancer. Cancer Lett (2012) 1.23
Crown ether-electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules. Proc Natl Acad Sci U S A (2012) 1.23
The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage. Prog Mol Biol Transl Sci (2012) 1.22
Recognition and removal of oxidized guanines in duplex DNA by the base excision repair enzymes hOGG1, yOGG1, and yOGG2. Biochemistry (2003) 1.21
Structural and functional analysis of the CspB protease required for Clostridium spore germination. PLoS Pathog (2013) 1.19
Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts. Biochemistry (2010) 1.18
Effect of the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin on proofreading by Escherichia coli DNA polymerase I (Klenow fragment) in different sequence contexts. Biochemistry (2003) 1.17
Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing. Proc Natl Acad Sci U S A (2010) 1.15
tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A (2010) 1.15
Caught bending the A-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide. Biochemistry (2007) 1.14
Human POLB gene is mutated in high percentage of colorectal tumors. J Biol Chem (2012) 1.12
Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation. J Biol Chem (2012) 1.12
Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts. J Mol Biol (2010) 1.12
The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding. Biochemistry (2008) 1.10
Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate. Biochemistry (2003) 1.09
DNA polymerase beta is critical for mouse meiotic synapsis. EMBO J (2009) 1.09
Targeting cancer with a lupus autoantibody. Sci Transl Med (2012) 1.09
Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Biochemistry (2010) 1.07
Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair. Mol Cell Biol (2011) 1.07
Bumps in the road: how replicative DNA polymerases see DNA damage. Curr Opin Struct Biol (2005) 1.07
DNA-protein cross-links between guanine and lysine depend on the mechanism of oxidation for formation of C5 vs C8 guanosine adducts. J Am Chem Soc (2008) 1.07
Chemical modification of siRNA bases to probe and enhance RNA interference. J Org Chem (2011) 1.06
Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context. J Biol Chem (2013) 1.05
A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. J Am Chem Soc (2011) 1.05
The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site. J Biol Chem (2003) 1.05
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia. Proc Natl Acad Sci U S A (2011) 1.04
A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. PLoS Genet (2012) 1.03
MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles. Mutat Res (2012) 1.02
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Cancer Res (2009) 1.02
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation. DNA Repair (Amst) (2012) 1.02
Spermine participates in oxidative damage of guanosine and 8-oxoguanosine leading to deoxyribosylurea formation. J Am Chem Soc (2004) 1.02
Sequence-specific single-molecule analysis of 8-oxo-7,8-dihydroguanine lesions in DNA based on unzipping kinetics of complementary probes in ion channel recordings. J Am Chem Soc (2011) 1.01
Structural characterization of a viral NEIL1 ortholog unliganded and bound to abasic site-containing DNA. J Biol Chem (2009) 1.01
G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA. Chem Res Toxicol (2013) 1.01
Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J Biol Chem (2011) 1.00
Human endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus. DNA Repair (Amst) (2007) 1.00
Crystal structure of the 25 kDa subunit of human cleavage factor Im. Nucleic Acids Res (2008) 0.99
Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing. J Am Chem Soc (2012) 0.99
Base-excision repair activity of uracil-DNA glycosylase monitored using the latch zone of α-hemolysin. J Am Chem Soc (2013) 0.98
Population-specific variation in haplotype composition and heterozygosity at the POLB locus. DNA Repair (Amst) (2009) 0.98
Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. J Biol Chem (2002) 0.97
Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin. Biochemistry (2010) 0.97
Kinetics of mismatch formation opposite lesions by the replicative DNA polymerase from bacteriophage RB69. Biochemistry (2010) 0.97
Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin. J Am Chem Soc (2013) 0.97
Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage. Mutat Res (2012) 0.96
The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. J Biol Chem (2005) 0.96
The structure of human cleavage factor I(m) hints at functions beyond UGUA-specific RNA binding: a role in alternative polyadenylation and a potential link to 5' capping and splicing. RNA Biol (2011) 0.96
Characterization of 2'-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H2O2/reductant in nucleoside and oligodeoxynucleotide contexts. Org Biomol Chem (2011) 0.96
Cryocooling of macromolecular crystals: optimization methods. Methods Enzymol (2003) 0.96
Interplay between DNA repair and inflammation, and the link to cancer. Crit Rev Biochem Mol Biol (2014) 0.96
Variant base excision repair proteins: contributors to genomic instability. Semin Cancer Biol (2010) 0.96
DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions. Curr Opin Struct Biol (2011) 0.96
Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA. J Biol Chem (2011) 0.95
Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA. Structure (2013) 0.95
Structural biology of poly(A) site definition. Wiley Interdiscip Rev RNA (2011) 0.94
The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery. Crit Rev Biochem Mol Biol (2012) 0.94
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin. DNA Repair (Amst) (2013) 0.94
The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts. DNA Repair (Amst) (2009) 0.93
Overproduction, crystallization and preliminary crystallographic analysis of a novel human DNA-repair enzyme that recognizes oxidative DNA damage. Acta Crystallogr D Biol Crystallogr (2004) 0.92
An exploration of mechanisms for the transformation of 8-oxoguanine to guanidinohydantoin and spiroiminodihydantoin by density functional theory. J Am Chem Soc (2008) 0.92
Loop II of DNA polymerase beta is important for polymerization activity and fidelity. Nucleic Acids Res (2007) 0.91
Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases. DNA Repair (Amst) (2009) 0.91
Structural destabilization of DNA duplexes containing single-base lesions investigated by nanopore measurements. Biochemistry (2013) 0.91
Determinants of substrate specificity in RNA-dependent nucleotidyl transferases. Biochim Biophys Acta (2007) 0.91
Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation. Proc Natl Acad Sci U S A (2013) 0.90
Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli Fpg. Biochemistry (2007) 0.90
Oxidatively induced DNA-protein cross-linking between single-stranded binding protein and oligodeoxynucleotides containing 8-oxo-7,8-dihydro-2'-deoxyguanosine. Biochemistry (2005) 0.90
Mechanism of two-electron oxidation of deoxyguanosine 5'-monophosphate by a platinum(IV) complex. J Am Chem Soc (2004) 0.89