Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 3961204)

Published in PLoS Negl Trop Dis on March 20, 2014

Authors

Chrissy H Roberts1, Sandra Molina1, Pateh Makalo2, Hassan Joof2, Emma M Harding-Esch1, Sarah E Burr3, David C W Mabey1, Robin L Bailey1, Matthew J Burton4, Martin J Holland3

Author Affiliations

1: Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
2: Medical Research Council Unit, The Gambia, Atlantic Boulevard, Fajara, The Gambia.
3: Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Unit, The Gambia, Atlantic Boulevard, Fajara, The Gambia.
4: International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Articles cited by this

Implementing a unified approach to family-based tests of association. Genet Epidemiol (2000) 10.96

The family based association test method: strategies for studying general genotype--phenotype associations. Eur J Hum Genet (2001) 9.09

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature (2008) 8.22

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science (2004) 8.22

Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet (2002) 7.58

Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet (2007) 6.83

Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science (1995) 5.41

Human diversity in killer cell inhibitory receptor genes. Immunity (1997) 4.82

Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J Exp Med (2001) 4.27

Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity (1997) 3.84

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J Exp Med (1993) 3.59

The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J Exp Med (1995) 3.43

Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med (2013) 3.41

Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol (2004) 3.39

Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci U S A (2000) 3.09

The chlamydial developmental cycle. FEMS Microbiol Rev (2005) 3.08

Design and baseline data of a randomized trial to evaluate coverage and frequency of mass treatment with azithromycin: the Partnership for Rapid Elimination of Trachoma (PRET) in Tanzania and The Gambia. Ophthalmic Epidemiol (2011) 3.05

High-resolution HLA alleles and haplotypes in the United States population. Hum Immunol (2007) 3.03

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. Proc Natl Acad Sci U S A (1993) 2.91

Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J Immunol (1998) 2.79

Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3. J Immunol (2008) 2.76

Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J Exp Med (1995) 2.75

Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. Proc Natl Acad Sci U S A (2001) 2.61

Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci U S A (2005) 2.55

Global diversity and evidence for coevolution of KIR and HLA. Nat Genet (2007) 2.40

Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells. J Exp Med (2000) 2.40

Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution. Nat Rev Immunol (2013) 2.38

Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans. Nat Genet (2007) 2.36

Trachoma in The Gambia. Br J Ophthalmol (1998) 2.29

The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol Rev (2002) 2.21

Worldwide patterns of infertility: is Africa different? Lancet (1985) 2.15

Common and well-documented HLA alleles: report of the Ad-Hoc committee of the american society for histocompatiblity and immunogenetics. Hum Immunol (2007) 2.08

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. J Exp Med (1996) 2.02

Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C. Science (1993) 1.98

Trachoma prevalence and associated risk factors in the gambia and Tanzania: baseline results of a cluster randomised controlled trial. PLoS Negl Trop Dis (2010) 1.81

Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression. Exp Lung Res (1996) 1.77

Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules. Philos Trans R Soc Lond B Biol Sci (2012) 1.55

Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses. J Clin Invest (2008) 1.52

Facilitation of KIR genotyping by a PCR-SSP method that amplifies short DNA fragments. Tissue Antigens (2007) 1.49

Role of NK cells in early host response to chlamydial genital infection. Infect Immun (1998) 1.48

T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring. Clin Exp Immunol (1996) 1.48

NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination. J Immunol (2010) 1.41

Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes. Immunogenetics (2002) 1.37

Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands. Proc Natl Acad Sci U S A (2009) 1.35

CPAF: a Chlamydial protease in search of an authentic substrate. PLoS Pathog (2012) 1.33

Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells. Eur J Immunol (1994) 1.32

Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. Proc Natl Acad Sci U S A (2005) 1.30

Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun (2002) 1.22

Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci. Genes Immun (2005) 1.21

Trachoma: protective and pathogenic ocular immune responses to Chlamydia trachomatis. PLoS Negl Trop Dis (2013) 1.20

KIR haplotype content at the allele level in 77 Northern Irish families. Immunogenetics (2007) 1.19

Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245. Blood (2009) 1.18

High KIR diversity in Amerindians is maintained using few gene-content haplotypes. Immunogenetics (2006) 1.17

Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians. Genes Immun (2007) 1.13

Optimizing buccal cell DNA yields in mothers and infants for human leukocyte antigen genotyping. Am J Epidemiol (2004) 1.12

Killer cell immunoglobulin-like receptor (KIR) gene content variation in the HGDP-CEPH populations. Immunogenetics (2012) 1.11

KIR haplotypes defined by segregation analysis in 59 Centre d'Etude Polymorphisme Humain (CEPH) families. Immunogenetics (2008) 1.10

Association of killer cell immunoglobulin-like receptor genes with Hodgkin's lymphoma in a familial study. PLoS One (2007) 1.09

PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. Hum Genomics (2005) 1.09

Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans. PLoS Genet (2013) 1.08

Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine. J Immunol (2012) 1.07

Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infection. Infect Immun (2010) 1.07

Association of KIR genotypes and haplotypes with susceptibility to chronic hepatitis B virus infection in Chinese Han population. Cell Mol Immunol (2008) 1.03

Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. PLoS Pathog (2012) 1.02

Memory of infections: an emerging role for natural killer cells. PLoS Pathog (2013) 1.00

Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand. Immunogenetics (2009) 1.00

Natural killer (NK) cell response after vaccination of volunteers with killed influenza vaccine. J Med Virol (1990) 0.98

NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvant. J Immunol (2010) 0.97

Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation. Hum Mol Genet (2007) 0.97

MyD88 deficiency leads to decreased NK cell gamma interferon production and T cell recruitment during Chlamydia muridarum genital tract infection, but a predominant Th1 response and enhanced monocytic inflammation are associated with infection resolution. Infect Immun (2010) 0.95

Innate immune responses and modified extracellular matrix regulation characterize bacterial infection and cellular/connective tissue changes in scarring trachoma. Infect Immun (2011) 0.93

Study of KIR genes in tuberculosis patients. Tissue Antigens (2006) 0.93

Conjunctival MicroRNA expression in inflammatory trachomatous scarring. PLoS Negl Trop Dis (2013) 0.93

Human natural killer cell inhibitory receptors bind to HLA class I molecules. Eur J Immunol (1996) 0.92

Study of KIR genes in Lebanese patients with tuberculosis. Int J Tuberc Lung Dis (2011) 0.91

Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals. J Immunol (2009) 0.91

Signatures of historical demography and pathogen richness on MHC class I genes. Immunogenetics (2011) 0.87

The molecular determination of HLA-Cw alleles in the Mandenka (West Africa) reveals a close genetic relationship between Africans and Europeans. Tissue Antigens (2000) 0.87

Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis. Front Microbiol (2011) 0.86

Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms. Infect Dis Obstet Gynecol (2011) 0.85

Modulation of MICA on the surface of Chlamydia trachomatis-infected endocervical epithelial cells promotes NK cell-mediated killing. FEMS Immunol Med Microbiol (2012) 0.83

Role of natural killer cell function in dendritic cell-based vaccines. Expert Rev Vaccines (2006) 0.82

Killer cell immunoglobulin like receptor gene association with tuberculosis. Hum Immunol (2012) 0.80

Killer-cell immunoglobulin-like receptors and malaria caused by Plasmodium falciparum in The Gambia. Tissue Antigens (2012) 0.79

Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han. Genet Mol Res (2012) 0.78

Natural killer cells: a virtual pick and mix. Nat Rev Immunol (2013) 0.78

Chlamydia trachomatis-infected epithelial cells and fibroblasts retain the ability to express surface-presented major histocompatibility complex class I molecules. Infect Immun (2013) 0.76