PubRank

E Dale Abel

Author PubWeight™ 156.10‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Diabetic cardiomyopathy revisited. Circulation 2007 6.76
2 PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 2005 5.80
3 Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation 2005 3.22
4 Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 2007 3.20
5 Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res 2008 2.88
6 Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol 2006 2.86
7 Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest 2004 2.76
8 Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res 2012 2.74
9 Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am J Physiol Heart Circ Physiol 2003 2.57
10 Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 2002 2.53
11 Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology 2005 2.43
12 Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes 2004 2.39
13 Recipes for creating animal models of diabetic cardiovascular disease. Circ Res 2007 2.34
14 Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol 2007 2.17
15 Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation 2009 1.91
16 Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 2002 1.86
17 Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail 2006 1.79
18 Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension 2009 1.78
19 Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res 2013 1.72
20 PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation. J Clin Invest 2010 1.63
21 Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res 2009 1.60
22 Lipotoxicity in the heart. Biochim Biophys Acta 2009 1.60
23 Rodent models of diabetic cardiomyopathy. Dis Model Mech 2009 1.56
24 Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes 2008 1.55
25 Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda) 2006 1.53
26 Molecular mechanisms of diabetic cardiomyopathy. Diabetologia 2014 1.53
27 The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol 2008 1.51
28 Mitochondria in the diabetic heart. Cardiovasc Res 2010 1.50
29 Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol 2010 1.50
30 Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. Cardiovasc Res 2009 1.46
31 Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes 2009 1.45
32 Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo. PLoS One 2011 1.43
33 The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology 2009 1.43
34 Akt1 in the cardiovascular system: friend or foe? J Clin Invest 2005 1.43
35 The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol 2005 1.42
36 A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab 2007 1.42
37 Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin Sci (Lond) 2008 1.41
38 Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. Am J Physiol Heart Circ Physiol 2006 1.41
39 Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail 2012 1.36
40 Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol 2014 1.35
41 Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest 2010 1.34
42 Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol 2008 1.33
43 Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem 2006 1.32
44 PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res 2011 1.31
45 Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes 2012 1.31
46 Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res 2010 1.30
47 Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. J Physiol 2009 1.29
48 Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res 2013 1.25
49 Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation 2008 1.23
50 Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1. Cardiovasc Res 2005 1.19
51 Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. Diabetes 2011 1.15
52 Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling. Endocrinology 2007 1.14
53 Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes 2010 1.13
54 Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. Am J Physiol Endocrinol Metab 2004 1.11
55 Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One 2012 1.10
56 Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse. Am J Physiol Endocrinol Metab 2010 1.10
57 Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action. J Biol Chem 2005 1.09
58 PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A 2007 1.09
59 Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction. J Mol Cell Cardiol 2009 1.09
60 Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev Endocr Metab Disord 2013 1.08
61 NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. J Biol Chem 2012 1.08
62 An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart. Am J Physiol Endocrinol Metab 2010 1.08
63 Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol 2008 1.07
64 Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling. Diabetes 2010 1.05
65 Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice. Diabetes 2011 1.05
66 UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice. Diabetes 2012 1.03
67 Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One 2009 1.03
68 Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med 2008 1.03
69 Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. J Mol Cell Cardiol 2009 1.01
70 Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation. Mol Endocrinol 2012 1.01
71 Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab 2007 1.00
72 Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice. J Physiol 2003 1.00
73 CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol Heart Circ Physiol 2007 0.99
74 Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One 2013 0.99
75 Mechanisms of lipotoxicity in the cardiovascular system. Curr Hypertens Rep 2012 0.98
76 Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity. Endocrinology 2012 0.97
77 Aberrant water homeostasis detected by stable isotope analysis. PLoS One 2010 0.97
78 Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest 2013 0.97
79 Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts. Endocrinology 2008 0.96
80 Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction. J Am Heart Assoc 2013 0.93
81 Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. FEBS J 2012 0.92
82 Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Invest 2015 0.91
83 Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. Drug Metab Dispos 2008 0.91
84 Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms. J Mol Cell Cardiol 2013 0.89
85 Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem 2012 0.89
86 Genetic loss of insulin receptors worsens cardiac efficiency in diabetes. J Mol Cell Cardiol 2012 0.89
87 Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J Neurosci 2009 0.88
88 Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice. Exp Biol Med (Maywood) 2010 0.88
89 Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload. Am J Physiol Heart Circ Physiol 2010 0.87
90 Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes 2013 0.87
91 Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α. Am J Physiol Heart Circ Physiol 2013 0.87
92 PGC-1 proteins and heart failure. Trends Cardiovasc Med 2012 0.85
93 Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol 2008 0.84
94 Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis. Diabetes 2011 0.84
95 Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia. J Mol Cell Cardiol 2011 0.83
96 Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res 2016 0.82
97 The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization. Am J Physiol Heart Circ Physiol 2013 0.82
98 Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice. Endocrinology 2010 0.82
99 IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter. FASEB J 2013 0.82
100 HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. PLoS One 2012 0.82
101 Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts. J Electrocardiol 2004 0.81
102 A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance. Am J Physiol Heart Circ Physiol 2013 0.80
103 Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate. PLoS One 2013 0.80
104 Spotlight on metabolic remodelling in heart failure. Cardiovasc Res 2011 0.79
105 Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest 2016 0.79
106 Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circ Heart Fail 2013 0.78
107 Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle 2008 0.78
108 Obesity stresses cardiac mitochondria even when you are young. J Am Coll Cardiol 2011 0.78
109 Insulin regulation of myocardial autophagy. Circ J 2014 0.78
110 Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Res Cardiol 2015 0.77
111 Reversal of oxidative stress in endothelial cells by controlled release of adiponectin. J Control Release 2008 0.77
112 Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia. Exp Physiol 2012 0.77
113 A new twist in the function of the cardiac lipid droplet. Nat Med 2011 0.76
114 Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function. Endocr J 2011 0.75
115 Glucose for the aging heart? Circulation 2007 0.75
116 Solid phase synthesis of mitochondrial triphenylphosphonium-vitamin E metabolite using a lysine linker for reversal of oxidative stress. PLoS One 2013 0.75
117 Endonuclease G: the link between mitochondria and cardiac hypertrophy? Circ Res 2012 0.75
118 The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts. IEEE Trans Biomed Eng 2011 0.75
119 Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep 2017 0.75
120 Time to look back and to look forward. Diabetes 2014 0.75
121 Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol 2017 0.75
122 Glucose transporter 4 (GLUT4) deficient hearts develop maladaptive hypertrophy in response to physiologic or pathologic stresses. Am J Physiol Heart Circ Physiol 2017 0.75
123 Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun 2017 0.75
124 Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep 2017 0.75
125 DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab 2017 0.75
126 Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol 2017 0.75