Published in Nucleic Acids Res on March 25, 2014
Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template. Sci Transl Med (2015) 1.30
Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance. Mol Ther Nucleic Acids (2016) 0.81
Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure (2016) 0.80
Recent advances in developing molecular tools for targeted genome engineering of mammalian cells. BMB Rep (2015) 0.77
Gene therapy for primary immune deficiencies: a Canadian perspective. Allergy Asthma Clin Immunol (2017) 0.75
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res (2011) 16.53
Yeast surface display for screening combinatorial polypeptide libraries. Nat Biotechnol (1997) 6.88
Homing endonucleases: keeping the house in order. Nucleic Acids Res (1997) 5.03
Tracking genome engineering outcome at individual DNA breakpoints. Nat Methods (2011) 4.05
Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification. Structure (2011) 2.43
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences. Nucleic Acids Res (2006) 2.38
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease. Nucleic Acids Res (2009) 2.14
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res (2012) 2.14
Exploitation of binding energy for catalysis and design. Nature (2009) 1.77
Large-scale high-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 1.76
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res (2010) 1.58
Frequent endonuclease cleavage at off-target locations in vivo. Mol Ther (2010) 1.52
Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Res (2008) 1.44
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display. Nucleic Acids Res (2009) 1.43
Targeted DNA mutagenesis for the cure of chronic viral infections. J Virol (2012) 1.36
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering. Nucleic Acids Res (2013) 1.30
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption. Nat Methods (2012) 1.28
The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function. Semin Immunol (1995) 1.22
Bruton's tyrosine kinase is a key regulator in B-cell development. Immunol Rev (1994) 1.10
B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia. Blood (2010) 1.06
Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders. Mol Ther (2010) 1.04
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases. Nucleic Acids Res (2012) 1.02
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks. Nucleic Acids Res (2013) 1.02
Homing endonucleases: DNA scissors on a mission. Genome (2012) 0.94
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood (2004) 0.89
Directed evolution of homing endonuclease I-SceI with altered sequence specificity. Protein Eng Des Sel (2009) 0.87
Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space. Nucleic Acids Res (2012) 0.86