Published in Comput Struct Biotechnol J on October 18, 2013
An appraisal of RECQ1 expression in cancer progression. Front Genet (2014) 0.88
RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin. Biochem J (2015) 0.82
Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure. Int J Toxicol (2014) 0.79
RECQL: a new breast cancer susceptibility gene. Cell Cycle (2015) 0.77
Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain. Mutat Res (2016) 0.76
Transcriptome guided identification of novel functions of RECQ1 helicase. Methods (2016) 0.76
Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers. Mol Cancer Ther (2016) 0.75
Analysis of a RECQL splicing mutation, c.1667_1667+3delAGTA, in breast cancer patients and controls from Central Europe. Fam Cancer (2016) 0.75
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
Structure and mechanism of helicases and nucleic acid translocases. Annu Rev Biochem (2007) 7.83
Double-strand break end resection and repair pathway choice. Annu Rev Genet (2011) 7.31
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
RecQ helicases: caretakers of the genome. Nat Rev Cancer (2003) 5.83
Playing the end game: DNA double-strand break repair pathway choice. Mol Cell (2012) 5.42
Chromosome fragile sites. Annu Rev Genet (2007) 4.95
Winged helix proteins. Curr Opin Struct Biol (2000) 4.80
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99
RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem J (2003) 3.71
RecQ helicases: multifunctional genome caretakers. Nat Rev Cancer (2009) 3.63
The Bloom's syndrome gene product interacts with topoisomerase III. J Biol Chem (2000) 3.52
Pathways of mammalian replication fork restart. Nat Rev Mol Cell Biol (2010) 3.26
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J Biol Chem (2000) 3.17
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J Biol Chem (2001) 3.05
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Novel pro- and anti-recombination activities of the Bloom's syndrome helicase. Genes Dev (2007) 2.82
Structural basis for DNA duplex separation by a superfamily-2 helicase. Nat Struct Mol Biol (2007) 2.77
Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem (1999) 2.77
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. Proc Natl Acad Sci U S A (2008) 2.70
High-resolution structure of the E.coli RecQ helicase catalytic core. EMBO J (2003) 2.61
Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ. J Biol Chem (1994) 2.54
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol Cell (2005) 2.47
DNA helicases required for homologous recombination and repair of damaged replication forks. Annu Rev Genet (2006) 2.43
Pathways for mitotic homologous recombination in mammalian cells. Mutat Res (2003) 2.43
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J (2004) 2.33
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci (2008) 2.24
Ku complex interacts with and stimulates the Werner protein. Genes Dev (2000) 2.21
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Cancer Res (2000) 2.13
Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem (2005) 2.11
Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12. Nucleic Acids Res (1994) 2.00
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
The RecQ DNA helicases in DNA repair. Annu Rev Genet (2010) 1.85
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol (2007) 1.71
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol (2013) 1.67
Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxid Redox Signal (2010) 1.65
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J (2007) 1.65
Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. Cancer Res (2010) 1.64
Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Nucleic Acids Res (2000) 1.63
Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A. Nucleic Acids Res (2004) 1.60
Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors. J Biol Chem (1997) 1.60
DNA helicases involved in DNA repair and their roles in cancer. Nat Rev Cancer (2013) 1.58
A conserved G4 DNA binding domain in RecQ family helicases. J Mol Biol (2006) 1.54
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol (2006) 1.53
Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proc Natl Acad Sci U S A (2009) 1.52
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem (2005) 1.52
The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. J Biol Chem (2008) 1.52
Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation. Mol Cell Biol (2010) 1.50
Differential regulation of human RecQ family helicases in cell transformation and cell cycle. Oncogene (2000) 1.46
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair (Amst) (2008) 1.44
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem (2009) 1.43
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci (2006) 1.42
Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1. Nucleic Acids Res (2001) 1.41
Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain. Structure (2005) 1.40
Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS One (2007) 1.38
Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J Biol Chem (2007) 1.38
The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability. J Cell Sci (2005) 1.38
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst) (2012) 1.37
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol Cell Biol (2003) 1.37
RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem (2005) 1.36
Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Cancer Res (2006) 1.36
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity. PLoS Biol (2007) 1.36
Structure and function of RecQ DNA helicases. Crit Rev Biochem Mol Biol (2004) 1.29
Chromosome fragility: molecular mechanisms and cellular consequences. Front Biosci (2007) 1.28
Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase. Cancer Sci (2007) 1.23
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress. Exp Cell Res (2006) 1.20
Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. Biochem Biophys Res Commun (1997) 1.20
RECQ1 possesses DNA branch migration activity. J Biol Chem (2008) 1.19
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer. J Biol Chem (2008) 1.18
Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A. J Biol Chem (2002) 1.16
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. DNA Repair (Amst) (2010) 1.16
Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes. J Biochem (1994) 1.13
DNA instability at chromosomal fragile sites in cancer. Curr Genomics (2010) 1.11
The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. J Biol Chem (2003) 1.09
Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle (2008) 1.09
A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. Nucleic Acids Res (2010) 1.09
Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models. Cancer Sci (2008) 1.06
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. J Biol Chem (2005) 1.05
Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst) (2010) 1.05
Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res (2006) 1.05
The zinc finger motif of Escherichia coli RecQ is implicated in both DNA binding and protein folding. J Biol Chem (2004) 1.05
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem (2009) 1.04
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism. J Biol Chem (2009) 1.04
Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J Biol Chem (2011) 1.04
The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6. Biol Chem (2003) 1.03
Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase. Nucleic Acids Res (2005) 1.02
Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein. Nucleic Acids Res (2007) 1.01
RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma. Int J Mol Med (2010) 1.01
RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst) (2012) 1.00
Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol Cancer (2013) 0.94
ATP depletion + pyrimidine depletion can markedly enhance cancer therapy: fresh insight for a new approach. Cancer Res (2000) 0.93
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks. PLoS One (2013) 0.92
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures. Cell Cycle (2012) 0.91
RECQL1 DNA repair helicase: a potential therapeutic target and a proliferative marker against ovarian cancer. PLoS One (2013) 0.91
FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Mol Cancer Res (2010) 0.90
Dissolution of double Holliday junctions by the concerted action of BLM and topoisomerase IIIalpha. Methods Mol Biol (2009) 0.89