Published in J Biol Chem on May 16, 2005
RecQ helicases: multifunctional genome caretakers. Nat Rev Cancer (2009) 3.63
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci (2008) 2.24
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Res (2006) 1.84
Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration. Proc Natl Acad Sci U S A (2006) 1.83
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
DNA helicases involved in DNA repair and their roles in cancer. Nat Rev Cancer (2013) 1.58
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci (2009) 1.54
Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol (2006) 1.53
Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proc Natl Acad Sci U S A (2009) 1.52
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proc Natl Acad Sci U S A (2011) 1.45
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem (2009) 1.43
Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS One (2007) 1.38
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity. PLoS Biol (2007) 1.36
Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Cancer Res (2006) 1.36
RecQ helicases: multiple structures for multiple functions? HFSP J (2009) 1.20
RECQ1 possesses DNA branch migration activity. J Biol Chem (2008) 1.19
Rad54, the motor of homologous recombination. DNA Repair (Amst) (2010) 1.18
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. DNA Repair (Amst) (2010) 1.16
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand. Nucleic Acids Res (2006) 1.15
Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity. Nucleic Acids Res (2007) 1.13
The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks. Biochemistry (2011) 1.11
Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle (2008) 1.09
Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins. BMC Mol Biol (2006) 1.08
Drosophila RecQ4 has a 3'-5' DNA helicase activity that is essential for viability. J Biol Chem (2009) 1.06
Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res (2006) 1.05
Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst) (2010) 1.05
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism. J Biol Chem (2009) 1.04
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem (2009) 1.04
Cockayne syndrome group B protein has novel strand annealing and exchange activities. Nucleic Acids Res (2006) 1.04
Who's who in human recombination: BRCA2 and RAD52. Proc Natl Acad Sci U S A (2010) 1.02
DNA strand displacement, strand annealing and strand swapping by the Drosophila Bloom's syndrome helicase. Nucleic Acids Res (2007) 1.00
RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst) (2012) 1.00
RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana. Plant Cell (2010) 0.99
Intrinsic ssDNA annealing activity in the C-terminal region of WRN. Biochemistry (2008) 0.98
Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage. J Biol Chem (2010) 0.97
Biochemical analysis of human PIF1 helicase and functions of its N-terminal domain. Nucleic Acids Res (2008) 0.95
An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs. EMBO J (2010) 0.94
Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol Cancer (2013) 0.94
Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans. Biochemistry (2008) 0.93
Mismatch repair during homologous and homeologous recombination. Cold Spring Harb Perspect Biol (2015) 0.92
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks. PLoS One (2013) 0.92
Hjm/Hel308A DNA helicase from Sulfolobus tokodaii promotes replication fork regression and interacts with Hjc endonuclease in vitro. J Bacteriol (2008) 0.92
The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1. DNA Repair (Amst) (2008) 0.91
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures. Cell Cycle (2012) 0.91
RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity. Biochim Biophys Acta (2012) 0.91
Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures. Proc Natl Acad Sci U S A (2015) 0.90
Replication protein A stimulates the Werner syndrome protein branch migration activity. J Biol Chem (2009) 0.90
Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases. J Nucleic Acids (2011) 0.90
Nucleic acid binding activity of human Cockayne syndrome B protein and identification of Ca(2+) as a novel metal cofactor. J Mol Biol (2009) 0.89
An appraisal of RECQ1 expression in cancer progression. Front Genet (2014) 0.88
Helicases as prospective targets for anti-cancer therapy. Anticancer Agents Med Chem (2008) 0.88
Functional deficit associated with a missense Werner syndrome mutation. DNA Repair (Amst) (2013) 0.87
Unwinding and rewinding: double faces of helicase? J Nucleic Acids (2012) 0.86
Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1 proteins. J Biol Chem (2012) 0.86
Probing Genome Maintenance Functions of human RECQ1. Comput Struct Biotechnol J (2013) 0.86
Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner. J Biol Chem (2014) 0.85
Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma. HPB (Oxford) (2009) 0.83
A SRS2 homolog from Arabidopsis thaliana disrupts recombinogenic DNA intermediates and facilitates single strand annealing. Nucleic Acids Res (2009) 0.83
RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin. Biochem J (2015) 0.82
A novel DNA helicase with strand-annealing activity from the crenarchaeon Sulfolobus solfataricus. Biochem J (2007) 0.82
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB. PLoS One (2012) 0.82
Catalytic Strand Separation by RECQ1 Is Required for RPA-Mediated Response to Replication Stress. Curr Biol (2015) 0.81
Close encounters for the first time: Helicase interactions with DNA damage. DNA Repair (Amst) (2015) 0.80
Biochemical characterization of AtRECQ3 reveals significant differences relative to other RecQ helicases. Plant Physiol (2009) 0.80
Roles of DNA helicases in the mediation and regulation of homologous recombination. Adv Exp Med Biol (2013) 0.79
DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion. J Biol Chem (2012) 0.79
Impact of age-associated cyclopurine lesions on DNA repair helicases. PLoS One (2014) 0.79
Legionella pneumophila transcriptional response following exposure to CuO nanoparticles. Appl Environ Microbiol (2013) 0.77
RECQL: a new breast cancer susceptibility gene. Cell Cycle (2015) 0.77
Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain. Mutat Res (2016) 0.76
Transcriptome guided identification of novel functions of RECQ1 helicase. Methods (2016) 0.76
Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers. Mol Cancer Ther (2016) 0.75
Multimerization domains are associated with apparent strand exchange activity in BLM and WRN DNA helicases. DNA Repair (Amst) (2014) 0.75
A new sub-pathway of long-patch base excision repair involving 5' gap formation. EMBO J (2017) 0.75
DNA repair is limiting for haematopoietic stem cells during ageing. Nature (2007) 4.71
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. Science (2009) 4.00
5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I. Proc Natl Acad Sci U S A (2009) 3.05
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A (2008) 2.19
Modulation of protein properties in living cells using nanobodies. Nat Struct Mol Biol (2009) 2.15
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses. PLoS Pathog (2013) 1.99
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J (2007) 1.86
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase. J Biol Chem (2002) 1.76
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA. Nucleic Acids Res (2009) 1.72
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer. J Biol Chem (2005) 1.67
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol (2013) 1.67
A topological mechanism for TRF2-enhanced strand invasion. Nat Struct Mol Biol (2007) 1.65
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A. Nucleic Acids Res (2004) 1.60
G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proc Natl Acad Sci U S A (2009) 1.52
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem (2005) 1.52
The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. J Biol Chem (2008) 1.52
Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation. Mol Cell Biol (2010) 1.50
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proc Natl Acad Sci U S A (2011) 1.45
DNA unwinding step-size of E. coli RecBCD helicase determined from single turnover chemical quenched-flow kinetic studies. J Mol Biol (2002) 1.44
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem (2009) 1.43
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS One (2007) 1.38
RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem (2005) 1.36
Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. EMBO J (2010) 1.36
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity. PLoS Biol (2007) 1.36
Localization of proteins bound to a replication origin of human DNA along the cell cycle. EMBO J (2003) 1.33
Cobalt(II)-Nitronyl Nitroxide Chains as Molecular Magnetic Nanowires The financial support of Italian MURST and CNR and of Brazilian CNPq and FUJB is acknowledged. The support from the European Community through the TMR program 3MD (contract no ERB4061PL97-0197) is also acknowledged. Angew Chem Int Ed Engl (2001) 1.32
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. Hum Mol Genet (2004) 1.21
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Nucleic Acids Res (2012) 1.20
RecQ helicases: multiple structures for multiple functions? HFSP J (2009) 1.20
Biochemical characterization of the WRN-FEN-1 functional interaction. Biochemistry (2002) 1.19
RECQ1 possesses DNA branch migration activity. J Biol Chem (2008) 1.19
Biochemical characterization of Warsaw breakage syndrome helicase. J Biol Chem (2011) 1.19
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair (Amst) (2007) 1.19
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. Nucleic Acids Res (2002) 1.16
Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A. J Biol Chem (2002) 1.16
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand. Nucleic Acids Res (2006) 1.15
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein. J Biol Chem (2004) 1.14
Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. J Virol (2011) 1.12
One-dimensional supramolecular organization of single-molecule magnets. J Am Chem Soc (2007) 1.11
The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. J Biol Chem (2003) 1.09
Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle (2008) 1.09
A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. Nucleic Acids Res (2010) 1.09
Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP. Nature (2011) 1.09
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Res (2005) 1.08
Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein. Nucleic Acids Res (2003) 1.07
Application of nanosized Fe3O4 in anticancer drug carriers with target-orientation and sustained-release properties. Biomed Mater (2007) 1.07
p53 modulates RPA-dependent and RPA-independent WRN helicase activity. Cancer Res (2005) 1.06
Proteomic studies on low- and high-grade human brain astrocytomas. J Proteome Res (2005) 1.06
Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene. Gene (2002) 1.06
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. J Biol Chem (2005) 1.05
Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst) (2010) 1.05
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol (2009) 1.05
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem (2009) 1.04
Cell cycle-dependent phosphorylation of human DNA ligase I at the cyclin-dependent kinase sites. J Biol Chem (2003) 1.04
Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing. Biochemistry (2008) 1.04
Cockayne syndrome group B protein has novel strand annealing and exchange activities. Nucleic Acids Res (2006) 1.04
MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1. PLoS One (2012) 1.03
Fluorescence anisotropy studies on the Ku-DNA interaction: anion and cation effects. J Biol Chem (2004) 1.02
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
A new method for translating the asymmetric Ni/Cr-mediated coupling reactions from stoichiometric to catalytic. Org Lett (2005) 1.02
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation. Mol Cancer (2011) 1.02
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Curr Mol Med (2009) 1.00