Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration.

PubWeight™: 0.90‹?›

🔗 View Article (PMID 24702007)

Published in Annu Rev Biophys on January 01, 2014

Authors

Sandra E Encalada1, Lawrence S B Goldstein

Author Affiliations

1: Department of Molecular and Experimental Medicine, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037; email: encalada@scripps.edu.

Articles citing this

Optogenetic control of organelle transport and positioning. Nature (2015) 1.99

Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia. Nat Cell Biol (2015) 1.03

The axonal cytoskeleton: from organization to function. Front Mol Neurosci (2015) 0.96

Neurodegeneration and microtubule dynamics: death by a thousand cuts. Front Cell Neurosci (2015) 0.82

The cellular mechanisms that maintain neuronal polarity. Nat Rev Neurosci (2016) 0.79

As the fat flies: The dynamic lipid droplets of Drosophila embryos. Biochim Biophys Acta (2015) 0.79

Cytoplasmic dynein is required for the spatial organization of protein aggregates in filamentous fungi. Cell Rep (2015) 0.78

A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation. Development (2015) 0.78

Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery. FEBS J (2017) 0.76

Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons. Bioessays (2015) 0.76

Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport. Sci Rep (2015) 0.75

The Roles of Microtubule-Based Transport at Presynaptic Nerve Terminals. Front Synaptic Neurosci (2016) 0.75

Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology. Mol Neurobiol (2016) 0.75

Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors. Nat Nanotechnol (2016) 0.75

Amyloid-β Impairs Vesicular Secretion in Neuronal and Astrocyte Peptidergic Transmission. Front Mol Neurosci (2017) 0.75

Articles by these authors

Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science (2005) 5.49

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature (2012) 5.47

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A (2003) 4.47

A standardized kinesin nomenclature. J Cell Biol (2004) 4.43

Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron (2003) 4.04

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron (2006) 3.51

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev (2010) 3.37

Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One (2011) 2.74

JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell (2003) 2.45

Sunday Driver links axonal transport to damage signaling. J Cell Biol (2005) 2.29

Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol (2003) 2.02

Axonal transport and Alzheimer's disease. Annu Rev Biochem (2006) 1.98

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A (2008) 1.84

Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem (2009) 1.84

Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet (2012) 1.80

Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Mol Biol Cell (2007) 1.67

A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell (2013) 1.59

Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A (2011) 1.52

Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr Opin Cell Biol (2004) 1.51

Principles of cargo attachment to cytoplasmic motor proteins. Curr Opin Cell Biol (2002) 1.51

The genetics of axonal transport and axonal transport disorders. PLoS Genet (2006) 1.49

Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre. Invest Ophthalmol Vis Sci (2006) 1.38

Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell (2011) 1.38

Patients beware: commercialized stem cell treatments on the web. Cell Stem Cell (2010) 1.32

Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Arch Neurol (2005) 1.28

Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci (2008) 1.26

ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A (2012) 1.25

Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol (2004) 1.20

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. J Neurosci (2009) 1.16

Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A (2011) 1.10

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet (2008) 1.06

The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep (2013) 1.00

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Mol Biol Cell (2012) 1.00

Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Hum Mol Genet (2010) 1.00

Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis (2009) 0.98

Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein. Traffic (2013) 0.94

Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A (2012) 0.90

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects. Hum Mol Genet (2012) 0.89

A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability. Genetics (2002) 0.89

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum Mol Genet (2013) 0.89

Alzheimer's disease in a dish: promises and challenges of human stem cell models. Hum Mol Genet (2012) 0.89

Kinesin-2 and photoreceptor cell death: requirement of motor subunits. Exp Eye Res (2005) 0.86

The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila. PLoS One (2013) 0.85

A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. Mol Biol Cell (2011) 0.80

Linking molecular motors to Alzheimer's disease. J Physiol Paris (2006) 0.79

Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. J Cell Sci (2014) 0.78

Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver. Semin Liver Dis (2013) 0.78

UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci (2014) 0.77

Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS One (2012) 0.76

Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem (2013) 0.75