Published in J Biomech on March 26, 2014
The myofibroblast in wound healing and fibrosis: answered and unanswered questions. F1000Res (2016) 0.83
Another dimension to the importance of the extracellular matrix in fibrosis. J Cell Commun Signal (2015) 0.82
Substrate modulus of 3D-printed scaffolds regulates the regenerative response in subcutaneous implants through the macrophage phenotype and Wnt signaling. Biomaterials (2015) 0.80
Extracellular superoxide dismutase deficiency impairs wound healing in advanced age by reducing neovascularization and fibroblast function. Exp Dermatol (2016) 0.79
Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells. Biol Open (2016) 0.78
A Combined In Vitro Imaging and Multi-Scale Modeling System for Studying the Role of Cell Matrix Interactions in Cutaneous Wound Healing. PLoS One (2016) 0.78
Engineering approaches to study fibrosis in 3-D in vitro systems. Curr Opin Biotechnol (2016) 0.76
Suction assisted liposuction does not impair the regenerative potential of adipose derived stem cells. J Transl Med (2016) 0.76
Biomechanics of Cardiac Function. Compr Physiol (2015) 0.75
Tissue mechanics regulate brain development, homeostasis and disease. J Cell Sci (2017) 0.75
Matrix stiffness regulates migration of human lung fibroblasts. Physiol Rep (2017) 0.75
Shape of chondrocytes within articular cartilage affects the solid but not the fluid microenvironment under unconfined compression. Acta Biomater (2015) 0.75
Development of a synthetic gene network to modulate gene expression by mechanical forces. Sci Rep (2016) 0.75
Going Nuclear: Evidence Implicating the Cell Nucleus in Mechanotransduction. J Biomech Eng (2016) 0.75
Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective. Ann Biomed Eng (2016) 0.75
The Contractile Phenotype of Dermal Fetal Fibroblasts in Scarless Wound Healing. Curr Pathobiol Rep (2017) 0.75
The Role of Focal Adhesion Kinase in Keratinocyte Fibrogenic Gene Expression. Int J Mol Sci (2017) 0.75
Tissue cells feel and respond to the stiffness of their substrate. Science (2005) 23.42
Cutaneous wound healing. N Engl J Med (1999) 19.12
Wound repair and regeneration. Nature (2008) 12.30
Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56
Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol (2006) 10.71
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med (2008) 10.15
TGF-beta signaling and the fibrotic response. FASEB J (2004) 9.81
The extracellular matrix: not just pretty fibrils. Science (2009) 8.52
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell (2012) 6.80
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest (2007) 6.56
Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci U S A (1979) 6.09
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A (1991) 5.60
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol (2009) 5.41
Idiopathic pulmonary fibrosis. Lancet (2011) 5.25
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science (2011) 4.76
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol (2011) 4.63
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59
Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys J (2007) 4.59
Origin and function of myofibroblasts in kidney fibrosis. Nat Med (2013) 4.55
Mechanotransduction gone awry. Nat Rev Mol Cell Biol (2009) 4.00
Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci (1995) 3.68
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med (2010) 3.44
Latent TGF-β structure and activation. Nature (2011) 3.42
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol (2007) 3.33
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mechanical control of tissue and organ development. Development (2010) 3.18
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02
Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum (2007) 2.80
Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship. Eur J Cell Biol (2008) 2.74
A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science (2005) 2.72
The embrace device significantly decreases scarring following scar revision surgery in a randomized controlled trial. Plast Reconstr Surg (2014) 2.66
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci U S A (2002) 2.55
Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension. Proc Natl Acad Sci U S A (2002) 2.43
Cell tension, matrix mechanics, and cancer development. Cancer Cell (2005) 2.42
Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE (2002) 2.36
Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett (2010) 2.35
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep (2010) 2.32
Control of scarring in adult wounds by neutralising antibody to transforming growth factor beta. Lancet (1992) 2.30
Transforming growth factor beta s and wound healing. Int J Biochem Cell Biol (1997) 2.28
Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics. Nat Commun (2012) 2.23
Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science (1981) 2.18
Close dependence of fibroblast proliferation on collagen scaffold matrix stiffness. J Tissue Eng Regen Med (2009) 2.11
Small animal models of heart failure: development of novel therapies, past and present. Circ Heart Fail (2009) 2.08
Neutralising antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents. J Cell Sci (1994) 2.07
Cell motility and mechanics in three-dimensional collagen matrices. Annu Rev Cell Dev Biol (2010) 2.06
Molecular regulation of cardiac hypertrophy. Int J Biochem Cell Biol (2008) 1.95
Tensegrity-based mechanosensing from macro to micro. Prog Biophys Mol Biol (2008) 1.90
Independent regulation of tumor cell migration by matrix stiffness and confinement. Proc Natl Acad Sci U S A (2012) 1.89
Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis. Curr Rheumatol Rep (2009) 1.87
Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J (2007) 1.87
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med (2011) 1.86
β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol (2010) 1.81
Influence of geometry on control of cell growth. Biochim Biophys Acta (1975) 1.79
Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci (2012) 1.76
Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? J Cell Sci (2010) 1.73
Surgical approaches to create murine models of human wound healing. J Biomed Biotechnol (2010) 1.71
Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. J Biomed Mater Res (2001) 1.69
Transglutaminase 2 and its role in pulmonary fibrosis. Am J Respir Crit Care Med (2011) 1.68
Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction. Am J Respir Cell Mol Biol (2012) 1.67
United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction. J Cell Sci (2012) 1.63
Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies. Ann Surg (2011) 1.58
Tissue engineering of cartilage in space. Proc Natl Acad Sci U S A (1997) 1.57
Cell traction forces direct fibronectin matrix assembly. Biophys J (2009) 1.54
Modeling pulmonary fibrosis with bleomycin. Curr Opin Pulm Med (2011) 1.51
How vinculin regulates force transmission. Proc Natl Acad Sci U S A (2013) 1.51
The architecture of life. Sci Am (1998) 1.46
Mechanotransduction from the ECM to the genome: are the pieces now in place? J Cell Biochem (2008) 1.45
Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma. J Immunol (1999) 1.45
Fibroblasts in post-infarction inflammation and cardiac repair. Biochim Biophys Acta (2012) 1.41
Effects of mechanical ventilation on the extracellular matrix. Intensive Care Med (2008) 1.38
Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res (2009) 1.38
Structure and function of focal adhesions. Curr Opin Cell Biol (2011) 1.38
LTBPs, more than just an escort service. J Cell Biochem (2012) 1.37
The single-molecule mechanics of the latent TGF-β1 complex. Curr Biol (2011) 1.37
Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3. J Biol Chem (2001) 1.36
Animal models of fibrotic lung disease. Am J Respir Cell Mol Biol (2013) 1.31
Matrix-dependent perturbation of TGFβ signaling and disease. FEBS Lett (2012) 1.31
Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts. J Clin Invest (1994) 1.28
Tissue engineering of ligaments. Annu Rev Biomed Eng (2004) 1.28
Influence of oxygen concentration and mechanical factors on differentiation of connective tissues in vitro. Nature (1961) 1.26
Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J Investig Dermatol Symp Proc (2006) 1.26
Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci (2007) 1.24
The control of cell division by tension or diffusion. Nature (1978) 1.24
In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung. Thorax (2006) 1.24
Mechanotransduction of bone cells in vitro: mechanobiology of bone tissue. Med Biol Eng Comput (2004) 1.19
Pretranslational regulation of extracellular matrix macromolecules and collagenase expression in fibroblasts by mechanical forces. Lab Invest (1992) 1.18
A review of fibroblast-populated collagen lattices. Wound Repair Regen (2008) 1.18
Pushing back: wound mechanotransduction in repair and regeneration. J Invest Dermatol (2011) 1.17
Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes. J Invest Dermatol (2004) 1.14
Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem (2011) 1.12
The guidance of stem cell differentiation by substrate alignment and mechanical stimulation. Biomaterials (2012) 1.08
Progressive induction of left ventricular pressure overload in a large animal model elicits myocardial remodeling and a unique matrix signature. J Thorac Cardiovasc Surg (2011) 1.06
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum (2012) 1.06
The biology of the extracellular matrix: novel insights. Curr Opin Rheumatol (2013) 1.06
Stem cell regulation by the Hippo pathway. Biochim Biophys Acta (2012) 1.04
Left ventricular assist device unloading effects on myocardial structure and function: current status of the field and call for action. Curr Opin Cardiol (2011) 1.04
Pressure therapy for the control of hypertrophic scar formation after burn injury. A history and review. J Burn Care Rehabil (1991) 1.03