Published in Immunol Rev on May 01, 2014
T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nat Immunol (2015) 1.65
IL233, A Novel IL-2 and IL-33 Hybrid Cytokine, Ameliorates Renal injury. J Am Soc Nephrol (2017) 1.38
Helios Controls a Limited Subset of Regulatory T Cell Functions. J Immunol (2015) 1.03
Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol (2015) 1.00
Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation. EMBO J (2015) 1.00
IL-27-induced modulation of autoimmunity and its therapeutic potential. Autoimmun Rev (2015) 0.94
Regulatory T cells and minimal change nephropathy: in the midst of a complex network. Clin Exp Immunol (2015) 0.93
Altered immunoregulation in rheumatoid arthritis: the role of regulatory T cells and proinflammatory th17 cells and therapeutic implications. Mediators Inflamm (2015) 0.92
Multiple Sclerosis and T Lymphocytes: An Entangled Story. J Neuroimmune Pharmacol (2015) 0.89
Epigenetic regulation of asthma and allergic disease. Allergy Asthma Clin Immunol (2014) 0.88
Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells. PLoS One (2015) 0.87
Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells. J Leukoc Biol (2014) 0.86
Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis. Proc Natl Acad Sci U S A (2015) 0.86
Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity. Oncotarget (2015) 0.84
Pathological conditions re-shape physiological Tregs into pathological Tregs. Burns Trauma (2015) 0.83
T Cells: Soldiers and Spies-The Surveillance and Control of Effector T Cells by Regulatory T Cells. Clin J Am Soc Nephrol (2015) 0.82
Treg stability: to be or not to be. Curr Opin Immunol (2016) 0.82
T cells and autoimmune kidney disease. Nat Rev Nephrol (2017) 0.80
LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(-) Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients. Biomed Res Int (2015) 0.79
Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy. Immunology (2015) 0.79
Regulatory cells in health and disease. Immunol Rev (2014) 0.78
Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun (2015) 0.78
Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4(+) recent thymic emigrants. Sci Rep (2016) 0.78
Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses. PLoS One (2016) 0.78
Extra-thymically induced T regulatory cell subsets: the optimal target for antigen-specific immunotherapy. Immunology (2015) 0.77
Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV. Clin Exp Immunol (2015) 0.77
Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate. PLoS One (2016) 0.77
Promises and paradoxes of regulatory T cells in inflammatory bowel disease. World J Gastroenterol (2015) 0.77
Tregs and kidney: From diabetic nephropathy to renal transplantation. World J Transplant (2016) 0.77
Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes. Philos Trans R Soc Lond B Biol Sci (2018) 0.76
Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells. Front Immunol (2016) 0.76
Looking beyond the induction of Th2 responses to explain immunomodulation by helminths. Parasite Immunol (2015) 0.76
Pasteurella multocida Toxin Manipulates T Cell Differentiation. Front Microbiol (2015) 0.76
Engineering an "infectious" T(reg) biomimetic through chemoselective tethering of TGF-β1 to PEG brush surfaces. Biomaterials (2015) 0.76
In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. Br J Haematol (2014) 0.76
The IL-33/ST2 axis is specifically required for development of adipose tissue-resident regulatory T cells. Cell Mol Immunol (2015) 0.76
Ex-vivo iTreg differentiation revisited: Convenient alternatives to existing strategies. J Immunol Methods (2016) 0.75
Adenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression. Purinergic Signal (2016) 0.75
Incomplete clonal deletion as prerequisite for tissue-specific minor antigen tolerization. JCI Insight (2016) 0.75
Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty. Breast Cancer Res (2017) 0.75
Modulation of Alloimmunity by Heat Shock Proteins. Front Immunol (2016) 0.75
Immune cell interplay in colorectal cancer prognosis. World J Gastrointest Oncol (2015) 0.75
Peripheral phenotype and gene expression profiles of combined liver-kidney transplant patients. Liver Int (2015) 0.75
Microbiota-Specific CD4CD8αα Tregs: Role in Intestinal Immune Homeostasis and Implications for IBD. Front Immunol (2015) 0.75
Emerging therapies provide new opportunities to reshape the multifaceted interactions between the immune system and lymphoma cells. Leukemia (2016) 0.75
The Ikaros family of zinc-finger proteins. Acta Pharm Sin B (2016) 0.75
Characterization of Regulatory T-Cell Markers in CD4+ T Cells of the Upper Airway Mucosa. PLoS One (2016) 0.75
Functional defects in CD4(+) CD25(high) FoxP3(+) regulatory cells in ankylosing spondylitis. Sci Rep (2016) 0.75
The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection. Prog Mol Biol Transl Sci (2015) 0.75
Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses. Proc Natl Acad Sci U S A (2017) 0.75
Deep sequencing of the TCRB repertoire of human Foxp3(+) and Foxp3(-) T cells suggests that they are completely distinct and non-overlapping. Clin Exp Immunol (2016) 0.75
Research Progress on Regulatory T Cells in Acute Kidney Injury. J Immunol Res (2015) 0.75
WNT5A transforms intestinal CD8αα(+) IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol (2015) 0.75
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination. Sci Rep (2016) 0.75
TGF-β Affects the Differentiation of Human GM-CSF(+) CD4(+) T Cells in an Activation- and Sodium-Dependent Manner. Front Immunol (2016) 0.75
Methylation of FOXP3 TSDR Underlies the Impaired Suppressive Function of Tregs from Long-term Belatacept-Treated Kidney Transplant Patients. Front Immunol (2017) 0.75
CD28(-) and CD28(low)CD8(+) Regulatory T Cells: Of Mice and Men. Front Immunol (2017) 0.75
mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections. Mediators Inflamm (2016) 0.75
Peripherally Induced Regulatory T Cells: Recruited Protectors of the Central Nervous System against Autoimmune Neuroinflammation. Front Immunol (2017) 0.75
Metabolic pressure and the breach of immunological self-tolerance. Nat Immunol (2017) 0.75
Tim3(+) Foxp3 (+) Treg Cells Are Potent Inhibitors of Effector T Cells and Are Suppressed in Rheumatoid Arthritis. Inflammation (2017) 0.75
The function of regulatory T cells at the ocular surface: Review. Ocul Surf (2017) 0.75
Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3(+) regulatory T cells. Oncotarget (2017) 0.75
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05
CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 12.67
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature (2002) 11.79
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 9.72
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med (2004) 8.00
Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol (2007) 7.86
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 7.73
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity (2007) 6.61
Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol (2007) 6.32
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood (2010) 5.79
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 4.96
Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol (2002) 4.95
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood (2011) 4.57
DNA methylation controls Foxp3 gene expression. Eur J Immunol (2008) 4.19
Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J Immunol (2007) 4.12
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol (2005) 4.11
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med (2009) 3.78
CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol (2000) 3.63
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med (2012) 3.40
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity (2008) 3.36
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med (2008) 2.72
First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. Clin Immunol (2009) 2.71
Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg. Eur J Immunol (2009) 2.71
Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature (2006) 2.64
CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. Immunity (2003) 2.59
Helios expression is a marker of T cell activation and proliferation. PLoS One (2011) 2.55
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A (2009) 2.51
Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc Natl Acad Sci U S A (2002) 2.35
Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells. J Immunol (2007) 2.32
Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13
MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc Natl Acad Sci U S A (2008) 2.13
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol (2004) 2.11
Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant (2011) 1.96
IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J Immunol (2008) 1.93
Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr Biol (1998) 1.92
IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol (2011) 1.89
Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node. J Exp Med (2005) 1.88
TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice. Eur J Immunol (2008) 1.80
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells. Nat Immunol (2012) 1.74
Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS One (2008) 1.73
Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med (2010) 1.73
Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance. J Immunol (2008) 1.71
Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo. J Immunol (2006) 1.70
Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J Immunol (2008) 1.63
Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease. J Immunol (2008) 1.61
Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H/K adenosine triphosphatase-reactive T cells. J Immunol (1996) 1.60
Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children. Diabetes Care (2012) 1.52
Helios deficiency has minimal impact on T cell development and function. J Immunol (2009) 1.50
CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells. J Immunol (2005) 1.49
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. J Exp Med (2011) 1.42
A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity. Eur J Immunol (2001) 1.41
Biological functions of regulatory T cells. Adv Immunol (2011) 1.37
Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion. Blood (2012) 1.36
GARP regulates the bioavailability and activation of TGFβ. Mol Biol Cell (2012) 1.28
The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity. Mol Immunol (2011) 1.27
Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells". J Immunol (2010) 1.27
Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol (2013) 1.19
Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid. PLoS One (2010) 1.16
Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism. J Immunol (2013) 1.13
Polyclonal Treg cells modulate T effector cell trafficking. Eur J Immunol (2011) 0.92
Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice. J Immunol (2004) 0.87
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med (2002) 4.56
The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev (2006) 3.59
Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood (2006) 2.42
Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells. Trends Immunol (2004) 1.42
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol (2007) 1.40
Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion. Blood (2012) 1.36
Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling. J Immunol (2008) 1.08
CD4+ CD25+ [corrected] regulatory T cells render naive CD4+ CD25- T cells anergic and suppressive. Immunology (2007) 1.04
Proliferative assays for T cell function. Curr Protoc Immunol (2004) 1.00
Control of T cell activation by CD4+CD25+ suppressor T cells. Novartis Found Symp (2003) 1.00
Modulation of Treg cells/T effector function by GITR signaling is context-dependent. Eur J Immunol (2013) 0.99
Subtractive cloning: new genes for studying inflammatory disorders. Ann Periodontol (2002) 0.93
A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease. J Immunol (2011) 0.91
The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells. J Biol Chem (2011) 0.89
CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice. Microbes Infect (2009) 0.78
Combating Non-nucleoside Reverse Transcriptase Inhibitor Resistance with a Focus On Etravirine (Intelence) for HIV-1 Infection. P T (2008) 0.78