Methuosis: nonapoptotic cell death associated with vacuolization of macropinosome and endosome compartments.

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Published in Am J Pathol on April 13, 2014

Authors

William A Maltese1, Jean H Overmeyer2

Author Affiliations

1: Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio. Electronic address: william.maltese@utoledo.edu.
2: Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.

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Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer (1972) 35.74

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44

Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol (1995) 9.35

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Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol (2010) 7.95

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Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78

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Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell (2012) 6.31

Endonuclease G is an apoptotic DNase when released from mitochondria. Nature (2001) 6.20

Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl) (1990) 6.11

The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol (1998) 5.96

Pathways and mechanisms of endocytic recycling. Nat Rev Mol Cell Biol (2009) 5.60

Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol (2004) 5.31

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07

Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science (1986) 4.99

Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev (2005) 4.72

Lysosomal membrane permeabilization in cell death. Oncogene (2008) 4.40

Macropinocytosis. Trends Cell Biol (1995) 4.03

A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell (2007) 3.97

Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol (2002) 3.89

Identification of the switch in early-to-late endosome transition. Cell (2010) 3.86

Vacuolar ATPase activity is required for endosomal carrier vesicle formation. J Biol Chem (1994) 3.40

Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell (2011) 3.37

Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat Rev Microbiol (2005) 3.25

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J Cell Sci (1999) 3.14

An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A (2000) 3.13

Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements. Mol Biol Cell (2004) 2.99

Ras signaling and therapies. Adv Cancer Res (2009) 2.93

Effect of bafilomycin A1 and nocodazole on endocytic transport in HeLa cells: implications for viral uncoating and infection. J Virol (1998) 2.93

Macropinosome maturation and fusion with tubular lysosomes in macrophages. J Cell Biol (1993) 2.86

The experimental production of watery vacuolation of the liver. J Physiol (1946) 2.78

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The dark side of Ras: regulation of apoptosis. Oncogene (2003) 2.60

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ (2011) 2.60

The morphology of various types of cell death in prenatal tissues. Teratology (1973) 2.50

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Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. Exp Mol Pathol (2009) 2.25

Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells. Mol Microbiol (1993) 2.24

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Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. J Biol Chem (2000) 2.02

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Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling. Cell Signal (2008) 1.88

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Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest (2009) 1.76

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Anoikis. Biochem Soc Trans (2004) 1.28

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Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation. J Biol Chem (2003) 1.18

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MECHANISM OF DRUG-INDUCED VACUOLIZATION IN TISSUE CULTURE. Exp Cell Res (1965) 1.08

Oncosis: an important non-apoptotic mode of cell death. Exp Mol Pathol (2012) 1.08

Intoxication strategy of Helicobacter pylori VacA toxin. Trends Microbiol (2012) 1.08

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Death pathways triggered by activated Ras in cancer cells. Front Biosci (Landmark Ed) (2011) 1.00

WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells. Cell Death Dis (2011) 0.99

Therapeutic agents triggering nonapoptotic cancer cell death. J Med Chem (2013) 0.98

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides. Nucleic Acids Res (2009) 0.97

The experimental production of watery vacuolation in the acinar cells of the submandibular gland. J Physiol (1967) 0.97

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Massive cell vacuolization induced by organic amines such as procainamide. J Pharmacol Exp Ther (2004) 0.93

F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system. Cancer Res (2008) 0.89

Cytoplasmic vacuolization during exposure to drugs and other substances. Cell Biol Toxicol (2012) 0.89

Coordination of the Rab5 cycle on macropinosomes. Traffic (2011) 0.88

Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus. Eukaryot Cell (2011) 0.86

Differential Induction of Cytoplasmic Vacuolization and Methuosis by Novel 2-Indolyl-Substituted Pyridinylpropenones. ACS Med Chem Lett (2014) 0.85

Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells. Brain Res (2012) 0.84

Furosemide induced hepatotoxicity. J Pathol (1981) 0.83

SnapShot: Mammalian Rab proteins in endocytic trafficking. Cell (2012) 0.83

Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: procainamide-induced autophagic cell vacuolization. Toxicol Appl Pharmacol (2008) 0.82

Methamphetamine induces macropinocytosis in differentiated SH-SY5Y human neuroblastoma cells. Brain Res (2010) 0.82

N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping. Mol Pharmacol (2005) 0.79

Vacuolar cytoplasmic phase separation in cultured mammalian cells involves the microfilament network and reduces motional properties of intracellular water. Int J Exp Pathol (1997) 0.78

Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II. Biochem Pharmacol (2011) 0.76