Published in Lancet Diabetes Endocrinol on March 19, 2014
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet (2016) 1.48
Metformin and the gastrointestinal tract. Diabetologia (2016) 1.06
The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell-Centric Classification Schema. Diabetes Care (2016) 1.04
Metformin for Reducing Racial/Ethnic Difference in Prostate Cancer Incidence for Men with Type II Diabetes. Cancer Prev Res (Phila) (2016) 0.81
Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents. Pharmgenomics Pers Med (2016) 0.79
Personalising metformin therapy: a clinician's perspective. Lancet Diabetes Endocrinol (2014) 0.79
Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery. Nat Rev Endocrinol (2016) 0.79
Genomic Characterization of Metformin Hepatic Response. PLoS Genet (2016) 0.79
Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome. Diabetologia (2017) 0.78
Personalized medicine in diabetes: the role of 'omics' and biomarkers. Diabet Med (2016) 0.78
The pharmacogenetics of metformin. Diabetologia (2017) 0.77
Metformin in the diabetic brain: friend or foe? Ann Transl Med (2014) 0.77
Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers. Eur J Clin Pharmacol (2015) 0.76
Genetic variants of OCT1 influence glycemic response to metformin in Han Chinese patients with type-2 diabetes mellitus in Shanghai. Int J Clin Exp Pathol (2015) 0.75
Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes. Diabetologia (2017) 0.75
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet (2010) 20.73
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Genome-wide efficient mixed-model analysis for association studies. Nat Genet (2012) 6.62
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med (1995) 6.51
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest (2007) 4.47
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 3.06
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy. Nature (2013) 2.46
Genome-wide association of lipid-lowering response to statins in combined study populations. PLoS One (2010) 2.43
Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials. Diabet Med (2010) 2.12
Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study. Diabetes (2007) 2.03
Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Diabetes (2010) 2.02
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet (2012) 1.96
Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study. Eur Heart J (2012) 1.75
Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study. Diabetes (2009) 1.72
Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study. Genet Epidemiol (2011) 1.61
Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin Pharmacol Ther (2008) 1.57
The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes. Diabet Med (2006) 1.26
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
The fine-scale genetic structure of the British population. Nature (2015) 2.26
Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Hum Mol Genet (2011) 2.21
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Mol Psychiatry (2012) 2.20
The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials. Eur Heart J (2015) 1.83
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet (2012) 1.81
Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24 week, double-blind, randomized Phase 3 trial. Int J Cardiol (2014) 1.71
Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychol Sci (2013) 1.57
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet (2012) 1.52
Common genetic determinants of intraocular pressure and primary open-angle glaucoma. PLoS Genet (2012) 1.33
Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol (2013) 1.30
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). Invest Ophthalmol Vis Sci (2011) 1.22
Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. PLoS Med (2013) 1.18
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One (2013) 1.16
Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Nat Genet (2013) 1.15
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nat Genet (2014) 1.13
Common variant at 16p11.2 conferring risk of psychosis. Mol Psychiatry (2012) 1.08
Comparison of methods to account for relatedness in genome-wide association studies with family-based data. PLoS Genet (2014) 1.07
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. Am J Hum Genet (2013) 1.06
Implication of a rare deletion at distal 16p11.2 in schizophrenia. JAMA Psychiatry (2013) 1.05
Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. Stroke (2014) 0.99
The correlation between reading and mathematics ability at age twelve has a substantial genetic component. Nat Commun (2014) 0.93
Genetic overlap between diagnostic subtypes of ischemic stroke. Stroke (2015) 0.92
Biomarkers of rapid chronic kidney disease progression in type 2 diabetes. Kidney Int (2015) 0.87
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. Nat Genet (2015) 0.84
Genome-wide estimates of inbreeding in unrelated individuals and their association with cognitive ability. Eur J Hum Genet (2013) 0.84
No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset. Schizophr Res (2014) 0.83
A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility. Genes Immun (2014) 0.82
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet (2014) 0.81
Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway. JAMA Psychiatry (2014) 0.81
Genetic loci for retinal arteriolar microcirculation. PLoS One (2013) 0.80
Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients. PLoS One (2013) 0.80
The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis. Psychol Med (2013) 0.78
The role of toll-like receptor variants in acute anterior uveitis. Mol Vis (2011) 0.78
Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis. Cardiovasc Diabetol (2013) 0.78
Genetic variants associated with non-typhoidal Salmonella bacteraemia in African children. Lancet (2015) 0.76
Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke. Stroke (2015) 0.76
Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. BMC Cardiovasc Disord (2016) 0.75
Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database. Diabetes Care (2015) 0.75
Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis. Sci Adv (2017) 0.75
Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. Nat Genet (2015) 0.75