Published in Nat Genet on May 08, 2011
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Rare and common variants: twenty arguments. Nat Rev Genet (2012) 6.67
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet (2012) 4.41
Improved heritability estimation from genome-wide SNPs. Am J Hum Genet (2012) 3.48
Searching for missing heritability: designing rare variant association studies. Proc Natl Acad Sci U S A (2014) 3.47
Genetic signatures of exceptional longevity in humans. PLoS One (2012) 3.20
Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 3.06
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Genomic and metabolic prediction of complex heterotic traits in hybrid maize. Nat Genet (2012) 2.70
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet (2013) 2.68
Genetic contributions to stability and change in intelligence from childhood to old age. Nature (2012) 2.63
Whole-genome sequence-based analysis of high-density lipoprotein cholesterol. Nat Genet (2013) 2.62
Polygenic modeling with bayesian sparse linear mixed models. PLoS Genet (2013) 2.59
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet (2014) 2.53
Advantages and pitfalls in the application of mixed-model association methods. Nat Genet (2014) 2.52
Genome-wide analysis of the heritability of amyotrophic lateral sclerosis. JAMA Neurol (2014) 2.22
The phenotypic legacy of admixture between modern humans and Neandertals. Science (2016) 2.20
Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS Genet (2013) 2.19
Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Mol Psychiatry (2013) 2.15
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron (2013) 2.13
Heritability and genetic correlations explained by common SNPs for metabolic syndrome traits. PLoS Genet (2012) 2.11
Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Nat Genet (2013) 2.09
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet (2013) 2.08
Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet (2012) 2.07
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet (2013) 1.96
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet (2012) 1.96
Detection and replication of epistasis influencing transcription in humans. Nature (2014) 1.95
Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples. PLoS Genet (2014) 1.92
The genetic architecture of economic and political preferences. Proc Natl Acad Sci U S A (2012) 1.89
The genetics of major depression. Neuron (2014) 1.80
No genetic influence for childhood behavior problems from DNA analysis. J Am Acad Child Adolesc Psychiatry (2013) 1.79
Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat Genet (2015) 1.79
Heritability in the genome-wide association era. Hum Genet (2012) 1.76
Genomics and the origin of species. Nat Rev Genet (2014) 1.75
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68
The Genome of the Netherlands: design, and project goals. Eur J Hum Genet (2013) 1.68
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet (2012) 1.68
Rare nonsynonymous exonic variants in addiction and behavioral disinhibition. Biol Psychiatry (2013) 1.67
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med (2013) 1.67
Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis. Lancet Diabetes Endocrinol (2014) 1.64
Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychol Sci (2013) 1.57
Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait. PLoS One (2015) 1.57
Investigating natural variation in Drosophila courtship song by the evolve and resequence approach. Genetics (2012) 1.55
Quantifying missing heritability at known GWAS loci. PLoS Genet (2013) 1.55
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. Am J Hum Genet (2016) 1.53
MultiBLUP: improved SNP-based prediction for complex traits. Genome Res (2014) 1.53
Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. Transl Psychiatry (2012) 1.52
A genome-wide association study of myasthenia gravis. JAMA Neurol (2015) 1.52
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke (2013) 1.51
Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers. PLoS Genet (2015) 1.49
Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12. Am J Hum Genet (2012) 1.46
A population genetic signal of polygenic adaptation. PLoS Genet (2014) 1.46
NIH working group report-using genomic information to guide weight management: From universal to precision treatment. Obesity (Silver Spring) (2016) 1.45
Genetics and intelligence differences: five special findings. Mol Psychiatry (2014) 1.45
Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Hum Mol Genet (2012) 1.43
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet (2015) 1.43
Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes. Am J Hum Genet (2013) 1.43
Estimation and partition of heritability in human populations using whole-genome analysis methods. Annu Rev Genet (2013) 1.41
HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis. Am J Hum Genet (2012) 1.41
Identifying causal variants at loci with multiple signals of association. Genetics (2014) 1.41
A genome-wide association study reveals loci influencing height and other conformation traits in horses. PLoS One (2012) 1.39
Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet (2016) 1.39
Genomic selection requires genomic control of inbreeding. Genet Sel Evol (2012) 1.38
Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model. PLoS Genet (2015) 1.38
A novel generalized ridge regression method for quantitative genetics. Genetics (2013) 1.36
Improved statistics for genome-wide interaction analysis. PLoS Genet (2012) 1.33
High trans-ethnic replicability of GWAS results implies common causal variants. PLoS Genet (2013) 1.32
Influence of gene interaction on complex trait variation with multilocus models. Genetics (2014) 1.31
The genetics of addiction-a translational perspective. Transl Psychiatry (2012) 1.30
Ubiquitous polygenicity of human complex traits: genome-wide analysis of 49 traits in Koreans. PLoS Genet (2013) 1.29
Satiety mechanisms in genetic risk of obesity. JAMA Pediatr (2014) 1.29
GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. PLoS Genet (2014) 1.29
Alzheimer's disease: analyzing the missing heritability. PLoS One (2013) 1.28
Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not so Different after all! Front Genet (2012) 1.27
Genic and nongenic contributions to natural variation of quantitative traits in maize. Genome Res (2012) 1.26
Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays (2013) 1.26
DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities. Behav Genet (2013) 1.26
A kernel of truth: statistical advances in polygenic variance component models for complex human pedigrees. Adv Genet (2013) 1.25
Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. Evolution (2012) 1.21
DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12. Mol Psychiatry (2013) 1.19
A modern ampelography: a genetic basis for leaf shape and venation patterning in grape. Plant Physiol (2013) 1.19
Novel genomic approaches unravel genetic architecture of complex traits in apple. BMC Genomics (2013) 1.18
Estimating quantitative genetic parameters in wild populations: a comparison of pedigree and genomic approaches. Mol Ecol (2014) 1.18
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet (2014) 1.17
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet (2012) 1.14
Genetic-based prediction of disease traits: prediction is very difficult, especially about the future. Front Genet (2014) 1.12
Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis. Int J Obes (Lond) (2013) 1.11
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes. Hypertension (2014) 1.11
What obesity research tells us about epigenetic mechanisms. Philos Trans R Soc Lond B Biol Sci (2013) 1.11
Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. Dev Psychopathol (2012) 1.10
Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation. PLoS Genet (2014) 1.09
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet (2010) 20.73
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Variance component model to account for sample structure in genome-wide association studies. Nat Genet (2010) 15.52
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Heritability in the genomics era--concepts and misconceptions. Nat Rev Genet (2008) 13.42
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
Genomewide association studies and assessment of the risk of disease. N Engl J Med (2010) 11.51
Genetic heterogeneity in human disease. Cell (2010) 10.67
Prospective study of alcohol consumption and risk of coronary disease in men. Lancet (1991) 8.64
Mixed linear model approach adapted for genome-wide association studies. Nat Genet (2010) 8.47
A versatile gene-based test for genome-wide association studies. Am J Hum Genet (2010) 8.44
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
The Nurses' Health Study: lifestyle and health among women. Nat Rev Cancer (2005) 8.19
The genetics of haemostasis: a twin study. Lancet (2001) 8.08
New approaches to population stratification in genome-wide association studies. Nat Rev Genet (2010) 7.97
Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol (2010) 4.83
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The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. Genet Epidemiol (2010) 3.48
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Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet (2010) 3.24
Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries. Twin Res (2003) 2.96
Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation (2010) 2.78
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Genome partitioning of genetic variation for height from 11,214 sibling pairs. Am J Hum Genet (2007) 2.27
Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. Proc Natl Acad Sci U S A (2010) 2.27
Estimating the additive genetic effect of the X chromosome. Genet Epidemiol (2005) 1.95
Factor VIII and factor IX in a twin population. Evidence for a major effect of ABO locus on factor VIII level. Am J Hum Genet (1985) 1.66
Heritability of ECG measurements in adult male twins. J Electrocardiol (1998) 1.64
Familial resemblance of body mass index and familial risk of high and low body mass index. A study of young men in Sweden. Int J Obes Relat Metab Disord (2002) 1.53
Amount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels. Arterioscler Thromb Vasc Biol (2002) 1.27
Heritability of QT interval: how much is explained by genes for resting heart rate? J Cardiovasc Electrophysiol (2007) 1.25
Genetics of cardiac repolarization. Nat Genet (2009) 1.02
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet (2010) 20.73
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Replicating genotype-phenotype associations. Nature (2007) 16.11
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet (2007) 13.78
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71
Heritability in the genomics era--concepts and misconceptions. Nat Rev Genet (2008) 13.42
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet (2008) 10.87
Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet (2011) 8.95
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
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How to interpret a genome-wide association study. JAMA (2008) 7.54
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet (2008) 7.15
A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med (2002) 7.14
dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions. Hum Mutat (2011) 6.97
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease. Epidemiology (2008) 6.87
High-resolution whole-genome association study of Parkinson disease. Am J Hum Genet (2005) 6.86
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Sizing up human height variation. Nat Genet (2008) 6.66
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (2008) 6.66
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Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet (2008) 6.10
DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet (2009) 5.99
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Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet (2008) 5.89
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Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol (2010) 5.79
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet (2011) 5.58
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
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Genomewide association studies of stroke. N Engl J Med (2009) 5.29
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27
Genetics in geographically structured populations: defining, estimating and interpreting F(ST). Nat Rev Genet (2009) 5.23
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
dbNSFP v2.0: a database of human non-synonymous SNVs and their functional predictions and annotations. Hum Mutat (2013) 5.11
Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J Clin Invest (2008) 5.05
A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A (2010) 4.94
Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
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