Published in Am J Hum Genet on December 17, 2010
Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet (2011) 8.95
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience (2015) 5.06
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet (2011) 5.01
Genomic inflation factors under polygenic inheritance. Eur J Hum Genet (2011) 4.89
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet (2012) 4.41
Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry (2011) 4.16
Most genetic risk for autism resides with common variation. Nat Genet (2014) 4.10
Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood. Bioinformatics (2012) 3.97
An atlas of genetic correlations across human diseases and traits. Nat Genet (2015) 3.90
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease. N Engl J Med (2016) 3.88
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet (2015) 3.82
Improved heritability estimation from genome-wide SNPs. Am J Hum Genet (2012) 3.48
New genetic loci link adipose and insulin biology to body fat distribution. Nature (2015) 3.38
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17
Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 3.06
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet (2015) 2.84
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Genomic and metabolic prediction of complex heterotic traits in hybrid maize. Nat Genet (2012) 2.70
A mixed-model approach for genome-wide association studies of correlated traits in structured populations. Nat Genet (2012) 2.69
Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism (2012) 2.67
Genetic contributions to stability and change in intelligence from childhood to old age. Nature (2012) 2.63
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet (2013) 2.60
Genome-wide genetic changes during modern breeding of maize. Nat Genet (2012) 2.60
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (2012) 2.57
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet (2014) 2.53
Advantages and pitfalls in the application of mixed-model association methods. Nat Genet (2014) 2.52
Top 10 Replicated Findings From Behavioral Genetics. Perspect Psychol Sci (2016) 2.36
Efficient multivariate linear mixed model algorithms for genome-wide association studies. Nat Methods (2014) 2.33
Molecular signatures of major depression. Curr Biol (2015) 2.28
Genome-wide analysis of the heritability of amyotrophic lateral sclerosis. JAMA Neurol (2014) 2.22
The phenotypic legacy of admixture between modern humans and Neandertals. Science (2016) 2.20
Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS Genet (2013) 2.19
Heritability and genetic correlations explained by common SNPs for metabolic syndrome traits. PLoS Genet (2012) 2.11
Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation (2013) 2.06
Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet (2015) 2.05
Heritability and genomics of gene expression in peripheral blood. Nat Genet (2014) 2.00
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet (2012) 1.96
Estimating kinship in admixed populations. Am J Hum Genet (2012) 1.95
Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples. PLoS Genet (2014) 1.92
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90
Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet (2016) 1.90
The genetic architecture of economic and political preferences. Proc Natl Acad Sci U S A (2012) 1.89
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature (2014) 1.88
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. Biol Psychiatry (2012) 1.86
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nat Genet (2013) 1.85
Genetic and educational assortative mating among US adults. Proc Natl Acad Sci U S A (2014) 1.84
A gene-based association method for mapping traits using reference transcriptome data. Nat Genet (2015) 1.82
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet (2012) 1.81
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. Nat Genet (2012) 1.81
No genetic influence for childhood behavior problems from DNA analysis. J Am Acad Child Adolesc Psychiatry (2013) 1.79
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Heritability in the genome-wide association era. Hum Genet (2012) 1.76
Inferences from genomic models in stratified populations. Genetics (2012) 1.76
Abundant contribution of short tandem repeats to gene expression variation in humans. Nat Genet (2015) 1.74
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68
A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? Biol Psychiatry (2014) 1.68
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet (2012) 1.68
The architecture of parent-of-origin effects in mice. Cell (2014) 1.68
Rare nonsynonymous exonic variants in addiction and behavioral disinhibition. Biol Psychiatry (2013) 1.67
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med (2013) 1.67
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nat Med (2015) 1.66
Estimation of SNP heritability from dense genotype data. Am J Hum Genet (2013) 1.64
Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis. Lancet Diabetes Endocrinol (2014) 1.64
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet (2012) 1.63
Multiple genetic variant association testing by collapsing and kernel methods with pedigree or population structured data. Genet Epidemiol (2013) 1.60
Measuring missing heritability: inferring the contribution of common variants. Proc Natl Acad Sci U S A (2014) 1.58
Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychol Sci (2013) 1.57
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. Nat Genet (2016) 1.56
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet (2015) 1.55
Quantifying missing heritability at known GWAS loci. PLoS Genet (2013) 1.55
Population structure can inflate SNP-based heritability estimates. Am J Hum Genet (2011) 1.54
MultiBLUP: improved SNP-based prediction for complex traits. Genome Res (2014) 1.53
Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. Transl Psychiatry (2012) 1.52
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet (2016) 1.52
A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. Mol Psychiatry (2010) 1.52
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nat Genet (2015) 1.51
Practitioner review: A critical perspective on gene-environment interaction models--what impact should they have on clinical perceptions and practice? J Child Psychol Psychiatry (2014) 1.51
Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels. Blood (2014) 1.51
Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers. PLoS Genet (2015) 1.49
Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet (2013) 1.47
Results of a "GWAS plus:" general cognitive ability is substantially heritable and massively polygenic. PLoS One (2014) 1.47
Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation. PLoS Genet (2016) 1.46
Genetics and intelligence differences: five special findings. Mol Psychiatry (2014) 1.45
The Genetic Landscape of Renal Complications in Type 1 Diabetes. J Am Soc Nephrol (2016) 1.44
Genetics of venous thrombosis: insights from a new genome wide association study. PLoS One (2011) 1.43
Novel genetic predictors of venous thromboembolism risk in African Americans. Blood (2016) 1.43
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet (2015) 1.43
Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes. Am J Hum Genet (2013) 1.43
Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia. Genome Res (2014) 1.42
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics (2003) 53.11
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Personal genomes: The case of the missing heritability. Nature (2008) 19.56
GenABEL: an R library for genome-wide association analysis. Bioinformatics (2007) 18.10
Efficient methods to compute genomic predictions. J Dairy Sci (2008) 16.76
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
Population stratification and spurious allelic association. Lancet (2003) 10.53
Demonstrating stratification in a European American population. Nat Genet (2005) 9.49
Increased accuracy of artificial selection by using the realized relationship matrix. Genet Res (Camb) (2009) 8.38
Best linear unbiased estimation and prediction under a selection model. Biometrics (1975) 8.23
Heritability of Threshold Characters. Genetics (1950) 7.79
Estimating genetic parameters in natural populations using the "animal model". Philos Trans R Soc Lond B Biol Sci (2004) 6.93
Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet (2009) 6.61
The Heritability of All-or-None Traits: Viability of Poultry. Genetics (1949) 5.79
Sequence-level population simulations over large genomic regions. Genetics (2007) 4.04
GENOME: a rapid coalescent-based whole genome simulator. Bioinformatics (2007) 3.65
Predicting genetic predisposition in humans: the promise of whole-genome markers. Nat Rev Genet (2010) 3.59
Technical note: Derivation of equivalent computing algorithms for genomic predictions and reliabilities of animal merit. J Dairy Sci (2009) 3.25
Hints of hidden heritability in GWAS. Nat Genet (2010) 3.04
Estimating the additive genetic effect of the X chromosome. Genet Epidemiol (2005) 1.95
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet (2011) 8.95
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res (2007) 8.48
A versatile gene-based test for genome-wide association studies. Am J Hum Genet (2010) 8.44
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet (2008) 7.15
Recent human effective population size estimated from linkage disequilibrium. Genome Res (2007) 6.79
Sizing up human height variation. Nat Genet (2008) 6.66
DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet (2009) 5.99
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Genomic inflation factors under polygenic inheritance. Eur J Hum Genet (2011) 4.89
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet (2010) 4.58
Predicting unobserved phenotypes for complex traits from whole-genome SNP data. PLoS Genet (2008) 4.57
Bias, precision and heritability of self-reported and clinically measured height in Australian twins. Hum Genet (2006) 3.84
Novel multilocus measure of linkage disequilibrium to estimate past effective population size. Genome Res (2003) 3.83
Reconciling the analysis of IBD and IBS in complex trait studies. Nat Rev Genet (2010) 3.62
Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Hum Mol Genet (2009) 3.53
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47
A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010). Twin Res Hum Genet (2010) 3.37
The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr (2007) 3.33
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
QTL Express: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics (2002) 3.24
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays. Nucleic Acids Res (2008) 3.08
Pitfalls of predicting complex traits from SNPs. Nat Rev Genet (2013) 3.06
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet (2011) 3.03
Geographical structure and differential natural selection among North European populations. Genome Res (2009) 3.03
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet (2003) 3.02
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Genetic contributions to stability and change in intelligence from childhood to old age. Nature (2012) 2.63
Synthetic associations created by rare variants do not explain most GWAS results. PLoS Biol (2011) 2.60
Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nat Genet (2009) 2.38
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet (2009) 2.29
Prediction of individual genetic risk of complex disease. Curr Opin Genet Dev (2008) 2.19
Comparing apples and oranges: equating the power of case-control and quantitative trait association studies. Genet Epidemiol (2010) 2.13
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis. Nucleic Acids Res (2002) 2.12
Accuracy of genomic selection using stochastic search variable selection in Australian Holstein Friesian dairy cattle. Genet Res (Camb) (2009) 2.05
Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet (2010) 2.04
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. Am J Hum Genet (2008) 2.01
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet (2012) 1.96
The genetic architecture of economic and political preferences. Proc Natl Acad Sci U S A (2012) 1.89
Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates. Nucleic Acids Res (2006) 1.88
Classification based upon gene expression data: bias and precision of error rates. Bioinformatics (2007) 1.88
Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data. Genetics (2011) 1.85
Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence. Genome Res (2012) 1.73
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophr Bull (2009) 1.71
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68
On Jim Watson's APOE status: genetic information is hard to hide. Eur J Hum Genet (2008) 1.67
Estimation of SNP heritability from dense genotype data. Am J Hum Genet (2013) 1.64
Human population dispersal "Out of Africa" estimated from linkage disequilibrium and allele frequencies of SNPs. Genome Res (2011) 1.64
A better coefficient of determination for genetic profile analysis. Genet Epidemiol (2012) 1.63
High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury. J Appl Physiol (1985) (2003) 1.62
Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent. Genome Res (2011) 1.58
A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies. Genet Epidemiol (2010) 1.57
Linkage disequilibrium in the domesticated pig. Genetics (2004) 1.50
The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics. PLoS One (2012) 1.49
Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations. Methods Mol Biol (2013) 1.42
Polymorphic regions affecting human height also control stature in cattle. Genetics (2011) 1.42
Estimation and partition of heritability in human populations using whole-genome analysis methods. Annu Rev Genet (2013) 1.41
Rapid inexpensive genome-wide association using pooled whole blood. Genome Res (2009) 1.41
The future of livestock breeding: genomic selection for efficiency, reduced emissions intensity, and adaptation. Trends Genet (2012) 1.41
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