Allergic sensitization: screening methods.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 3990213)

Published in Clin Transl Allergy on April 15, 2014

Authors

Gregory S Ladics1, Jeremy Fry, Richard Goodman, Corinne Herouet-Guicheney, Karin Hoffmann-Sommergruber, Charlotte B Madsen, André Penninks, Anna Pomés, Erwin L Roggen, Joost Smit, Jean-Michel Wal

Author Affiliations

1: DuPont Pioneer Agricultural Biotechnology, DuPont Experimental Station, 200 Powder Mill Road, Wilmington, DE 19880-0400, USA. gregory.s.ladics@usa.dupont.com.

Articles cited by this

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18

Epitopes on protein antigens: misconceptions and realities. Cell (1990) 3.32

Immunophysiology of experimental food allergy. Mucosal Immunol (2008) 2.76

Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up. JAMA (2011) 2.73

Identification of a Brazil-nut allergen in transgenic soybeans. N Engl J Med (1996) 2.41

The prevalence of plant food allergies: a systematic review. J Allergy Clin Immunol (2008) 1.77

Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J Allergy Clin Immunol (2008) 1.77

Allergenicity assessment of genetically modified crops--what makes sense? Nat Biotechnol (2008) 1.67

Structural biology of allergens. J Allergy Clin Immunol (2000) 1.67

Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit Rev Food Sci Nutr (1996) 1.40

Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem (2008) 1.35

Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol (2006) 1.30

New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol (2009) 1.23

Structural biology of allergens. Curr Allergy Asthma Rep (2005) 1.22

Effector activity of peanut allergens: a critical role for Ara h 2, Ara h 6, and their variants. Clin Exp Allergy (2009) 1.17

Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity. J Agric Food Chem (2005) 1.11

Relevant B cell epitopes in allergic disease. Int Arch Allergy Immunol (2009) 1.08

Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. Allergy (2011) 1.08

Molecular determinants for antibody binding on group 1 house dust mite allergens. J Biol Chem (2011) 1.05

Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses. PLoS One (2011) 1.04

Oral administration of recombinant Lactococcus lactis expressing bovine beta-lactoglobulin partially prevents mice from sensitization. Clin Exp Allergy (2005) 1.03

Oral sensitization to food proteins: a Brown Norway rat model. Clin Exp Allergy (1998) 0.99

Allergic sensitization: host-immune factors. Clin Transl Allergy (2014) 0.97

Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis. Allergy (2010) 0.95

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding. PLoS One (2011) 0.94

Regulation by intestinal γδ T cells during establishment of food allergic sensitization in mice. Allergy (2010) 0.92

Principles and characteristics of food allergens. Crit Rev Food Sci Nutr (1996) 0.92

Immune-mediated effects upon oral challenge of ovalbumin-sensitized Brown Norway rats: further characterization of a rat food allergy model. Toxicol Appl Pharmacol (1999) 0.91

Peanut- and cow's milk-specific IgE, Th2 cells and local anaphylactic reaction are induced in Balb/c mice orally sensitized with cholera toxin. Allergy (2005) 0.90

Current codex guidelines for assessment of potential protein allergenicity. Food Chem Toxicol (2008) 0.90

Comparison of the α-amylase inhibitor-1 from common bean (Phaseolus vulgaris) varieties and transgenic expression in other legumes--post-translational modifications and immunogenicity. J Agric Food Chem (2011) 0.89

Allergic sensitization: food- and protein-related factors. Clin Transl Allergy (2014) 0.89

Comparison of antibody responses to hen's egg and cow's milk proteins in orally sensitized rats and food-allergic patients. Allergy (2000) 0.89

Food allergen protein families and their structural characteristics and application in component-resolved diagnosis: new data from the EuroPrevall project. Anal Bioanal Chem (2009) 0.87

Identification and characterization of adverse effects in 21st century toxicology. Toxicol Sci (2012) 0.87

Determination of protein allergenicity: studies in rats. Toxicol Lett (2001) 0.87

Elicitation of the allergic reaction in beta-lactoglobulin-sensitized Balb/c mice: biochemical and clinical manifestations differ according to the structure of the allergen used for challenge. Clin Exp Allergy (2003) 0.87

The role of intestinal dendritic cells subsets in the establishment of food allergy. Clin Exp Allergy (2011) 0.86

Oral tolerance and Treg cells are induced in BALB/c mice after gavage with bovine β-lactoglobulin. Allergy (2011) 0.86

Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendations. Regul Toxicol Pharmacol (2011) 0.86

Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops. Regul Toxicol Pharmacol (2009) 0.85

Recent developments with B-cell epitope identification for predictive studies. J Immunotoxicol (2006) 0.85

Continued expression of anti-soy protein antibodies in rats bred on a soy protein-free diet for one generation: the importance of dietary control in oral sensitization research. J Allergy Clin Immunol (1998) 0.84

Digested Ara h 1 has sensitizing capacity in Brown Norway rats. Clin Exp Allergy (2009) 0.84

Sensitization prevalence, antibody cross-reactivity and immunogenic peptide profile of Api g 2, the non-specific lipid transfer protein 1 of celery. PLoS One (2011) 0.82

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. Cell Mol Life Sci (2010) 0.82

Sensitization with 7S globulins from peanut, hazelnut, soy or pea induces IgE with different biological activities which are modified by soy tolerance. Int Arch Allergy Immunol (2011) 0.82

Toxicology in the 21st century--working our way towards a visionary reality. Toxicol In Vitro (2011) 0.81

Bet v 1 and its homologous food allergen Api g 1 stimulate dendritic cells from birch pollen-allergic individuals to induce different Th-cell polarization. Allergy (2010) 0.81

Genetic engineering and the allergy issue. Plant Physiol (2001) 0.81

Humoral and cellular immune responses in different rat strains on oral exposure to ovalbumin. Food Chem Toxicol (1999) 0.81

Oral sensitization to peanut is highly enhanced by application of peanut extracts to intact skin, but is prevented when CpG and cholera toxin are added. Int Arch Allergy Immunol (2006) 0.81

Genetically modified α-amylase inhibitor peas are not specifically allergenic in mice. PLoS One (2013) 0.81

Sensitizing properties of proteins: executive summary. Clin Transl Allergy (2014) 0.80

The application of post-market monitoring to novel foods. Food Chem Toxicol (2007) 0.79

Workshop overview: approaches to the assessment of the allergenic potential of food from genetically modified crops. Toxicol Sci (2003) 0.79

A comparative study of the allergenic potency of wild-type and glyphosate-tolerant gene-modified soybean cultivars. APMIS (2004) 0.79

Suggested improvements for the allergenicity assessment of genetically modified plants used in foods. Curr Allergy Asthma Rep (2011) 0.79

Allergenic and immunogenic potential of cow's milk β-lactoglobulin and caseins evidenced without adjuvant in germ-free mice. Mol Nutr Food Res (2011) 0.79

Serum testing of genetically modified soybeans with special emphasis on potential allergenicity of the heterologous protein CP4 EPSPS. Mol Nutr Food Res (2007) 0.79

A cross-sectional study among detergent workers exposed to liquid detergent enzymes. Occup Environ Med (2009) 0.78

Challenges in testing genetically modified crops for potential increases in endogenous allergen expression for safety. Allergy (2012) 0.78

T-cell epitope mapping. Ann Allergy Asthma Immunol (2009) 0.78

Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells. Toxicol In Vitro (2009) 0.77

The local lymph node assay and skin sensitization testing. Methods Mol Biol (2010) 0.76

B-cell epitope engineering: A matter of recognizing protein features and motives. Drug Discov Today Technol (2008) 0.76

Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats. Toxicology (2007) 0.76

Articles by these authors

Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE). Arch Toxicol (2014) 2.91

Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools. J Mol Recognit (2007) 2.02

Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J (2002) 1.66

Clinical Use of Probiotics in Pediatric Allergy (CUPPA): A World Allergy Organization Position Paper. World Allergy Organ J (2012) 1.60

Nomenclature and structural biology of allergens. J Allergy Clin Immunol (2006) 1.45

Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem (2008) 1.35

Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol (2006) 1.30

Proteases as Th2 adjuvants. Curr Allergy Asthma Rep (2007) 1.30

Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production. J Immunol (2012) 1.24

The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. J Allergy Clin Immunol (2010) 1.20

Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J Mol Biol (2005) 1.15

Evaluating the effect of food processing on the potential human allergenicity of novel proteins: international workshop report. Food Chem Toxicol (2007) 1.13

Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy. Vaccine (2003) 1.10

IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3. J Allergy Clin Immunol (2013) 1.07

Distribution of peanut allergen in the environment. J Allergy Clin Immunol (2004) 1.06

Molecular determinants for antibody binding on group 1 house dust mite allergens. J Biol Chem (2011) 1.05

Use of native lactococci as vehicles for delivery of DNA into mammalian epithelial cells. Appl Environ Microbiol (2006) 1.05

Genetic basis and detection of unintended effects in genetically modified crop plants. Transgenic Res (2015) 1.04

Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol (2008) 1.03

Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. Int Arch Allergy Immunol (2005) 1.02

Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergy. J Allergy Clin Immunol (2007) 1.01

Cockroach allergen Bla g 2: an unusual aspartic proteinase. J Allergy Clin Immunol (2005) 1.01

Molecular diagnosis of fruit and vegetable allergy. Curr Opin Allergy Clin Immunol (2011) 1.00

Evaluation of protein safety in the context of agricultural biotechnology. Food Chem Toxicol (2008) 0.99

IgE-mediated food allergy diagnosis: Current status and new perspectives. Mol Nutr Food Res (2007) 0.98

Research needs in allergy: an EAACI position paper, in collaboration with EFA. Clin Transl Allergy (2012) 0.97

Efficient production and secretion of bovine beta-lactoglobulin by Lactobacillus casei. Microb Cell Fact (2007) 0.96

Der p 5 crystal structure provides insight into the group 5 dust mite allergens. J Biol Chem (2010) 0.94

Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients. FASEB J (2003) 0.94

Effect of heating and glycation on the allergenicity of 2S albumins (Ara h 2/6) from peanut. PLoS One (2011) 0.94

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding. PLoS One (2011) 0.94

Immunological and metabolomic impacts of administration of Cry1Ab protein and MON 810 maize in mouse. PLoS One (2011) 0.93

Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody. J Immunol (2010) 0.93

Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level. Eur J Immunol (2003) 0.93

In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars. J Allergy Clin Immunol (2005) 0.93

Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. Mol Nutr Food Res (2008) 0.93

An in silico method using an epitope motif database for predicting the location of antigenic determinants on proteins in a structural context. J Mol Recognit (2005) 0.92

Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens. J Allergy Clin Immunol (2010) 0.91

Enzyme immunoassay for a urinary metabolite of 4-hydroxynonenal as a marker of lipid peroxidation. Free Radic Biol Med (2005) 0.91

The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment. J Allergy Clin Immunol (2013) 0.91

Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi. J Allergy Clin Immunol (2012) 0.91

Purification and characterisation of a panel of peanut allergens suitable for use in allergy diagnosis. Mol Nutr Food Res (2008) 0.89

Bla g 6: a troponin C allergen from Blattella germanica with IgE binding calcium dependence. J Allergy Clin Immunol (2006) 0.89

Intranasal coadministration of live lactococci producing interleukin-12 and a major cow's milk allergen inhibits allergic reaction in mice. Clin Vaccine Immunol (2007) 0.88

Efficacy of recombinant allergens for diagnosis of cockroach allergy in patients with asthma and/or rhinitis. Int Arch Allergy Immunol (2013) 0.88

A novel approach for investigation of specific and cross-reactive IgE epitopes on Bet v 1 and homologous food allergens in individual patients. Mol Immunol (2006) 0.88

Silencing the major apple allergen Mal d 1 by using the RNA interference approach. J Allergy Clin Immunol (2005) 0.88

Characterization of a Lactococcus lactis strain that secretes a major epitope of bovine beta-lactoglobulin and evaluation of its immunogenicity in mice. Appl Environ Microbiol (2003) 0.88

Purification and structural stability of the peach allergens Pru p 1 and Pru p 3. Mol Nutr Food Res (2008) 0.87

Differential T-cell responses and allergen uptake after exposure of dendritic cells to the birch pollen allergens Bet v 1.0101, Bet v 1.0401 and Bet v 1.1001. Immunobiology (2009) 0.87

Validation of a phage display and computational algorithm by mapping a conformational epitope of Bla g 2. Int Arch Allergy Immunol (2011) 0.87

Assessment of component-resolved in vitro diagnosis of celeriac allergy. J Allergy Clin Immunol (2009) 0.87

Quantitation of soybean allergens using tandem mass spectrometry. J Proteome Res (2010) 0.87

Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendations. Regul Toxicol Pharmacol (2011) 0.86

Kiwifruit allergy across Europe: clinical manifestation and IgE recognition patterns to kiwifruit allergens. J Allergy Clin Immunol (2012) 0.86

Recent developments with B-cell epitope identification for predictive studies. J Immunotoxicol (2006) 0.85

Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity. BMC Plant Biol (2008) 0.85

Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma. Contrib Microbiol (2007) 0.85

Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides. PLoS One (2013) 0.85

Boiling peanut Ara h 1 results in the formation of aggregates with reduced allergenicity. Mol Nutr Food Res (2011) 0.85

Recombinant allergens for diagnosis of cockroach allergy. Curr Allergy Asthma Rep (2014) 0.85

Murine models for evaluating the allergenicity of novel proteins and foods. Regul Toxicol Pharmacol (2008) 0.84

Effect of postharvest storage on the expression of the apple allergen Mal d 1. J Agric Food Chem (2006) 0.84

Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration. J Leukoc Biol (2013) 0.84

In vitro digestion of Cry1Ab proteins and analysis of the impact on their immunoreactivity. J Agric Food Chem (2010) 0.84

Component-resolved IgE profiles in Austrian patients with a convincing history of peanut allergy. Int Arch Allergy Immunol (2015) 0.83

Current and future methods for evaluating the allergenic potential of proteins: international workshop report 23-25 October 2007. Food Chem Toxicol (2008) 0.83

Scientific advancement of novel protein allergenicity evaluation: an overview of work from the HESI Protein Allergenicity Technical Committee (2000-2008). Food Chem Toxicol (2009) 0.82

Sensitization with 7S globulins from peanut, hazelnut, soy or pea induces IgE with different biological activities which are modified by soy tolerance. Int Arch Allergy Immunol (2011) 0.82

The diagnosis of food allergy: protocol for a systematic review. Clin Transl Allergy (2013) 0.82

Molecular characterization of recombinant T1, a non-allergenic periwinkle (Catharanthus roseus) protein, with sequence similarity to the Bet v 1 plant allergen family. Biochem J (2003) 0.82

Block copolymers have differing adjuvant effects on the primary immune response elicited by genetic immunization and on further induced allergy. Clin Vaccine Immunol (2009) 0.82

Implementation challenges for designing integrated in vitro testing strategies (ITS) aiming at reducing and replacing animal experimentation. Toxicol In Vitro (2012) 0.82

Purification and characterisation of relevant natural and recombinant apple allergens. Mol Nutr Food Res (2008) 0.81

Toxicology in the 21st century--working our way towards a visionary reality. Toxicol In Vitro (2011) 0.81

Breast milk alpha-defensins are associated with HIV type 1 RNA and CC chemokines in breast milk but not vertical HIV type 1 transmission. AIDS Res Hum Retroviruses (2007) 0.81

Oral sensitization to peanut is highly enhanced by application of peanut extracts to intact skin, but is prevented when CpG and cholera toxin are added. Int Arch Allergy Immunol (2006) 0.81

Towards defining molecular determinants recognized by adaptive immunity in allergic disease: an inventory of the available data. J Allergy (Cairo) (2011) 0.81

Allergy therapy by intranasal administration with recombinant Lactococcus lactis Producing bovine beta-lactoglobulin. Int Arch Allergy Immunol (2009) 0.81

Lab scale and medium scale production of recombinant allergens in Escherichia coli. Methods (2004) 0.81

An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010". ALTEX (2011) 0.80

Digested Ara h 1 loses sensitizing capacity when separated into fractions. J Agric Food Chem (2012) 0.80

Structure of the major carrot allergen Dau c 1. Acta Crystallogr D Biol Crystallogr (2009) 0.80

Cysteine proteinase inhibitor Act d 4 is a functional allergen contributing to the clinical symptoms of kiwifruit allergy. Mol Nutr Food Res (2010) 0.80

Every cockroach is beautiful to its mother. Int Arch Allergy Immunol (2013) 0.80

Update on optimized purification and characterization of natural milk allergens. Mol Nutr Food Res (2008) 0.80

Isolation of high-affinity human IgE and IgG antibodies recognising Bet v 1 and Humicola lanuginosa lipase from combinatorial phage libraries. Mol Immunol (2004) 0.80

The panel of egg allergens, Gal d 1-Gal d 5: Their improved purification and characterization. Mol Nutr Food Res (2008) 0.80

Immunotoxicology: opportunities for non-animal test development. Altern Lab Anim (2009) 0.79

Immunochemical characterisation of structure and allergenicity of peanut 2S albumins using different formats of immunoassays. Anal Bioanal Chem (2009) 0.79

Delayed bacterial colonization of the gut alters the host immune response to oral sensitization against cow's milk proteins. Mol Nutr Food Res (2012) 0.79

Allergenic and immunogenic potential of cow's milk β-lactoglobulin and caseins evidenced without adjuvant in germ-free mice. Mol Nutr Food Res (2011) 0.79

Production and characterization of an allergen panel for component-resolved diagnosis of celery allergy. Mol Nutr Food Res (2008) 0.79

Toxicological evaluation of proteins introduced into food crops. Crit Rev Toxicol (2013) 0.79

Differences in the allergenicity of 6 different kiwifruit cultivars analyzed by prick-to-prick testing, open food challenges, and ELISA. J Allergy Clin Immunol (2010) 0.79

Synthesis of cross-reactive carbohydrate determinants fragments as tools for in vitro allergy diagnosis. Bioorg Med Chem (2010) 0.78

Trypsin resistance of the major peanut allergen Ara h 6 and allergenicity of the digestion products are abolished after selective disruption of disulfide bonds. Mol Nutr Food Res (2012) 0.78

Evaluating biological variation in non-transgenic crops: executive summary from the ILSI Health and Environmental Sciences Institute workshop, November 16-17, 2009, Paris, France. Regul Toxicol Pharmacol (2010) 0.78

The utility of an international sera bank for use in evaluating the potential human allergenicity of novel proteins. Toxicol Sci (2007) 0.78