Published in Proc Natl Acad Sci U S A on July 16, 2002
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev (2008) 6.18
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell (2003) 4.63
Cellular strategies for controlling protein aggregation. Nat Rev Mol Cell Biol (2010) 3.54
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci U S A (2009) 3.44
Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol (2010) 3.36
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A (2004) 2.89
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell (2009) 2.87
FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol (2013) 2.83
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell (2010) 2.66
Polyglutamine neurodegeneration: protein misfolding revisited. Trends Neurosci (2008) 2.63
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell (2008) 2.32
The aging stress response. Mol Cell (2010) 2.19
The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci (2008) 2.10
Aging as an event of proteostasis collapse. Cold Spring Harb Perspect Biol (2011) 2.06
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet (2008) 2.03
The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation. Nat Struct Mol Biol (2009) 1.98
The biology of proteostasis in aging and disease. Annu Rev Biochem (2015) 1.96
Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol (2010) 1.93
Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression. Proc Natl Acad Sci U S A (2006) 1.85
A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A (2003) 1.84
Protein homeostasis and aging in neurodegeneration. J Cell Biol (2010) 1.76
Hypertonic stress induces rapid and widespread protein damage in C. elegans. Am J Physiol Cell Physiol (2011) 1.75
Cellular strategies of protein quality control. Cold Spring Harb Perspect Biol (2011) 1.74
The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug. J Mol Biol (2012) 1.70
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol (2008) 1.69
Cellular stress response pathways and ageing: intricate molecular relationships. EMBO J (2011) 1.66
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. PLoS Genet (2007) 1.66
Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol (2011) 1.64
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. PLoS One (2010) 1.62
DNA instability in postmitotic neurons. Proc Natl Acad Sci U S A (2008) 1.61
Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity. PLoS Genet (2009) 1.56
Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2008) 1.54
Modulation of the maladaptive stress response to manage diseases of protein folding. PLoS Biol (2014) 1.54
Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase. Curr Biol (2014) 1.54
Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell (2015) 1.50
Protein homeostasis in models of aging and age-related conformational disease. Adv Exp Med Biol (2010) 1.48
Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proc Natl Acad Sci U S A (2011) 1.46
Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab (2010) 1.46
Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. Proc Natl Acad Sci U S A (2002) 1.46
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A (2008) 1.44
Spontaneous age-related neurite branching in Caenorhabditis elegans. J Neurosci (2011) 1.44
Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization. J Mol Biol (2008) 1.43
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells. Genes Dev (2007) 1.43
Chaperone networks: tipping the balance in protein folding diseases. Neurobiol Dis (2010) 1.42
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis. Cold Spring Harb Perspect Biol (2011) 1.41
Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener (2015) 1.41
The nascent polypeptide-associated complex is a key regulator of proteostasis. EMBO J (2013) 1.40
Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity. Cell (2015) 1.39
The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils. J Am Chem Soc (2011) 1.37
Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence. J Mol Biol (2012) 1.37
Integrating the stress response: lessons for neurodegenerative diseases from C. elegans. Trends Cell Biol (2008) 1.36
FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci (2014) 1.32
Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. Aging Cell (2011) 1.26
Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis. Nat Chem Biol (2010) 1.26
Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. PLoS One (2007) 1.25
O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol (2009) 1.22
Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Mol Cell Biol (2003) 1.21
Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Am J Physiol Cell Physiol (2008) 1.20
A genetic screening strategy identifies novel regulators of the proteostasis network. PLoS Genet (2011) 1.19
TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling. Hum Mol Genet (2011) 1.19
Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal (2011) 1.18
Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments. J Mol Biol (2011) 1.17
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Rep (2014) 1.17
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proc Natl Acad Sci U S A (2012) 1.14
Discovery and characterization of a mammalian amyloid disaggregation activity. Protein Sci (2010) 1.13
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. EMBO J (2011) 1.13
Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides. Biophys Chem (2011) 1.13
Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell (2009) 1.13
A FRET sensor for non-invasive imaging of amyloid formation in vivo. Chemphyschem (2011) 1.12
Genetics, life span, health span, and the aging process in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci (2012) 1.11
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell (2015) 1.10
Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem (2012) 1.10
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
Basic Caenorhabditis elegans methods: synchronization and observation. J Vis Exp (2012) 1.08
Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans. Pediatr Res (2009) 1.07
Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One (2011) 1.06
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab (2015) 1.05
Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Proc Natl Acad Sci U S A (2003) 1.05
Glucose delays age-dependent proteotoxicity. Aging Cell (2012) 1.05
Neurodegenerative processes in Huntington's disease. Cell Death Dis (2011) 1.03
Ageing and protein aggregation-mediated disorders: from invertebrates to mammals. Philos Trans R Soc Lond B Biol Sci (2011) 1.03
Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates. J Mol Biol (2011) 1.03
Autophagy - An Emerging Anti-Aging Mechanism. J Clin Exp Pathol (2012) 1.01
Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans. PLoS Genet (2013) 1.00
Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart. PLoS Genet (2013) 1.00
Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Mol Med (2009) 1.00
O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases. Proc Natl Acad Sci U S A (2012) 1.00
Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet (2011) 1.00
Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans. PLoS One (2011) 0.99
Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J Med Chem (2009) 0.99
What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases? Mol Neurodegener (2009) 0.98
A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Sci (2009) 0.98
Assays for studying nucleated aggregation of polyglutamine proteins. Methods (2011) 0.97
The impact of ataxin-1-like histidine insertions on polyglutamine aggregation. Protein Eng Des Sel (2009) 0.97
Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans. Neurobiol Dis (2010) 0.97
Aging and the aggregating proteome. Front Genet (2012) 0.97
The role of interruptions in polyQ in the pathology of SCA1. PLoS Genet (2013) 0.96
Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proc Natl Acad Sci U S A (2009) 0.96
C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. PLoS Genet (2012) 0.96
The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem (2011) 0.95
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature (1997) 13.09
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell (1996) 12.59
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science (1997) 11.60
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene (2001) 11.09
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell (1997) 9.57
A Drosophila model of Parkinson's disease. Nature (2000) 7.82
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell (1998) 7.13
Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet (1993) 6.53
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature (1996) 6.32
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell (1998) 6.24
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science (2001) 6.15
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nat Genet (1993) 5.82
Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nat Genet (1993) 5.70
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics (1988) 5.60
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J (2000) 5.30
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans. Gene (1990) 5.27
Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A (1995) 5.18
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet (1999) 4.93
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology. Proc Natl Acad Sci U S A (1999) 4.58
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Nat Genet (1998) 4.27
A conserved regulatory system for aging. Cell (2001) 4.19
A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions. Proc Natl Acad Sci U S A (2000) 4.19
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (2001) 4.13
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell (1998) 4.07
Identification of genes that modify ataxin-1-induced neurodegeneration. Nature (2000) 4.02
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci U S A (2000) 4.01
Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1993) 3.97
Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc Natl Acad Sci U S A (2000) 3.82
Glutamine repeats and neurodegenerative diseases: molecular aspects. Trends Biochem Sci (1999) 3.48
The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size. Am J Hum Genet (1997) 2.84
Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity. J Mol Biol (2001) 2.80
Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2000) 2.63
An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics (1998) 2.46
Deadly conformations--protein misfolding in prion disease. Cell (1997) 2.30
Conformational disease. Nat Cell Biol (2000) 2.29
Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. Cell (1997) 2.13
Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila. Hum Mol Genet (2000) 2.04
Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proc Natl Acad Sci U S A (1999) 1.84
Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human. Nat Genet (2000) 1.67
Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proc Natl Acad Sci U S A (2001) 1.53
Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc Natl Acad Sci U S A (1990) 1.51
Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold. Am J Hum Genet (1999) 1.45
Beyond the Qs in the polyglutamine diseases. Genes Dev (2001) 1.41
Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. J Biol Chem (1994) 1.38
Gene expression in the Caenorhabditis elegans dauer larva: developmental regulation of Hsp90 and other genes. Dev Biol (1992) 1.23
Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults. J Mol Biol (2000) 1.22
Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract. Hum Mol Genet (2000) 1.04
Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. Exp Neurol (1999) 0.92
Adapting proteostasis for disease intervention. Science (2008) 13.22
Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science (2006) 5.39
Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (2009) 4.80
Heat shock factors: integrators of cell stress, development and lifespan. Nat Rev Mol Cell Biol (2010) 4.63
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell (2003) 4.63
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci U S A (2009) 3.44
Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem (2005) 2.95
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A (2004) 2.89
Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science (2008) 2.59
Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J Cell Sci (2002) 2.58
Molecular chaperones and the stress of oncogenesis. Oncogene (2004) 2.51
Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem (2004) 2.45
Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state. Nat Cell Biol (2006) 2.37
Inefficient degradation of truncated polyglutamine proteins by the proteasome. EMBO J (2004) 2.24
Polyglutamine protein aggregates are dynamic. Nat Cell Biol (2002) 2.21
The biology of proteostasis in aging and disease. Annu Rev Biochem (2015) 1.96
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. J Biol Chem (2006) 1.91
Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates. J Cell Biol (2005) 1.74
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell (2008) 1.69
Regulation of organismal proteostasis by transcellular chaperone signaling. Cell (2013) 1.66
Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. J Neurosci (2006) 1.65
Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol (2011) 1.64
Metazoan Hsp70 machines use Hsp110 to power protein disaggregation. EMBO J (2012) 1.62
In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress. J Cell Biol (2002) 1.59
Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity. PLoS Genet (2009) 1.56
Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments. Genetics (2004) 1.49
The stress of protein misfolding: from single cells to multicellular organisms. Cold Spring Harb Perspect Biol (2011) 1.48
Protein homeostasis in models of aging and age-related conformational disease. Adv Exp Med Biol (2010) 1.48
Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med (2014) 1.47
Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proc Natl Acad Sci U S A (2011) 1.46
Huntingtin and mutant SOD1 form aggregate structures with distinct molecular properties in human cells. J Biol Chem (2005) 1.46
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells. Genes Dev (2007) 1.43
Chaperone networks: tipping the balance in protein folding diseases. Neurobiol Dis (2010) 1.42
The nascent polypeptide-associated complex is a key regulator of proteostasis. EMBO J (2013) 1.40
Integrating the stress response: lessons for neurodegenerative diseases from C. elegans. Trends Cell Biol (2008) 1.36
Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell (2003) 1.32
Huntington's disease: underlying molecular mechanisms and emerging concepts. Trends Biochem Sci (2013) 1.31
The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging. Adv Exp Med Biol (2007) 1.30
Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. J Med Chem (2011) 1.22
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Cell Rep (2013) 1.20
A genetic screening strategy identifies novel regulators of the proteostasis network. PLoS Genet (2011) 1.19
Modeling polyglutamine pathogenesis in C. elegans. Methods Enzymol (2006) 1.15
Mathematical modeling of the eukaryotic heat-shock response: dynamics of the hsp70 promoter. Biophys J (2004) 1.15
A cellular perspective on conformational disease: the role of genetic background and proteostasis networks. Curr Opin Struct Biol (2010) 1.13
Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2010) 1.12
Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem (2012) 1.10
Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2009) 1.08
Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. J Biol Chem (2001) 1.08
Identification of a tissue-selective heat shock response regulatory network. PLoS Genet (2013) 1.07
Disease-modifying pathways in neurodegeneration. J Neurosci (2006) 1.06
Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proc Natl Acad Sci U S A (2014) 1.05
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. Hum Mol Genet (2007) 1.03
Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans. PLoS Genet (2013) 1.00
Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet (2011) 1.00
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorg Med Chem (2010) 0.99
Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases. Dis Model Mech (2014) 0.92
Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease. J Biol Chem (2013) 0.91
Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. ACS Chem Biol (2012) 0.90
Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Dev Dyn (2010) 0.90
In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proc Natl Acad Sci U S A (2012) 0.89
Macro-level modeling of the response of C. elegans reproduction to chronic heat stress. PLoS Comput Biol (2012) 0.88
Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorg Med Chem (2011) 0.87
Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses. J Exp Biol (2014) 0.86
raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis. Dev Biol (2012) 0.85
Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. J Am Chem Soc (2011) 0.85
Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX. J Struct Biol (2012) 0.84
Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1. ACS Chem Biol (2014) 0.84
Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease. BMC Biol (2013) 0.84
Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo. J Biol Chem (2012) 0.84
Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo. Biophys J (2005) 0.83
Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1. Genes Cells (2014) 0.82
Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. ACS Med Chem Lett (2012) 0.81
Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response. PLoS Genet (2013) 0.80
Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis. ACS Chem Neurosci (2014) 0.78
Ribosome-associated chaperones act as proteostasis sentinels. Cell Cycle (2013) 0.78
Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. J Med Chem (2013) 0.78
Peptides signal mitochondrial stress. Cell Metab (2010) 0.77
Physically grounded approach for estimating gene expression from microarray data. Proc Natl Acad Sci U S A (2010) 0.76
Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell (2017) 0.75
Correction to "Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS". ACS Med Chem Lett (2017) 0.75