Published in PLoS One on April 21, 2014
A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin. PLoS One (2015) 0.80
Optineurin: The autophagy connection. Exp Eye Res (2015) 0.78
Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics. PLoS One (2014) 0.76
From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models. Toxicol Sci (2016) 0.75
Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep (2016) 0.75
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Primary open-angle glaucoma. Lancet (2004) 7.63
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci U S A (2002) 6.84
Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science (2002) 6.53
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46
Mutations of optineurin in amyotrophic lateral sclerosis. Nature (2010) 4.54
A forensic path to RGC-5 cell line identification: lessons learned. Invest Ophthalmol Vis Sci (2013) 3.31
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma. FEBS Lett (2008) 2.17
Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr Biol (2007) 1.98
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol (2007) 1.95
Swelling and loss of photoreceptors in chronic human and experimental glaucomas. Arch Ophthalmol (2000) 1.89
Recharacterization of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci (2009) 1.74
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Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim Biophys Acta (2012) 1.43
Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection. PLoS Pathog (2010) 1.39
Different optineurin mutation pattern in primary open-angle glaucoma. Invest Ophthalmol Vis Sci (2003) 1.36
Neuronal autophagy and neurodegenerative diseases. Exp Mol Med (2012) 1.28
Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma. Invest Ophthalmol Vis Sci (2004) 1.28
NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB. PLoS One (2009) 1.18
Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation. Cell Mol Life Sci (2011) 1.17
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Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging. Br J Ophthalmol (2010) 1.13
Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Hum Mol Genet (2010) 1.13
Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population. J Glaucoma (2004) 1.10
NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein. PLoS Pathog (2009) 1.08
Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma. Hum Mol Genet (2013) 1.06
Processing of optineurin in neuronal cells. J Biol Chem (2010) 1.04
Toward an integrative view of Optineurin functions. Cell Cycle (2012) 1.04
Cellular and molecular biology of optineurin. Int Rev Cell Mol Biol (2012) 1.02
Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression. Mol Cell (2012) 1.02
A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants. Invest Ophthalmol Vis Sci (2007) 1.02
Impairment of protein trafficking upon overexpression and mutation of optineurin. PLoS One (2010) 1.01
Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss mice. Exp Eye Res (2010) 0.98
Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation. PLoS One (2011) 0.98
M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy (2013) 0.96
Variation in optineurin (OPTN) allele frequencies between and within populations. Mol Vis (2007) 0.94
Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain. J Biol Chem (2003) 0.94
Functional damage to inner and outer retinal cells in experimental glaucoma. Invest Ophthalmol Vis Sci (2003) 0.93
Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant. BMC Cell Biol (2010) 0.93
Optineurin in neurodegenerative diseases. Neuropathology (2011) 0.92
Decrease of cone opsin mRNA in experimental ocular hypertension. Mol Vis (2006) 0.92
Anatomical and functional damage in experimental glaucoma. Curr Opin Pharmacol (2012) 0.90
Optineurin and its mutants: molecules associated with some forms of glaucoma. Ophthalmic Res (2009) 0.89
Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER. J Cell Sci (2006) 0.89
Defining the pathogenicity of optineurin in juvenile open-angle glaucoma. Invest Ophthalmol Vis Sci (2004) 0.88
Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17. J Cell Sci (2012) 0.87
A novel optineurin genetic mutation associated with open-angle glaucoma in a Chinese family. Mol Vis (2009) 0.81
How to design a highly effective siRNA. J Biosci (2004) 0.81