Published in Biochim Biophys Acta on December 05, 2012
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Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration. Biomed Res Int (2014) 1.13
Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. EMBO Rep (2015) 1.09
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Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication. J Virol (2014) 1.04
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How to take autophagy and endocytosis up a notch. Biomed Res Int (2014) 0.85
A Vps21 endocytic module regulates autophagy. Mol Biol Cell (2014) 0.85
A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy (2015) 0.84
Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation. Mol Cell Biol (2015) 0.81
Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice. Autophagy (2015) 0.81
LRRK2 transport is regulated by its novel interacting partner Rab32. PLoS One (2014) 0.80
Vaccinia Virus Infection Requires Maturation of Macropinosomes. Traffic (2015) 0.80
E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy. PLoS One (2014) 0.80
High ω3-polyunsaturated fatty acids in fat-1 mice prevent streptozotocin-induced Purkinje cell degeneration through BDNF-mediated autophagy. Sci Rep (2015) 0.79
Rab-mediated vesicle trafficking in cancer. J Biomed Sci (2016) 0.78
Endolysosomal two-pore channels regulate autophagy in cardiomyocytes. J Physiol (2016) 0.78
Drosophila Vps13 Is Required for Protein Homeostasis in the Brain. PLoS One (2017) 0.78
Charcot-Marie-Tooth 2b associated Rab7 mutations cause axon growth and guidance defects during vertebrate sensory neuron development. Neural Dev (2016) 0.78
Arf-like GTPase Arl8: Moving from the periphery to the center of lysosomal biology. Cell Logist (2015) 0.78
The activation of KSHV lytic cycle blocks autophagy in PEL cells. Autophagy (2015) 0.78
Autophagic flux, a possible mechanism for delayed gentamicin-induced ototoxicity. Sci Rep (2017) 0.78
LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes. Biol Open (2016) 0.78
Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs. J Clin Invest (2017) 0.77
Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells. Oncotarget (2017) 0.77
Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO. Cancers (Basel) (2014) 0.77
Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells. J Biol Chem (2016) 0.77
Intact endothelial autophagy is required to maintain vascular lipid homeostasis. Aging Cell (2015) 0.77
HBV secretion is regulated through the activation of endocytic and autophagic compartments mediated by Rab7 stimulation. J Cell Sci (2015) 0.76
Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A. Autophagy (2016) 0.76
Spatio-temporal uncoupling of miRNA-mediated translational repression and target RNA degradation controls miRNP recycling in mammalian cells. Mol Cell Biol (2016) 0.76
Intermittent fasting is neuroprotective in focal cerebral ischemia by minimizing autophagic flux disturbance and inhibiting apoptosis. Exp Ther Med (2016) 0.76
"Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders. J Neuromuscul Dis (2016) 0.76
High mannose-binding Pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells. BMC Cancer (2016) 0.76
Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila. PLoS Genet (2015) 0.75
MMP-2 and 9 in Chronic Kidney Disease. Int J Mol Sci (2017) 0.75
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. Elife (2017) 0.75
Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. J Biol Chem (2017) 0.75
The Intracellular Cholesterol Transport Inhibitor U18666A Inhibits the Exosome-Dependent Release of Mature Hepatitis C Virus. J Virol (2016) 0.75
A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. Sci Rep (2016) 0.75
Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation. Oncotarget (2015) 0.75
Docosahexaenoic acid-supplementation prior to fasting prevents muscle atrophy in mice. J Cachexia Sarcopenia Muscle (2016) 0.75
Autophagy and Autophagy-Related Proteins in CNS Autoimmunity. Front Immunol (2017) 0.75
Regulation of mTORC1 by lysosomal calcium and calmodulin. Elife (2016) 0.75
Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging. Int J Mol Sci (2017) 0.75
The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals. EMBO J (2017) 0.75
Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis (2016) 0.75
A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells. Sci Rep (2016) 0.75
Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation. Cell Death Dis (2017) 0.75
The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. Nat Commun (2017) 0.75
HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy. Sci Rep (2017) 0.75
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AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) (2011) 2.26
Clusterin: a forgotten player in Alzheimer's disease. Brain Res Rev (2009) 2.00
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev (2007) 1.96
Regulation of the aging process by autophagy. Trends Mol Med (2009) 1.69
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal (2013) 1.65
Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) (2012) 1.58
Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors. Prog Neurobiol (2009) 1.57
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev (2011) 1.53
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J Neuroinflammation (2009) 1.46
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD). Immunol Lett (2012) 1.46
Celastrol: Molecular targets of Thunder God Vine. Biochem Biophys Res Commun (2010) 1.45
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal (2011) 1.41
Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers. Acta Ophthalmol Suppl (Oxf ) (2008) 1.39
Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling. Cell Signal (2009) 1.34
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy (2013) 1.34
Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. Acta Ophthalmol (2011) 1.31
Age-related macular degeneration (AMD): Alzheimer's disease in the eye? J Alzheimers Dis (2011) 1.30
SIRT1: regulation of longevity via autophagy. Cell Signal (2009) 1.29
Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication. Acta Ophthalmol (2010) 1.29
Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. J Neurosci (2007) 1.28
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. Eur J Neurosci (2011) 1.26
Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization. Mol Med (2010) 1.22
Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS One (2013) 1.20
Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol (2006) 1.19
Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell Mol Life Sci (2012) 1.19
Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90. Immunol Lett (2008) 1.18
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation? Bioessays (2008) 1.17
Regulatory role of HIF-1alpha in the pathogenesis of age-related macular degeneration (AMD). Ageing Res Rev (2009) 1.16
AMP-activated protein kinase: a potential player in Alzheimer's disease. J Neurochem (2011) 1.16
Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology. J Cell Mol Med (2008) 1.16
Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med (2008) 1.14
Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration. Int J Mol Sci (2013) 1.13
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol (2013) 1.12
Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging. Cell Signal (2010) 1.11
Heat shock proteins as gatekeepers of proteolytic pathways-Implications for age-related macular degeneration (AMD). Ageing Res Rev (2009) 1.10
NF-kappaB signaling in the aging process. J Clin Immunol (2009) 1.10
Protein aggregation and degradation mechanisms in neurodegenerative diseases. Am J Neurodegener Dis (2013) 1.09
Regulation of microglial inflammatory response by histone deacetylase inhibitors. J Neurochem (2003) 1.08
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cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. Biochim Biophys Acta (2002) 1.06
Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids. Br J Pharmacol (2004) 1.05
ER stress and hormetic regulation of the aging process. Ageing Res Rev (2010) 1.04
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation. Proc Natl Acad Sci U S A (2002) 1.04
Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process. Ageing Res Rev (2012) 1.03
Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells. J Neuroinflammation (2012) 1.03
Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. PLoS One (2008) 1.03
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog Neurobiol (2011) 1.02
Comparison of three intraocular pressure measurement methods including biomechanical properties of the cornea. Invest Ophthalmol Vis Sci (2014) 1.01
Apoptosis and aging: increased resistance to apoptosis enhances the aging process. Cell Mol Life Sci (2010) 1.01
An in silico approach to discovering novel inhibitors of human sirtuin type 2. J Med Chem (2004) 0.99
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Prog Neurobiol (2010) 0.99
Efflux protein expression in human retinal pigment epithelium cell lines. Pharm Res (2009) 0.97
Symptom score questionnaire for nasolacrimal duct obstruction in adults--a novel tool to assess the outcome after endoscopic dacryocystorhinostomy. Rhinology (2010) 0.97
Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors. J Med Chem (2008) 0.95
p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells. Mol Vis (2010) 0.95
Retinal arterial macroaneurysms. Acta Ophthalmol (2013) 0.95
Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons. Neurosci Lett (2004) 0.94
The role of topoisomerase II in the excision of DNA loop domains during apoptosis. J Biol Chem (2002) 0.93
A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices. J Neuroinflammation (2005) 0.93
Comparative and pharmacophore model for deacetylase SIRT1. J Comput Aided Mol Des (2006) 0.93
Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells. Biochem Biophys Res Commun (2007) 0.93
Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). Biogerontology (2013) 0.92
Siglec receptors and hiding plaques in Alzheimer's disease. J Mol Med (Berl) (2009) 0.90
A prospective study on postoperative pain after cataract surgery. Clin Ophthalmol (2013) 0.90
Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process. J Cell Physiol (2010) 0.90
Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating. Tissue Eng Part A (2014) 0.90
Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells. Neurosci Lett (2005) 0.89
Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization. Int J Biochem Cell Biol (2013) 0.89
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis. Mol Pharmacol (2006) 0.89
The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells. Immunol Lett (2007) 0.89
The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells. Mol Vis (2012) 0.88
Regression of necrotizing scleritis in Wegener's granulomatosis after infliximab treatment. Acta Ophthalmol (2009) 0.88
Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells. Eur J Pharmacol (2008) 0.88
N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors. J Med Chem (2009) 0.88
Selective regulation of class I and class II histone deacetylases expression by inhibitors of histone deacetylases in cultured mouse neural cells. Neurosci Lett (2004) 0.87
Immunolocalization of EMMPRIN (CD147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids. Curr Eye Res (2006) 0.87
Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process. Int J Cell Biol (2012) 0.87
Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney. Antioxid Redox Signal (2007) 0.87
Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells. Neurosci Lett (2003) 0.87
Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2. J Med Chem (2011) 0.87
Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells. J Neuroimmunol (2008) 0.87
Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone. Bioorg Med Chem (2008) 0.86
Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma. Mol Vis (2007) 0.86
Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease. Neurosci Lett (2010) 0.86
Interferon-β sensitivity of tumor cells correlates with poor response to VA7 virotherapy in mouse glioma models. Mol Ther (2012) 0.86
Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells. Pharmacol Res (2011) 0.85
ROCK, PAK, and Toll of synapses in Alzheimer's disease. Biochem Biophys Res Commun (2008) 0.85