The TRPV4 channel.

Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways. Cell Death Dis (2015) 0.90

L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel. Proc Natl Acad Sci U S A (2015) 0.83

TRPV1: A Target for Rational Drug Design. Pharmaceuticals (Basel) (2016) 0.82

Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy. Neurol Genet (2015) 0.80

Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice. Front Cell Neurosci (2015) 0.78

A channelopathy mechanism revealed by direct calmodulin activation of TrpV4. Proc Natl Acad Sci U S A (2015) 0.78

TRP functions in the broncho-pulmonary system. Semin Immunopathol (2016) 0.77

Activation of Transient Receptor Potential Vanilloid 4 Promotes the Proliferation of Stem Cells in the Adult Hippocampal Dentate Gyrus. Mol Neurobiol (2016) 0.76

TRPV4: physiological role and therapeutic potential in respiratory diseases. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.76

Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. PLoS One (2017) 0.75

Acidic microenvironment and bone pain in cancer-colonized bone. Bonekey Rep (2015) 0.75

Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. Am J Physiol Renal Physiol (2017) 0.75

Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons. Front Mol Neurosci (2016) 0.75

Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons. Front Physiol (2016) 0.75

Transition-metal-catalyzed direct arylation of (hetero)arenes by C-H bond cleavage. Angew Chem Int Ed Engl (2009) 2.29

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet (2010) 1.83

Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. J Clin Invest (2004) 1.70

TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol (2005) 1.68

Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem (2005) 1.61

Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation. Cardiovasc Res (2012) 1.45

TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. Proc Natl Acad Sci U S A (2008) 1.36

Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel. J Gen Physiol (2006) 1.33

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A (2009) 1.25

Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem (2004) 1.22

IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. J Cell Biol (2008) 1.22

Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction. J Hypertens (2008) 1.19

Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line. Am J Physiol Cell Physiol (2002) 1.19

Potassium channels: new targets in cancer therapy. Cancer Detect Prev (2006) 1.18

Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. Circ Res (2005) 1.16

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration. Hum Mol Genet (2007) 1.10

Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma. J Biol Chem (2010) 1.08

Kv1.3/Kv1.5 heteromeric channels compromise pharmacological responses in macrophages. Biochem Biophys Res Commun (2006) 1.08

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. J Clin Invest (2007) 1.05

Transient receptor potential genes, smoking, occupational exposures and cough in adults. Respir Res (2012) 1.02

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc Natl Acad Sci U S A (2013) 0.99

Copper-catalyzed "click" reaction/direct arylation sequence: modular syntheses of 1,2,3-triazoles. Org Lett (2008) 0.99

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain (2009) 0.96

KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies. J Cell Physiol (2005) 0.96

IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site. J Biol Chem (2008) 0.96

Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells. Neurobiol Aging (2007) 0.94

Cu(I)-catalyzed regioselective synthesis of polysubstituted furans from propargylic esters via postulated (2-furyl)carbene complexes. J Am Chem Soc (2008) 0.94

ORMDL3 modulates store-operated calcium entry and lymphocyte activation. Hum Mol Genet (2012) 0.93

Late-onset episodic ataxia type 2 associated with a novel loss-of-function mutation in the CACNA1A gene. J Neurol Sci (2009) 0.93

Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch (2008) 0.92

Plasma membrane voltage-dependent anion channel mediates antiestrogen-activated maxi Cl- currents in C1300 neuroblastoma cells. J Biol Chem (2003) 0.92

Rearrangement of propargylic esters: metal-based stereospecific synthesis of (E)- and (Z)-knoevenagel derivatives. J Am Chem Soc (2007) 0.91

Ruthenium-catalyzed regioselective direct alkylation of arenes with unactivated alkyl halides through C-H bond cleavage. Angew Chem Int Ed Engl (2009) 0.90

Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences. J Gen Physiol (2010) 0.89

A review of TRP channels splicing. Semin Cell Dev Biol (2006) 0.89

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis. PLoS One (2013) 0.87

The progesterone receptor regulates the expression of TRPV4 channel. Pflugers Arch (2009) 0.87

Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. J Biol Chem (2012) 0.86

Ruthenium-catalyzed direct arylations of N-aryl 1,2,3-triazoles with aryl chlorides as electrophiles. ChemSusChem (2009) 0.84

Assisted ruthenium-catalyzed C-H bond activation: carboxylic acids as cocatalysts for generally applicable direct arylations in apolar solvents. Org Lett (2008) 0.84

A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction. Cardiovasc Res (2011) 0.84

A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis. Proc Natl Acad Sci U S A (2010) 0.83

Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant. J Neurosci (2002) 0.83

Multiple Kv1.5 targeting to membrane surface microdomains. J Cell Physiol (2008) 0.83

Ion channels in asthma. J Biol Chem (2011) 0.82

The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition. Pflugers Arch (2009) 0.82

Metal-free direct arylations of indoles and pyrroles with diaryliodonium salts. Org Lett (2011) 0.82

Voltage-dependent K+ channel beta subunits in muscle: differential regulation during postnatal development and myogenesis. J Cell Physiol (2003) 0.82

Voltage-dependent anion channel localises to the plasma membrane and peripheral but not perinuclear mitochondria. Pflugers Arch (2003) 0.82

Chloride secretion in a morphologically differentiated human colonic cell line that expresses the epithelial Na+ channel. J Physiol (2003) 0.82

Gold-catalyzed synthesis of tetrahydrocarbazole derivatives through an intermolecular cycloaddition of vinyl indoles and N-allenamides. Chem Commun (Camb) (2013) 0.81

Air-stable secondary phosphine oxide as preligand for palladium-catalyzed intramolecular alpha-arylations with chloroarenes. Org Lett (2009) 0.80

Carboxylate-assisted ruthenium-catalyzed direct alkylations of ketimines. Org Lett (2011) 0.80

IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. J Gen Physiol (2008) 0.80

Mechanistic insight into direct arylations with ruthenium(II) carboxylate catalysts. Org Lett (2010) 0.80

Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death. Oxid Med Cell Longev (2013) 0.80

Catalytic direct arylations in polyethylene glycol (PEG): recyclable palladium(0) catalyst for C-H bond cleavages in the presence of air. Org Lett (2009) 0.79

BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating. Pflugers Arch (2013) 0.79

Highly chemo-, regio-, and stereoselective [3+2]-cyclization of activated and deactivated allenes with alkenyl Fischer carbene complexes: a straightforward access to alkylidenecyclopentanone derivatives. J Am Chem Soc (2006) 0.78

Gold-catalyzed functionalization of unactivated C(sp3)-H bonds by hydride transfer facilitated by alkynylspirocyclopropanes. Angew Chem Int Ed Engl (2012) 0.78

Mechanistic studies on the rearrangement of 1-alkenyl-2-alkynylcyclopropanes: from allylic gold(I) cations to stable carbocations. Angew Chem Int Ed Engl (2014) 0.77

Metal-controlled selective [3+2] cyclization reactions of alkenyl Fischer carbene complexes and allenes. J Am Chem Soc (2004) 0.77

Impaired voltage-gated K+ channel expression in brain during experimental cancer cachexia. FEBS Lett (2003) 0.77

Altered sarcoplasmic reticulum calcium transport in the presence of the heavy metal chelator TPEN. Cell Calcium (2009) 0.77

TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells. Elife (2013) 0.77

Base- and metal-free C-H direct arylations of naphthalene and other unbiased arenes with diaryliodonium salts. Chem Commun (Camb) (2012) 0.77

New Fischer carbene complexes of rhodium(i): preparation and 2-cyclopentenone ring synthesis by annelation to alkynes. J Am Chem Soc (2004) 0.77

Specific synthesis of 1,2- and 1,3-dialkylidenecycloheptanes by [3+2+2] cyclization of alkenyl Fischer carbene complexes and allenes. J Am Chem Soc (2004) 0.76

Ruthenium-catalyzed direct arylations through C-H bond cleavages. Top Curr Chem (2010) 0.76

Zinc-catalyzed synthesis of functionalized furans and triarylmethanes from enynones and alcohols or azoles: dual X-H bond activation by zinc. Angew Chem Int Ed Engl (2013) 0.76

Gold-catalyzed rearrangements: reaction pathways using 1-alkenyl-2-alkynylcyclopropane substrates. Angew Chem Int Ed Engl (2011) 0.76

Rhodium-catalyzed carbene transfer to alkynes via 2-furylcarbenes generated from enynones. Chem Commun (Camb) (2013) 0.75

Alkynylcyclopropanes from terminal alkynes through consecutive coupling to Fischer carbene complexes and selective propargylene transfer. Chemistry (2011) 0.75

Zinc-catalyzed cyclopropenation of alkynes via 2-furylcarbenoids. Org Lett (2014) 0.75

Correction: Cutting Edge: TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity. J Immunol (2016) 0.75

Zinc-catalyzed synthesis of 2-alkenylfurans via cross-coupling of enynones and diazo compounds. Chem Commun (Camb) (2014) 0.75

Transmetalation reactions from Fischer carbene complexes to late transition metals: a DFT study. Chemistry (2008) 0.75