Published in Eur J Immunol on September 01, 1989
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol (1994) 10.03
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol (1994) 4.34
CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J Virol (1996) 3.39
Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity. Proc Natl Acad Sci U S A (1995) 2.66
Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice. J Exp Med (1990) 2.59
Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide. J Exp Med (1990) 2.58
Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen. J Exp Med (1992) 2.22
Molecular basis of organ-specific selection of viral variants during chronic infection. J Virol (1991) 2.10
T cell priming versus T cell tolerance induced by synthetic peptides. J Exp Med (1995) 2.07
Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes. J Virol (1995) 1.90
Peptide-induced antiviral protection by cytotoxic T cells. Proc Natl Acad Sci U S A (1991) 1.89
A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge. J Virol (1993) 1.86
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought. J Virol (2006) 1.78
DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. J Virol (1997) 1.69
Restricted V-segment usage in T-cell receptors from cytotoxic T lymphocytes specific for a major epitope of lymphocytic choriomeningitis virus. J Virol (1990) 1.65
Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule. J Virol (1992) 1.64
Infection of lymphocytes by a virus that aborts cytotoxic T lymphocyte activity and establishes persistent infection. J Exp Med (1991) 1.62
Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon. J Virol (2002) 1.42
DNA vaccination against persistent viral infection. J Virol (1995) 1.33
Induction of protective cytotoxic T cell responses in the presence of high titers of virus-neutralizing antibodies: implications for passive and active immunization. J Exp Med (1998) 1.29
CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability. J Exp Med (2000) 1.29
Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. J Virol (1998) 1.21
Intralymphatic immunization enhances DNA vaccination. Proc Natl Acad Sci U S A (2001) 1.19
Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue. J Virol (1997) 1.14
Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization. J Virol (2000) 1.13
A common antiviral cytotoxic T-lymphocyte epitope for diverse major histocompatibility complex haplotypes: implications for vaccination. Proc Natl Acad Sci U S A (1992) 1.12
Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model. Proc Natl Acad Sci U S A (1994) 1.12
Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II. Virology (2007) 1.11
Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus. J Virol (2000) 1.09
Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses. J Virol (2008) 1.08
Neonatal DNA immunization with a plasmid encoding an internal viral protein is effective in the presence of maternal antibodies and protects against subsequent viral challenge. J Virol (1997) 1.03
Emergence of virus escape mutants after immunization with epitope vaccine. J Virol (1995) 1.01
Design of high-affinity major histocompatibility complex-specific antagonist peptides that inhibit cytotoxic T-lymphocyte activity: implications for control of viral disease. J Virol (1992) 0.99
A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge. Vaccine (2011) 0.97
CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting. J Virol (2001) 0.95
Borna disease virus nucleoprotein (p40) is a major target for CD8(+)-T-cell-mediated immune response. J Virol (1999) 0.94
Vaccination with a synthetic peptide modulates lymphocytic choriomeningitis virus-mediated immunopathology. J Virol (1992) 0.93
Cytotoxic T-lymphocyte epitopes fused to anthrax toxin induce protective antiviral immunity. Infect Immun (1999) 0.90
Extensive peptide ligand exchange by surface class I major histocompatibility complex molecules independent of exogenous beta 2-microglobulin. Proc Natl Acad Sci U S A (1992) 0.88
Generation of cellular immunity to lymphocytic choriomeningitis virus is independent of CD1d1 expression. Immunology (2001) 0.86
Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells. J Virol (2007) 0.85
CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene. Clin Exp Immunol (2000) 0.85
Specific prolongation of allograft survival by a T-cell-receptor-derived peptide. Proc Natl Acad Sci U S A (1993) 0.84
The peptide p2Ca is immunodominant in allorecognition of Ld by beta chain variable region V beta 8+ but not V beta 8- strains. Proc Natl Acad Sci U S A (1994) 0.84
Nuclear myxovirus-resistance protein Mx is a minor histocompatibility antigen. Proc Natl Acad Sci U S A (1990) 0.82
Stable antigen is most effective for eliciting CD8+ T-cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo. J Virol (2012) 0.81
Virus-specific, CD8+ major histocompatibility complex class I-restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus-infected beta2-microglobulin-deficient mice. J Virol (1997) 0.79
Molecular and functional dissection of the H-2Db-restricted subdominant cytotoxic T-cell response to lymphocytic choriomeningitis virus. J Virol (2001) 0.78
Specificity of the H-2 L(d)-restricted cytotoxic T-lymphocyte response to the mouse hepatitis virus nucleocapsid protein. J Virol (1996) 0.76
Functional role of type I and type II interferons in antiviral defense. Science (1994) 18.92
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol (1979) 15.58
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature (1974) 13.24
Immune response in mice that lack the interferon-gamma receptor. Science (1993) 12.15
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (1994) 11.22
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature (1993) 9.81
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? J Exp Med (1978) 9.51
Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity. Transplant Rev (1976) 8.10
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (1989) 7.52
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (1994) 7.34
Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature (1974) 6.99
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell (1991) 6.49
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature (1991) 5.98
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science (2000) 5.78
Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med (1998) 5.78
Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature (1990) 5.41
Evidence for a differential avidity model of T cell selection in the thymus. Cell (1994) 5.24
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell (1996) 4.74
Control of early viral and bacterial distribution and disease by natural antibodies. Science (1999) 4.73
T-cell-mediated immunopathology in viral infections. Transplant Rev (1974) 4.72
Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex. Nature (1975) 4.41
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol (1994) 4.34
The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help. J Exp Med (1978) 4.27
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J Virol (1995) 4.16
H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. J Exp Med (1975) 4.16
CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell (1991) 4.05
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature (1988) 4.04
Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature (2001) 3.99
Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature (1998) 3.78
Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J Virol Methods (1991) 3.78
Antigen localization and migration in immunity and tolerance. N Engl J Med (1998) 3.71
Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol (1998) 3.52
Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex. Nature (1975) 3.49
A biological role for the major histocompatibility antigens. Lancet (1975) 3.40
The influence of antigen organization on B cell responsiveness. Science (1993) 3.32
Immune responses in interleukin-2-deficient mice. Science (1993) 3.29
On immunity against infections and vaccines: credo 2004. Scand J Immunol (2004) 3.29
Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur J Immunol (1979) 3.27
IgA production without mu or delta chain expression in developing B cells. Nat Immunol (2001) 3.26
Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts. J Exp Med (1996) 3.26
On immunological memory. Annu Rev Immunol (1996) 3.21
A crucial role for B cells in neuroinvasive scrapie. Nature (1998) 3.19
Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin Exp Immunol (2005) 3.12
Functional analysis of T lymphocyte subsets in antiviral host defense. J Immunol (1987) 3.11
Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J Exp Med (1998) 3.03
Decreased tumor surveillance in perforin-deficient mice. J Exp Med (1996) 3.00
Immune defence in mice lacking type I and/or type II interferon receptors. Immunol Rev (1995) 2.97
Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol (1996) 2.96
Neutralizing antiviral B cell responses. Annu Rev Immunol (1997) 2.86
H-2 restriction of cell-mediated immunity to an intracellular bacterium: effector T cells are specific for Listeria antigen in association with H-21 region-coded self-markers. J Exp Med (1977) 2.71
Gene technology and democracy. Science (1997) 2.68
Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature (1991) 2.66
Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol Rev (1997) 2.58
Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide. J Exp Med (1990) 2.58
A non-retroviral RNA virus persists in DNA form. Nature (1997) 2.57
Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control. Immunol Rev (1978) 2.56
On the role of antigen in maintaining cytotoxic T-cell memory. Proc Natl Acad Sci U S A (1996) 2.55
Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Nature (1978) 2.51
Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. J Exp Med (1997) 2.47
The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur J Immunol (1995) 2.47
Structure and function of human perforin. Nature (1988) 2.47
The role of antibody concentration and avidity in antiviral protection. Science (1997) 2.45
H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras. J Exp Med (1976) 2.45
Characteristics of the interaction in vitro between cytotoxic thymus-derived lymphocytes and target monolayers infected with lymphocytic choriomeningitis virus. Scand J Immunol (1974) 2.42
Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc Natl Acad Sci U S A (1991) 2.41
PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat Med (1998) 2.40
Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse. Proc Natl Acad Sci U S A (1978) 2.38
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity. Cell (1986) 2.38
Natural antibodies and complement link innate and acquired immunity. Immunol Today (2000) 2.37
Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes. Nature (1974) 2.35
Complement facilitates early prion pathogenesis. Nat Med (2001) 2.30
Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment. Nature (1988) 2.28
Specific cytotoxic T cells eliminate B cells producing virus-neutralizing antibodies [corrected]. Nature (1996) 2.25