Published in Annu Rev Immunol on January 01, 1996
Immunity to murine chlamydial genital infection. Infect Immun (2002) 4.64
Migratory properties of naive, effector, and memory CD8(+) T cells. J Exp Med (2001) 4.17
Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. J Virol (1997) 3.93
The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J (1998) 3.17
High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability. Am J Pathol (1999) 2.80
Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. J Virol (2005) 2.75
Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood (2006) 2.42
Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nat Immunol (2002) 2.31
Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity. J Exp Med (2000) 2.30
Virus-specific CD8+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C. J Virol (2002) 2.26
Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs. J Exp Med (1999) 2.13
A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol (1999) 1.84
Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. J Exp Med (2000) 1.73
Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma. Am J Pathol (2002) 1.70
Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. J Exp Med (1998) 1.65
Protective CD8 T cells against Plasmodium liver stages: immunobiology of an 'unnatural' immune response. Immunol Rev (2008) 1.64
Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis. Arthritis Res Ther (2012) 1.55
Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs. J Virol (2008) 1.53
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells. J Exp Med (2015) 1.52
A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production. J Exp Med (2001) 1.48
A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma. J Exp Med (1997) 1.47
Kinetics of antiviral activity by human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL) and rapid selection of CTL escape virus in vitro. J Virol (1998) 1.39
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells. J Exp Med (2005) 1.35
Human CD4+ T-cell response to hepatitis delta virus: identification of multiple epitopes and characterization of T-helper cytokine profiles. J Virol (1997) 1.35
Signaling defects in anti-tumor T cells. Immunol Rev (2008) 1.28
Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure. J Virol (2009) 1.27
Human natural killer cells mediate killing of intracellular Mycobacterium tuberculosis H37Rv via granule-independent mechanisms. Infect Immun (2001) 1.27
CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity. Am J Pathol (2007) 1.26
Implication of Th17 and Th1 cells in patients with chronic active hepatitis B. J Clin Immunol (2009) 1.26
Role of tumor necrosis factor-related apoptosis-inducing ligand in immune response to influenza virus infection in mice. J Virol (2005) 1.24
Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection. J Virol (2004) 1.24
Alveolar epithelial cell chemokine expression triggered by antigen-specific cytolytic CD8(+) T cell recognition. J Clin Invest (2000) 1.24
New flow cytometric assays for monitoring cell-mediated cytotoxicity. Expert Rev Vaccines (2010) 1.18
Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury. Proc Natl Acad Sci U S A (2003) 1.18
A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response. Infect Immun (2005) 1.16
The transcriptional control of the perforin locus. Immunol Rev (2010) 1.15
CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines. J Virol (1999) 1.14
Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells. J Immunol (2004) 1.13
T cells cause acute immunopathology and are required for long-term survival in mouse adenovirus type 1-induced encephalomyelitis. J Virol (2003) 1.07
Fas-dependent CD4+ cytotoxic T-cell-mediated pathogenesis during virus infection. Proc Natl Acad Sci U S A (1996) 1.07
Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol (2001) 1.05
Fas (CD95)-dependent cell-mediated immunity to Listeria monocytogenes. Infect Immun (1998) 1.03
Specific ablation of antiviral gene expression in macrophages by antibody-dependent enhancement of Ross River virus infection. J Virol (2000) 1.02
Suppression of innate immune pathology by regulatory T cells during Influenza A virus infection of immunodeficient mice. J Virol (2010) 1.01
Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells. Neuron Glia Biol (2006) 1.00
Vaccinia virus infection disarms the mitochondrion-mediated pathway of the apoptotic cascade by modulating the permeability transition pore. J Virol (2001) 1.00
TNF-α acts as an immunoregulator in the mouse brain by reducing the incidence of severe disease following Japanese encephalitis virus infection. PLoS One (2013) 1.00
Complex adaptive immunity to enteric fevers in humans: lessons learned and the path forward. Front Immunol (2014) 0.99
Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function. Am J Pathol (1997) 0.98
Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection. J Virol (2009) 0.97
Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL. J Immunol (2007) 0.97
A nonself recognition gene complex in Neurospora crassa. Genetics (2006) 0.96
CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. Eur J Immunol (2007) 0.96
Epidemiology of BK virus in renal allograft recipients: independent risk factors for BK virus replication. Transplantation (2008) 0.95
Immunohistochemical study of caspase-3-expressing cells within the pancreas of non-obese diabetic mice during cyclophosphamide-accelerated diabetes. Histochem Cell Biol (2003) 0.95
CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure. Exp Mol Pathol (2007) 0.94
Neurons are MHC class I-dependent targets for CD8 T cells upon neurotropic viral infection. PLoS Pathog (2011) 0.94
beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis. Am J Pathol (2003) 0.93
Toward improved immunocompetence of adoptively transferred CD8+ T cells. J Clin Invest (2005) 0.93
Neural route of cerebral Listeria monocytogenes murine infection: role of immune response mechanisms in controlling bacterial neuroinvasion. Infect Immun (2001) 0.93
Acute cardiac allograft rejection by directly cytotoxic CD4 T cells: parallel requirements for Fas and perforin. Transplantation (2010) 0.92
Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus. J Virol (2005) 0.90
Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B. World J Gastroenterol (2006) 0.90
PKC-θ is a drug target for prevention of T cell-mediated autoimmunity and allograft rejection. Endocr Metab Immune Disord Drug Targets (2010) 0.90
Epidermal powder immunization induces both cytotoxic T-lymphocyte and antibody responses to protein antigens of influenza and hepatitis B viruses. J Virol (2001) 0.90
Perforin-deficient CD8+ T cells mediate fatal lymphocytic choriomeningitis despite impaired cytokine production. J Virol (2006) 0.89
Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity. Diabetes (2012) 0.89
Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation. Immunology (2003) 0.89
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. Mol Cell Biol (2012) 0.88
Baculovirus capsid display potentiates OVA cytotoxic and innate immune responses. PLoS One (2011) 0.88
Effector Th-1 cells with cytotoxic function in the intestinal lamina propria of patients with Crohn's disease. Dig Dis Sci (2000) 0.88
Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion. Am J Pathol (2008) 0.87
Clinical relevance of Fas expression in oesophageal squamous cell carcinoma. J Clin Pathol (2006) 0.87
On the cell biology of pit cells, the liver-specific NK cells. World J Gastroenterol (2000) 0.86
Fas expression on antigen-specific T cells has costimulatory, helper, and down-regulatory functions in vivo for cytotoxic T cell responses but not for T cell-dependent B cell responses. J Immunol (2008) 0.86
Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts. J Clin Invest (1998) 0.86
The IL-10 and IFN-gamma pathways are essential to the potent immunosuppressive activity of cultured CD8+ NKT-like cells. Genome Biol (2008) 0.86
The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo. J Immunol (2008) 0.85
Switch from perforin-expressing to perforin-deficient CD8(+) T cells accounts for two distinct types of effector cytotoxic T lymphocytes in vivo. Immunology (2009) 0.85
Reduced cell turnover in bovine leukemia virus-infected, persistently lymphocytotic cattle. J Virol (2003) 0.85
The great balancing act: regulation and fate of antiviral T-cell interactions. Immunol Rev (2013) 0.85
CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforin. J Virol (2001) 0.85
Permanent CD8(+) T cell depletion prevents proteinuria in active Heymann nephritis. J Exp Med (1998) 0.84
Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1. PLoS Pathog (2014) 0.84
Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics. J Biol Chem (2010) 0.83
Toll-like receptors signaling contributes to immunopathogenesis of HBV infection. Gastroenterol Res Pract (2011) 0.82
Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice. J Virol (2012) 0.82
Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification. Virol J (2007) 0.82
Asthma increases susceptibility to heterologous but not homologous secondary influenza. J Virol (2014) 0.82
Immune Surveillance of the CNS following Infection and Injury. Trends Immunol (2015) 0.81
Epitope specificity of memory CD8+ T cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice. Eur J Immunol (2012) 0.81
Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice. J Virol (1999) 0.81
A novel role of HLA class I in the pathology of medulloblastoma. J Transl Med (2009) 0.81
Tc1/Tc2 ratio in the inflammatory process in patients with Behçet's disease. Mediators Inflamm (2004) 0.81
OVA-specific CD8+ T cells do not express granzyme B during anterior chamber associated immune deviation. Graefes Arch Clin Exp Ophthalmol (2006) 0.80
Human immunodeficiency virus (HIV) gag antigen-specific T-helper and granule-dependent CD8 T-cell activities in exposed but uninfected heterosexual partners of HIV type 1-infected individuals in North India. Clin Vaccine Immunol (2007) 0.80
Processing and major histocompatibility complex class II presentation of Legionella pneumophila antigens by infected macrophages. Infect Immun (2005) 0.80
Functional role of type I and type II interferons in antiviral defense. Science (1994) 18.92
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol (1979) 15.58
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature (1974) 13.24
Immune response in mice that lack the interferon-gamma receptor. Science (1993) 12.15
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (1994) 11.22
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature (1993) 9.81
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? J Exp Med (1978) 9.51
Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity. Transplant Rev (1976) 8.10
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (1989) 7.52
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (1994) 7.34
Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature (1974) 6.99
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell (1991) 6.49
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature (1991) 5.98
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science (2000) 5.78
Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med (1998) 5.78
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A (1997) 5.66
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature (1989) 5.48
Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature (1990) 5.41
Evidence for a differential avidity model of T cell selection in the thymus. Cell (1994) 5.24
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell (1996) 4.74
Control of early viral and bacterial distribution and disease by natural antibodies. Science (1999) 4.73
T-cell-mediated immunopathology in viral infections. Transplant Rev (1974) 4.72
Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex. Nature (1975) 4.41
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol (1994) 4.34
The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help. J Exp Med (1978) 4.27
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J Virol (1995) 4.16
H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. J Exp Med (1975) 4.16
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature (1988) 4.04
Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature (2001) 3.99
Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature (1998) 3.78
Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J Virol Methods (1991) 3.78
Antigen localization and migration in immunity and tolerance. N Engl J Med (1998) 3.71
Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol (1998) 3.52
Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex. Nature (1975) 3.49
The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev (1998) 3.42
A biological role for the major histocompatibility antigens. Lancet (1975) 3.40
The influence of antigen organization on B cell responsiveness. Science (1993) 3.32
Immune responses in interleukin-2-deficient mice. Science (1993) 3.29
On immunity against infections and vaccines: credo 2004. Scand J Immunol (2004) 3.29
Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur J Immunol (1979) 3.27
IgA production without mu or delta chain expression in developing B cells. Nat Immunol (2001) 3.26
Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts. J Exp Med (1996) 3.26
On immunological memory. Annu Rev Immunol (1996) 3.21
A crucial role for B cells in neuroinvasive scrapie. Nature (1998) 3.19
Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin Exp Immunol (2005) 3.12
Functional analysis of T lymphocyte subsets in antiviral host defense. J Immunol (1987) 3.11
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science (2000) 3.07
Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J Exp Med (1998) 3.03
Decreased tumor surveillance in perforin-deficient mice. J Exp Med (1996) 3.00
Immune defence in mice lacking type I and/or type II interferon receptors. Immunol Rev (1995) 2.97
Neutralizing antiviral B cell responses. Annu Rev Immunol (1997) 2.86
Major histocompatibility complex--dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease. Eur J Immunol (1989) 2.71
H-2 restriction of cell-mediated immunity to an intracellular bacterium: effector T cells are specific for Listeria antigen in association with H-21 region-coded self-markers. J Exp Med (1977) 2.71
Gene technology and democracy. Science (1997) 2.68
Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature (1991) 2.66
Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol Rev (1997) 2.58
Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide. J Exp Med (1990) 2.58
A non-retroviral RNA virus persists in DNA form. Nature (1997) 2.57
Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control. Immunol Rev (1978) 2.56
On the role of antigen in maintaining cytotoxic T-cell memory. Proc Natl Acad Sci U S A (1996) 2.55
Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol (1997) 2.53
Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Nature (1978) 2.51
Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. J Exp Med (1997) 2.47
The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur J Immunol (1995) 2.47