Published in Biochemistry on May 08, 2014
Divalent Metal Ions Mg(2+) and Ca(2+) Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol (2015) 0.82
Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J Biol Chem (2015) 0.81
A QM/MM study of the associative mechanism for the phosphorylation reaction catalyzed by protein kinase A and its D166A mutant. J Comput Aided Mol Des (2014) 0.76
A short history of SHELX. Acta Crystallogr A (2007) 7339.18
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. Acta Crystallogr D Biol Crystallogr (2006) 13.29
Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions. J Biol Chem (1991) 3.93
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry (1993) 3.88
Kinetic and catalytic mechanisms of protein kinases. Chem Rev (2001) 3.80
Dynamics of cAMP-dependent protein kinase. Chem Rev (2001) 3.18
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Concentration of MgATP2- and other ions in solution. Calculation of the true concentrations of species present in mixtures of associating ions. Biochem J (1976) 2.75
2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr (1993) 2.66
cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci (1994) 2.62
Physiological substrates of cAMP-dependent protein kinase. Chem Rev (2001) 2.56
Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit. Biochemistry (1982) 2.37
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol (2002) 2.07
Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol (2010) 1.95
Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J Biol Chem (1989) 1.89
The apparent ionization constants of the adenosinephosphates and related compounds. J Biol Chem (1951) 1.76
Mapping the transition state for ATP hydrolysis: implications for enzymatic catalysis. Chem Biol (1995) 1.70
Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.65
Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55
How does the cAMP-dependent protein kinase catalyze the phosphorylation reaction: an ab initio QM/MM study. J Am Chem Soc (2005) 1.51
Domain movements in protein kinases. Curr Opin Struct Biol (1994) 1.47
Mg X ATP2-dependent interaction of the inhibitor protein of the cAMP-dependent protein kinase with the catalytic subunit. J Biol Chem (1983) 1.43
Pre-steady-state kinetic analysis of cAMP-dependent protein kinase using rapid quench flow techniques. Biochemistry (1996) 1.41
Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry (1999) 1.29
Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy. Biochemistry (1997) 1.27
Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: role in catalysis, P-site specificity, and interaction with inhibitors. Biochemistry (2000) 1.23
Divalent metal ions influence catalysis and active-site accessibility in the cAMP-dependent protein kinase. Protein Sci (1993) 1.19
So do we understand how enzymes work? Structure (2000) 1.13
Detection of conformational changes along the kinetic pathway of protein kinase A using a catalytic trapping technique. Biochemistry (1999) 1.13
Adenosine cyclic 3',5'-monophosphate dependent protein kinase: a new fluorescence displacement titration technique for characterizing the nucleotide binding site on the catalytic subunit. Biochemistry (1983) 1.11
Identification of electrostatic interactions that determine the phosphorylation site specificity of the cAMP-dependent protein kinase. Biochemistry (1991) 1.07
Magnetic resonance and kinetic studies of the manganese(II) ion and substrate complexes of the catalytic subunit of adenosine 3',5'-monophosphate dependent protein kinase from bovine heart. Biochemistry (1979) 1.02
Chelation of divalent cations by ATP, studied by titration calorimetry. Anal Biochem (1991) 1.01
Heat-stable inhibitor protein derived peptide substrate analogs: phosphorylation by cAMP-dependent and cGMP-dependent protein kinases. Biochemistry (1995) 0.96
Electronic measurements of single-molecule catalysis by cAMP-dependent protein kinase A. J Am Chem Soc (2013) 0.95
An ATP-linked structural change in protein kinase A precedes phosphoryl transfer under physiological magnesium concentrations. Biochemistry (1999) 0.92
Cyclic AMP-dependent ATPase activity of bovine heart protein kinase. Proc Natl Acad Sci U S A (1979) 0.88
Low- and room-temperature X-ray structures of protein kinase A ternary complexes shed new light on its activity. Acta Crystallogr D Biol Crystallogr (2012) 0.88
A QM/MM study of the phosphoryl transfer to the Kemptide substrate catalyzed by protein kinase A. The effect of the phosphorylation state of the protein on the mechanism. Phys Chem Chem Phys (2010) 0.85
Physical nature of intermolecular interactions within cAMP-dependent protein kinase active site: differential transition state stabilization in phosphoryl transfer reaction. J Phys Chem B (2008) 0.83
Insights into the phosphoryl transfer catalyzed by cAMP-dependent protein kinase: an X-ray crystallographic study of complexes with various metals and peptide substrate SP20. Biochemistry (2013) 0.82
Influence of the enzyme phosphorylation state and the substrate on PKA enzyme dynamics. Biophys Chem (2011) 0.81
pH dependence of the kinetic mechanism of the adenosine 3',5'-monophosphate dependent protein kinase catalytic subunit in the direction of magnesium adenosine 5'-diphosphate phosphorylation. Biochemistry (1993) 0.77
Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell (2004) 6.92
Generalized X-ray and neutron crystallographic analysis: more accurate and complete structures for biological macromolecules. Acta Crystallogr D Biol Crystallogr (2009) 3.69
Crystal structure and hydrogen-bonding system in cellulose Ibeta from synchrotron X-ray and neutron fiber diffraction. J Am Chem Soc (2002) 2.86
Crystal structure and hydrogen bonding system in cellulose I(alpha) from synchrotron X-ray and neutron fiber diffraction. J Am Chem Soc (2003) 2.55
Neutron crystallography: opportunities, challenges, and limitations. Curr Opin Struct Biol (2008) 2.36
Metal ion roles and the movement of hydrogen during reaction catalyzed by D-xylose isomerase: a joint x-ray and neutron diffraction study. Structure (2010) 2.20
Corynebacterium species isolated from patients with mastitis. Clin Infect Dis (2002) 2.12
Comet 81P/Wild 2 under a microscope. Science (2006) 1.83
Joint X-ray and neutron refinement with phenix.refine. Acta Crystallogr D Biol Crystallogr (2010) 1.80
Elemental compositions of comet 81P/Wild 2 samples collected by Stardust. Science (2006) 1.76
Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol (2013) 1.75
Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proc Natl Acad Sci U S A (2006) 1.70
The treatment of melasma: a review of clinical trials. J Am Acad Dermatol (2006) 1.67
Evolutionary rescue from extinction is contingent on a lower rate of environmental change. Nature (2013) 1.53
PKA: lessons learned after twenty years. Biochim Biophys Acta (2013) 1.52
Locating active-site hydrogen atoms in D-xylose isomerase: time-of-flight neutron diffraction. Proc Natl Acad Sci U S A (2006) 1.51
Harnessing a university to address rural health workforce shortages in Australia. Aust J Rural Health (2007) 1.42
Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci (2012) 1.40
Epidemiology and diagnostic testing for meningitis in adults as the meningococcal epidemic declined at Middlemore Hospital. N Z Med J (2015) 1.38
Rapid determination of hydrogen positions and protonation states of diisopropyl fluorophosphatase by joint neutron and X-ray diffraction refinement. Proc Natl Acad Sci U S A (2009) 1.38
Hydrogen location in stages of an enzyme-catalyzed reaction: time-of-flight neutron structure of D-xylose isomerase with bound D-xylulose. Biochemistry (2008) 1.37
Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science (2012) 1.35
The catalytic mechanism of an aspartic proteinase explored with neutron and X-ray diffraction. J Am Chem Soc (2008) 1.33
Identification of the elusive hydronium ion exchanging roles with a proton in an enzyme at lower pH values. Angew Chem Int Ed Engl (2011) 1.32
Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1. J Mol Biol (2007) 1.32
Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. J Mol Biol (2004) 1.30
Restructuring the crystalline cellulose hydrogen bond network enhances its depolymerization rate. J Am Chem Soc (2011) 1.30
Identification of a molecular target for the Yersinia protein kinase A. Mol Cell (2007) 1.29
A preliminary time-of-flight neutron diffraction study of Streptomyces rubiginosus D-xylose isomerase. Acta Crystallogr D Biol Crystallogr (2004) 1.22
Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). J Mol Biol (2002) 1.19
The fractalkine/CX3CR1 system regulates β cell function and insulin secretion. Cell (2013) 1.16
Reliability assessment and validation of the Melasma Area and Severity Index (MASI) and a new modified MASI scoring method. J Am Acad Dermatol (2010) 1.15
Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem (2012) 1.14
High-resolution neutron crystallographic studies of the hydration of the coenzyme cob(II)alamin. Acta Crystallogr D Biol Crystallogr (2011) 1.13
Preliminary time-of-flight neutron diffraction study on diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 1.13
Australian national strategy for pharmacy preceptor education and support. Aust J Rural Health (2005) 1.12
A new structural framework for integrating replication protein A into DNA processing machinery. Nucleic Acids Res (2013) 1.12
Preliminary neutron and ultrahigh-resolution X-ray diffraction studies of the aspartic proteinase endothiapepsin cocrystallized with a gem-diol inhibitor. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 1.11
Protein crystallography with spallation neutrons. J Synchrotron Radiat (2003) 1.09
RDX and TNT residues from live-fire and blow-in-place detonations. Chemosphere (2005) 1.08
Photoinduced linkage isomers of transition-metal nitrosyl compounds and related complexes. Chem Rev (2002) 1.08
The effect of deuteration on protein structure: a high-resolution comparison of hydrogenous and perdeuterated haloalkane dehalogenase. Acta Crystallogr D Biol Crystallogr (2007) 1.07
Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. J Mol Biol (2004) 1.07
The IMAGINE instrument: first neutron protein structure and new capabilities for neutron macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2013) 1.06
Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network "switch" is observed between pH 7.8 and 10.0. Biochemistry (2011) 1.06
Macromolecular neutron crystallography at the Protein Crystallography Station (PCS). Acta Crystallogr D Biol Crystallogr (2010) 1.05
Breakdown of cell wall nanostructure in dilute acid pretreated biomass. Biomacromolecules (2010) 1.03
Direct observation of hydrogen atom dynamics and interactions by ultrahigh resolution neutron protein crystallography. Proc Natl Acad Sci U S A (2012) 1.03
Ca2+-induced structural changes in phosphorylase kinase detected by small-angle X-ray scattering. Protein Sci (2005) 1.02
A large 12-month extension study of an 8-week trial to evaluate the safety and efficacy of triple combination (TC) cream in melasma patients previously treated with TC cream or one of its dyads. J Drugs Dermatol (2005) 1.01
Neutron crystallography, molecular dynamics, and quantum mechanics studies of the nature of hydrogen bonding in cellulose Ibeta. Biomacromolecules (2008) 1.01
A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. J Biol Chem (2002) 1.00
Ionic-liquid induced changes in cellulose structure associated with enhanced biomass hydrolysis. Biomacromolecules (2011) 1.00
Joint X-ray/neutron crystallographic study of HIV-1 protease with clinical inhibitor amprenavir: insights for drug design. J Med Chem (2013) 0.99
Reintroducing electrostatics into macromolecular crystallographic refinement: application to neutron crystallography and DNA hydration. Structure (2011) 0.98
Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol (2012) 0.98
Detection and whole genome sequence analysis of an enterovirus 68 cluster. Virol J (2013) 0.96
Preliminary joint neutron and X-ray crystallographic study of human carbonic anhydrase II. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.96
Evaluation of the national pharmacy preceptor education program. Aust J Rural Health (2007) 0.95
Inorganic pyrophosphatase crystals from Thermococcus thioreducens for X-ray and neutron diffraction. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.95
Structural basis for the differential regulation of DNA by the methionine repressor MetJ. J Biol Chem (2006) 0.95
Protein structures by spallation neutron crystallography. J Synchrotron Radiat (2008) 0.94
Conformational flexibility of soluble cellulose oligomers: chain length and temperature dependence. J Am Chem Soc (2009) 0.94
X-ray structure of perdeuterated diisopropyl fluorophosphatase (DFPase): perdeuteration of proteins for neutron diffraction. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.93
Patient outcomes following an intervention involving community pharmacists in the management of depression. Aust J Rural Health (2006) 0.93
The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering. Arch Biochem Biophys (2008) 0.93
An evaluation of a community pharmacy-based rural asthma management service. Aust J Rural Health (2008) 0.93
Facial Soft-Tissue Fillers conference: Assessing the State of the Science. J Am Acad Dermatol (2011) 0.92
Small angle neutron scattering reveals pH-dependent conformational changes in Trichoderma reesei cellobiohydrolase I: implications for enzymatic activity. J Biol Chem (2011) 0.91
Direct determination of protonation states of histidine residues in a 2 A neutron structure of deoxy-human normal adult hemoglobin and implications for the Bohr effect. J Mol Biol (2010) 0.90
The structure of Sindbis virus produced from vertebrate and invertebrate hosts as determined by small-angle neutron scattering. J Virol (2010) 0.90
A model for the three-dimensional structure of human plasma vitronectin from small-angle scattering measurements. Biochemistry (2005) 0.90
Current Understanding of Seborrheic Keratosis: Prevalence, Etiology, Clinical Presentation, Diagnosis, and Management. J Drugs Dermatol (2015) 0.90
Invasive group A streptococcal infection and vaccine implications, Auckland, New Zealand. Emerg Infect Dis (2011) 0.89
Reversible swelling of the cell wall of poplar biomass by ionic liquid at room temperature. Bioresour Technol (2010) 0.89
Low- and room-temperature X-ray structures of protein kinase A ternary complexes shed new light on its activity. Acta Crystallogr D Biol Crystallogr (2012) 0.88
W3Y single mutant of rubredoxin from Pyrococcus furiosus: a preliminary time-of-flight neutron study. Acta Crystallogr D Biol Crystallogr (2003) 0.88
Self-assembled colloidal crystals from ZrO2 nanoparticles. J Phys Chem B (2006) 0.86
Assembly and organization of poly(3-hexylthiophene) brushes and their potential use as novel anode buffer layers for organic photovoltaics. Nanoscale (2013) 0.86
Differential binding of bispyridinium oxime drugs with acetylcholinesterase. Acta Pharmacol Sin (2010) 0.85
Solution structure of heavy meromyosin by small-angle scattering. J Biol Chem (2002) 0.85
Periodic disorder along ramie cellulose microfibrils. Biomacromolecules (2003) 0.85
X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. J Struct Biol (2009) 0.84
Dapsone gel 5% for the treatment of acne vulgaris: safety and efficacy of long-term (1 year) treatment. J Drugs Dermatol (2007) 0.84
Neutron structure and mechanistic studies of diisopropyl fluorophosphatase (DFPase). Acta Crystallogr D Biol Crystallogr (2010) 0.84
Increasing our understanding of pigmentary disorders. J Am Acad Dermatol (2006) 0.84
X-ray crystallographic, scanning microprobe X-ray diffraction, and cross-polarized/magic angle spinning 13C NMR studies of the structure of cellulose III(II). Biomacromolecules (2009) 0.84
Hematologic safety of dapsone gel, 5%, for topical treatment of acne vulgaris. Arch Dermatol (2008) 0.84
Preliminary joint X-ray and neutron protein crystallographic studies of endoxylanase II from the fungus Trichoderma longibrachiatum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.84
Nature and kinetic analysis of carbon-carbon bond fragmentation reactions of cation radicals derived from SET-oxidation of lignin model compounds. J Org Chem (2010) 0.83
Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiol (2013) 0.83
Vibrio vulnificus necrotising fasciitis and septicaemia. N Z Med J (2002) 0.83
Direct determination of the hydrogen bonding arrangement in anhydrous β-chitin by neutron fiber diffraction. Biomacromolecules (2011) 0.83
Preliminary neutron and X-ray crystallographic studies of equine cyanomethemoglobin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.83
Skin care in ethnic populations. Semin Plast Surg (2009) 0.82