Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy.

PubWeight™: 1.65‹?› | Rank: Top 3%

🔗 View Article (PMC 3084134)

Published in Proc Natl Acad Sci U S A on April 06, 2011

Authors

Larry R Masterson1, Lei Shi, Emily Metcalfe, Jiali Gao, Susan S Taylor, Gianluigi Veglia

Author Affiliations

1: Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455-0431, USA.

Articles citing this

cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban. J Mol Biol (2011) 1.90

PKA: lessons learned after twenty years. Biochim Biophys Acta (2013) 1.52

Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci (2012) 1.40

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat Chem Biol (2013) 1.28

Connecting protein conformational dynamics with catalytic function as illustrated in dihydrofolate reductase. Biochemistry (2013) 1.12

The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants. Biophys J (2012) 1.10

Protein structural ensembles are revealed by redefining X-ray electron density noise. Proc Natl Acad Sci U S A (2013) 1.10

Kinases and pseudokinases: lessons from RAF. Mol Cell Biol (2014) 1.10

Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Mol Cell (2014) 1.08

Intrinsic disorder modulates protein self-assembly and aggregation. Proc Natl Acad Sci U S A (2012) 1.05

NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors. Proc Natl Acad Sci U S A (2013) 1.03

NMR insights into protein allostery. Arch Biochem Biophys (2011) 1.02

Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc (2013) 1.01

A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. J Biol Chem (2014) 1.01

Phosphorylation releases constraints to domain motion in ERK2. Proc Natl Acad Sci U S A (2014) 1.00

NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding. Phys Chem Chem Phys (2014) 0.99

A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes. J Mol Biol (2011) 0.98

Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein. J Biol Chem (2011) 0.98

Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol (2012) 0.98

Differential dynamic engagement within 24 SH3 domain: peptide complexes revealed by co-linear chemical shift perturbation analysis. PLoS One (2012) 0.97

Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. Structure (2014) 0.96

Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci (2015) 0.96

Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A (2014) 0.94

Pseudokinases from a structural perspective. Biochem Soc Trans (2013) 0.94

Cracking the molecular origin of intrinsic tyrosine kinase activity through analysis of pathogenic gain-of-function mutations. Cell Rep (2013) 0.93

Allostery and binding cooperativity of the catalytic subunit of protein kinase A by NMR spectroscopy and molecular dynamics simulations. Adv Protein Chem Struct Biol (2012) 0.93

Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC). J Biol Chem (2011) 0.93

Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A. J Biol Chem (2012) 0.92

Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor. Biochemistry (2012) 0.90

Peptide modulation of class I major histocompatibility complex protein molecular flexibility and the implications for immune recognition. J Biol Chem (2013) 0.89

Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry (2012) 0.88

Low- and room-temperature X-ray structures of protein kinase A ternary complexes shed new light on its activity. Acta Crystallogr D Biol Crystallogr (2012) 0.88

Role of conformational entropy in the activity and regulation of the catalytic subunit of protein kinase A. FEBS J (2013) 0.85

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife (2014) 0.85

Molecular features of product release for the PKA catalytic cycle. Biochemistry (2014) 0.84

Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proc Natl Acad Sci U S A (2015) 0.84

Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase. Proc Natl Acad Sci U S A (2012) 0.82

Insights into the phosphoryl transfer catalyzed by cAMP-dependent protein kinase: an X-ray crystallographic study of complexes with various metals and peptide substrate SP20. Biochemistry (2013) 0.82

Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J Biol Chem (2015) 0.81

Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry (2013) 0.81

Substrate-specific reorganization of the conformational ensemble of CSK implicates novel modes of kinase function. PLoS Comput Biol (2012) 0.81

Computationally unraveling how ceritinib overcomes drug-resistance mutations in ALK-rearranged lung cancer. J Mol Model (2015) 0.81

Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions. PLoS One (2014) 0.79

Heteronuclear Adiabatic Relaxation Dispersion (HARD) for quantitative analysis of conformational dynamics in proteins. J Magn Reson (2012) 0.79

An intrinsically disordered photosystem II subunit, PsbO, provides a structural template and a sensor of the hydrogen-bonding network in photosynthetic water oxidation. J Biol Chem (2013) 0.79

A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv (2017) 0.78

Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure (2016) 0.78

Structural basis of valmerins as dual inhibitors of GSK3β/CDK5. J Mol Model (2014) 0.78

Metal-free cAMP-dependent protein kinase can catalyze phosphoryl transfer. Biochemistry (2014) 0.78

Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry (2015) 0.77

The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B. PLoS One (2014) 0.77

Dynamics of protein kinases: insights from nuclear magnetic resonance. Acc Chem Res (2015) 0.76

A QM/MM study of the associative mechanism for the phosphorylation reaction catalyzed by protein kinase A and its D166A mutant. J Comput Aided Mol Des (2014) 0.76

Photonic crystal kinase biosensor. J Am Chem Soc (2014) 0.76

Using NMR spectroscopy to elucidate the role of molecular motions in enzyme function. Prog Nucl Magn Reson Spectrosc (2015) 0.76

NMR reveals a dynamic allosteric pathway in thrombin. Sci Rep (2017) 0.75

cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry. Biochem J (2016) 0.75

Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways. PLoS One (2016) 0.75

Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol (2016) 0.75

Binding mechanism and dynamic conformational change of C subunit of PKA with different pathways. Proc Natl Acad Sci U S A (2017) 0.75

Articles cited by this

NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94

Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. Biochemistry (1994) 13.94

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution. Proc Natl Acad Sci U S A (1997) 13.28

The dynamic energy landscape of dihydrofolate reductase catalysis. Science (2006) 7.55

Protein kinases--the major drug targets of the twenty-first century? Nat Rev Drug Discov (2002) 7.38

The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol (2009) 7.36

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature (2007) 5.78

Linking folding and binding. Curr Opin Struct Biol (2009) 5.19

The role of dynamics in allosteric regulation. Curr Opin Struct Biol (2003) 4.82

Dynamically driven protein allostery. Nat Struct Mol Biol (2006) 4.53

Relating protein motion to catalysis. Annu Rev Biochem (2006) 4.50

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins. Proc Natl Acad Sci U S A (2003) 4.36

Conformational entropy in molecular recognition by proteins. Nature (2007) 3.98

Folding and binding cascades: dynamic landscapes and population shifts. Protein Sci (2000) 3.74

Sending signals dynamically. Science (2009) 3.64

Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39

Dynamics of cAMP-dependent protein kinase. Chem Rev (2001) 3.18

The changing landscape of protein allostery. Curr Opin Struct Biol (2006) 2.90

Estimation of the available free energy in a LOV2-J alpha photoswitch. Nat Chem Biol (2008) 2.63

Dynamic activation of an allosteric regulatory protein. Nature (2009) 2.61

Large amplitude conformational change in proteins explored with a plastic network model: adenylate kinase. J Mol Biol (2005) 2.59

Physiological substrates of cAMP-dependent protein kinase. Chem Rev (2001) 2.56

A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A (2008) 2.51

Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science (2005) 2.47

PKA: a portrait of protein kinase dynamics. Biochim Biophys Acta (2004) 2.43

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit. Biochemistry (1982) 2.37

Nmr probes of molecular dynamics: overview and comparison with other techniques. Annu Rev Biophys Biomol Struct (2001) 2.31

Protein dynamics and conformational disorder in molecular recognition. J Mol Recognit (2010) 2.31

Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state. Structure (2009) 2.13

Enzyme millisecond conformational dynamics do not catalyze the chemical step. Proc Natl Acad Sci U S A (2009) 2.08

Allosteric cooperativity in protein kinase A. Proc Natl Acad Sci U S A (2008) 1.99

Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol (2010) 1.95

Anisotropic rotational diffusion of perdeuterated HIV protease from 15N NMR relaxation measurements at two magnetic fields. J Biomol NMR (1996) 1.94

Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol (2008) 1.93

Multiple conformational changes in enzyme catalysis. Biochemistry (2002) 1.90

The propagation of binding interactions to remote sites in proteins: analysis of the binding of the monoclonal antibody D1.3 to lysozyme. Proc Natl Acad Sci U S A (1999) 1.87

Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta (2009) 1.76

Structural and dynamic basis of phospholamban and sarcolipin inhibition of Ca(2+)-ATPase. Biochemistry (2007) 1.66

Cation-chromatin binding as shown by ion microscopy is essential for the structural integrity of chromosomes. J Cell Biol (2001) 1.63

Enzyme dynamics point to stepwise conformational selection in catalysis. Curr Opin Chem Biol (2010) 1.61

A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction. Structure (2008) 1.45

Mg X ATP2-dependent interaction of the inhibitor protein of the cAMP-dependent protein kinase with the catalytic subunit. J Biol Chem (1983) 1.43

Multiple pathway signal transduction by the cAMP-dependent protein kinase. FASEB J (1994) 1.43

Dynamically driven ligand selectivity in cyclic nucleotide binding domains. J Biol Chem (2009) 1.38

Mapping chemical exchange in proteins with MW > 50 kD. J Am Chem Soc (2003) 1.36

Secondary structure and orientation of phospholamban reconstituted in supported bilayers from polarized attenuated total reflection FTIR spectroscopy. Biochemistry (1995) 1.35

Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. J Mol Biol (2004) 1.30

Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry (1999) 1.29

Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor. Biophys J (2007) 1.28

Protein kinase inhibitor peptide (PKI): a family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function. Neuropeptides (2006) 1.24

Nanometer propagation of millisecond motions in V-type allostery. Structure (2010) 1.23

The flexibility of a distant loop modulates active site motion and product release in ribonuclease A. Biochemistry (2009) 1.22

AKAP-scaffolding proteins and regulation of cardiac physiology. Physiology (Bethesda) (2009) 1.20

Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein. J Biol Chem (1986) 1.16

NMR spectroscopy of the ligand-binding core of ionotropic glutamate receptor 2 bound to 5-substituted willardiine partial agonists. J Mol Biol (2008) 1.15

A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry (2009) 1.10

Structural aspects of protein kinase control-role of conformational flexibility. Pharmacol Ther (2002) 1.09

Intracellular targeting of protein kinases and phosphatases. Diabetes (2002) 1.06

Mysteries of magnesium homeostasis. Circ Res (2000) 1.04

Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA. Biochem J (2008) 1.02

Value of a hydrogen bond in triosephosphate isomerase loop motion. Biochemistry (2007) 0.99

Backbone flexibility of five sites on the catalytic subunit of cAMP-dependent protein kinase in the open and closed conformations. Biochemistry (1998) 0.99

Relationship between total and free cellular Mg(2+) during metabolic stimulation of rat cardiac myocytes and perfused hearts. Arch Biochem Biophys (2000) 0.99

Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase. J Mol Biol (2002) 0.94

Allosteric suppression of HIV-1 reverse transcriptase structural dynamics upon inhibitor binding. Biophys J (2011) 0.94

Protein kinase inhibition: natural and synthetic variations on a theme. Curr Opin Chem Biol (1997) 0.92

Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy. J Biol Chem (1997) 0.90

Ribosome biogenesis and nucleolar ultrastructure in neuronal and oligodendroglial rat brain cells. J Neurochem (1985) 0.89

Nuclear magnetic resonance study of the role of M42 in the solution dynamics of Escherichia coli dihydrofolate reductase. Biochemistry (2010) 0.88

Nascent structure in the kinase anchoring domain of microtubule-associated protein 2. Biochem Biophys Res Commun (2003) 0.79

Articles by these authors

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86

How enzymes work: analysis by modern rate theory and computer simulations. Science (2004) 4.30

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A (2006) 4.09

Structural and functional diversity of the microbial kinome. PLoS Biol (2007) 3.74

Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet (2012) 3.34

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34

Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science (2005) 3.28

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol (2006) 3.23

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell (2007) 3.19

The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem (2008) 3.01

Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J (2008) 2.99

SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A (2006) 2.89

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. J Biol Chem (2002) 2.75

The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72

The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A (2007) 2.65

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A (2007) 2.60

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation (2012) 2.55

Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature (2005) 2.54

A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A (2008) 2.51

Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase. Biochemistry (2003) 2.49

Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature (2010) 2.41

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A (2005) 2.33

The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A (2004) 2.32

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci (2006) 2.30

A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell (2006) 2.27

Twin-spot MARCM to reveal the developmental origin and identity of neurons. Nat Neurosci (2009) 2.26

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A (2009) 2.25

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat Struct Mol Biol (2010) 2.20

Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900 MHz. J Magn Reson (2006) 2.19

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature (2011) 2.18

Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions. Chem Rev (2006) 2.16

Local resistance switching at grain and grain boundary surfaces of polycrystalline tungsten oxide films. Nanotechnology (2011) 2.09

An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem (2008) 2.07

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol (2002) 2.07

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. J Biol Chem (2006) 2.01

Allosteric cooperativity in protein kinase A. Proc Natl Acad Sci U S A (2008) 1.99

NMR solution structure and topological orientation of monomeric phospholamban in dodecylphosphocholine micelles. Biophys J (2003) 1.96

Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol (2010) 1.95

Additional support for a revised Gibbs analysis. Langmuir (2010) 1.94

ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem (2010) 1.91

cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban. J Mol Biol (2011) 1.90

Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. J Immunol (2005) 1.89

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. J Med Chem (2012) 1.87

cAMP activation of PKA defines an ancient signaling mechanism. Proc Natl Acad Sci U S A (2006) 1.79

Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach. Proc Natl Acad Sci U S A (2009) 1.79

Spectroscopic validation of the pentameric structure of phospholamban. Proc Natl Acad Sci U S A (2007) 1.77

Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta (2009) 1.76

Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol (2013) 1.75

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol (2005) 1.69

Stress erythropoiesis: new signals and new stress progenitor cells. Curr Opin Hematol (2011) 1.68

Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J Mol Biol (2003) 1.68

The Design of a Next Generation Force Field: The X-POL Potential. J Chem Theory Comput (2007) 1.68

NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell (2013) 1.67

Structural and dynamic basis of phospholamban and sarcolipin inhibition of Ca(2+)-ATPase. Biochemistry (2007) 1.66

Dipolar waves as NMR maps of protein structure. J Am Chem Soc (2002) 1.66

The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66

NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry (2008) 1.65

Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones. ChemMedChem (2008) 1.64

SABIO-RK--database for biochemical reaction kinetics. Nucleic Acids Res (2011) 1.63

Metronidazole-flavonoid derivatives as anti-Helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8 production by AGS cells. ChemMedChem (2007) 1.62

Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A (2003) 1.61

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell (2012) 1.61

PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science (2007) 1.61

Allosteric activation of functionally asymmetric RAF kinase dimers. Cell (2013) 1.60

HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol Cell (2011) 1.59

microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis (2010) 1.59

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol (2006) 1.59

A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J Virol (2005) 1.59

Rapid learning in cortical coding of visual scenes. Nat Neurosci (2007) 1.58

Overexpression, purification, and characterization of recombinant Ca-ATPase regulators for high-resolution solution and solid-state NMR studies. Protein Expr Purif (2003) 1.58

Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. Eur J Med Chem (2007) 1.57

Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method. Proc Natl Acad Sci U S A (2011) 1.57

Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55

Generalized hybrid-orbital method for combining density functional theory with molecular mechanicals. Chemphyschem (2005) 1.55

Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology (2005) 1.54

Polarized Molecular Orbital Model Chemistry. II. The PMO Method. J Chem Theory Comput (2011) 1.52

Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Mol Biol (2004) 1.51

Specific inhibition of type I interferon signal transduction by respiratory syncytial virus. Am J Respir Cell Mol Biol (2004) 1.49

Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. Infect Immun (2005) 1.48

The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS One (2011) 1.48

Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy. Biochemistry (2008) 1.47

Small temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase. J Phys Chem B (2005) 1.47

The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem (2008) 1.47

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins (2002) 1.45

Retracted Downregulation of ADAM10 expression inhibits metastasis and invasiveness of human hepatocellular carcinoma HepG2 cells. Biomed Res Int (2013) 1.44

The incorporation of quantum effects in enzyme kinetics modeling. Acc Chem Res (2002) 1.44

Evolution of allostery in the cyclic nucleotide binding module. Genome Biol (2007) 1.44

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A (2011) 1.44

A combined quantum mechanical and molecular mechanical study of the reaction mechanism and alpha-amino acidity in alanine racemase. J Am Chem Soc (2006) 1.44

A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci U S A (2005) 1.43

A functional genomics resource for Brassica napus: development of an EMS mutagenized population and discovery of FAE1 point mutations by TILLING. New Phytol (2008) 1.41