Published in PLoS One on May 07, 2014
Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease. Neural Regen Res (2015) 0.94
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem (2014) 0.87
Programming apoptosis and autophagy with novel approaches for diabetes mellitus. Curr Neurovasc Res (2015) 0.81
Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson's Disease. Int J Mol Sci (2015) 0.79
Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease. J Neurochem (2015) 0.78
Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model. Neurotoxicology (2015) 0.77
Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer. Front Oncol (2017) 0.75
Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress. Am J Neurodegener Dis (2016) 0.75
Parkinson's disease: mechanisms and models. Neuron (2003) 14.84
Molecular pathways of neurodegeneration in Parkinson's disease. Science (2003) 7.55
Oxidative stress in neurodegeneration: cause or consequence? Nat Med (2004) 4.72
Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol (2004) 4.49
LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell (2011) 3.78
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J (2003) 2.68
Gbetagamma-mediated regulation of Golgi organization is through the direct activation of protein kinase D. Cell (1999) 2.67
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol (2004) 2.51
Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol (2005) 2.44
Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu. J Biol Chem (1999) 2.37
Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility. Curr Biol (2004) 2.07
Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol (2005) 2.00
BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem (2005) 1.92
Protein kinase D signaling: multiple biological functions in health and disease. Physiology (Bethesda) (2011) 1.89
Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain. J Biol Chem (2002) 1.89
Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol Cell Biol (2006) 1.85
Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. J Biol Chem (2004) 1.79
Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci (1999) 1.58
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease. Ann N Y Acad Sci (2003) 1.53
Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci (2002) 1.47
Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. J Biol Chem (2003) 1.47
Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways. J Biol Chem (2001) 1.46
ERK and cell death: ERK1/2 in neuronal death. FEBS J (2009) 1.42
6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radic Biol Med (2008) 1.37
The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. J Biol Chem (2004) 1.37
Mitochondrial ROS--radical detoxification, mediated by protein kinase D. Trends Cell Biol (2006) 1.36
Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. J Neurosci (2007) 1.31
Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916. J Biol Chem (2008) 1.24
The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta (1999) 1.23
Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. J Biol Chem (2005) 1.22
6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. J Biol Chem (2005) 1.21
Pathogenesis of nigral cell death in Parkinson's disease. Parkinsonism Relat Disord (2005) 1.20
Regulated nucleocytoplasmic transport of protein kinase D in response to G protein-coupled receptor activation. J Biol Chem (2001) 1.18
Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling. Immunity (1996) 1.17
α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J Neurosci (2011) 1.16
Protein kinase D1: a protein of emerging translational interest. Front Biosci (2007) 1.13
Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB. Mol Pharmacol (2004) 1.13
Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells. J Biol Chem (2001) 1.09
Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration. Mol Cell Neurosci (2004) 1.07
Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells. PLoS One (2012) 1.06
Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation. J Neurochem (2012) 1.05
Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol Neurodegener (2009) 1.05
Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. J Biol Chem (2002) 1.05
Protein kinase D is a downstream target of protein kinase Ctheta. Biochem Biophys Res Commun (2002) 1.05
A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med (2006) 1.04
Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim Biophys Acta (2013) 1.04
Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death. J Biol Chem (2011) 1.01
Platelet-derived growth factor stimulates protein kinase D through the activation of phospholipase Cgamma and protein kinase C. J Biol Chem (1998) 0.96
PI3K/Akt signaling pathway is required for neuroprotection of thalidomide on hypoxic-ischemic cortical neurons in vitro. Brain Res (2010) 0.93
Emerging roles of protein kinase D1 in cancer. Mol Cancer Res (2011) 0.93
MAP kinase pathways in neuronal cell death. CNS Neurol Disord Drug Targets (2008) 0.93
Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease. Toxicol Appl Pharmacol (2011) 0.92
PKD prevents H2O2-induced apoptosis via NF-kappaB and p38 MAPK in RIE-1 cells. Biochem Biophys Res Commun (2008) 0.89
Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Neuroscience (2012) 0.88
6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease. Cell Mol Neurobiol (2001) 0.87
N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells. Parkinsons Dis (2012) 0.86
The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. J Biol Chem (2013) 0.86
Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease. Neurotoxicology (2011) 0.86
Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease. Prion (2014) 0.85
PKD: a new protein kinase C-dependent pathway in platelets. Blood (2002) 0.85
Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model. Parkinsons Dis (2011) 0.84
Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Mol Neurodegener (2011) 0.84
Activation of Retinoid X Receptor increases dopamine cell survival in models for Parkinson's disease. BMC Neurosci (2009) 0.83
Efficacy of grafted immortalized dopamine neurons in an animal model of parkinsonism: a review. Mol Genet Metab (1998) 0.83
Neuroprotective effect of resveratrol against methamphetamine-induced dopaminergic apoptotic cell death in a cell culture model of neurotoxicity. Curr Neuropharmacol (2011) 0.83
Proteolytic cleavage of protein kinase Cmu upon induction of apoptosis in U937 cells. FEBS Lett (1999) 0.83
Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species. Neurotoxicology (2009) 0.79