Published in J Biol Chem on November 24, 2008
Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro. PLoS One (2015) 1.38
Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology. EMBO Rep (2011) 1.30
G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Diabetologia (2012) 1.21
M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proc Natl Acad Sci U S A (2010) 1.15
Regulation of protein kinase D1 activity. Mol Pharmacol (2011) 1.13
Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2. Mol Cell Biol (2010) 1.10
Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein. J Biol Chem (2011) 1.02
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line. Biochem Pharmacol (2011) 1.01
Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem J (2010) 0.99
Reactive oxygen species decrease cAMP response element binding protein expression in cardiomyocytes via a protein kinase D1-dependent mechanism that does not require Ser133 phosphorylation. Mol Pharmacol (2009) 0.97
A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini. Am J Physiol Gastrointest Liver Physiol (2010) 0.93
Emerging roles of protein kinase D1 in cancer. Mol Cancer Res (2011) 0.93
Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes. J Biol Chem (2010) 0.92
Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction. J Biol Chem (2010) 0.86
Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters. J Biol Chem (2009) 0.85
Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. PLoS One (2014) 0.83
Protein kinase D-HDAC5 signaling regulates erythropoiesis and contributes to erythropoietin cross-talk with GATA1. Blood (2012) 0.81
Protein kinase Cδ mediates the activation of protein kinase D2 in platelets. Biochem Pharmacol (2011) 0.79
Protein kinase D1 has a key role in wound healing and skin carcinogenesis. J Invest Dermatol (2013) 0.79
Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms. Cell Commun Signal (2013) 0.77
Regulatory domain determinants that control PKD1 activity. J Biol Chem (2012) 0.75
The protein kinase D1 COOH terminus: marker or regulator of enzyme activity? Am J Physiol Cell Physiol (2014) 0.75
Emergency Spatiotemporal Shift: The Response of Protein Kinase D to Stress Signals in the Cardiovascular System. Front Pharmacol (2017) 0.75
Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle. FEBS Lett (2015) 0.75
PKD3 deficiency causes alterations in microtubule dynamics during the cell cycle. Cell Cycle (2016) 0.75
Potein Kinase D Signaling in Cancer: A Friend or Foe? Biochim Biophys Acta (2017) 0.75
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99
Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol (2004) 4.49
Protein kinase D signaling. J Biol Chem (2005) 3.32
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol (2004) 2.51
Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function. Circ Res (2004) 2.44
Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu. J Biol Chem (1999) 2.37
Requirement of protein kinase D1 for pathological cardiac remodeling. Proc Natl Acad Sci U S A (2008) 2.12
A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. J Biol Chem (2005) 2.03
Regulation of cardiac stress signaling by protein kinase d1. Mol Cell Biol (2006) 2.01
Identification of in vivo phosphorylation sites required for protein kinase D activation. J Biol Chem (1998) 1.99
BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem (2005) 1.92
Protein kinase d in the cardiovascular system: emerging roles in health and disease. Circ Res (2008) 1.59
Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment. J Cell Biol (2002) 1.57
Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation. J Biol Chem (2008) 1.50
Protein kinase D activation by mutations within its pleckstrin homology domain. J Biol Chem (1998) 1.46
Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways. J Biol Chem (2001) 1.46
Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes. J Biol Chem (2004) 1.43
Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes. Circ Res (2007) 1.43
Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C. J Biol Chem (1997) 1.41
Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart. J Biol Chem (2008) 1.29
Protein kinase D intracellular localization and activity control kinase D-interacting substrate of 220-kDa traffic through a postsynaptic density-95/discs large/zonula occludens-1-binding motif. J Biol Chem (2006) 1.27
Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. J Biol Chem (1999) 1.26
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal (2008) 1.20
Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D. J Biol Chem (2004) 1.15
Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell (2003) 1.15
Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB. Mol Pharmacol (2004) 1.13
Protein kinase D induces transcription through direct phosphorylation of the cAMP-response element-binding protein. J Biol Chem (2007) 1.11
Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem (1998) 1.11
Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span. J Biol Chem (2007) 1.00
Characterization of a novel protein kinase D: Caenorhabditis elegans DKF-1 is activated by translocation-phosphorylation and regulates movement and growth in vivo. J Biol Chem (2006) 0.89
Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D. J Biol Chem (2006) 0.87
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem (2002) 2.06
Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms. J Biol Chem (2004) 1.51
Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa,L. Circ Res (2003) 1.47
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I. J Biol Chem (2008) 1.46
Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes. J Biol Chem (2004) 1.43
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation (2003) 1.36
Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations. J Biol Chem (2003) 1.35
Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart. J Biol Chem (2008) 1.29
Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure. Mol Cell Biochem (2003) 1.20
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. Circ Res (2009) 1.12
Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanism. J Biol Chem (2003) 1.10
Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation. Am J Physiol Endocrinol Metab (2010) 1.09
DUSP1 is controlled by p53 during the cellular response to oxidative stress. Mol Cancer Res (2008) 1.09
Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes. J Biol Chem (2007) 1.07
Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem (2004) 1.06
Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains. Mol Pharmacol (2003) 1.05
Mechanisms of protease-activated receptor-4 actions in cardiomyocytes. Role of Src tyrosine kinase. J Biol Chem (2003) 0.99
Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes. Circ Res (2006) 0.98
Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility. Circ Res (2002) 0.98
Reactive oxygen species decrease cAMP response element binding protein expression in cardiomyocytes via a protein kinase D1-dependent mechanism that does not require Ser133 phosphorylation. Mol Pharmacol (2009) 0.97
Phorbol 12-myristate 13-acetate-dependent protein kinase C delta-Tyr311 phosphorylation in cardiomyocyte caveolae. J Biol Chem (2008) 0.93
Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3. Am J Physiol Heart Circ Physiol (2003) 0.93
c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. J Biol Chem (2011) 0.93
Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes. J Biol Chem (2010) 0.92
Distinct signaling functions for Shc isoforms in the heart. J Biol Chem (2006) 0.92
Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. J Mol Cell Cardiol (2012) 0.90
Redox signaling and cardiac sarcomeres. J Biol Chem (2011) 0.88
Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295. Biochemistry (2009) 0.86
Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation. Diabetes (2009) 0.85
Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis. Circ Res (2007) 0.85
Beta 2-adrenergic receptor signaling acts via NO release to mediate ACh-induced activation of ATP-sensitive K+ current in cat atrial myocytes. J Gen Physiol (2002) 0.84
Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes. Am J Physiol Cell Physiol (2010) 0.84
Immunoblotting PKC-delta: a cautionary note from the bench. Am J Physiol Cell Physiol (2005) 0.83
Raf-1: a novel cardiac troponin T kinase. J Muscle Res Cell Motil (2009) 0.82
S49G and R389G polymorphisms of the β₁-adrenergic receptor influence signaling via the cAMP-PKA and ERK pathways. Physiol Genomics (2013) 0.82
G protein betagamma dimer expression in cardiomyocytes: developmental acquisition of Gbeta3. Biochem Biophys Res Commun (2008) 0.80
Age-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatin. Pflugers Arch (2008) 0.79
Alpha(1)-adrenergic receptor subtype function in cardiomyocytes: lessons from genetic models in mice. J Mol Cell Cardiol (2002) 0.78
Cardiac hypertrophy served with protein kinase Cepsilon: delta isoform substitution available at additional cost. Circ Res (2005) 0.78
Focus on "targeted expression of activated Q227L G(alpha)(s) in vivo". Am J Physiol Cell Physiol (2002) 0.76
Regulatory domain determinants that control PKD1 activity. J Biol Chem (2012) 0.75